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Aliases for OR6K2 Gene

Aliases for OR6K2 Gene

  • Olfactory Receptor, Family 6, Subfamily K, Member 2 2 3
  • Olfactory Receptor OR1-17 3 4
  • OR1-17 3

External Ids for OR6K2 Gene

Previous GeneCards Identifiers for OR6K2 Gene

  • GC01U990391
  • GC01M155482
  • GC01M156937

Summaries for OR6K2 Gene

Entrez Gene Summary for OR6K2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6K2 Gene

OR6K2 (Olfactory Receptor, Family 6, Subfamily K, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is OR6K3.

UniProtKB/Swiss-Prot for OR6K2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6K2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6K2 Gene

Genomics for OR6K2 Gene

Regulatory Elements for OR6K2 Gene

Genomic Location for OR6K2 Gene

Chromosome:
1
Start:
158,699,678 bp from pter
End:
158,700,652 bp from pter
Size:
975 bases
Orientation:
Minus strand

Genomic View for OR6K2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6K2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6K2 Gene

Proteins for OR6K2 Gene

  • Protein details for OR6K2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGY2-OR6K2_HUMAN
    Recommended name:
    Olfactory receptor 6K2
    Protein Accession:
    Q8NGY2
    Secondary Accessions:
    • B9EH33
    • Q6IFR6

    Protein attributes for OR6K2 Gene

    Size:
    324 amino acids
    Molecular mass:
    36513 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6K2 Gene

Proteomics data for OR6K2 Gene at MOPED

Post-translational modifications for OR6K2 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6K2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6K2 Gene

Domains & Families for OR6K2 Gene

Gene Families for OR6K2 Gene

Suggested Antigen Peptide Sequences for OR6K2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGY2

UniProtKB/Swiss-Prot:

OR6K2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6K2: view

Function for OR6K2 Gene

Molecular function for OR6K2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6K2: view

Phenotypes for OR6K2 Gene

GenomeRNAi human phenotypes for OR6K2:
genes like me logo Genes that share phenotypes with OR6K2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6K2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6K2 Gene

Localization for OR6K2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6K2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6K2 Gene COMPARTMENTS Subcellular localization image for OR6K2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6K2: view

Pathways & Interactions for OR6K2 Gene

genes like me logo Genes that share pathways with OR6K2: view

Pathways by source for OR6K2 Gene

Interacting Proteins for OR6K2 Gene

Gene Ontology (GO) - Biological Process for OR6K2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050907 detection of chemical stimulus involved in sensory perception IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6K2: view

No data available for SIGNOR curated interactions for OR6K2 Gene

Drugs & Compounds for OR6K2 Gene

No Compound Related Data Available

Transcripts for OR6K2 Gene

mRNA/cDNA for OR6K2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6K2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6K2 Gene

No ASD Table

Relevant External Links for OR6K2 Gene

GeneLoc Exon Structure for
OR6K2
ECgene alternative splicing isoforms for
OR6K2

Expression for OR6K2 Gene

mRNA expression in normal human tissues for OR6K2 Gene

Protein differential expression in normal tissues from HIPED for OR6K2 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6K2 Gene



SOURCE GeneReport for Unigene cluster for OR6K2 Gene Hs.554489

genes like me logo Genes that share expression patterns with OR6K2: view

Protein tissue co-expression partners for OR6K2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6K2 Gene

Orthologs for OR6K2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6K2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR6K2 35
  • 87.47 (n)
  • 85.99 (a)
OR6K2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr420 35
  • 84.57 (n)
  • 87.14 (a)
Olfr420 16
Olfr420 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC744555 35
  • 98.35 (n)
  • 96.3 (a)
OR6K2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1596 35
  • 83.17 (n)
  • 87.14 (a)
dog
(Canis familiaris)
Mammalia OR6K2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for OR6K2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6K2 Gene

ENSEMBL:
Gene Tree for OR6K2 (if available)
TreeFam:
Gene Tree for OR6K2 (if available)

Paralogs for OR6K2 Gene

Paralogs for OR6K2 Gene

(447) SIMAP similar genes for OR6K2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6K2 Gene

genes like me logo Genes that share paralogs with OR6K2: view

Variants for OR6K2 Gene

Sequence variations from dbSNP and Humsavar for OR6K2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6686179 - 158,700,178(+) GGCAA(A/T)CTCAG reference, missense
rs423141 - 158,700,187(-) CACCC(C/G)TTCCT reference, missense
rs413029 - 158,700,636(-) CAATC(A/G)AACCA missense, reference
rs781501189 -- 158,699,868(+) AGAAG(C/T)GTAGG missense, reference
rs781434431 -- 158,700,355(+) ATACA(A/T)CTGCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR6K2 Gene

Variant ID Type Subtype PubMed ID
dgv394n71 CNV Loss 21882294

Variation tolerance for OR6K2 Gene

Residual Variation Intolerance Score: 95.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6K2 Gene

HapMap Linkage Disequilibrium report
OR6K2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6K2 Gene

Disorders for OR6K2 Gene

Relevant External Links for OR6K2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6K2
genes like me logo Genes that share disorders with OR6K2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6K2 Gene

Publications for OR6K2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR6K2 Gene

Sources for OR6K2 Gene

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