Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR6N1 Gene

Aliases for OR6N1 Gene

  • Olfactory Receptor Family 6 Subfamily N Member 1 2 3 5
  • Olfactory Receptor, Family 6, Subfamily N, Member 1 2
  • Olfactory Receptor OR1-22 3
  • Olfactory Receptor 6N1 3
  • OR1-22 3

External Ids for OR6N1 Gene

Previous GeneCards Identifiers for OR6N1 Gene

  • GC01U990386
  • GC01M155632
  • GC01M155548
  • GC01M157002
  • GC01M158735

Summaries for OR6N1 Gene

Entrez Gene Summary for OR6N1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6N1 Gene

OR6N1 (Olfactory Receptor Family 6 Subfamily N Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N2.

UniProtKB/Swiss-Prot for OR6N1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6N1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6N1 Gene

Genomics for OR6N1 Gene

Regulatory Elements for OR6N1 Gene

Enhancers for OR6N1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F159141 1 FANTOM5 Ensembl 15.9 -375.4 -375407 1.0 TBP SREBF2 SIN3A REST POLR2H JUND SMARCA4 POLR3A POLR2A ZBTB48 OR6K3 OR6N1 FCER1A CADM3 ACKR1 CADM3-AS1 OR6N2 OR10J5 AIM2 OR10J1
GH01F158799 1.1 FANTOM5 Ensembl 11.2 -35.3 -35319 4.8 CBX3 TAL1 JUN ZNF175 ZNF316 FOXK2 TRIM24 ZNF584 E2F6 MAFK MNDA OR6N1 OR6N2 PYHIN1 IFI16 OR10AA1P OR2AQ1P
GH01F158808 0.6 FANTOM5 Ensembl 10.4 -44.6 -44619 5.4 MNDA OR6N2 OR6N1 OR6K2 PYHIN1 IFI16 OR10AA1P
GH01F158969 0.6 ENCODE 10.1 -203.3 -203318 1.1 ARID1B PKNOX1 ATF3 PBX2 TAL1 NFE2 FOS KDM1A OR6N2 OR6N1 OR10X1 ACKR1 PIR57461 IFI16
GH01F158654 0.5 Ensembl ENCODE 10 +111.8 111809 0.9 SPTA1 OR6K2 OR6N1 OR6P1 OR6K6 OR10Z1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6N1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6N1 Gene

Chromosome:
1
Start:
158,765,744 bp from pter
End:
158,766,682 bp from pter
Size:
939 bases
Orientation:
Minus strand

Genomic View for OR6N1 Gene

Genes around OR6N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6N1 Gene

Proteins for OR6N1 Gene

  • Protein details for OR6N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY5-OR6N1_HUMAN
    Recommended name:
    Olfactory receptor 6N1
    Protein Accession:
    Q8NGY5
    Secondary Accessions:
    • Q5VUU8
    • Q96R35

    Protein attributes for OR6N1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34869 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6N1 Gene

Post-translational modifications for OR6N1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6N1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6N1 Gene

Domains & Families for OR6N1 Gene

Gene Families for OR6N1 Gene

Protein Domains for OR6N1 Gene

Suggested Antigen Peptide Sequences for OR6N1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NGY5

UniProtKB/Swiss-Prot:

OR6N1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6N1: view

Function for OR6N1 Gene

Molecular function for OR6N1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6N1: view

Phenotypes for OR6N1 Gene

genes like me logo Genes that share phenotypes with OR6N1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6N1 Gene

Localization for OR6N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6N1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6N1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6N1: view

Pathways & Interactions for OR6N1 Gene

genes like me logo Genes that share pathways with OR6N1: view

Pathways by source for OR6N1 Gene

Gene Ontology (GO) - Biological Process for OR6N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA,IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6N1: view

No data available for SIGNOR curated interactions for OR6N1 Gene

Transcripts for OR6N1 Gene

mRNA/cDNA for OR6N1 Gene

(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6N1 Gene

No ASD Table

Relevant External Links for OR6N1 Gene

GeneLoc Exon Structure for
OR6N1
ECgene alternative splicing isoforms for
OR6N1

Expression for OR6N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6N1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6N1 Gene:

OR6N1

SOURCE GeneReport for Unigene cluster for OR6N1 Gene:

Hs.553592
genes like me logo Genes that share expression patterns with OR6N1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR6N1 Gene

Orthologs for OR6N1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6N1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469536 34
  • 99.25 (n)
OR6N1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR16E08 35
  • 87 (a)
OneToOne
OR6N1 34
  • 84.52 (n)
cow
(Bos Taurus)
Mammalia OR6N1 34 35
  • 86.71 (n)
mouse
(Mus musculus)
Mammalia Or6n1 55 Olfr429 34 16 35
  • 85.32 (n)
oppossum
(Monodelphis domestica)
Mammalia OR6N1 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1589 34
  • 84.94 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496592 34
  • 56.17 (n)
Species where no ortholog for OR6N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6N1 Gene

ENSEMBL:
Gene Tree for OR6N1 (if available)
TreeFam:
Gene Tree for OR6N1 (if available)

Paralogs for OR6N1 Gene

(459) SIMAP similar genes for OR6N1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6N1: view

Variants for OR6N1 Gene

Sequence variations from dbSNP and Humsavar for OR6N1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10218787 -- 158,828,823(+) cttct(G/T)cctgg intron-variant
rs10489843 -- 158,750,968(+) CCTTA(C/T)GAATC intron-variant
rs10489844 -- 158,758,599(+) TCTCT(C/T)CTATT intron-variant
rs10680954 -- 158,779,032(+) AAAAA(-/AAAAAAAAA)GAATG intron-variant, upstream-variant-2KB
rs1102289 -- 158,823,165(+) ctgaa(G/T)atttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR6N1 Gene

Variant ID Type Subtype PubMed ID
nsv997861 CNV loss 25217958
nsv824975 CNV loss 20364138
nsv1002401 CNV loss 25217958
dgv589n54 CNV loss 21841781

Variation tolerance for OR6N1 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.56; 82.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6N1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6N1 Gene

Disorders for OR6N1 Gene

Relevant External Links for OR6N1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6N1

No disorders were found for OR6N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6N1 Gene

Publications for OR6N1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR6N1 Gene

Sources for OR6N1 Gene

Content
Loading form....