OR6C2 Gene

Aliases
for OR6C2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC00U990939 GC12P054132

Summaries
for OR6C2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for OR6C2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000012.11  NC_018923.2  NT_029419.13  

SwitchGear Promoter luciferase reporter plasmid: OR6C2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6C2

OR6C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055845:  view genomic region     (about GC identifiers)

Proteins
for OR6C2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2

Explore proteomics data for OR6C2 at MOPED

Post-translational modifications: 

OR6C2 Human Recombinant Protein Products:

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OR6C2 Antibody Products:

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	antibodies-online antibodies for OR6C2 (11 products)

OR6C2 Assay Products:

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	antibodies-online kits for OR6C2 (14 products)

Domains /
Families
for OR6C2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9NZP2

Find genes that share domains with OR6C2           About GenesLikeMe

Function
for OR6C2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for OR6C2

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		Predesigned siRNA for gene silencing in human, mouse, rat OR6C2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for OR6C2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OR6C2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2

Localization
for OR6C2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for OR6C2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for OR6C2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Olfactory Signaling Pathway	Olfactory Signaling Pathway 0.82 Olfactory transduction 0.82
2	Signaling by GPCR	Signaling by GPCR 0.90 Signal Transduction 0.58 GPCR downstream signaling 0.90

1 Reactome Pathway for OR6C2

Olfactory Signaling Pathway

1 Kegg Pathway  (Kegg details for OR6C2)

Olfactory transduction

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for OR6C2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for OR6C2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for OR6C2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OR6C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTGTGGTTT

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for OR6C2
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat OR6C2
		QuantiTect SYBR Green Assays in human, mouse, rat OR6C2
		QuantiFast Probe-based Assays in human, mouse, rat OR6C2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2

Orthologs
for OR6C2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for OR6C2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for OR6C2 gene

OR6C70²  OR6C65²  OR6C75²  OR6C6²  OR2AP1²  OR6C3²  OR6C4²  OR6C76²  

OR6C1²  OR6C68²  OR6C74²  

Selected SIMAP similar genes for OR6C2 using alignment to 1 protein entry:     OR6C2_HUMAN(see all similar genes):

OR6C68    OR6C74    OR6C76    OR6C3    OR6C4    OR6C75

OR6C65    OR6C1    OR2AP1    OR6C6    OR6C70    OR6M1

OR6F1    OR6T1    OR10R3P    OR5B12    OR6S1    OR8J3

Find genes that share paralogs with OR6C2           About GenesLikeMe


5 Pseudogenes.org Pseudogenes for OR6C2
PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629

Genomic Variants
for OR6C2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OR6C2 (see all 111)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1403324831,2	C	untested1	55846490(+)	AGCTCA/GAATTC	2	K E	mis1		0	--	--	--	--
rs1510726131,2	C	--	55844115(+)	GCAGAC/TAAGAG	1	--	us2k1		0	--	--	--	--
rs43969351,2	C,F,A,H	--	55844172(-)	TTCATG/AGCTCA	1	--	us2k1		26		NS EA NA WA CSA	2486
rs1142789141,2	C,F	--	55844238(+)	CCCATG/AAAGAG	1	--	us2k1		1		WA	118
rs1157225411,2	F	--	55844404(+)	TTTTAC/TCTGAT	1	--	us2k1		1		WA	118
rs1845371861,2		--	55844459(+)	GTAGAA/GGGTAA	1	--	us2k1		0	--	--	--	--
rs1894208061,2		--	55844465(+)	GGTAAA/GAAGAG	1	--	us2k1		0	--	--	--	--
rs1409253131,2	C	--	55844510(+)	GATTAA/TTGAGA	1	--	us2k1		0	--	--	--	--
rs79800981,2	C,F,H	--	55844694(+)	GCTTCA/GACAGT	1	--	us2k1		9		NS EA NA WA	772
rs79667701,2	C,F,H	--	55844717(+)	GCAGAT/CTCTTC	1	--	us2k1		21		NS EA NA WA	2756

HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OR6C2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv832422	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing OR6C2

DNA2.0 Custom Variant and Variant Library Synthesis for OR6C2

Disorders / Diseases
for OR6C2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for OR6C2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (Nature 2006)
2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)^{1, 2} Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)

External Searches for OR6C2 gene

Genome Databases showing OR6C2 gene

Other Databases showing OR6C2 gene

Specialized Databases showing OR6C2 gene

Products
for OR6C2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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