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Aliases for OR6K3 Gene

Aliases for OR6K3 Gene

  • Olfactory Receptor, Family 6, Subfamily K, Member 3 2 3
  • Olfactory Receptor OR1-18 3 4
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor 6K3 3
  • OR1-18 3

External Ids for OR6K3 Gene

Summaries for OR6K3 Gene

Entrez Gene Summary for OR6K3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K3 Gene

OR6K3 (Olfactory Receptor, Family 6, Subfamily K, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6N1.

UniProtKB/Swiss-Prot for OR6K3 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6K3 Gene

Genomics for OR6K3 Gene

Genomic Location for OR6K3 Gene

Start:
158,717,168 bp from pter
End:
158,718,163 bp from pter
Size:
996 bases
Orientation:
Minus strand

Genomic View for OR6K3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K3 Gene

Regulatory Elements for OR6K3 Gene

Proteins for OR6K3 Gene

  • Protein details for OR6K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY3-OR6K3_HUMAN
    Recommended name:
    Olfactory receptor 6K3
    Protein Accession:
    Q8NGY3
    Secondary Accessions:
    • Q5VUV0
    • Q6IFR5

    Protein attributes for OR6K3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37352 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05859.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OR6K3 Gene

Proteomics data for OR6K3 Gene at MOPED

Post-translational modifications for OR6K3 Gene

Other Protein References for OR6K3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR6K3 Gene

Domains for OR6K3 Gene

Gene Families for OR6K3 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6K3 Gene

Suggested Antigen Peptide Sequences for OR6K3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGY3

UniProtKB/Swiss-Prot:

OR6K3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGY3
genes like me logo Genes that share domains with OR6K3: view

Function for OR6K3 Gene

Molecular function for OR6K3 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K3: view

Phenotypes for OR6K3 Gene

GenomeRNAi human phenotypes for OR6K3:
genes like me logo Genes that share phenotypes with OR6K3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR6K3 Gene

Localization for OR6K3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6K3 Gene COMPARTMENTS Subcellular localization image for OR6K3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6K3: view

Pathways for OR6K3 Gene

genes like me logo Genes that share pathways with OR6K3: view

Pathways by source for OR6K3 Gene

Interacting Proteins for OR6K3 Gene

Gene Ontology (GO) - Biological Process for OR6K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6K3: view

Transcripts for OR6K3 Gene

mRNA/cDNA for OR6K3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K3 Gene

No ASD Table

Relevant External Links for OR6K3 Gene

GeneLoc Exon Structure for
OR6K3
ECgene alternative splicing isoforms for
OR6K3

Expression for OR6K3 Gene

mRNA expression in normal human tissues for OR6K3 Gene

mRNA differential expression in normal tissues according to GTEx for OR6K3 Gene

This gene is overexpressed in Lung (22.6), Whole Blood (19.0), and Testis (4.9).

SOURCE GeneReport for Unigene cluster for OR6K3 Gene Hs.554488

genes like me logo Genes that share expressions with OR6K3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR6K3 Gene

Orthologs for OR6K3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC744589 35
  • 98.52 (n)
  • 97.46 (a)
OR6K3 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR6K3 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607515 35
  • 84.74 (n)
  • 84.74 (a)
OR6K3 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr424 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
ManyToMany
Species with no ortholog for OR6K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K3 Gene

ENSEMBL:
Gene Tree for OR6K3 (if available)
TreeFam:
Gene Tree for OR6K3 (if available)

Paralogs for OR6K3 Gene

Paralogs for OR6K3 Gene

Selected SIMAP similar genes for OR6K3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6K3 Gene

genes like me logo Genes that share paralogs with OR6K3: view

Variants for OR6K3 Gene

Sequence variations from dbSNP and Humsavar for OR6K3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs857700 -- 158,717,066(+) tgagc(C/T)aagat downstream-variant-500B
rs857701 -- 158,717,219(+) TTAAT(C/T)GCATT synonymous-codon, reference
rs857702 - 158,717,329(+) AGTGT(C/T)GCTGA missense, reference
rs857703 - 158,717,434(+) AGAGG(A/G)AATCC reference, missense
rs857704 - 158,717,687(+) GAGAG(C/G/T)TGAGC reference, missense, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR6K3 Gene

Variant ID Type Subtype PubMed ID
dgv394n71 CNV Loss 21882294

Relevant External Links for OR6K3 Gene

HapMap Linkage Disequilibrium report
OR6K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K3 Gene

Disorders for OR6K3 Gene

No disorders were found for OR6K3 Gene.

No data available for UniProtKB/Swiss-Prot for OR6K3 Gene

Publications for OR6K3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4

Products for OR6K3 Gene

Sources for OR6K3 Gene

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