OR6C2 Gene protein-coding GIFtS : 44 GCID: GC12 P055845
Olfactory Receptor, Family 6, Subfamily C, Member 2
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Aliasesfor OR6C2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases Olfactory Receptor, Family 6, Subfamily C, Member 2 1 2 HSA32 3 OR6C672 Olfactory Receptor 6C22
Export aliases for OR6C2 gene to outside databases Previous GC identifers: GC00U990939 GC12P054132
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Summariesfor OR6C2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for OR6C2 Gene: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupledreceptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domainstructure with many neurotransmitter and hormone receptors and are responsible for the recognition and Gprotein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in thegenome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independentof other organisms. (provided by RefSeq, Jul 2008) GeneCards Summary for OR6C2 Gene: OR6C2 (olfactory receptor, family 6, subfamily C, member 2) is a protein-coding gene. Diseases associated with OR6C2 include rosacea neuronitis related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR . GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity . An important paralog of this gene is OR6C70 . UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 Function : Odorant receptor (Potential)Gene Wiki entry for OR6C2 Gene
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Genomic Viewsfor OR6C2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.2 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OR6C2 gene promoter:Nkx3-1 Nkx3-1 v4 AML1a Nkx3-1 v1 FOXL1 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3 Other transcription factors Search SABiosciences Chromatin IP Primers for OR6C2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6C2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2 OR6C2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P055845: view genomic region
(about GC identifiers )
Start: 55,845,998 bp from pter End:
55,846,933 bp from pter
Size: 936 bases Orientation:
plus strand
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Proteinsfor OR6C2 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 See
protein sequence )Recommended Name: Size : 312 amino acids; 35178 DaSubcellular location : Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2 Explore proteomics data for OR6C2 at MOPED HORDE protein sequence for OR6C2 OR6C2 Protein expression data from MOPED1 2 3 : About this image
REFSEQ proteins: NP_473446.1 ENSEMBL proteins: ENSP00000323606 Reactome Protein details: Q9NZP2 Human Recombinant Protein Products for OR6C2: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing OR6C2 Antibody Products: Assay Products for OR6C2:
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Protein
Domains /for OR6C2 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: OR6: GPCR / Class A : Olfactory receptors 3 InterPro protein domains :
Graphical View of Domain Structure for InterPro Entry Q9NZP2 ProtoNet protein and cluster: Q9NZP2
1 Blocks protein domain : IPB000725 UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 Similarity : Belongs to the G-protein coupled receptor 1 familyAbout GeneDecksing
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Functionfor OR6C2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: OR6C2_HUMAN, Q9NZP2 Function : Odorant receptor (Potential)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004930 G-protein coupled receptor activity
IEA -- GO:0004984 olfactory receptor activity
NAS 10706615
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for OR6C2 :Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for OR6C2 Search LifeMap BioReagents cell lines for OR6C2 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2
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Pathways & Interactionsfor OR6C2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for OR6C2 About See pathways by source SuperPath Contained pathways About 1 Olfactory transduction 2 Signaling by GPCR
Pathways by source See SuperPaths Show all pathways 4 1 (Kegg details for OR6C2) :About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6C2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/273 Interacting proteins for OR6C2 (ENSP00000323606 4 via UniProtKB, MINT, STRING , and/or I2D (see all 273 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007186 G-protein coupled receptor signaling pathway
-- -- GO:0007608 sensory perception of smell
NAS 10706615 GO:0050911 detection of chemical stimulus involved in sensory perception of smell
NAS 10706615
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Drugs & Compoundsfor OR6C2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for OR6C2 OR6C2
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Transcriptsfor OR6C2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for OR6C2 gene: NM_054105.1 Unigene Cluster for OR6C2:
Olfactory receptor, family 6, subfamily C, member 2 Hs.524483 Unigene Representative Sequence: NM_054105 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000322678 (uc001sgz.1 ) Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
GeneLoc Exon Structure
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Expression for OR6C2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section OR6C2 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: ATTGTGGTTTAbout this image
See OR6C2 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.524483 SABiosciences Custom PCR Arrays for OR6C2 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2
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Orthologsfor OR6C2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for OR6C2 gene from 1/6 species (see all 6 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Olfr7915 1
olfactory receptor 7915 1
76.92(n) 1 76.92(a) 1
10 (77.37 cM) 5 258281 1 NM_146284.1 1 NP_666396.1 1 129526229 5
ENSEMBL Gene Tree for OR6C2 (if available)TreeFam Gene Tree for OR6C2 (if available)
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Paralogsfor OR6C2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for OR6C2 gene OR6C70 2 OR6C65 2 OR6C75 2 OR6C6 2 OR2AP1 2 OR6C3 2 OR6C4 2 OR6C76 2 OR6C1 2 OR6C68 2 OR6C74 2 18/444 SIMAP similar genes for OR6C2 using alignment to 1 protein entry: OR6C2_HUMAN (see all similar genes ):OR6C68 OR6C74 OR6C76 OR6C3 OR6C4 OR6C75 OR6C65 OR6C1 OR2AP1 OR6C6 OR6C70 OR6M1 OR6F1 OR6T1 OR10R3P OR5B12 OR6S1 OR8J3 About GeneDecksing 5 Pseudogenes.org Pseudogenes for OR6C2 PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629
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Genomic Variantsfor OR6C2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)
Structural Variations Database of Genomic Variants (DGV) 1 variation for OR6C2 : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor OR6C2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section 2 : About MalaCards rosacea neuronitis About GeneDecksing Export disorders for OR6C2 gene to outside databases
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Publicationsfor OR6C2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for OR6C2 gene integrated from 9 sources :(articles sorted by number of sources associating them with OR6C2) Utopia : connect your pdf to the dynamic
The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 1 , 2 (2006) The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615) 1 , 2 (2000)
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External Searches for OR6C2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OR6C2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OR6C2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing OR6C2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for OR6C2 Pharmacogenomics, SNPs, Pathways HORDE entry for OR6C2The H uman O lfactory R eceptor D ata E xplorer at the Weizmann Institute of Science
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About This Section Patent Information for OR6C2 gene: OR6C2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OR6C2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR6C2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6C2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for OR6C2
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2
Search ThermoFisher Antibodies for OR6C2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat OR6C2
LSBio Antibodies in human mouse rat
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