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Aliases for OR6C6 Gene

Aliases for OR6C6 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 6 2 3 5
  • Olfactory Receptor, Family 6, Subfamily C, Member 6 2

External Ids for OR6C6 Gene

Previous GeneCards Identifiers for OR6C6 Gene

  • GC12M053975
  • GC12U900482
  • GC12M053878
  • GC12M055688

Summaries for OR6C6 Gene

Entrez Gene Summary for OR6C6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C6 Gene

OR6C6 (Olfactory Receptor Family 6 Subfamily C Member 6) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot for OR6C6 Gene

  • Odorant receptor.

Additional gene information for OR6C6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C6 Gene

Genomics for OR6C6 Gene

Regulatory Elements for OR6C6 Gene

Enhancers for OR6C6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H055020 0.5 FANTOM5 dbSUPER 5.5 +275.7 275720 0 OR6C3 OR6C65 OR9K2 OR6C75 NEUROD4 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12H055756 0.3 FANTOM5 3.9 -459.9 -459875 0.3 CD63 ORMDL2 SARNP MMP19 RPS26 IKZF4 OR6C6 ENSG00000257509 GDF11
GH12H055629 0.5 FANTOM5 dbSUPER 1.8 -332.7 -332714 0 MMP19 OR6C4 OR10P1 OR6C65 ZC3H10 OR6C74 OR9K2 OR6C3 OR6C2 OR6C6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6C6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR6C6 Gene

Genomic Locations for OR6C6 Gene
2,582 bases
Minus strand

Genomic View for OR6C6 Gene

Genes around OR6C6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C6 Gene

Proteins for OR6C6 Gene

  • Protein details for OR6C6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C6
    Protein Accession:

    Protein attributes for OR6C6 Gene

    314 amino acids
    Molecular mass:
    35963 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C6 Gene

Post-translational modifications for OR6C6 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C6 Gene

Domains & Families for OR6C6 Gene

Gene Families for OR6C6 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR6C6 Gene

Suggested Antigen Peptide Sequences for OR6C6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C6: view

Function for OR6C6 Gene

Molecular function for OR6C6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C6: view
genes like me logo Genes that share phenotypes with OR6C6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C6 Gene

Localization for OR6C6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR6C6 Gene

Pathways & Interactions for OR6C6 Gene

genes like me logo Genes that share pathways with OR6C6: view

Pathways by source for OR6C6 Gene

Interacting Proteins for OR6C6 Gene

Gene Ontology (GO) - Biological Process for OR6C6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C6: view

No data available for SIGNOR curated interactions for OR6C6 Gene

Drugs & Compounds for OR6C6 Gene

No Compound Related Data Available

Transcripts for OR6C6 Gene

mRNA/cDNA for OR6C6 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C6 Gene

No ASD Table

Relevant External Links for OR6C6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C6 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR6C6 Gene:


SOURCE GeneReport for Unigene cluster for OR6C6 Gene:

genes like me logo Genes that share expression patterns with OR6C6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C6 Gene

Orthologs for OR6C6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC467022 33
  • 99.26 (n)
OR6C6 34
  • 99 (a)
(Canis familiaris)
Mammalia OR6C6 34
  • 90 (a)
LOC100855433 33
  • 88.89 (n)
(Mus musculus)
Mammalia Or6c6 52 Olfr782 33 34
  • 85.47 (n)
Or6c6c 52 Olfr804 16 34
  • 85 (a)
Or6c208 52 Olfr784
  • chr10:129,387,635-129,388,591
Or6c211 52 Olfr801
  • chr10:129,669,564-129,670,640
Or6c212 52 Olfr805
  • chr10:129,722,586-129,723,542
Or6c213 52 Olfr806
  • chr10:129,737,977-129,738,915
Or6c215 52 Olfr811
  • chr10:129,801,567-129,802,523
Or6c216 52 Olfr812
  • chr10:129,842,111-129,843,040
Or6c218 52 Olfr817
  • chr10:129,929,513-129,930,481
Or6c6b 52 Olfr779
  • chr10:129,311,266-129,312,105
(Rattus norvegicus)
Mammalia Olr1007 33
  • 84.62 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
(Bos Taurus)
Mammalia -- 34
  • 68 (a)
Species where no ortholog for OR6C6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C6 Gene

Gene Tree for OR6C6 (if available)
Gene Tree for OR6C6 (if available)

Paralogs for OR6C6 Gene

Paralogs for OR6C6 Gene

(446) SIMAP similar genes for OR6C6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6C6: view

Variants for OR6C6 Gene

Sequence variations from dbSNP and Humsavar for OR6C6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1002378954 -- 55,294,545(+) TTGCT(A/G)TGCAG reference, stop-gained
rs1004184207 -- 55,294,166(+) GTCTC(A/G)AACTC downstream-variant-500B
rs1004276113 -- 55,294,517(+) AAGTA(C/T)AGGTG reference, missense
rs1006174801 -- 55,296,169(+) ACTCA(C/T)TAGTA upstream-variant-2KB
rs1006225574 -- 55,295,870(+) AAATG(A/C)AAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6C6 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781
nsv826381 CNV loss 20364138

Variation tolerance for OR6C6 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C6 Gene

Disorders for OR6C6 Gene

Relevant External Links for OR6C6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6C6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6C6 Gene

Publications for OR6C6 Gene

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 60
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 60

Products for OR6C6 Gene

Sources for OR6C6 Gene

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