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OR6C2 Gene

protein-coding   GIFtS: 46
GCID: GC12P055845

Olfactory Receptor, Family 6, Subfamily C, Member 2

  Search for OR6C2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 21 2
HSA32 3
OR6C672
Olfactory Receptor 6C22

External Ids:    HGNC: 154361   Entrez Gene: 3414162   Ensembl: ENSG000001796957   UniProtKB: Q9NZP23   

Export aliases for OR6C2 gene to outside databases

Previous GC identifers: GC00U990939 GC12P054132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR6C2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6C2 Gene:
OR6C2 (olfactory receptor, family 6, subfamily C, member 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR6C2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   FOXL1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR6C2 promoter sequence
   Search Chromatin IP Primers for OR6C2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

OR6C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055845:  view genomic region     (about GC identifiers)

Start:
55,845,998 bp from pter      End:
55,846,933 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 (See protein sequence)
Recommended Name: Olfactory receptor 6C2  
Size: 312 amino acids; 35178 Da

Explore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2

Explore proteomics data for OR6C2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn82
  • HORDE protein sequence for OR6C2

    See OR6C2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_473446.1  
    ENSEMBL proteins: 
     ENSP00000323606  
    Reactome Protein details: Q9NZP2

    OR6C2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for OR6C2
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    Novus Biologicals OR6C2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR6C2

     
    Search eBioscience for Proteins for OR6C2 

    OR6C2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for OR6C2
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    LSBio Antibodies in human, mouse, rat for OR6C2

    OR6C2 Assay Products:

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    Cloud-Clone Corp. ELISAs for OR6C2
    Cloud-Clone Corp. CLIAs for OR6C2
    Search eBioscience for ELISAs for OR6C2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR6: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NZP2

    ProtoNet protein and cluster: Q9NZP2

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR6C2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR6C2_HUMAN, Q9NZP2
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS10706615
         
    Find genes that share ontologies with OR6C2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OR6C2:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR6C2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OR6C2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR6C2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OR6C2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat OR6C2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate OR6C2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OR6C2
    Predesigned siRNA for gene silencing in human, mouse, rat OR6C2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OR6C2

    Clone
    Products:
         
    OriGene clones in human, mouse for OR6C2 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OR6C2 (NM_054105)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR6C2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR6C2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OR6C2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR6C2_HUMAN, Q9NZP2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS10706615

    Find genes that share ontologies with OR6C2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR6C2 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR6C2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR6C2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR6C2):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR6C2
    Interactions:

