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Aliases for OR6F1 Gene

Aliases for OR6F1 Gene

  • Olfactory Receptor, Family 6, Subfamily F, Member 1 2 3
  • Olfactory Receptor OR1-38 3 4
  • Olfactory Receptor OR1-34 Pseudogene 3
  • Olfactory Receptor 6F1 3
  • OR1-34 3
  • OR1-38 3
  • OST731 3

External Ids for OR6F1 Gene

Summaries for OR6F1 Gene

Entrez Gene Summary for OR6F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6F1 Gene

OR6F1 (Olfactory Receptor, Family 6, Subfamily F, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR9A4.

UniProtKB/Swiss-Prot for OR6F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6F1 Gene

Genomics for OR6F1 Gene

Genomic Location for OR6F1 Gene

Start:
247,711,829 bp from pter
End:
247,712,755 bp from pter
Size:
927 bases
Orientation:
Minus strand

Genomic View for OR6F1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6F1 Gene

Regulatory Elements for OR6F1 Gene

Proteins for OR6F1 Gene

  • Protein details for OR6F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGZ6-OR6F1_HUMAN
    Recommended name:
    Olfactory receptor 6F1
    Protein Accession:
    Q8NGZ6
    Secondary Accessions:
    • B2RNV6
    • Q6IF02
    • Q96R39

    Protein attributes for OR6F1 Gene

    Size:
    308 amino acids
    Molecular mass:
    33961 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6F1 Gene

Proteomics data for OR6F1 Gene at MOPED

Post-translational modifications for OR6F1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn5

Other Protein References for OR6F1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR6F1 Gene

Domains for OR6F1 Gene

Gene Families for OR6F1 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6F1 Gene

UniProtKB/Swiss-Prot:

OR6F1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGZ6
genes like me logo Genes that share domains with OR6F1: view

Function for OR6F1 Gene

Molecular function for OR6F1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6F1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR6F1 Gene

Localization for OR6F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6F1 Gene COMPARTMENTS Subcellular localization image for OR6F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6F1: view

Pathways for OR6F1 Gene

genes like me logo Genes that share pathways with OR6F1: view

Pathways by source for OR6F1 Gene

Interacting Proteins for OR6F1 Gene

Gene Ontology (GO) - Biological Process for OR6F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6F1: view

Transcripts for OR6F1 Gene

mRNA/cDNA for OR6F1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6F1 Gene

Olfactory receptor, family 6, subfamily F, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR6F1 Gene

No ASD Table

Relevant External Links for OR6F1 Gene

GeneLoc Exon Structure for
OR6F1
ECgene alternative splicing isoforms for
OR6F1

Expression for OR6F1 Gene

mRNA expression in normal human tissues for OR6F1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6F1 Gene

This gene is overexpressed in Testis (44.4).

SOURCE GeneReport for Unigene cluster for OR6F1 Gene Hs.591529

genes like me logo Genes that share expressions with OR6F1: view

Orthologs for OR6F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6F1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC469750 36
  • 98.92 (n)
  • 98.05 (a)
OR6F1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR6F1 36
  • 86.36 (n)
  • 89.94 (a)
OR6F1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC482210 36
  • 86.26 (n)
  • 89.61 (a)
OR6F1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr308 36
  • 79.65 (n)
  • 83.12 (a)
Olfr308 16
Olfr308 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR6F1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909966 36
  • 81.26 (n)
  • 83.99 (a)
lizard
(Anolis carolinensis)
Reptilia OR6F1 37
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii or101-1 37
  • 35 (a)
OneToMany
Species with no ortholog for OR6F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OR6F1 Gene

ENSEMBL:
Gene Tree for OR6F1 (if available)
TreeFam:
Gene Tree for OR6F1 (if available)

Paralogs for OR6F1 Gene

Paralogs for OR6F1 Gene

Selected SIMAP similar genes for OR6F1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6F1: view

Variants for OR6F1 Gene

Sequence variations from dbSNP and Humsavar for OR6F1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1416105 -- 247,714,369(-) TATAA(A/G)GGTTA upstream-variant-2KB
rs1416106 -- 247,714,250(-) GGGGC(A/G)GCCAG upstream-variant-2KB
rs2282316 - 247,712,113(-) TCACC(C/T)TTGTC missense, reference
rs2282317 -- 247,711,490(-) TTGTC(C/T)TAGTA downstream-variant-500B
rs6587382 -- 247,712,306(+) CCACA(C/G)ACCCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for OR6F1 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv5310 CNV Loss 18451855
nsv873441 CNV Loss 21882294

Relevant External Links for OR6F1 Gene

HapMap Linkage Disequilibrium report
OR6F1

Disorders for OR6F1 Gene

No disorders were found for OR6F1 Gene.

No data available for UniProtKB/Swiss-Prot for OR6F1 Gene

Publications for OR6F1 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y. … Paabo S. (Am. J. Hum. Genet. 2003) 3

Products for OR6F1 Gene

Sources for OR6F1 Gene

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