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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR6C2 Gene

protein-coding   GIFtS: 44
GCID: GC12P055845

Olfactory Receptor, Family 6, Subfamily C, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 6, Subfamily C, Member 21 2
HSA32 3
OR6C672
Olfactory Receptor 6C22

External Ids:    HGNC: 154361   Entrez Gene: 3414162   Ensembl: ENSG000001796957   UniProtKB: Q9NZP23   

Export aliases for OR6C2 gene to outside databases

Previous GC identifers: GC00U990939 GC12P054132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6C2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6C2 Gene: 
OR6C2 (olfactory receptor, family 6, subfamily C, member 2) is a protein-coding gene. Diseases associated with OR6C2 include rosacea, and neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C70.

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6C2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR6C2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   Nkx3-1 v1   FOXL1   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR6C2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR6C2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6C2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

OR6C2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6C2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P055845:  view genomic region     (about GC identifiers)

Start:
55,845,998 bp from pter      End:
55,846,933 bp from pter
Size:
936 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2 (See protein sequence)
Recommended Name: Olfactory receptor 6C2  
Size: 312 amino acids; 35178 Da
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR6C2: NX_Q9NZP2

Explore proteomics data for OR6C2 at MOPED 

HORDE protein sequence for OR6C2
OR6C2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OR6C2 Protein Expression

REFSEQ proteins: NP_473446.1  
ENSEMBL proteins: 
 ENSP00000323606  
Reactome Protein details: Q9NZP2
Human Recombinant Protein Products for OR6C2: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for OR6C2
OriGene Custom MassSpec 
OriGene Custom Protein Services for OR6C2
GenScript Custom Purified and Recombinant Proteins Services for OR6C2
Novus Biologicals OR6C2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for OR6C2 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0016021integral to membrane NAS10706615

OR6C2 for ontologies           About GeneDecksing



OR6C2 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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OriGene Custom Antibody Services for OR6C2
GenScript Custom Superior Antibodies Services for OR6C2
Novus Biologicals OR6C2 Antibody
Search for Antibodies for OR6C2 at Abcam
Cloud-Clone Corp. Antibodies for OR6C2 
Search ThermoFisher Antibodies for OR6C2
LSBio Antibodies in human, mouse, rat for OR6C2 

Assay Products for OR6C2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for OR6C2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for OR6C2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for OR6C2 
Cloud-Clone Corp. CLIAs for OR6C2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
OR6: GPCR / Class A : Olfactory receptors

3 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR000725 Olfact_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q9NZP2

ProtoNet protein and cluster: Q9NZP2

1 Blocks protein domain: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6C2_HUMAN, Q9NZP2
Similarity: Belongs to the G-protein coupled receptor 1 family


OR6C2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: OR6C2_HUMAN, Q9NZP2
Function: Odorant receptor (Potential)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
GO:0004984olfactory receptor activity NAS10706615
     
OR6C2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for OR6C2:
 Proliferating cells 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for OR6C2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OR6C2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OR6C2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OR6C2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OR6C2
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OR6C2
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for OR6C2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR6C2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for OR6C2
Sirion Biotech Customized adenovirus for overexpression of OR6C2

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for OR6C2 (see all 6)
OriGene ORF clones in mouse, rat for OR6C2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: OR6C2 (NM_054105)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OR6C2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR6C2
Sirion Biotech Customized lentivirus for stable overexpression of OR6C2 
                     Customized lentivirus expression plasmids for stable overexpression of OR6C2 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for OR6C2
Search LifeMap BioReagents cell lines for OR6C2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6C2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OR6C2 About                                                                                                See pathways by source

SuperPathContained pathways About
1Olfactory transduction
Olfactory Signaling Pathway0.81
Olfactory transduction0.81
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


4        Reactome Pathways for OR6C2
    GPCR downstream signaling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR


1         Kegg Pathway  (Kegg details for OR6C2):
    Olfactory transduction


OR6C2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6C2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