        Search GeneGlobe Interaction Network for OR6C2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    273 Interacting proteins for OR6C2 (ENSP000003236064) via UniProtKB, MINT, STRING, and/or I2D (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR1J2ENSP000003355754STRING: ENSP00000335575
    OR2S2ENSP000003440404STRING: ENSP00000344040
    OR2Z1ENSP000003162844STRING: ENSP00000316284
    OR4C15ENSP000003249584STRING: ENSP00000324958
    OR4Q3ENSP000003300494STRING: ENSP00000330049
    OR56A1ENSP000003212464STRING: ENSP00000321246
    OR56A4ENSP000003282154STRING: ENSP00000328215
    OR5AC2ENSP000003514664STRING: ENSP00000351466
    OR6A2ENSP000003303844STRING: ENSP00000330384
    OR6C3ENSP000003689894STRING: ENSP00000368989
    OR8A1ENSP000002842874STRING: ENSP00000284287
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10A6ENSP000003124704STRING: ENSP00000312470
    OR10A7ENSP000003267184STRING: ENSP00000326718
    OR10AD1ENSP000003086894STRING: ENSP00000308689
    OR10AG1ENSP000003114774STRING: ENSP00000311477
    OR10G3ENSP000003024374STRING: ENSP00000302437
    OR10G4ENSP000003250764STRING: ENSP00000325076
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10H3ENSP000003071304STRING: ENSP00000307130
    OR10H4ENSP000003188344STRING: ENSP00000318834
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR10J3ENSP000003317894STRING: ENSP00000331789
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR10K1ENSP000002894514STRING: ENSP00000289451
    OR10K2ENSP000003242514STRING: ENSP00000324251
    OR10P1ENSP000003080824STRING: ENSP00000308082
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR10R2ENSP000003571344STRING: ENSP00000357134
    OR10T2ENSP000003341154STRING: ENSP00000334115
    OR10V1ENSP000003021994STRING: ENSP00000302199
    OR10W1ENSP000003785164STRING: ENSP00000378516
    OR11G2ENSP000003499304STRING: ENSP00000349930
    OR14A16ENSP000003502484STRING: ENSP00000350248
    OR14A2ENSP000003554414STRING: ENSP00000355441
    OR14C36ENSP000003245344STRING: ENSP00000324534
    OR14I1ENSP000003397264STRING: ENSP00000339726
    OR14K1ENSP000002832254STRING: ENSP00000283225
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    OR1B1ENSP000003031514STRING: ENSP00000303151
    OR1C1ENSP000003861384STRING: ENSP00000386138
    OR1D2ENSP000003275854STRING: ENSP00000327585
    OR1F1ENSP000003054244STRING: ENSP00000305424
    OR1G1ENSP000003315454STRING: ENSP00000331545
    OR1I1ENSP000002095404STRING: ENSP00000209540
    OR1J1ENSP000002593574STRING: ENSP00000259357
    OR1J4ENSP000003435214STRING: ENSP00000343521
    OR1K1ENSP000002773094STRING: ENSP00000277309
    OR1L1ENSP000003627904STRING: ENSP00000362790
    OR1L3ENSP000003028634STRING: ENSP00000302863
    OR1L8ENSP000003066074STRING: ENSP00000306607
    OR1M1ENSP000004019664STRING: ENSP00000401966
    OR1N1ENSP000003069744STRING: ENSP00000306974
    OR1N2ENSP000003627924STRING: ENSP00000362792
    OR1Q1ENSP000002979134STRING: ENSP00000297913
    OR2A12ENSP000003861744STRING: ENSP00000386174
    OR2A14ENSP000003861374STRING: ENSP00000386137
    OR2A2ENSP000003862094STRING: ENSP00000386209
    OR2A25ENSP000003861674STRING: ENSP00000386167
    OR2A5ENSP000003862084STRING: ENSP00000386208
    OR2AE1ENSP000003139364STRING: ENSP00000313936
    OR2AG1ENSP000003074474STRING: ENSP00000307447
    OR2AG2ENSP000003426974STRING: ENSP00000342697
