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Aliases for OR6N2 Gene

Aliases for OR6N2 Gene

  • Olfactory Receptor Family 6 Subfamily N Member 2 2 3 5
  • Olfactory Receptor, Family 6, Subfamily N, Member 2 2 3
  • Olfactory Receptor OR1-23 3 4
  • OR1-23 3

External Ids for OR6N2 Gene

Previous GeneCards Identifiers for OR6N2 Gene

  • GC01U990385
  • GC01M155559
  • GC01M157014
  • GC01M158746

Summaries for OR6N2 Gene

Entrez Gene Summary for OR6N2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6N2 Gene

OR6N2 (Olfactory Receptor Family 6 Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR11G2.

UniProtKB/Swiss-Prot for OR6N2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6N2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6N2 Gene

Genomics for OR6N2 Gene

Regulatory Elements for OR6N2 Gene

Enhancers for OR6N2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR6N2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6N2 Gene

Chromosome:
1
Start:
158,776,682 bp from pter
End:
158,777,635 bp from pter
Size:
954 bases
Orientation:
Minus strand

Genomic View for OR6N2 Gene

Genes around OR6N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6N2 Gene

Proteins for OR6N2 Gene

  • Protein details for OR6N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY6-OR6N2_HUMAN
    Recommended name:
    Olfactory receptor 6N2
    Protein Accession:
    Q8NGY6
    Secondary Accessions:
    • Q6IFR2

    Protein attributes for OR6N2 Gene

    Size:
    317 amino acids
    Molecular mass:
    35692 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6N2 Gene

Proteomics data for OR6N2 Gene at MOPED

Post-translational modifications for OR6N2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6N2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6N2 Gene

Domains & Families for OR6N2 Gene

Gene Families for OR6N2 Gene

Protein Domains for OR6N2 Gene

Suggested Antigen Peptide Sequences for OR6N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGY6

UniProtKB/Swiss-Prot:

OR6N2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6N2: view

Function for OR6N2 Gene

Molecular function for OR6N2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR6N2: view
genes like me logo Genes that share phenotypes with OR6N2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6N2 Gene

Localization for OR6N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6N2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6N2 Gene COMPARTMENTS Subcellular localization image for OR6N2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR6N2: view

Pathways & Interactions for OR6N2 Gene

genes like me logo Genes that share pathways with OR6N2: view

Pathways by source for OR6N2 Gene

Interacting Proteins for OR6N2 Gene

Gene Ontology (GO) - Biological Process for OR6N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6N2: view

No data available for SIGNOR curated interactions for OR6N2 Gene

Drugs & Compounds for OR6N2 Gene

No Compound Related Data Available

Transcripts for OR6N2 Gene

mRNA/cDNA for OR6N2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6N2 Gene

No ASD Table

Relevant External Links for OR6N2 Gene

GeneLoc Exon Structure for
OR6N2
ECgene alternative splicing isoforms for
OR6N2

Expression for OR6N2 Gene

mRNA expression in normal human tissues for OR6N2 Gene

Protein differential expression in normal tissues from HIPED for OR6N2 Gene

This gene is overexpressed in Heart (48.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6N2 Gene



SOURCE GeneReport for Unigene cluster for OR6N2 Gene Hs.554487

genes like me logo Genes that share expression patterns with OR6N2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6N2 Gene

Orthologs for OR6N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6N2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC790121 35
  • 87.22 (n)
  • 86.58 (a)
OR6N2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488619 35
  • 86.5 (n)
  • 88.29 (a)
OR6N2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr430 35
  • 84.6 (n)
  • 86.08 (a)
Olfr430 16
Olfr430 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC744684 35
  • 99.37 (n)
  • 98.42 (a)
OR6N2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1588 35
  • 83.23 (n)
  • 85.13 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734698 35
  • 56.22 (n)
  • 51.49 (a)
Species with no ortholog for OR6N2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6N2 Gene

ENSEMBL:
Gene Tree for OR6N2 (if available)
TreeFam:
Gene Tree for OR6N2 (if available)

Paralogs for OR6N2 Gene

(457) SIMAP similar genes for OR6N2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6N2 Gene

genes like me logo Genes that share paralogs with OR6N2: view

Variants for OR6N2 Gene

Sequence variations from dbSNP and Humsavar for OR6N2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12027473 - 158,777,025(+) TGAAA(A/G)CATTA reference, missense
rs41273541 - 158,776,888(+) GAAGA(C/T)GAGGA reference, missense
rs857835 -- 158,777,702(+) GCCAA(A/G)ACTTC upstream-variant-2KB
rs857836 -- 158,778,769(+) CAGCA(C/T)TTTGG upstream-variant-2KB
rs1652291 -- 158,778,253(+) CCCTG(C/T)AGAGA upstream-variant-2KB

Variation tolerance for OR6N2 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OR6N2 Gene

Disorders for OR6N2 Gene

Relevant External Links for OR6N2

Genetic Association Database (GAD)
OR6N2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6N2

No disorders were found for OR6N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6N2 Gene

Publications for OR6N2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67

Products for OR6N2 Gene

Sources for OR6N2 Gene

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