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Aliases for OR6K3 Gene

Aliases for OR6K3 Gene

  • Olfactory Receptor Family 6 Subfamily K Member 3 2 3 5
  • Olfactory Receptor, Family 6, Subfamily K, Member 3 2 3
  • Olfactory Receptor OR1-18 3 4
  • Seven Transmembrane Helix Receptor 3
  • OR1-18 3

External Ids for OR6K3 Gene

Previous GeneCards Identifiers for OR6K3 Gene

  • GC01U990390
  • GC01M155905
  • GC01M155500
  • GC01M156953

Summaries for OR6K3 Gene

Entrez Gene Summary for OR6K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K3 Gene

OR6K3 (Olfactory Receptor Family 6 Subfamily K Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR11G2.

UniProtKB/Swiss-Prot for OR6K3 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6K3 Gene

Genomics for OR6K3 Gene

Regulatory Elements for OR6K3 Gene

Enhancers for OR6K3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR6K3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6K3 Gene

158,717,168 bp from pter
158,718,163 bp from pter
996 bases
Minus strand

Genomic View for OR6K3 Gene

Genes around OR6K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K3 Gene

Proteins for OR6K3 Gene

  • Protein details for OR6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6K3
    Protein Accession:
    Secondary Accessions:
    • Q5VUV0
    • Q6IFR5

    Protein attributes for OR6K3 Gene

    331 amino acids
    Molecular mass:
    37352 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05859.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR6K3 Gene

Proteomics data for OR6K3 Gene at MOPED

Post-translational modifications for OR6K3 Gene

  • Glycosylation at Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K3 Gene

Domains & Families for OR6K3 Gene

Gene Families for OR6K3 Gene

Protein Domains for OR6K3 Gene

Suggested Antigen Peptide Sequences for OR6K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K3: view

Function for OR6K3 Gene

Molecular function for OR6K3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K3: view
genes like me logo Genes that share phenotypes with OR6K3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K3 Gene

Localization for OR6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6K3 Gene COMPARTMENTS Subcellular localization image for OR6K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with OR6K3: view

Pathways & Interactions for OR6K3 Gene

genes like me logo Genes that share pathways with OR6K3: view

Pathways by source for OR6K3 Gene

Interacting Proteins for OR6K3 Gene

Gene Ontology (GO) - Biological Process for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6K3: view

No data available for SIGNOR curated interactions for OR6K3 Gene

Drugs & Compounds for OR6K3 Gene

No Compound Related Data Available

Transcripts for OR6K3 Gene

mRNA/cDNA for OR6K3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K3 Gene

No ASD Table

Relevant External Links for OR6K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6K3 Gene

mRNA expression in normal human tissues for OR6K3 Gene

mRNA differential expression in normal tissues according to GTEx for OR6K3 Gene

This gene is overexpressed in Lung (x22.6), Whole Blood (x19.0), and Testis (x4.9).

SOURCE GeneReport for Unigene cluster for OR6K3 Gene Hs.554488

genes like me logo Genes that share expression patterns with OR6K3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6K3 Gene

Orthologs for OR6K3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC607515 35
  • 84.74 (n)
  • 84.74 (a)
OR6K3 36
  • 79 (a)
(Pan troglodytes)
Mammalia LOC744589 35
  • 98.52 (n)
  • 97.46 (a)
OR6K3 36
  • 93 (a)
(Bos Taurus)
Mammalia OR6K3 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
-- 36
  • 73 (a)
(Mus musculus)
Mammalia Olfr424 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
Species with no ortholog for OR6K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K3 Gene

Gene Tree for OR6K3 (if available)
Gene Tree for OR6K3 (if available)

Paralogs for OR6K3 Gene

(454) SIMAP similar genes for OR6K3 Gene using alignment to 1 proteins: Pseudogenes for OR6K3 Gene

genes like me logo Genes that share paralogs with OR6K3: view

Variants for OR6K3 Gene

Sequence variations from dbSNP and Humsavar for OR6K3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs857705 - 158,718,106(+) GTTTC(C/T)GCTCT reference, missense
rs857703 - 158,717,434(+) AGAGG(A/G)AATCC reference, missense
rs28568406 - 158,717,373(+) ATATC(A/G)GGAAG reference, missense
rs16840675 - 158,717,241(+) TGTTT(C/T)TCAGG reference, missense
rs857704 - 158,717,687(+) GAGAG(C/G/T)TGAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR6K3 Gene

Variant ID Type Subtype PubMed ID
dgv394n71 CNV Loss 21882294

Variation tolerance for OR6K3 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.02; 95.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR6K3 Gene

Disorders for OR6K3 Gene

Relevant External Links for OR6K3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6K3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K3 Gene

Publications for OR6K3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for OR6K3 Gene

Sources for OR6K3 Gene