    OR2AJ1ENSP000003250784STRING: ENSP00000325078
    OR2AK2ENSP000003554364STRING: ENSP00000355436
    OR2AP1ENSP000003234234STRING: ENSP00000323423
    OR2AT4ENSP000003048464STRING: ENSP00000304846
    OR2B11ENSP000003256824STRING: ENSP00000325682
    OR2B2ENSP000003044194STRING: ENSP00000304419
    OR2B6ENSP000002446234STRING: ENSP00000244623
    OR2C1ENSP000003077264STRING: ENSP00000307726
    OR2C3ENSP000003554434STRING: ENSP00000355443
    OR2D2ENSP000002994594STRING: ENSP00000299459
    OR2D3ENSP000003205604STRING: ENSP00000320560
    OR2G2ENSP000003263494STRING: ENSP00000326349
    OR2G3ENSP000003263014STRING: ENSP00000326301
    OR2G6ENSP000003412914STRING: ENSP00000341291
    OR2K2ENSP000003050554STRING: ENSP00000305055
    OR2L13ENSP000003508364STRING: ENSP00000350836
    OR2M4ENSP000003066884STRING: ENSP00000306688
    OR2T1ENSP000003554304STRING: ENSP00000355430
    OR2T10ENSP000003292104STRING: ENSP00000329210
    OR2T11ENSP000003289344STRING: ENSP00000328934
    OR2T27ENSP000003420084STRING: ENSP00000342008
    OR2T6ENSP000003479654STRING: ENSP00000347965
    OR2V1ENSP000004041024STRING: ENSP00000404102
    OR2V2ENSP000003321854STRING: ENSP00000332185
    OR2W3ENSP000003535164STRING: ENSP00000353516
    OR2Y1ENSP000003124034STRING: ENSP00000312403
    OR3A1ENSP000003138034STRING: ENSP00000313803
    OR4A16ENSP000003251284STRING: ENSP00000325128
    OR4A5ENSP000003676644STRING: ENSP00000367664
    OR4B1ENSP000003116054STRING: ENSP00000311605
    OR4C11ENSP000003066514STRING: ENSP00000306651
    OR4C12ENSP000003344184STRING: ENSP00000334418
    OR4C16ENSP000003249134STRING: ENSP00000324913
    OR4C3ENSP000003214194STRING: ENSP00000321419
    OR4C46ENSP000003290564STRING: ENSP00000329056
    OR4C5ENSP000003213384STRING: ENSP00000321338
    OR4C6ENSP000003247694STRING: ENSP00000324769
    OR4D11ENSP000003200774STRING: ENSP00000320077
    OR4D5ENSP000003059704STRING: ENSP00000305970
    OR4D6ENSP000003001274STRING: ENSP00000300127
    OR4D9ENSP000003285634STRING: ENSP00000328563
    OR4E2ENSP000003861954STRING: ENSP00000386195
    OR4F15ENSP000003331844STRING: ENSP00000333184
    OR4F6ENSP000003275254STRING: ENSP00000327525
    OR4K1ENSP000002856004STRING: ENSP00000285600
    OR4K13ENSP000003193224STRING: ENSP00000319322
    OR4K14ENSP000003050114STRING: ENSP00000305011
    OR4K15ENSP000003040774STRING: ENSP00000304077
    OR4K17ENSP000003191974STRING: ENSP00000319197
    OR4K2ENSP000002986424STRING: ENSP00000298642
    OR4K5ENSP000003195114STRING: ENSP00000319511
    OR4L1ENSP000003192174STRING: ENSP00000319217
    OR4N2ENSP000003196014STRING: ENSP00000319601
    OR4N4ENSP000003325004STRING: ENSP00000332500
    OR4N5ENSP000003321104STRING: ENSP00000332110
    OR4P4ENSP000003248314STRING: ENSP00000324831
    OR4S1ENSP000003214474STRING: ENSP00000321447
    OR4S2ENSP000003103374STRING: ENSP00000310337
    OR4X1ENSP000003215064STRING: ENSP00000321506
    OR4X2ENSP000003077514STRING: ENSP00000307751
    OR51A7ENSP000003523054STRING: ENSP00000352305
    OR51B2ENSP000003275404STRING: ENSP00000327540
    OR51B4ENSP000003695734STRING: ENSP00000369573
    OR51B5ENSP000003007734STRING: ENSP00000300773
    OR51B6ENSP000003695684STRING: ENSP00000369568
    OR51D1ENSP000003502224STRING: ENSP00000350222
    OR51E1ENSP000003801554STRING: ENSP00000380155
    OR51E2ENSP000003801534STRING: ENSP00000380153
    OR51F1ENSP000003451634STRING: ENSP00000345163
