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Aliases for OR6C74 Gene

Aliases for OR6C74 Gene

  • Olfactory Receptor, Family 6, Subfamily C, Member 74 2 3

External Ids for OR6C74 Gene

Previous GeneCards Identifiers for OR6C74 Gene

  • GC12P053928
  • GC12U900474
  • GC12P055640

Summaries for OR6C74 Gene

Entrez Gene Summary for OR6C74 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C74 Gene

OR6C74 (Olfactory Receptor, Family 6, Subfamily C, Member 74) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C1.

UniProtKB/Swiss-Prot for OR6C74 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C74 Gene

Genomics for OR6C74 Gene

Regulatory Elements for OR6C74 Gene

Genomic Location for OR6C74 Gene

Chromosome:
12
Start:
55,239,762 bp from pter
End:
55,248,302 bp from pter
Size:
8,541 bases
Orientation:
Plus strand

Genomic View for OR6C74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6C74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C74 Gene

Proteins for OR6C74 Gene

  • Protein details for OR6C74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCV1-O6C74_HUMAN
    Recommended name:
    Olfactory receptor 6C74
    Protein Accession:
    A6NCV1

    Protein attributes for OR6C74 Gene

    Size:
    312 amino acids
    Molecular mass:
    35253 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C74 Gene

Proteomics data for OR6C74 Gene at MOPED

Post-translational modifications for OR6C74 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C74 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C74 Gene

Domains & Families for OR6C74 Gene

Gene Families for OR6C74 Gene

Protein Domains for OR6C74 Gene

Suggested Antigen Peptide Sequences for OR6C74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCV1

UniProtKB/Swiss-Prot:

O6C74_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C74: view

Function for OR6C74 Gene

Molecular function for OR6C74 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Phenotypes for OR6C74 Gene

GenomeRNAi human phenotypes for OR6C74:
genes like me logo Genes that share phenotypes with OR6C74: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C74

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C74 Gene

Localization for OR6C74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C74 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6C74 Gene COMPARTMENTS Subcellular localization image for OR6C74 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Pathways & Interactions for OR6C74 Gene

genes like me logo Genes that share pathways with OR6C74: view

Pathways by source for OR6C74 Gene

Interacting Proteins for OR6C74 Gene

Gene Ontology (GO) - Biological Process for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for SIGNOR curated interactions for OR6C74 Gene

Drugs & Compounds for OR6C74 Gene

No Compound Related Data Available

Transcripts for OR6C74 Gene

mRNA/cDNA for OR6C74 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C74 Gene

No ASD Table

Relevant External Links for OR6C74 Gene

GeneLoc Exon Structure for
OR6C74
ECgene alternative splicing isoforms for
OR6C74

Expression for OR6C74 Gene

mRNA expression in normal human tissues for OR6C74 Gene

SOURCE GeneReport for Unigene cluster for OR6C74 Gene Hs.554556

genes like me logo Genes that share expression patterns with OR6C74: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6C74 Gene

Orthologs for OR6C74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC788372 35
  • 89 (n)
  • 87.5 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR6C74 35
  • 88.03 (n)
  • 87.82 (a)
OR6C74 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr821 35
  • 86.02 (n)
  • 88.71 (a)
Olfr821 16
Olfr821 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC467021 35
  • 99.25 (n)
  • 98.72 (a)
OR6C74 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1064 35
  • 85.9 (n)
  • 88.46 (a)
oppossum
(Monodelphis domestica)
Mammalia OR6C74 36
  • 85 (a)
OneToOne
Species with no ortholog for OR6C74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C74 Gene

ENSEMBL:
Gene Tree for OR6C74 (if available)
TreeFam:
Gene Tree for OR6C74 (if available)

Paralogs for OR6C74 Gene

Paralogs for OR6C74 Gene

(452) SIMAP similar genes for OR6C74 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6C74: view

Variants for OR6C74 Gene

Sequence variations from dbSNP and Humsavar for OR6C74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4321039 - 55,247,645(+) ATGAG(C/T)GCTAT reference, missense
rs4337129 -- 55,244,185(+) AGGAA(C/T)GTAAG intron-variant
rs4388990 - 55,247,511(+) TGTCT(A/G)CATTC reference, missense
rs4408392 -- 55,244,524(+) TAAAT(C/T)AGTTA intron-variant
rs4522268 -- 55,247,471(+) TCCTC(C/T)GAAAT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for OR6C74 Gene

Variant ID Type Subtype PubMed ID
nsv899104 CNV Loss 21882294

Variation tolerance for OR6C74 Gene

Residual Variation Intolerance Score: 79.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.02; 98.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C74 Gene

HapMap Linkage Disequilibrium report
OR6C74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C74 Gene

Disorders for OR6C74 Gene

Relevant External Links for OR6C74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6C74
genes like me logo Genes that share disorders with OR6C74: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C74 Gene

Publications for OR6C74 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 67
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR6C74 Gene

Sources for OR6C74 Gene

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