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OR6C68 Gene

protein-coding   GIFtS: 40
GCID: GC12P055887

Olfactory Receptor, Family 6, Subfamily C, Member 68

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 681 2
Olfactory Receptor 6C682

External Ids:    HGNC: 312971   Entrez Gene: 4032842   Ensembl: ENSG000002053277   UniProtKB: A6NDL83   

Export aliases for OR6C68 gene to outside databases

Previous GC identifers: GC12U900420 GC12P054173


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR6C68 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Mar 2014)

GeneCards Summary for OR6C68 Gene:
OR6C68 (olfactory receptor, family 6, subfamily C, member 68) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: O6C68_HUMAN, A6NDL8
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR6C68 gene promoter:
         AML1a   Tal-1   NRSF form 1   STAT5A   NRSF form 2   E47   POU2F1   HSF2   POU2F1a   MRF-2   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6C68


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

OR6C68 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C68 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055887:  view genomic region     (about GC identifiers)

Start:
55,886,147 bp from pter      End:
55,887,097 bp from pter
Size:
951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: O6C68_HUMAN, A6NDL8 (See protein sequence)
Recommended Name: Olfactory receptor 6C68  
Size: 312 amino acids; 35296 Da
Sequence caution: Sequence=EAW96814.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for OR6C68: NX_A6NDL8

Explore proteomics data for OR6C68 at MOPED

HORDE protein sequence for OR6C68

See OR6C68 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001005519.2  
ENSEMBL proteins: 
 ENSP00000448811   ENSP00000368983  
Reactome Protein details: A6NDL8

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
OR6: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry A6NDL8

ProtoNet protein and cluster: A6NDL8

UniProtKB/Swiss-Prot: O6C68_HUMAN, A6NDL8
Similarity: Belongs to the G-protein coupled receptor 1 family


Find genes that share domains with OR6C68           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: O6C68_HUMAN, A6NDL8
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity IEA--
     
Find genes that share ontologies with OR6C68           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for OR6C68:
 Decreased viability with pacli 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for OR6C68

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
O6C68_HUMAN, A6NDL8: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with OR6C68           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OR6C68 About    
See pathways by source

SuperPathContained pathways About
1Olfactory Signaling Pathway
Olfactory Signaling Pathway0.82
Olfactory transduction0.82
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90


Find genes that share SuperPaths with OR6C68           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for OR6C68
    Olfactory Signaling Pathway


1 Kegg Pathway  (Kegg details for OR6C68):
    Olfactory transduction

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Interactions:

    Search GeneGlobe Interaction Network for OR6C68

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR6C68 (ENSP000003689834) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR5AK2ENSP000003227844STRING: ENSP00000322784
OR5AN1ENSP000003203024STRING: ENSP00000320302
OR5W2ENSP000003424484STRING: ENSP00000342448
OR6C6ENSP000003512114STRING: ENSP00000351211
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for OR6C68 (O6C68)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OR6C68 gene: 
NM_001005519.2  

Unigene Cluster for OR6C68:

Olfactory receptor, family 6, subfamily C, member 68
Hs.626886  [show with all ESTs]
Unigene Representative Sequence: NM_001005519
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000548615 ENST00000379662(uc010spo.2)
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1 DOTS entry:

DT.91758735 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR6C68 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTCACTCAA
OR6C68 Expression
About this image

OR6C68 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OR6C68 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.626886
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for OR6C68 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr7811 , 5 olfactory receptor 7811, 5 74.92(n)1
72.96(a)1
  10 (77.30 cM)5
2587231  NM_146728.11  NP_666939.11 
 1293328835 


ENSEMBL Gene Tree for OR6C68 (if available)
TreeFam Gene Tree for OR6C68 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OR6C68 gene
OR6C702  OR6C652  OR6C752  OR6C62  OR2AP12  OR6C32  OR6C42  OR6C762  
OR6C12  OR6C22  OR6C742  
Selected SIMAP similar genes for OR6C68 using alignment to 1 protein entry:     O6C68_HUMAN(see all similar genes):
OR6C2    OR6C74    OR6C4    OR6C1    OR6C3    OR6C75
OR6C76    OR6C65    OR6C6    OR6C70    OR2AP1    OR6M1
OR5B12    OR5L2    OR6T1    OR8K1    OR2G3    OR6S1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR6C68 (see all 109)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1452950371,2
--55884208(+) ATACTA/GGCAGA 1 -- us2k10--------
rs774306971,2
C,F--55884267(+) TAAAGC/TTCTTG 1 -- us2k11Minor allele frequency- T:0.04WA 118
rs1815655241,2
--55884298(+) TTTGAA/GGGAAA 1 -- us2k10--------
rs1867511221,2
--55884315(+) AAAACA/CATAAG 1 -- us2k10--------
rs73103351,2
C,F,A,H--55884439(+) ATACAC/TAACAG 1 -- us2k123Minor allele frequency- T:0.36NA NS EA WA 2664
rs1150087731,2
C--55884551(+) CAATAC/TACTAA 1 -- us2k10--------
rs73106931,2
C,F,A--55884576(+) AAGATG/TGGGAA 1 -- us2k118Minor allele frequency- N:0.00EA NA NS WA 1004
rs1915921511,2
--55884582(+) GGGAAA/CATTAG 1 -- us2k10--------
rs1829347491,2
--55884600(+) CACTTC/TGGCAA 1 -- us2k10--------
rs1404893371,2
C--55884714(+) ACCAGC/TTGTAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OR6C68 ( 55886147 - 55887097 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OR6C68:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832422CNV Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed article for OR6C68 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR6C68)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 403284 HGNC: 31297 Ensembl:ENSG00000205327 euGenes: HUgn403284 ECgene: OR6C68 Kegg: 403284
H-InvDB: OR6C68

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OR6C68 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6C68 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OR6C68 gene:
Search GeneIP for patents involving OR6C68

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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