    OR51F2ENSP000003239524STRING: ENSP00000323952
    OR51G1ENSP000003225464STRING: ENSP00000322546
    OR51G2ENSP000003225934STRING: ENSP00000322593
    OR51H1PENSP000003227244STRING: ENSP00000322724
    OR51I1ENSP000003695594STRING: ENSP00000369559
    OR51I2ENSP000003419874STRING: ENSP00000341987
    OR51J1ENSP000003324734STRING: ENSP00000332473
    OR51L1ENSP000003221564STRING: ENSP00000322156
    OR51M1ENSP000003331964STRING: ENSP00000333196
    OR51Q1ENSP000003007784STRING: ENSP00000300778
    OR51S1ENSP000003227544STRING: ENSP00000322754
    OR51T1ENSP000003697384STRING: ENSP00000369738
    OR51V1ENSP000003217294STRING: ENSP00000321729
    OR52A5ENSP000003034694STRING: ENSP00000303469
    OR52B4ENSP000003861604STRING: ENSP00000386160
    OR52B6ENSP000003415814STRING: ENSP00000341581
    OR52D1ENSP000003262324STRING: ENSP00000326232
    OR52E2ENSP000003220884STRING: ENSP00000322088
    OR52E4ENSP000003214264STRING: ENSP00000321426
    OR52H1ENSP000003262594STRING: ENSP00000326259
    OR52J3ENSP000003697284STRING: ENSP00000369728
    OR52M1ENSP000003533434STRING: ENSP00000353343
    OR52N1ENSP000003228234STRING: ENSP00000322823
    OR52N2ENSP000003228014STRING: ENSP00000322801
    OR52N4ENSP000003232244STRING: ENSP00000323224
    OR52N5ENSP000003228664STRING: ENSP00000322866
    OR52R1ENSP000003697424STRING: ENSP00000369742
    OR52W1ENSP000003096734STRING: ENSP00000309673
    OR56A3ENSP000003315724STRING: ENSP00000331572
    OR56B1ENSP000003229394STRING: ENSP00000322939
    OR56B4ENSP000003211964STRING: ENSP00000321196
    OR5A1ENSP000003030964STRING: ENSP00000303096
    OR5A2ENSP000003038344STRING: ENSP00000303834
    OR5AK2ENSP000003227844STRING: ENSP00000322784
    OR5AN1ENSP000003203024STRING: ENSP00000320302
    OR5AP2ENSP000003031114STRING: ENSP00000303111
    OR5AR1ENSP000003026394STRING: ENSP00000302639
    OR5AS1ENSP000003241114STRING: ENSP00000324111
    OR5AU1ENSP000003020574STRING: ENSP00000302057
    OR5B12ENSP000003066574STRING: ENSP00000306657
    OR5B17ENSP000003499454STRING: ENSP00000349945
    OR5B2ENSP000003030764STRING: ENSP00000303076
    OR5B21ENSP000003535374STRING: ENSP00000353537
    OR5B3ENSP000003082704STRING: ENSP00000308270
    OR5C1ENSP000003627844STRING: ENSP00000362784
    OR5D13ENSP000003548004STRING: ENSP00000354800
    OR5D14ENSP000003344564STRING: ENSP00000334456
    OR5D16ENSP000003676494STRING: ENSP00000367649
    OR5D18ENSP000003350254STRING: ENSP00000335025
    OR5F1ENSP000002784094STRING: ENSP00000278409
    OR5H14ENSP000004017064STRING: ENSP00000401706
    OR5H2ENSP000003474184STRING: ENSP00000347418
    OR5I1ENSP000003015324STRING: ENSP00000301532
    OR5J2ENSP000003107884STRING: ENSP00000310788
    OR5K3ENSP000003731944STRING: ENSP00000373194
    OR5K4ENSP000003470034STRING: ENSP00000347003
    OR5M8ENSP000003233544STRING: ENSP00000323354
    OR5M9ENSP000002797914STRING: ENSP00000279791
    OR5P2ENSP000003318234STRING: ENSP00000331823
    OR5P3ENSP000003320684STRING: ENSP00000332068
    OR5R1ENSP000003085954STRING: ENSP00000308595
    OR5T1ENSP000003236124STRING: ENSP00000323612
    OR5T2ENSP000003236884STRING: ENSP00000323688
    OR5T3ENSP000003054034STRING: ENSP00000305403
    OR5W2ENSP000003424484STRING: ENSP00000342448
    OR6B1ENSP000003861514STRING: ENSP00000386151
    OR6C1ENSP000003689904STRING: ENSP00000368990
    OR6C4ENSP000003777994STRING: ENSP00000377799
    OR6C6ENSP000003512114STRING: ENSP00000351211
