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OR6C2 Gene

protein-coding GIFtS: 46
GCID: GC12P055845

Olfactory Receptor, Family 6, Subfamily C, Member 2

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 2¹ ²
HSA3² ³
OR6C67²
Olfactory Receptor 6C2²

External Ids:	HGNC: 15436¹	Entrez Gene: 341416²	Ensembl: ENSG00000179695⁷	UniProtKB: Q9NZP2³

Export aliases for OR6C2 gene to outside databases

Previous GC identifers: GC00U990939 GC12P054132

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6C2 Gene:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled

receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain

structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G

protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the

genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent

of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6C2 Gene:

OR6C2 (olfactory receptor, family 6, subfamily C, member 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2

Function: Odorant receptor (Potential)

Gene Wiki entry for OR6C2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the OR6C2 gene promoter:
Nkx3-1 Nkx3-1 v4 AML1a Nkx3-1 v1 FOXL1 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR6C2 promoter sequence

Search Chromatin IP Primers for OR6C2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6C2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.2

OR6C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P055845: view genomic region (about GC identifiers)

Start:	55,845,998 bp from pter	End:	55,846,933 bp from pter
Size:	936 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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About This Section

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 (See protein sequence)

Recommended Name: Olfactory receptor 6C2

Size: 312 amino acids; 35178 Da

Explore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2

Explore proteomics data for OR6C2 at MOPED

Post-translational modifications:

Glycosylation² at Asn3, Asn82

HORDE protein sequence for OR6C2

See OR6C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_473446.1

ENSEMBL proteins:

ENSP00000323606

Reactome Protein details: Q9NZP2

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

OR6: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9NZP2

ProtoNet protein and cluster: Q9NZP2

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2

Similarity: Belongs to the G-protein coupled receptor 1 family

Find genes that share domains with OR6C2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OR6C2_HUMAN, Q9NZP2

Function: Odorant receptor (Potential)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	NAS	10706615

Find genes that share ontologies with OR6C2 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for OR6C2:

Proliferating cells

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

OR6C2_HUMAN, Q9NZP2: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral component of membrane	NAS	10706615

Find genes that share ontologies with OR6C2 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

SuperPaths for OR6C2 About

See pathways by source

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by

SuperPath

Contained pathways About

Olfactory Signaling Pathway

Olfactory Signaling Pathway

0.82

Olfactory transduction

0.82

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

Find genes that share SuperPaths with OR6C2 About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for OR6C2

Olfactory Signaling Pathway

1 Kegg Pathway (Kegg details for OR6C2):

Olfactory transduction

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Interactions:

Search GeneGlobe Interaction Network for OR6C2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OR6C2 (ENSP00000323606⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 273)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR52E6	ENSP00000328878⁴	STRING: ENSP00000369279 STRING: ENSP00000328878
OR1J2	ENSP00000335575⁴	STRING: ENSP00000335575
OR2S2	ENSP00000344040⁴	STRING: ENSP00000344040
OR2Z1	ENSP00000316284⁴	STRING: ENSP00000316284
OR4C15	ENSP00000324958⁴	STRING: ENSP00000324958

About this table

Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0007608	sensory perception of smell	NAS	10706615
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	NAS	10706615

Find genes that share ontologies with OR6C2 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for OR6C2 gene:

NM_054105.1

Unigene Cluster for OR6C2:

Olfactory receptor, family 6, subfamily C, member 2

Hs.524483

Unigene Representative Sequence: NM_054105

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000322678(uc001sgz.1)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR6C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTGTGGTTT

About this image

OR6C2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

OR6C2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.524483

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR6C2 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Olfr791^{1 , 5}	olfactory receptor 791^{1, 5}	86.22(n)¹ 89.74(a)¹		10 (77.37 cM)⁵ 258932¹ NM_146930.1¹ NP_667141.1¹ 129526229⁵
tropical clawed frog (Xenopus tropicalis)	Amphibia	LOC100497273¹	olfactory receptor 11L1-like	52.09(n) 39.55(a)		100497273 XM_002937059.1 XP_002937105.1

