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Aliases for OR6C3 Gene

Aliases for OR6C3 Gene

  • Olfactory Receptor Family 6 Subfamily C Member 3 2 3 5
  • HSA8 3 4
  • Olfactory Receptor, Family 6, Subfamily C, Member 3 2
  • Olfactory Receptor 6C3 3
  • OST709 3

External Ids for OR6C3 Gene

Previous GeneCards Identifiers for OR6C3 Gene

  • GC00U990938
  • GC12P054011
  • GC12P055725

Summaries for OR6C3 Gene

Entrez Gene Summary for OR6C3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C3 Gene

OR6C3 (Olfactory Receptor Family 6 Subfamily C Member 3) is a Protein Coding gene. Diseases associated with OR6C3 include Cataract 21, Multiple Types and Cataract 37. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C1.

UniProtKB/Swiss-Prot for OR6C3 Gene

  • Odorant receptor.

Gene Wiki entry for OR6C3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C3 Gene

Genomics for OR6C3 Gene

Regulatory Elements for OR6C3 Gene

Enhancers for OR6C3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G055020 0.8 FANTOM5 dbSUPER 10.1 -310.9 -310852 0.0 NFIC TFAP4 NFIA GABPB1 NR2C1 NR2F6 OR6C3 OR6C65 OR9K2 OR6C75 NEUROD4 OR6C6 OR6C2 OR10A7 OR6C74 OR6C76
GH12G055799 1 FANTOM5 3.1 +467.8 467768 0.2 HDGF NFRKB INSM2 ARID4B RAD21 YY1 ZNF335 ZNF766 ZNF143 KLF7 ENSG00000258199 ENSG00000257740 SMARCC2 NABP2 SUOX OR6C3 OR6C75 SARNP ENSG00000257509
GH12G054932 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.2 -396.4 -396427 5.6 CBX3 ATF1 NFIB CREB3L1 NFRKB RAD21 ZNF766 ELK1 GATA2 CBX5 TESPA1 NEUROD4 MUCL1 NCKAP1L OR6C65 OR6C3 LOC105369778 GC12P054906
GH12G055826 1 FANTOM5 1.4 +494.5 494478 0.2 ZNF493 ZFP64 INSM2 ZEB1 ZNF366 ZNF354C KLF7 ZNF202 ZNF680 ZNF654 ANKRD52 PHC1P1 SMARCC2 STAT2 BAZ2A RN7SL809P ENSG00000257740 ENSG00000258199 RBMS2 RNU6-343P
GH12G055825 0.7 FANTOM5 Ensembl 1.7 +493.6 493563 0.5 GLIS1 OR10P1 OR6C4 OR6C65 OR6C3 IKZF4 OR6C2 ENSG00000257390 ORMDL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR6C3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6C3 Gene

Chromosome:
12
Start:
55,331,701 bp from pter
End:
55,332,636 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR6C3 Gene

Genes around OR6C3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6C3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6C3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C3 Gene

Proteins for OR6C3 Gene

  • Protein details for OR6C3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZP0-OR6C3_HUMAN
    Recommended name:
    Olfactory receptor 6C3
    Protein Accession:
    Q9NZP0

    Protein attributes for OR6C3 Gene

    Size:
    311 amino acids
    Molecular mass:
    35531 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C3 Gene

Post-translational modifications for OR6C3 Gene

  • Glycosylation at Asn2
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6C3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6C3 Gene

Domains & Families for OR6C3 Gene

Gene Families for OR6C3 Gene

Protein Domains for OR6C3 Gene

Suggested Antigen Peptide Sequences for OR6C3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZP0

UniProtKB/Swiss-Prot:

OR6C3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6C3: view

Function for OR6C3 Gene

Molecular function for OR6C3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Phenotypes for OR6C3 Gene

GenomeRNAi human phenotypes for OR6C3:
genes like me logo Genes that share phenotypes with OR6C3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6C3 Gene

Localization for OR6C3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR6C3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10706615
genes like me logo Genes that share ontologies with OR6C3: view

Pathways & Interactions for OR6C3 Gene

genes like me logo Genes that share pathways with OR6C3: view

Pathways by source for OR6C3 Gene

1 BioSystems pathway for OR6C3 Gene
1 KEGG pathway for OR6C3 Gene

Interacting Proteins for OR6C3 Gene

Gene Ontology (GO) - Biological Process for OR6C3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 10706615
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C3: view

No data available for SIGNOR curated interactions for OR6C3 Gene

Drugs & Compounds for OR6C3 Gene

No Compound Related Data Available

Transcripts for OR6C3 Gene

mRNA/cDNA for OR6C3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C3 Gene

No ASD Table

Relevant External Links for OR6C3 Gene

GeneLoc Exon Structure for
OR6C3
ECgene alternative splicing isoforms for
OR6C3

Expression for OR6C3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR6C3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6C3 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR6C3 Gene:

OR6C3

SOURCE GeneReport for Unigene cluster for OR6C3 Gene:

Hs.553653
genes like me logo Genes that share expression patterns with OR6C3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR6C3 Gene

Orthologs for OR6C3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OR04C01 35
  • 94 (a)
OneToOne
LOC102156012 34
  • 80.97 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
LOC787991 34
  • 80.22 (n)
mouse
(Mus musculus)
Mammalia Or6c3 55 Olfr788 35
  • 88 (a)
OneToOne
Or6c3b 55 Olfr803 34 16
  • 78.32 (n)
rat
(Rattus norvegicus)
Mammalia Olr952 34
  • 76.77 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 61 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
Species where no ortholog for OR6C3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C3 Gene

ENSEMBL:
Gene Tree for OR6C3 (if available)
TreeFam:
Gene Tree for OR6C3 (if available)

Paralogs for OR6C3 Gene

(456) SIMAP similar genes for OR6C3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6C3 Gene

genes like me logo Genes that share paralogs with OR6C3: view

Variants for OR6C3 Gene

Sequence variations from dbSNP and Humsavar for OR6C3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000303231 -- 55,330,090(+) GCCTG(C/G)ACTTT upstream-variant-2KB
rs1000458288 -- 55,331,354(+) CAACA(A/G)AAAAG upstream-variant-2KB
rs1001020418 -- 55,332,496(+) AGGCA(C/T)CATTG reference, missense
rs1001180299 -- 55,330,929(+) CTTGT(A/G)AGTCA upstream-variant-2KB
rs1001400638 -- 55,330,722(+) AAAAC(C/T)TTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6C3 Gene

Variant ID Type Subtype PubMed ID
esv3629572 CNV gain 21293372
nsv438211 CNV loss 16468122
nsv509469 CNV insertion 20534489
nsv559001 CNV loss 21841781
nsv718 CNV insertion 18451855
nsv826381 CNV loss 20364138

Variation tolerance for OR6C3 Gene

Residual Variation Intolerance Score: 84.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6C3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR6C3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6C3 Gene

Disorders for OR6C3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OR6C3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 21, multiple types
  • cataract 21 multiple types
cataract 37
  • cca5
- elite association - COSMIC cancer census association via MalaCards
Search OR6C3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OR6C3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6C3
genes like me logo Genes that share disorders with OR6C3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR6C3 Gene

Publications for OR6C3 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S. … Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3 64

Products for OR6C3 Gene

Sources for OR6C3 Gene

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