    OR6C65ENSP000003689864STRING: ENSP00000368986
    OR6C68ENSP000003689834STRING: ENSP00000368983
    OR6C70ENSP000003291534STRING: ENSP00000329153
    OR6C74ENSP000003428364STRING: ENSP00000342836
    OR6C75ENSP000003689874STRING: ENSP00000368987
    OR6C76ENSP000003284024STRING: ENSP00000328402
    OR6F1ENSP000003056404STRING: ENSP00000305640
    OR6K2ENSP000003526264STRING: ENSP00000352626
    OR6K3ENSP000003571284STRING: ENSP00000357128
    OR6K6ENSP000003571264STRING: ENSP00000357126
    OR6M1ENSP000003110384STRING: ENSP00000311038
    OR6N1ENSP000003355354STRING: ENSP00000335535
    OR6N2ENSP000003441014STRING: ENSP00000344101
    OR6P1ENSP000003347214STRING: ENSP00000334721
    OR6Q1ENSP000003077344STRING: ENSP00000307734
    OR6S1ENSP000003131104STRING: ENSP00000313110
    OR6T1ENSP000003252034STRING: ENSP00000325203
    OR6V1ENSP000003960854STRING: ENSP00000396085
    OR6X1ENSP000003337244STRING: ENSP00000333724
    OR6Y1ENSP000003048074STRING: ENSP00000304807
    OR7A10ENSP000002480584STRING: ENSP00000248058
    OR7A17ENSP000003281444STRING: ENSP00000328144
    OR7A5ENSP000003169554STRING: ENSP00000316955
    OR7C1ENSP000002480734STRING: ENSP00000248073
    OR7C2ENSP000002480724STRING: ENSP00000248072
    OR7D2ENSP000003455634STRING: ENSP00000345563
    OR7D4ENSP000003104884STRING: ENSP00000310488
    OR7E24ENSP000003875234STRING: ENSP00000387523
    OR7G1ENSP000002936144STRING: ENSP00000293614
    OR7G2ENSP000003038224STRING: ENSP00000303822
    OR7G3ENSP000003028674STRING: ENSP00000302867
    OR8B12ENSP000003071594STRING: ENSP00000307159
    OR8B4ENSP000003484494STRING: ENSP00000348449
    OR8B8ENSP000003302804STRING: ENSP00000330280
    OR8D1ENSP000003504744STRING: ENSP00000350474
    OR8D2ENSP000003500224STRING: ENSP00000350022
    OR8D4ENSP000003253814STRING: ENSP00000325381
    OR8H1ENSP000003235954STRING: ENSP00000323595
    OR8I2ENSP000003038644STRING: ENSP00000303864
    OR8J1ENSP000003040604STRING: ENSP00000304060
    OR8J3ENSP000003015294STRING: ENSP00000301529
    OR8K1ENSP000002797834STRING: ENSP00000279783
    OR8K3ENSP000003235554STRING: ENSP00000323555
    OR8K5ENSP000003238534STRING: ENSP00000323853
    OR8S1ENSP000003106324STRING: ENSP00000310632
    OR8U1ENSP000003041884STRING: ENSP00000304188
    OR9A2ENSP000003165184STRING: ENSP00000316518
    OR9G1ENSP000003090124STRING: ENSP00000309012
    OR9G4ENSP000003075154STRING: ENSP00000307515
    OR9I1ENSP000003026064STRING: ENSP00000302606
    OR9K2ENSP000003075984STRING: ENSP00000307598
    OR9Q1ENSP000003349344STRING: ENSP00000334934
    OR9Q2ENSP000003087144STRING: ENSP00000308714
    ADRBK2ENSP000003175784STRING: ENSP00000317578
    ARRB2ENSP000002692604STRING: ENSP00000269260
    --ENSP000003443874STRING: ENSP00000344387
    --ENSP000004079654STRING: ENSP00000407965
    --ENSP000003970244STRING: ENSP00000397024
    --ENSP000003861484STRING: ENSP00000386148
    --ENSP000003677004STRING: ENSP00000367700
    --ENSP000003539474STRING: ENSP00000353947
    --ENSP000003444534STRING: ENSP00000344453
    --ENSP000003275644STRING: ENSP00000327564
    --ENSP000003213984STRING: ENSP00000321398
    --ENSP000003088214STRING: ENSP00000308821
    --ENSP000003038174STRING: ENSP00000303817
    --ENSP000002840814STRING: ENSP00000284081
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS10706615
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS10706615