ENSEMBL Gene Tree for OR6C2 (if available)
TreeFam Gene Tree for OR6C2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR6C2 gene

OR6C70² OR6C65² OR6C75² OR6C6² OR2AP1² OR6C3² OR6C4² OR6C76²

OR6C1² OR6C68² OR6C74²

Selected SIMAP similar genes for OR6C2 using alignment to 1 protein entry: OR6C2_HUMAN(see all similar genes):

OR6C68 OR6C74 OR6C76 OR6C3 OR6C4 OR6C75

OR6C65 OR6C1 OR2AP1 OR6C6 OR6C70 OR6M1

OR6F1 OR6T1 OR10R3P OR5B12 OR6S1 OR8J3

Find genes that share paralogs with OR6C2 About GenesLikeMe

5 Pseudogenes.org Pseudogenes for OR6C2
PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs140332483^1,2	C	untested¹	55846490(+)	`AGCTCA/GAATTC`	2	K E	mis¹		0	--	--	--	--
rs151072613^1,2	C	--	55844115(+)	`GCAGAC/TAAGAG`	1	--	us2k¹		0	--	--	--	--
rs4396935^1,2	C,F,A,H	--	55844172(-)	`TTCATG/AGCTCA`	1	--	us2k¹		26		NS EA NA WA CSA	2486
rs114278914^1,2	C,F	--	55844238(+)	`CCCATG/AAAGAG`	1	--	us2k¹		1		WA	118
rs115722541^1,2	F	--	55844404(+)	`TTTTAC/TCTGAT`	1	--	us2k¹		1		WA	118
rs184537186^1,2		--	55844459(+)	`GTAGAA/GGGTAA`	1	--	us2k¹		0	--	--	--	--
rs189420806^1,2		--	55844465(+)	`GGTAAA/GAAGAG`	1	--	us2k¹		0	--	--	--	--
rs140925313^1,2	C	--	55844510(+)	`GATTAA/TTGAGA`	1	--	us2k¹		0	--	--	--	--
rs7980098^1,2	C,F,H	--	55844694(+)	`GCTTCA/GACAGT`	1	--	us2k¹		9		NS EA NA WA	772
rs7966770^1,2	C,F,H	--	55844717(+)	`GCAGAT/CTCTTC`	1	--	us2k¹		21		NS EA NA WA	2756

HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for OR6C2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv832422	CNV	Loss	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR6C2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with OR6C2)

Utopia: connect your pdf to the dynamic
world of online information

The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (Nature 2006)
The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)^{1, 2} Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 341416	HGNC: 15436	Ensembl:ENSG00000179695	euGenes: HUgn341416	ECgene: OR6C2	Kegg: 341416
H-InvDB: OR6C2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR6C2	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6C2	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR6C2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR6C2 gene:
Search GeneIP for patents involving OR6C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	QuantiFast Probe-based Assays in human, mouse, rat OR6C2		QuantiTect SYBR Green Assays in human, mouse, rat OR6C2
	Custom PCR Arrays for OR6C2		Search Chromatin IP Primers for OR6C2
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat OR6C2		Search GeneGlobe Interaction Network for OR6C2
	Regulatory tfbs in OR6C2 promoter

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Hot genes Disease genes OR6C2 gene at Home site.

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OR6C2 Gene

Olfactory Receptor, Family 6, Subfamily C, Member 2

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OR6C2 Gene

Olfactory Receptor, Family 6, Subfamily C, Member 2

Aliasesfor OR6C2 gene

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OR6C2 Human Recombinant Protein Products:

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for OR6C2 gene

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for OR6C2 gene

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for OR6C2 gene

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for OR6C2 gene

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for OR6C2 gene

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