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Aliases for OR6C74 Gene

Aliases for OR6C74 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 74 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 74 2

External Ids for OR6C74 Gene

Previous GeneCards Identifiers for OR6C74 Gene

  • GC12P053928
  • GC12U900474
  • GC12P055640

Summaries for OR6C74 Gene

Entrez Gene Summary for OR6C74 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C74 Gene

OR6C74 (Olfactory Receptor Family 6 Subfamily C Member 74) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C75.

UniProtKB/Swiss-Prot for OR6C74 Gene

  • Odorant receptor.

Additional gene information for OR6C74 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C74 Gene

Genomics for OR6C74 Gene

Regulatory Elements for OR6C74 Gene

Enhancers for OR6C74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H054354 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -881.8 -881761 6 FEZF1 YBX1 YY1 ZNF143 SP3 MCM3 NFYC MEF2D ZNF610 GLIS1 SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
GH12H055715 1.7 Ensembl ENCODE dbSUPER 14.6 +478.9 478910 7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D BAZ2A DNAJC14 RN7SL809P TMEM198B PAN2 ENSG00000257740 CDK2 STAT2 ENSG00000258317 ENSG00000258199
GH12H056040 1.7 FANTOM5 ENCODE dbSUPER 14.6 +802.2 802238 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC BAZ2A ZC3H10 RN7SL809P STAT2 ENSG00000258199 ENSG00000258317 RNU6-343P PAN2 ENSG00000257740 DNAJC14
GH12H054306 1.6 FANTOM5 Ensembl ENCODE 14.6 -932.6 -932557 2 HDGF PKNOX1 ATF1 ZNF121 ZNF766 ATF7 DEK SP3 SP5 YY2 NFE2 LOC105378250 OR10A7 OR6C74 MIR148B GPR84 SMUG1 NCKAP1L ZNF385A COPZ1
GH12H054381 1.6 Ensembl ENCODE dbSUPER 14.6 -853.0 -853022 10 HDGF PKNOX1 FOS SP3 ZNF592 SMARCA4 GLIS1 ZNF624 NBN HMBOX1 LOC105378250 GPR84 OR10A7 OR6C74 MAP3K12 ZNF385A MIR148B ITGA5 RNU6-950P COPZ1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6C74 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6C74 Gene

Chromosome:
12
Start:
55,239,762 bp from pter
End:
55,248,302 bp from pter
Size:
8,541 bases
Orientation:
Plus strand

Genomic View for OR6C74 Gene

Genes around OR6C74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C74 Gene

Proteins for OR6C74 Gene

  • Protein details for OR6C74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCV1-O6C74_HUMAN
    Recommended name:
    Olfactory receptor 6C74
    Protein Accession:
    A6NCV1

    Protein attributes for OR6C74 Gene

    Size:
    312 amino acids
    Molecular mass:
    35253 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C74 Gene

Post-translational modifications for OR6C74 Gene

  • Glycosylation at posLast=33
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C74 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C74 Gene

Domains & Families for OR6C74 Gene

Gene Families for OR6C74 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C74 Gene

Suggested Antigen Peptide Sequences for OR6C74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NCV1

UniProtKB/Swiss-Prot:

O6C74_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C74: view

Function for OR6C74 Gene

Molecular function for OR6C74 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR6C74 Gene

Gene Ontology (GO) - Molecular Function for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C74: view

Phenotypes for OR6C74 Gene

genes like me logo Genes that share phenotypes with OR6C74: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR6C74
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C74 Gene

Localization for OR6C74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C74 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C74 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C74 Gene

Pathways & Interactions for OR6C74 Gene

genes like me logo Genes that share pathways with OR6C74: view

Pathways by source for OR6C74 Gene

Interacting Proteins for OR6C74 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342836%0d%0a9606.ENSP00000334051%0d%0a9606.ENSP00000367869%0d%0a9606.ENSP00000248572%0d%0a9606.ENSP00000269260%0d%0a9606.ENSP00000248150%0d%0a
Selected Interacting proteins: ENSP00000342836 A6NCV1-O6C74_HUMAN for OR6C74 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR6C74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C74: view

No data available for SIGNOR curated interactions for OR6C74 Gene

Drugs & Compounds for OR6C74 Gene

No Compound Related Data Available

Transcripts for OR6C74 Gene

mRNA/cDNA for OR6C74 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR6C74
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C74 Gene

No ASD Table

Relevant External Links for OR6C74 Gene

GeneLoc Exon Structure for
OR6C74
ECgene alternative splicing isoforms for
OR6C74

Expression for OR6C74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C74 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C74 Gene:

OR6C74

SOURCE GeneReport for Unigene cluster for OR6C74 Gene:

Hs.554556
genes like me logo Genes that share expression patterns with OR6C74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C74 Gene

Orthologs for OR6C74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467021 33
  • 99.25 (n)
OR6C74 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC788372 33
  • 89 (n)
-- 34
  • 88 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia OR6C74 33 34
  • 88.03 (n)
mouse
(Mus musculus)
Mammalia Or6c74 52 Olfr821 33 16 34
  • 86.02 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910928 33
  • 85.9 (n)
oppossum
(Monodelphis domestica)
Mammalia OR6C74 34
  • 85 (a)
OneToOne
Species where no ortholog for OR6C74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C74 Gene

ENSEMBL:
Gene Tree for OR6C74 (if available)
TreeFam:
Gene Tree for OR6C74 (if available)

Paralogs for OR6C74 Gene

Paralogs for OR6C74 Gene

(452) SIMAP similar genes for OR6C74 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6C74: view

Variants for OR6C74 Gene

Sequence variations from dbSNP and Humsavar for OR6C74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000240326 -- 55,243,320(+) ATGCC(A/G)ATGGA upstream-variant-2KB
rs1000839163 -- 55,244,755(+) TTTAA(A/T)TTAAT intron-variant
rs1001358247 -- 55,245,020(+) GTTTG(C/G)AAAAA intron-variant
rs1001623900 -- 55,244,170(+) TTGAG(A/G)GTGAA utr-variant-5-prime
rs1002012119 -- 55,244,435(+) TTTGC(C/T)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR6C74 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR6C74 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.02; 98.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C74 Gene

Disorders for OR6C74 Gene

Relevant External Links for OR6C74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6C74

No disorders were found for OR6C74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C74 Gene

Publications for OR6C74 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 60
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 60
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR6C74 Gene

Sources for OR6C74 Gene

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