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Aliases for OR6C70 Gene

Aliases for OR6C70 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 70 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 70 2

External Ids for OR6C70 Gene

Previous GeneCards Identifiers for OR6C70 Gene

  • GC12M054151
  • GC12U900479
  • GC12M055862

Summaries for OR6C70 Gene

Entrez Gene Summary for OR6C70 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C70 Gene

OR6C70 (Olfactory Receptor Family 6 Subfamily C Member 70) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C6.

UniProtKB/Swiss-Prot for OR6C70 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C70 Gene

Genomics for OR6C70 Gene

Regulatory Elements for OR6C70 Gene

Enhancers for OR6C70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F055498 0.8 ENCODE 10.4 +160.2 160236 2.5 ELF3 ATF1 ARID4B RARA GATA4 CREM ZNF680 MIER2 PPARG PBX2 OR6C70 MIP ENSG00000257303 OR6C68 GC12M055509
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR6C70 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6C70 Gene

Chromosome:
12
Start:
55,469,200 bp from pter
End:
55,659,844 bp from pter
Size:
190,645 bases
Orientation:
Minus strand

Genomic View for OR6C70 Gene

Genes around OR6C70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C70 Gene

Proteins for OR6C70 Gene

  • Protein details for OR6C70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIJ9-O6C70_HUMAN
    Recommended name:
    Olfactory receptor 6C70
    Protein Accession:
    A6NIJ9

    Protein attributes for OR6C70 Gene

    Size:
    312 amino acids
    Molecular mass:
    35468 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C70 Gene

Post-translational modifications for OR6C70 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C70 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C70 Gene

Domains & Families for OR6C70 Gene

Gene Families for OR6C70 Gene

Protein Domains for OR6C70 Gene

Suggested Antigen Peptide Sequences for OR6C70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIJ9

UniProtKB/Swiss-Prot:

O6C70_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C70: view

Function for OR6C70 Gene

Molecular function for OR6C70 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C70: view
genes like me logo Genes that share phenotypes with OR6C70: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C70 Gene

Localization for OR6C70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C70 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6C70 Gene COMPARTMENTS Subcellular localization image for OR6C70 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C70: view

Pathways & Interactions for OR6C70 Gene

genes like me logo Genes that share pathways with OR6C70: view

Pathways by source for OR6C70 Gene

Gene Ontology (GO) - Biological Process for OR6C70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C70: view

No data available for SIGNOR curated interactions for OR6C70 Gene

Transcripts for OR6C70 Gene

mRNA/cDNA for OR6C70 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C70 Gene

No ASD Table

Relevant External Links for OR6C70 Gene

GeneLoc Exon Structure for
OR6C70
ECgene alternative splicing isoforms for
OR6C70

Expression for OR6C70 Gene

mRNA expression in normal human tissues for OR6C70 Gene

Protein differential expression in normal tissues from HIPED for OR6C70 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C70 Gene



Protein tissue co-expression partners for OR6C70 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C70 Gene:

OR6C70

SOURCE GeneReport for Unigene cluster for OR6C70 Gene:

Hs.632718
genes like me logo Genes that share expression patterns with OR6C70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6C70 Gene

Orthologs for OR6C70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C70 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or6c70 55 Olfr814 35
  • 80 (a)
OneToMany
Or6c217 55 Olfr815 35
  • 78 (a)
OneToMany
Olfr810 34 16
  • 67.63 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 70 (a)
ManyToMany
COR6C13 34
  • 66.77 (n)
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 70 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia LOC788357 34
  • 66.99 (n)
-- 35
  • 62 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1002 34
  • 66.77 (n)
Species where no ortholog for OR6C70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C70 Gene

ENSEMBL:
Gene Tree for OR6C70 (if available)
TreeFam:
Gene Tree for OR6C70 (if available)

Paralogs for OR6C70 Gene

Paralogs for OR6C70 Gene

(452) SIMAP similar genes for OR6C70 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6C70: view

Variants for OR6C70 Gene

Sequence variations from dbSNP and Humsavar for OR6C70 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10652433 -- 55,468,894(+) TTTAG(-/CAG)ATCAA downstream-variant-500B
rs10747756 -- 55,469,597(+) GGATA(A/G)GAGAA reference, missense
rs111353770 -- 55,469,092(+) AGTCA(A/T)ACAAA downstream-variant-500B
rs111636907 -- 55,469,328(+) TACTC(A/C)TTTGC reference, stop-gained
rs11171485 -- 55,469,028(+) AAAAA(C/G)AGAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR6C70 Gene

Variant ID Type Subtype PubMed ID
esv3629576 CNV loss 21293372
nsv1054105 CNV loss 25217958
nsv437144 CNV loss 16327808
nsv559001 CNV loss 21841781
nsv832422 CNV loss 17160897

Variation tolerance for OR6C70 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C70 Gene

Disorders for OR6C70 Gene

Relevant External Links for OR6C70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6C70

No disorders were found for OR6C70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C70 Gene

Publications for OR6C70 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3 64
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64

Products for OR6C70 Gene

Sources for OR6C70 Gene

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