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Aliases for OR6C65 Gene

Aliases for OR6C65 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 65 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 65 2

External Ids for OR6C65 Gene

Previous GeneCards Identifiers for OR6C65 Gene

  • GC12U900418
  • GC12P054080
  • GC12P055794

Summaries for OR6C65 Gene

Entrez Gene Summary for OR6C65 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C65 Gene

OR6C65 (Olfactory Receptor Family 6 Subfamily C Member 65) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot for OR6C65 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C65 Gene

Genomics for OR6C65 Gene

Regulatory Elements for OR6C65 Gene

Enhancers for OR6C65 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR6C65 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6C65 Gene

55,400,430 bp from pter
55,401,505 bp from pter
1,076 bases
Plus strand

Genomic View for OR6C65 Gene

Genes around OR6C65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C65 Gene

Proteins for OR6C65 Gene

  • Protein details for OR6C65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C65
    Protein Accession:
    Secondary Accessions:
    • B2RNH9

    Protein attributes for OR6C65 Gene

    312 amino acids
    Molecular mass:
    35198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C65 Gene

Proteomics data for OR6C65 Gene at MOPED

Post-translational modifications for OR6C65 Gene

  • Glycosylation at Asn 3 and Asn 93
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C65 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C65 Gene

Domains & Families for OR6C65 Gene

Gene Families for OR6C65 Gene

Protein Domains for OR6C65 Gene

Suggested Antigen Peptide Sequences for OR6C65 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C65: view

Function for OR6C65 Gene

Molecular function for OR6C65 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes for OR6C65 Gene

GenomeRNAi human phenotypes for OR6C65:
genes like me logo Genes that share phenotypes with OR6C65: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C65 Gene

Localization for OR6C65 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C65 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6C65 Gene COMPARTMENTS Subcellular localization image for OR6C65 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C65: view

Pathways & Interactions for OR6C65 Gene

genes like me logo Genes that share pathways with OR6C65: view

Pathways by source for OR6C65 Gene

Interacting Proteins for OR6C65 Gene

Gene Ontology (GO) - Biological Process for OR6C65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C65: view

No data available for SIGNOR curated interactions for OR6C65 Gene

Drugs & Compounds for OR6C65 Gene

No Compound Related Data Available

Transcripts for OR6C65 Gene

mRNA/cDNA for OR6C65 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C65 Gene

No ASD Table

Relevant External Links for OR6C65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C65 Gene

mRNA expression in normal human tissues for OR6C65 Gene

Protein differential expression in normal tissues from HIPED for OR6C65 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C65 Gene

SOURCE GeneReport for Unigene cluster for OR6C65 Gene Hs.554553

genes like me logo Genes that share expression patterns with OR6C65: view

Protein tissue co-expression partners for OR6C65 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6C65 Gene

Orthologs for OR6C65 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C65 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC788322 35
  • 68.92 (n)
  • 68.17 (a)
-- 36
  • 67 (a)
(Canis familiaris)
Mammalia COR6C47 35
  • 68.38 (n)
  • 69.45 (a)
-- 36
  • 65 (a)
(Mus musculus)
Mammalia Olfr822 35
  • 65.81 (n)
  • 65.71 (a)
Olfr822 16
Olfr808 36
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 72 (a)
-- 36
  • 73 (a)
-- 36
  • 74 (a)
-- 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
-- 36
  • 63 (a)
-- 36
  • 64 (a)
-- 36
  • 63 (a)
-- 36
  • 61 (a)
-- 36
  • 63 (a)
-- 36
  • 64 (a)
-- 36
  • 57 (a)
-- 36
  • 64 (a)
Species with no ortholog for OR6C65:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C65 Gene

Gene Tree for OR6C65 (if available)
Gene Tree for OR6C65 (if available)

Paralogs for OR6C65 Gene

Paralogs for OR6C65 Gene

(453) SIMAP similar genes for OR6C65 Gene using alignment to 1 proteins: Pseudogenes for OR6C65 Gene

genes like me logo Genes that share paralogs with OR6C65: view

Variants for OR6C65 Gene

Sequence variations from dbSNP and Humsavar for OR6C65 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12424958 - 55,400,566(+) TCTTC(A/T)GGGAT reference, missense
rs7971073 - 55,401,192(+) TTAAA(A/G)CAATT reference, missense
rs7486820 -- 55,399,964(+) ACGCC(C/T)GGCTA upstream-variant-2KB
rs79807163 -- 55,400,594(+) TTACA(A/G)GTTGT reference, synonymous-codon
rs7488269 -- 55,398,759(+) GAGCA(C/T)CACTA upstream-variant-2KB

Variation tolerance for OR6C65 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OR6C65 Gene

Disorders for OR6C65 Gene

Relevant External Links for OR6C65

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6C65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C65 Gene

Publications for OR6C65 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR6C65 Gene

Sources for OR6C65 Gene