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Aliases for OR6C4 Gene

Aliases for OR6C4 Gene

  • Olfactory Receptor, Family 6, Subfamily C, Member 4 2 3
  • Olfactory Receptor OR12-10 3 4
  • Olfactory Receptor 6C4 3
  • OR12-10 3

External Ids for OR6C4 Gene

Previous GeneCards Identifiers for OR6C4 Gene

  • GC00U903092
  • GC12P054232
  • GC12U900485
  • GC12P055946

Summaries for OR6C4 Gene

Entrez Gene Summary for OR6C4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C4 Gene

OR6C4 (Olfactory Receptor, Family 6, Subfamily C, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot for OR6C4 Gene

  • Odorant receptor.

Gene Wiki entry for OR6C4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C4 Gene

Genomics for OR6C4 Gene

Regulatory Elements for OR6C4 Gene

Genomic Location for OR6C4 Gene

55,551,199 bp from pter
55,552,244 bp from pter
1,046 bases
Plus strand

Genomic View for OR6C4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6C4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C4 Gene

Proteins for OR6C4 Gene

  • Protein details for OR6C4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6C4
    Protein Accession:
    Secondary Accessions:
    • A8MZG7
    • B2RNN2
    • Q6IFK1

    Protein attributes for OR6C4 Gene

    309 amino acids
    Molecular mass:
    35010 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C4 Gene

Proteomics data for OR6C4 Gene at MOPED

Post-translational modifications for OR6C4 Gene

Other Protein References for OR6C4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C4 Gene

Domains for OR6C4 Gene

Gene Families for OR6C4 Gene

Protein Domains for OR6C4 Gene

Suggested Antigen Peptide Sequences for OR6C4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C4: view

Function for OR6C4 Gene

Molecular function for OR6C4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C4 Gene

Localization for OR6C4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6C4 Gene COMPARTMENTS Subcellular localization image for OR6C4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C4: view

Pathways for OR6C4 Gene

genes like me logo Genes that share pathways with OR6C4: view

Pathways by source for OR6C4 Gene

Interacting Proteins for OR6C4 Gene

Gene Ontology (GO) - Biological Process for OR6C4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C4: view

Transcripts for OR6C4 Gene

mRNA/cDNA for OR6C4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C4 Gene

No ASD Table

Relevant External Links for OR6C4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6C4 Gene

mRNA expression in normal human tissues for OR6C4 Gene

Protein differential expression in normal tissues for OR6C4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR6C4 Gene

SOURCE GeneReport for Unigene cluster for OR6C4 Gene Hs.495021

genes like me logo Genes that share expressions with OR6C4: view

Expression partners for OR6C4 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR6C4 Gene

Orthologs for OR6C4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC510046 35
  • 89.36 (n)
  • 91.53 (a)
-- 36
  • 91 (a)
-- 36
  • 91 (a)
(Canis familiaris)
Mammalia LOC100683286 35
  • 88.31 (n)
  • 90.58 (a)
OR6C4 36
  • 91 (a)
(Pan troglodytes)
Mammalia LOC467024 35
  • 99.35 (n)
  • 99.03 (a)
OR6C4 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
-- 36
  • 69 (a)
-- 36
  • 70 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Olfr820 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
Species with no ortholog for OR6C4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C4 Gene

Gene Tree for OR6C4 (if available)
Gene Tree for OR6C4 (if available)

Paralogs for OR6C4 Gene

(454) SIMAP similar genes for OR6C4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6C4: view

Variants for OR6C4 Gene

Sequence variations from dbSNP and Humsavar for OR6C4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1896048 -- 55,549,242(-) atgat(A/G)taaat upstream-variant-2KB
rs7313899 - 55,551,335(+) TAAGT(A/G)TCCTA reference, missense
rs11836580 -- 55,549,604(+) CAGAG(A/G)TGCCC upstream-variant-2KB
rs11836608 -- 55,549,702(+) ATTCA(A/G)TAACT upstream-variant-2KB
rs12580939 -- 55,549,423(+) ACCTC(C/T)CTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6C4 Gene

Variant ID Type Subtype PubMed ID
nsv832422 CNV Loss 17160897

Relevant External Links for OR6C4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C4 Gene

Disorders for OR6C4 Gene

No disorders were found for OR6C4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR6C4 Gene

Publications for OR6C4 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4
  5. Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated. (PMID: 7509350) Youngblood K. … Davidson A. (J. Clin. Invest. 1994) 3

Products for OR6C4 Gene

Sources for OR6C4 Gene

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