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Aliases for OR6C65 Gene

Aliases for OR6C65 Gene

  • Olfactory Receptor, Family 6, Subfamily C, Member 65 2 3

External Ids for OR6C65 Gene

Previous GeneCards Identifiers for OR6C65 Gene

  • GC12U900418
  • GC12P054080
  • GC12P055794

Summaries for OR6C65 Gene

Entrez Gene Summary for OR6C65 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C65 Gene

OR6C65 (Olfactory Receptor, Family 6, Subfamily C, Member 65) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot for OR6C65 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C65 Gene

Genomics for OR6C65 Gene

Regulatory Elements for OR6C65 Gene

Genomic Location for OR6C65 Gene

Chromosome:
12
Start:
55,400,430 bp from pter
End:
55,401,505 bp from pter
Size:
1,076 bases
Orientation:
Plus strand

Genomic View for OR6C65 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6C65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C65 Gene

Proteins for OR6C65 Gene

  • Protein details for OR6C65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJZ3-O6C65_HUMAN
    Recommended name:
    Olfactory receptor 6C65
    Protein Accession:
    A6NJZ3
    Secondary Accessions:
    • B2RNH9

    Protein attributes for OR6C65 Gene

    Size:
    312 amino acids
    Molecular mass:
    35198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C65 Gene

Proteomics data for OR6C65 Gene at MOPED

Post-translational modifications for OR6C65 Gene

  • Glycosylation at Asn 3 and Asn 93
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C65 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C65 Gene

Domains & Families for OR6C65 Gene

Gene Families for OR6C65 Gene

Protein Domains for OR6C65 Gene

Suggested Antigen Peptide Sequences for OR6C65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NJZ3

UniProtKB/Swiss-Prot:

O6C65_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C65: view

Function for OR6C65 Gene

Molecular function for OR6C65 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C65: view

Phenotypes for OR6C65 Gene

GenomeRNAi human phenotypes for OR6C65:
genes like me logo Genes that share phenotypes with OR6C65: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C65

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C65 Gene

Localization for OR6C65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6C65 Gene COMPARTMENTS Subcellular localization image for OR6C65 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C65: view

Pathways & Interactions for OR6C65 Gene

genes like me logo Genes that share pathways with OR6C65: view

Pathways by source for OR6C65 Gene

Interacting Proteins for OR6C65 Gene

Gene Ontology (GO) - Biological Process for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C65: view

No data available for SIGNOR curated interactions for OR6C65 Gene

Drugs & Compounds for OR6C65 Gene

No Compound Related Data Available

Transcripts for OR6C65 Gene

mRNA/cDNA for OR6C65 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C65

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C65 Gene

No ASD Table

Relevant External Links for OR6C65 Gene

GeneLoc Exon Structure for
OR6C65
ECgene alternative splicing isoforms for
OR6C65

Expression for OR6C65 Gene

mRNA expression in normal human tissues for OR6C65 Gene

Protein differential expression in normal tissues from HIPED for OR6C65 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C65 Gene



SOURCE GeneReport for Unigene cluster for OR6C65 Gene Hs.554553

genes like me logo Genes that share expression patterns with OR6C65: view

Protein tissue co-expression partners for OR6C65 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6C65 Gene

Orthologs for OR6C65 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C65 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC788322 35
  • 68.92 (n)
  • 68.17 (a)
-- 36
  • 67 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia COR6C47 35
  • 68.38 (n)
  • 69.45 (a)
-- 36
  • 65 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr822 35
  • 65.81 (n)
  • 65.71 (a)
Olfr798 16
Olfr808 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
Species with no ortholog for OR6C65:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C65 Gene

ENSEMBL:
Gene Tree for OR6C65 (if available)
TreeFam:
Gene Tree for OR6C65 (if available)

Paralogs for OR6C65 Gene

Paralogs for OR6C65 Gene

(453) SIMAP similar genes for OR6C65 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6C65 Gene

genes like me logo Genes that share paralogs with OR6C65: view

Variants for OR6C65 Gene

Sequence variations from dbSNP and Humsavar for OR6C65 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3935215 -- 55,398,617(+) CATGT(A/T)ATCTG upstream-variant-2KB
rs6581042 -- 55,399,308(+) CATGG(G/T)TCACT upstream-variant-2KB
rs7486820 -- 55,399,964(+) ACGCC(C/T)GGCTA upstream-variant-2KB
rs7488269 -- 55,398,759(+) GAGCA(C/T)CACTA upstream-variant-2KB
rs7967395 -- 55,400,480(+) TTGAC(A/G)TTCAC upstream-variant-2KB

Variation tolerance for OR6C65 Gene

Residual Variation Intolerance Score: 60.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C65 Gene

HapMap Linkage Disequilibrium report
OR6C65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR6C65 Gene

Disorders for OR6C65 Gene

Relevant External Links for OR6C65

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6C65
genes like me logo Genes that share disorders with OR6C65: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C65 Gene

Publications for OR6C65 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 67
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR6C65 Gene

Sources for OR6C65 Gene

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