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Aliases for OR6C3 Gene

Aliases for OR6C3 Gene

  • Olfactory Receptor, Family 6, Subfamily C, Member 3 2 3
  • HSA8 3 4
  • Olfactory Receptor 6C3 3
  • OST709 3

External Ids for OR6C3 Gene

Previous GeneCards Identifiers for OR6C3 Gene

  • GC00U990938
  • GC12P054011
  • GC12P055725

Summaries for OR6C3 Gene

Entrez Gene Summary for OR6C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C3 Gene

OR6C3 (Olfactory Receptor, Family 6, Subfamily C, Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2AP1.

UniProtKB/Swiss-Prot for OR6C3 Gene

  • Odorant receptor.

Gene Wiki entry for OR6C3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C3 Gene

Genomics for OR6C3 Gene

Genomic Location for OR6C3 Gene

Start:
55,331,701 bp from pter
End:
55,332,636 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR6C3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C3 Gene

Proteins for OR6C3 Gene

  • Protein details for OR6C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZP0-OR6C3_HUMAN
    Recommended name:
    Olfactory receptor 6C3
    Protein Accession:
    Q9NZP0
    Secondary Accessions:

    Protein attributes for OR6C3 Gene

    Size:
    311 amino acids
    Molecular mass:
    35531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C3 Gene

Proteomics data for OR6C3 Gene at MOPED

Post-translational modifications for OR6C3 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

No data available for DME Specific Peptides for OR6C3 Gene

Domains for OR6C3 Gene

Gene Families for OR6C3 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6C3 Gene

Suggested Antigen Peptide Sequences for OR6C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZP0

UniProtKB/Swiss-Prot:

OR6C3_HUMAN :
  • Q9NZP0
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C3: view

Function for OR6C3 Gene

Molecular function for OR6C3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR6C3 Gene

Localization for OR6C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6C3 Gene COMPARTMENTS Subcellular localization image for OR6C3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Pathways for OR6C3 Gene

genes like me logo Genes that share pathways with OR6C3: view

Pathways by source for OR6C3 Gene

Interacting Proteins for OR6C3 Gene

Gene Ontology (GO) - Biological Process for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 10706615
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Transcripts for OR6C3 Gene

mRNA/cDNA for OR6C3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR6C3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C3 Gene

No ASD Table

Relevant External Links for OR6C3 Gene

GeneLoc Exon Structure for
OR6C3
ECgene alternative splicing isoforms for
OR6C3

Expression for OR6C3 Gene

mRNA expression in normal human tissues for OR6C3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OR6C3 Gene

SOURCE GeneReport for Unigene cluster for OR6C3 Gene Hs.553653

genes like me logo Genes that share expressions with OR6C3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for OR6C3 Gene

Orthologs for OR6C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC787991 35
  • 80.22 (n)
  • 83.87 (a)
-- 36
  • 93 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC102156012 35
  • 80.97 (n)
  • 85.81 (a)
OR04C01 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr803 35
  • 78.32 (n)
  • 82.68 (a)
Olfr788 16
Olfr788 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr952 35
  • 76.77 (n)
  • 80 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 65 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
Species with no ortholog for OR6C3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C3 Gene

ENSEMBL:
Gene Tree for OR6C3 (if available)
TreeFam:
Gene Tree for OR6C3 (if available)

Paralogs for OR6C3 Gene

Selected SIMAP similar genes for OR6C3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6C3 Gene

genes like me logo Genes that share paralogs with OR6C3: view

Variants for OR6C3 Gene

Sequence variations from dbSNP and Humsavar for OR6C3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4318060 - 55,331,906(-) TAAAT(A/G)AGATT reference, missense
rs4448777 -- 55,331,197(-) TTATG(A/G)TATGA upstream-variant-2KB
rs4590978 -- 55,331,302(-) GTATA(A/C)ATTAA upstream-variant-2KB
rs4759138 -- 55,330,518(+) TAAAA(C/T)ATGGA upstream-variant-2KB
rs5798346 -- 55,331,313(+) AAAAA(-/A)GAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6C3 Gene

Variant ID Type Subtype PubMed ID
nsv826381 CNV Loss 20364138
nsv718 CNV Insertion 18451855
nsv438211 CNV Loss 16468122
nsv509469 CNV Insertion 20534489

Relevant External Links for OR6C3 Gene

HapMap Linkage Disequilibrium report
OR6C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C3 Gene

Disorders for OR6C3 Gene

(1) University of Copenhagen DISEASES for OR6C3 Gene

genes like me logo Genes that share disorders with OR6C3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for OR6C3 Gene

Publications for OR6C3 Gene

  1. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S. … Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3

Products for OR6C3 Gene

Sources for OR6C3 Gene

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