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Aliases for OR6C74 Gene

Aliases for OR6C74 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 74 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 74 2

External Ids for OR6C74 Gene

Previous GeneCards Identifiers for OR6C74 Gene

  • GC12P053928
  • GC12U900474
  • GC12P055640

Summaries for OR6C74 Gene

Entrez Gene Summary for OR6C74 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C74 Gene

OR6C74 (Olfactory Receptor Family 6 Subfamily C Member 74) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C76.

UniProtKB/Swiss-Prot for OR6C74 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C74 Gene

Genomics for OR6C74 Gene

Regulatory Elements for OR6C74 Gene

Enhancers for OR6C74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F054354 1.9 FANTOM5 Ensembl ENCODE 16.2 -881.7 -881706 6.7 FEZF1 YBX1 YY1 ZNF143 ZNF263 MCM3 SP3 NFYC TBX21 MEF2D SP1 ENSG00000258344 GPR84 ZNF385A LOC100652999 OR10A7 OR6C74 LOC105378250 MAP3K12 ENSG00000258086
GH12F054303 1.8 FANTOM5 Ensembl ENCODE 16.2 -934.0 -934026 5.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B DMAP1 KLF13 DEK SP3 SP5 NFE2 MAP3K12 AAAS OR6C74 OR10A7 LOC105378250 MIR148B GPR84 GTSF1 SMUG1
GH12F056040 1.5 FANTOM5 ENCODE 16.2 +802.2 802238 3.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 BAZ2A RNU6-343P RBMS2 RN7SL809P RPL41 ENSG00000258199 CDK2 STAT2 SUOX RAB5B
GH12F056102 1.2 ENCODE 16.2 +865.0 865023 5.4 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 LOC100131294 OR10A7 OR6C74 RPL41 RNU6-343P CDK2 RAB5B RBMS2 ESYT1 SMARCC2
GH12F055715 1.2 ENCODE 16.2 +478.9 478910 7.1 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF263 SP3 BAZ2A RN7SL809P CDK2 ZC3H10 RDH5 TMEM198B RNU6-343P ENSG00000258199 ENSG00000258317 ORMDL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6C74 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6C74 Gene

55,239,762 bp from pter
55,248,302 bp from pter
8,541 bases
Plus strand

Genomic View for OR6C74 Gene

Genes around OR6C74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C74 Gene

Proteins for OR6C74 Gene

  • Protein details for OR6C74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C74
    Protein Accession:

    Protein attributes for OR6C74 Gene

    312 amino acids
    Molecular mass:
    35253 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C74 Gene

Post-translational modifications for OR6C74 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C74 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C74 Gene

Domains & Families for OR6C74 Gene

Gene Families for OR6C74 Gene

Protein Domains for OR6C74 Gene

Suggested Antigen Peptide Sequences for OR6C74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C74: view

Function for OR6C74 Gene

Molecular function for OR6C74 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Phenotypes for OR6C74 Gene

genes like me logo Genes that share phenotypes with OR6C74: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C74 Gene

Localization for OR6C74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C74 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C74 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Pathways & Interactions for OR6C74 Gene

genes like me logo Genes that share pathways with OR6C74: view

Pathways by source for OR6C74 Gene

Gene Ontology (GO) - Biological Process for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for SIGNOR curated interactions for OR6C74 Gene

Transcripts for OR6C74 Gene

mRNA/cDNA for OR6C74 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C74 Gene

No ASD Table

Relevant External Links for OR6C74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6C74 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C74 Gene:


SOURCE GeneReport for Unigene cluster for OR6C74 Gene:

genes like me logo Genes that share expression patterns with OR6C74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR6C74 Gene

Orthologs for OR6C74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC467021 34
  • 99.25 (n)
OR6C74 35
  • 99 (a)
(Bos Taurus)
Mammalia LOC788372 34
  • 89 (n)
-- 35
  • 88 (a)
-- 35
  • 87 (a)
-- 35
  • 83 (a)
(Canis familiaris)
Mammalia OR6C74 34 35
  • 88.03 (n)
(Mus musculus)
Mammalia Or6c74 55 Olfr821 34 16 35
  • 86.02 (n)
(Rattus norvegicus)
Mammalia Olr1064 34
  • 85.9 (n)
(Monodelphis domestica)
Mammalia OR6C74 35
  • 85 (a)
Species where no ortholog for OR6C74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C74 Gene

Gene Tree for OR6C74 (if available)
Gene Tree for OR6C74 (if available)

Paralogs for OR6C74 Gene

Paralogs for OR6C74 Gene

(452) SIMAP similar genes for OR6C74 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6C74: view

Variants for OR6C74 Gene

Sequence variations from dbSNP and Humsavar for OR6C74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10876729 -- 55,242,373(+) ACAGA(C/T)GCCAG upstream-variant-2KB
rs10876730 -- 55,246,014(+) TTCAC(C/T)CCAGA intron-variant, upstream-variant-2KB
rs111281884 -- 55,243,724(+) ACGTG(A/G/T)ATATA upstream-variant-2KB
rs111323551 -- 55,242,382(+) AGCAG(A/C)CCGGC upstream-variant-2KB
rs11171382 -- 55,242,156(+) ttgca(A/C)ttatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6C74 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR6C74 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.02; 98.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C74 Gene

Disorders for OR6C74 Gene

Relevant External Links for OR6C74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6C74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C74 Gene

Publications for OR6C74 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR6C74 Gene

Sources for OR6C74 Gene

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