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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR6P1 Gene

protein-coding   GIFtS: 39
GCID: GC01M158532

Olfactory Receptor, Family 6, Subfamily P, Member 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 6, Subfamily P, Member 11 2
Olfactory Receptor OR1-122 3
Olfactory Receptor 6P12
Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 150361   Entrez Gene: 1283662   Ensembl: ENSG000001864407   UniProtKB: Q8NGX93   

Export aliases for OR6P1 gene to outside databases

Previous GC identifers: GC01U990384 GC01M155750 GC01M155345 GC01M156799


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6P1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6P1 Gene: 
OR6P1 (olfactory receptor, family 6, subfamily P, member 1) is a protein-coding gene. Diseases associated with OR6P1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6B1.

UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6P1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OR6P1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

OR6P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6P1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158532:  view genomic region     (about GC identifiers)

Start:
158,532,444 bp from pter      End:
158,533,394 bp from pter
Size:
951 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9 (See protein sequence)
Recommended Name: Olfactory receptor 6P1  
Size: 317 amino acids; 35831 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IFR9

Explore the universe of human proteins at neXtProt for OR6P1: NX_Q8NGX9

Explore proteomics data for OR6P1 at MOPED 

HORDE protein sequence for OR6P1
OR6P1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR6P1 Protein Expression

REFSEQ proteins: NP_001153797.1  
ENSEMBL proteins: 
 ENSP00000334721  
Reactome Protein details: Q8NGX9
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane IEA--

OR6P1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR6: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGX9

ProtoNet protein and cluster: Q8NGX9

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9
Similarity: Belongs to the G-protein coupled receptor 1 family


OR6P1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR6P1_HUMAN, Q8NGX9
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
OR6P1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR6P1 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR6P1
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR6P1):
    Olfactory transduction


OR6P1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6P1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/271 Interacting proteins for OR6P1 (ENSP000003347214) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
OR10A3ENSP000003539884STRING: ENSP00000353988
OR10A4ENSP000003691574STRING: ENSP00000369157
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

OR6P1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR6P1

Search CenterWatch for drugs/clinical trials and news about OR6P1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR6P1 gene: 
NM_001160325.1  

Unigene Cluster for OR6P1:

Olfactory receptor, family 6, subfamily P, member 1
Hs.723122
Unigene Representative Sequence: NM_001160325
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000334632(uc010pim.2)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR6P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
OR6P1 Expression
About this image


See OR6P1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.723122
    SABiosciences Custom PCR Arrays for OR6P1
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR6P1 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr4141 , 5 olfactory receptor 4141, 5 86.01(n)1
89.91(a)1
  1 (81.01 cM)5
2587561  NM_146761.21  NP_666972.21 
 1744304305 
chicken
(Gallus gallus)
Aves COR7A6
chick olfactory receptor 7a
50(a)
possible ortholog
10(276437-277408)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
55(a)
53(a)
possible ortholog
possible ortholog
GL343253.1(670958-672170)
GL343253.1(663313-664281)


ENSEMBL Gene Tree for OR6P1 (if available)
TreeFam Gene Tree for OR6P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR6P1 gene
OR6B12  OR6Q12  OR2AT42  OR6Y12  OR6B32  OR6B22  OR6A22  OR11L12  
18/452 SIMAP similar genes for OR6P1 using alignment to 1 protein entry:     OR6P1_HUMAN(see all similar genes):
OR6A2    OR6Y1    OR6B2    OR6B3    OR6B1    OR1L4
OR5A1    OR5F1    OR11A1    OR10J4    OR10Z1    OR1L6
OR5A2    OR8H3    OR10A4    OR10T2    OR11L1    OR2AK2

OR6P1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/109 SNPs in OR6P1 are shown (see all 109)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1451869451,2
C--158532052(+) TTATAA/TTTTCT 1 -- ds50010--------
rs75121171,2
C,F,A,H--158532064(+) ACTTAT/CGAAAT 1 -- ds50016Minor allele frequency- C:0.43WA NA EA 370
rs75341121,2
C,F,A,H--158532065(+) CTTACA/GAAATA 1 -- ds50018Minor allele frequency- G:0.36NA WA EA 374
rs1824225071,2
--158532131(+) GGAAGA/TTTTGA 1 -- ds50010--------
rs104898361,2
C,F,H--158532183(+) AGACTC/TTCCAC 1 -- ds500117Minor allele frequency- T:0.02NS NA EA 786
rs1870978491,2
C--158532198(+) TTTTTG/TGGGGG 1 -- ds50010--------
rs1148594611,2
C,F--158532202(+) TTGGGG/AGAATC 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1919010551,2
--158532255(+) CAACCA/TTAGTT 1 -- ds50010--------
rs75343191,2
C,F,A,H--158532295(+) ATAAAC/GTTTCA 1 -- ds500124Minor allele frequency- G:0.44NS NA EA WA CSA 1039
rs1843758631,2
--158532353(+) TTATAG/TTTATG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for OR6P1 ( 158532444 - 158533394 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for OR6P1: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR6P1:    About MalaCards
neuronitis    


OR6P1 for disorders           About GeneDecksing


Export disorders for OR6P1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR6P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR6P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)1 Menashe I....Lancet D. (2006)
  4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 128366 HGNC: 15036 Ensembl:ENSG00000186440 euGenes: HUgn128366 ECgene: OR6P1 Kegg: 128366
H-InvDB: OR6P1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR6P1 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6P1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR6P1 gene:
Search GeneIP for patents involving OR6P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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