    Find genes that share ontologies with OR6C2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR6C2 gene: 
    NM_054105.1  

    Unigene Cluster for OR6C2:

    Olfactory receptor, family 6, subfamily C, member 2
    Hs.524483
    Unigene Representative Sequence: NM_054105
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322678(uc001sgz.1)
    miRNA
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR6C2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTGGTTT
    OR6C2 Expression
    About this image

    OR6C2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR6C2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524483
        Custom PCR Arrays for OR6C2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR6C2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr7911 , 5 olfactory receptor 7911, 5 86.22(n)1
    89.74(a)1
      10 (77.37 cM)5
    2589321  NM_146930.11  NP_667141.11 
     1295262295 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004972731 olfactory receptor 11L1-like 52.09(n)
    39.55(a)
      100497273  XM_002937059.1  XP_002937105.1 


    ENSEMBL Gene Tree for OR6C2 (if available)
    TreeFam Gene Tree for OR6C2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR6C2 gene
    OR6C702  OR6C652  OR6C752  OR6C62  OR2AP12  OR6C32  OR6C42  OR6C762  
    OR6C12  OR6C682  OR6C742  
    Selected SIMAP similar genes for OR6C2 using alignment to 1 protein entry:     OR6C2_HUMAN(see all similar genes):
    OR6C68    OR6C74    OR6C76    OR6C3    OR6C4    OR6C75
    OR6C65    OR6C1    OR2AP1    OR6C6    OR6C70    OR6M1
    OR6F1    OR6T1    OR10R3P    OR5B12    OR6S1    OR8J3

    Find genes that share paralogs with OR6C2           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for OR6C2
    PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR6C2 (see all 111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403324831,2
    Cuntested155846490(+) AGCTCA/GAATTC 2 K E mis10--------
    rs1510726131,2
    C--55844115(+) GCAGAC/TAAGAG 1 -- us2k10--------
    rs43969351,2
    C,F,A,H--55844172(-) TTCATG/AGCTCA 1 -- us2k126Minor allele frequency- A:0.18NS EA NA WA CSA 2486
    rs1142789141,2
    C,F--55844238(+) CCCATG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1157225411,2
    F--55844404(+) TTTTAC/TCTGAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1845371861,2
    --55844459(+) GTAGAA/GGGTAA 1 -- us2k10--------
    rs1894208061,2
    --55844465(+) GGTAAA/GAAGAG 1 -- us2k10--------
    rs1409253131,2
    C--55844510(+) GATTAA/TTGAGA 1 -- us2k10--------
    rs79800981,2
    C,F,H--55844694(+) GCTTCA/GACAGT 1 -- us2k19Minor allele frequency- G:0.31NS EA NA WA 772
    rs79667701,2
    C,F,H--55844717(+) GCAGAT/CTCTTC 1 -- us2k121Minor allele frequency- C:0.32NS EA NA WA 2756

    HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR6C2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832422CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR6C2
    DNA2.0 Custom Variant and Variant Library Synthesis for OR6C2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR6C2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR6C2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 341416 HGNC: 15436 Ensembl:ENSG00000179695 euGenes: HUgn341416 ECgene: OR6C2 Kegg: 341416
    H-InvDB: OR6C2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OR6C2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR6C2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OR6C2 gene:
    Search GeneIP for patents involving OR6C2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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