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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR6C74 Gene

protein-coding   GIFtS: 38
GCID: GC12P055640

Olfactory Receptor, Family 6, Subfamily C, Member 74

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 741 2
Olfactory Receptor 6C742

External Ids:    HGNC: 313031   Entrez Gene: 2547832   Ensembl: ENSG000001977067   UniProtKB: A6NCV13   

Export aliases for OR6C74 gene to outside databases

Previous GC identifers: GC12P053928 GC12U900474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6C74 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6C74 Gene: 
OR6C74 (olfactory receptor, family 6, subfamily C, member 74) is a protein-coding gene. Diseases associated with OR6C74 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: O6C74_HUMAN, A6NCV1
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR6C74 gene promoter:
         Max1   POU2F1   POU2F1b   POU2F1a   POU2F1c   Meis-1a   c-Myc   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OR6C74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6C74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

OR6C74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C74 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055640:  view genomic region     (about GC identifiers)

Start:
55,641,072 bp from pter      End:
55,642,007 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: O6C74_HUMAN, A6NCV1 (See protein sequence)
Recommended Name: Olfactory receptor 6C74  
Size: 312 amino acids; 35253 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR6C74: NX_A6NCV1

Explore proteomics data for OR6C74 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NCV1

  • HORDE protein sequence for OR6C74
    OR6C74 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR6C74 Protein Expression
    REFSEQ proteins: NP_001005490.1  
    ENSEMBL proteins: 
     ENSP00000342836  
    Reactome Protein details: A6NCV1
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR6C74 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR6: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry A6NCV1

    ProtoNet protein and cluster: A6NCV1

    UniProtKB/Swiss-Prot: O6C74_HUMAN, A6NCV1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR6C74 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O6C74_HUMAN, A6NCV1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR6C74 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR6C74 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for OR6C74
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR6C74):
        Olfactory transduction


    OR6C74 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6C74

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR6C74 (ENSP000003428364) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR6C74 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR6C74 (O6C74)

    Search CenterWatch for drugs/clinical trials and news about OR6C74 / O6C74

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR6C74 gene: 
    NM_001005490.1  

    Unigene Cluster for OR6C74:

    Olfactory receptor, family 6, subfamily C, member 74
    Hs.554556
    Unigene Representative Sequence: BC140754
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343870(uc010spg.2)
    miRNA
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    Additional mRNA sequence: BC140754.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR6C74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR6C74 Expression
    About this image


    See OR6C74 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.554556
        SABiosciences Custom PCR Arrays for OR6C74
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR6C74 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr8211 , 5 olfactory receptor 8211, 5 86.99(n)1
    90.16(a)1
      10 (77.67 cM)5
    2587721  NM_146776.11  NP_666987.11 
     1300336285 


    ENSEMBL Gene Tree for OR6C74 (if available)
    TreeFam Gene Tree for OR6C74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR6C74 gene
    OR6C702  OR6C652  OR6C752  OR6C62  OR2AP12  OR6C32  OR6C42  OR6C762  
    OR6C12  OR6C682  OR6C22  
    18/453 SIMAP similar genes for OR6C74 using alignment to 2 protein entries:     O6C74_HUMAN (see all proteins) (see all similar genes):
    OR6C75    OR6C2    OR6C3    OR6C65    OR6C76    OR6C70
    OR6C4    OR6C6    OR6C68    OR6C1    OR2AP1    OR10R3P
    OR6X1    OR5B21    OR6M1    OR4Q2    OR5B12    OR6F1

    OR6C74 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 SNPs in OR6C74 are shown (see all 120)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844387351,2
    --55639106(+) TTTTCC/TCTTCT 1 -- us2k10--------
    rs71384441,2
    C,F,A,H--55639107(+) TTTCCC/TTTCTG 1 -- us2k1 trp314Minor allele frequency- T:0.14NA NS EA CSA WA 883
    rs1888812401,2
    --55639159(+) AAACAC/TTGTGA 1 -- us2k10--------
    rs74854621,2
    H--55639216(+) TTTCCC/GTATAT 1 -- us2k14Minor allele frequency- G:0.00NS EA 396
    rs567939161,2
    C--55639253(+) TAAACA/GTTTCA 1 -- us2k15Minor allele frequency- G:0.15NA CSA WA EA 361
    rs71385841,2
    C,F,H--55639304(+) CCTATA/GACTTG 1 -- us2k110Minor allele frequency- G:0.14NS EA NA CSA WA 763
    rs111713851,2
    A,H--55639312(+) TTGCCA/CAAACA 1 -- us2k14Minor allele frequency- C:0.00NS EA 402
    rs617037341,2
    C--55639336(+) TTGGGA/GCTATA 1 -- us2k15Minor allele frequency- G:0.14NA CSA WA EA 361
    rs733228741,2
    C--55639347(+) CTGGTG/AGTTGG 1 -- us2k13Minor allele frequency- A:0.05WA EA 240
    rs575903581,2
    C--55639399(+) TGTGGT/GATTCA 1 -- us2k15Minor allele frequency- G:0.15NA CSA WA EA 361

    HapMap Linkage Disequilibrium report for OR6C74 ( 55641072 - 55642007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR6C74:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899104CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OR6C74:    About MalaCards
    neuronitis    


    OR6C74 for disorders           About GeneDecksing


    Export disorders for OR6C74 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR6C74 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR6C74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 254783 HGNC: 31303 Ensembl:ENSG00000197706 euGenes: HUgn254783 ECgene: OR6C74 Kegg: 254783
    H-InvDB: OR6C74

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR6C74 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR6C74 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR6C74 gene:
    Search GeneIP for patents involving OR6C74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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