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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR6C2 Gene

protein-coding   GIFtS: 44
GCID: GC12P055845

Olfactory Receptor, Family 6, Subfamily C, Member 2
  2 related diseases
at
MalaCards
 

Aliases
for OR6C2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 21 2
HSA32 3
OR6C672
Olfactory Receptor 6C22

External Ids:    HGNC: 154361   Entrez Gene: 3414162   Ensembl: ENSG000001796957   UniProtKB: Q9NZP23   

Export aliases for OR6C2 gene to outside databases

Previous GC identifers: GC00U990939 GC12P054132


Summaries
for OR6C2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for OR6C2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

GeneCards Summary for OR6C2 Gene: 
OR6C2 (olfactory receptor, family 6, subfamily C, member 2) is a protein-coding gene. Diseases associated with OR6C2 include rosacea, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6C2 Gene


Genomic Views
for OR6C2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR6C2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   FOXL1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR6C2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR6C2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

OR6C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055845:  view genomic region     (about GC identifiers)

Start:
 55,845,998 bp from pter      End:
 55,846,933 bp from pter
Size:
 936 bases      Orientation:
 plus strand

Proteins
for OR6C2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 (See protein sequence)
Recommended Name: Olfactory receptor 6C2  
Size: 312 amino acids; 35178 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2

Explore proteomics data for OR6C2 at MOPED 

HORDE protein sequence for OR6C2
OR6C2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR6C2 Protein Expression

REFSEQ proteins: NP_473446.1  
ENSEMBL proteins: 
 ENSP00000323606  
Reactome Protein details: Q9NZP2
Human Recombinant Protein Products for OR6C2: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane NAS10706615

OR6C2 for ontologies           About GeneDecksing



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Protein Domains /
Families
for OR6C2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
OR6: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9NZP2

ProtoNet protein and cluster: Q9NZP2

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
Similarity: Belongs to the G-protein coupled receptor 1 family


OR6C2 for domains           About GeneDecksing


Function
for OR6C2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR6C2_HUMAN, Q9NZP2
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity NAS10706615
     
OR6C2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR6C2:
 Proliferating cells 

Animal Models:
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In Situ Assay
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Pathways & Interactions
for OR6C2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR6C2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR6C2
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR6C2):
    Olfactory transduction


OR6C2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6C2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR6C2 (ENSP000003236064) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR1J2ENSP000003355754STRING: ENSP00000335575
OR2Z1ENSP000003162844STRING: ENSP00000316284
OR4Q3ENSP000003300494STRING: ENSP00000330049
OR5AC2ENSP000003514664STRING: ENSP00000351466
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007608sensory perception of smell NAS10706615
GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS10706615

OR6C2 for ontologies           About GeneDecksing



Drugs & Compounds
for OR6C2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR6C2

Search CenterWatch for drugs/clinical trials and news about OR6C2

Transcripts
for OR6C2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for OR6C2 gene: 
NM_054105.1  

Unigene Cluster for OR6C2:

Olfactory receptor, family 6, subfamily C, member 2
Hs.524483
Unigene Representative Sequence: NM_054105
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000322678(uc001sgz.1)
miRNA
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GeneLoc Exon Structure


Expression
for OR6C2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR6C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTGTGGTTT
OR6C2 Expression
About this image


See OR6C2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.524483
    SABiosciences Custom PCR Arrays for OR6C2
Primer
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In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2

Orthologs
for OR6C2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for OR6C2 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Olfr7915
Olfr7801		 olfactory receptor 7915
olfactory receptor 7801		 76.92(n)1
76.92(a)1		   10 (77.37 cM)5
2582811  NM_146284.11  NP_666396.11 
 1295262295 


ENSEMBL Gene Tree for OR6C2 (if available)
TreeFam Gene Tree for OR6C2 (if available)

Paralogs
for OR6C2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR6C2 gene
OR6C702  OR6C652  OR6C752  OR6C62  OR2AP12  OR6C32  OR6C42  OR6C762  
OR6C12  OR6C682  OR6C742  
18/444 SIMAP similar genes for OR6C2 using alignment to 1 protein entry:     OR6C2_HUMAN(see all similar genes):
OR6C68    OR6C74    OR6C76    OR6C3    OR6C4    OR6C75
OR6C65    OR6C1    OR2AP1    OR6C6    OR6C70    OR6M1
OR6F1    OR6T1    OR10R3P    OR5B12    OR6S1    OR8J3

OR6C2 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for OR6C2
PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629


Genomic Variants
for OR6C2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/111 SNPs in OR6C2 are shown (see all 111)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 12 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1403324831,2
Cuntested155846490(+) AGCTCA/GAATTC 2 K E mis10--------
rs1510726131,2
C--55844115(+) GCAGAC/TAAGAG 1 -- us2k10--------
rs43969351,2
C,F,A,H--55844172(-) TTCATG/AGCTCA 1 -- us2k126Minor allele frequency- A:0.18NS EA NA WA CSA 2486
rs1142789141,2
C,F--55844238(+) CCCATG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.07WA 118
rs1157225411,2
F--55844404(+) TTTTAC/TCTGAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs1845371861,2
--55844459(+) GTAGAA/GGGTAA 1 -- us2k10--------
rs1894208061,2
--55844465(+) GGTAAA/GAAGAG 1 -- us2k10--------
rs1409253131,2
C--55844510(+) GATTAA/TTGAGA 1 -- us2k10--------
rs79800981,2
C,F,H--55844694(+) GCTTCA/GACAGT 1 -- us2k19Minor allele frequency- G:0.31NS EA NA WA 772
rs79667701,2
C,F,H--55844717(+) GCAGAT/CTCTTC 1 -- us2k121Minor allele frequency- C:0.32NS EA NA WA 2756

HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OR6C2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832422CNV Loss17160897

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Disorders / Diseases
for OR6C2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OR6C2 for disorders           About GeneDecksing

2 diseases for OR6C2:    About MalaCards
rosacea    neuronitis


Export disorders for OR6C2 gene to outside databases

Publications
for OR6C2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR6C2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR6C2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (2000)

External Searches for OR6C2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing OR6C2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 341416 HGNC: 15436 Ensembl:ENSG00000179695 euGenes: HUgn341416 ECgene: OR6C2 Kegg: 341416
H-InvDB: OR6C2

Other Databases showing OR6C2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing OR6C2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR6C2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6C2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property
for OR6C2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR6C2 gene:
Search GeneIP for patents involving OR6C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for OR6C2 gene

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

 
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