273 Interacting proteins for OR6C2 (ENSP000003236064) via UniProtKB, MINT, STRING, and/or I2D (see top 5)
InteractantInteraction Details
GeneCardExternal ID(s)
OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
OR1J2ENSP000003355754STRING: ENSP00000335575
OR2Z1ENSP000003162844STRING: ENSP00000316284
OR4Q3ENSP000003300494STRING: ENSP00000330049
OR5AC2ENSP000003514664STRING: ENSP00000351466
OR6C3ENSP000003689894STRING: ENSP00000368989
GNALENSP000003340514STRING: ENSP00000334051
GNGT1ENSP000002485724STRING: ENSP00000248572
OR10A3ENSP000003539884STRING: ENSP00000353988
OR10A4ENSP000003691574STRING: ENSP00000369157
OR10A6ENSP000003124704STRING: ENSP00000312470
OR10A7ENSP000003267184STRING: ENSP00000326718
OR10AD1ENSP000003086894STRING: ENSP00000308689
OR10AG1ENSP000003114774STRING: ENSP00000311477
OR10G3ENSP000003024374STRING: ENSP00000302437
OR10G4ENSP000003250764STRING: ENSP00000325076
OR10H2ENSP000003060954STRING: ENSP00000306095
OR10H3ENSP000003071304STRING: ENSP00000307130
OR10H4ENSP000003188344STRING: ENSP00000318834
OR10J1ENSP000003990784STRING: ENSP00000399078
OR10J3ENSP000003317894STRING: ENSP00000331789
OR10J5ENSP000003344414STRING: ENSP00000334441
OR10K1ENSP000002894514STRING: ENSP00000289451
OR10K2ENSP000003242514STRING: ENSP00000324251
OR10P1ENSP000003080824STRING: ENSP00000308082
OR10Q1ENSP000003143244STRING: ENSP00000314324
OR10R2ENSP000003571344STRING: ENSP00000357134
OR10T2ENSP000003341154STRING: ENSP00000334115
OR10V1ENSP000003021994STRING: ENSP00000302199
OR10W1ENSP000003785164STRING: ENSP00000378516
OR11G2ENSP000003499304STRING: ENSP00000349930
OR14A16ENSP000003502484STRING: ENSP00000350248
OR14A2ENSP000003554414STRING: ENSP00000355441
OR14C36ENSP000003245344STRING: ENSP00000324534
OR14I1ENSP000003397264STRING: ENSP00000339726
OR14K1ENSP000002832254STRING: ENSP00000283225
OR1A1ENSP000003052074STRING: ENSP00000305207
OR1A2ENSP000003713774STRING: ENSP00000371377
OR1B1ENSP000003031514STRING: ENSP00000303151
OR1C1ENSP000003861384STRING: ENSP00000386138
OR1D2ENSP000003275854STRING: ENSP00000327585
OR1F1ENSP000003054244STRING: ENSP00000305424
OR1G1ENSP000003315454STRING: ENSP00000331545
OR1I1ENSP000002095404STRING: ENSP00000209540
OR1J1ENSP000002593574STRING: ENSP00000259357
OR1J4ENSP000003435214STRING: ENSP00000343521
OR1K1ENSP000002773094STRING: ENSP00000277309
OR1L1ENSP000003627904STRING: ENSP00000362790
OR1L3ENSP000003028634STRING: ENSP00000302863
OR1L8ENSP000003066074STRING: ENSP00000306607
OR1M1ENSP000004019664STRING: ENSP00000401966
OR1N1ENSP000003069744STRING: ENSP00000306974
OR1N2ENSP000003627924STRING: ENSP00000362792
OR1Q1ENSP000002979134STRING: ENSP00000297913
OR2A12ENSP000003861744STRING: ENSP00000386174
OR2A14ENSP000003861374STRING: ENSP00000386137
OR2A2ENSP000003862094STRING: ENSP00000386209
OR2A25ENSP000003861674STRING: ENSP00000386167
OR2A5ENSP000003862084STRING: ENSP00000386208
OR2AE1ENSP000003139364STRING: ENSP00000313936
OR2AG1ENSP000003074474STRING: ENSP00000307447
OR2AG2ENSP000003426974STRING: ENSP00000342697
OR2AJ1ENSP000003250784STRING: ENSP00000325078
OR2AK2ENSP000003554364STRING: ENSP00000355436
OR2AP1ENSP000003234234STRING: ENSP00000323423
OR2AT4ENSP000003048464STRING: ENSP00000304846
OR2B11ENSP000003256824STRING: ENSP00000325682
OR2B2ENSP000003044194STRING: ENSP00000304419
OR2B6ENSP000002446234STRING: ENSP00000244623
OR2C1ENSP000003077264STRING: ENSP00000307726
OR2C3ENSP000003554434STRING: ENSP00000355443
OR2D2ENSP000002994594STRING: ENSP00000299459
OR2D3ENSP000003205604STRING: ENSP00000320560
OR2G2ENSP000003263494STRING: ENSP00000326349
OR2G3ENSP000003263014STRING: ENSP00000326301
OR2G6ENSP000003412914STRING: ENSP00000341291
OR2K2ENSP000003050554STRING: ENSP00000305055
OR2L13ENSP000003508364STRING: ENSP00000350836
OR2M4ENSP000003066884STRING: ENSP00000306688
OR2S2ENSP000003440404STRING: ENSP00000344040
OR2T1ENSP000003554304STRING: ENSP00000355430
OR2T10ENSP000003292104STRING: ENSP00000329210
OR2T11ENSP000003289344STRING: ENSP00000328934
OR2T27ENSP000003420084STRING: ENSP00000342008
OR2T6ENSP000003479654STRING: ENSP00000347965
OR2V1ENSP000004041024STRING: ENSP00000404102
OR2V2ENSP000003321854STRING: ENSP00000332185
OR2W3ENSP000003535164STRING: ENSP00000353516
OR2Y1ENSP000003124034STRING: ENSP00000312403
OR3A1ENSP000003138034STRING: ENSP00000313803
OR4A16ENSP000003251284STRING: ENSP00000325128
OR4A5ENSP000003676644STRING: ENSP00000367664
OR4B1ENSP000003116054STRING: ENSP00000311605
OR4C11ENSP000003066514STRING: ENSP00000306651
OR4C12ENSP000003344184STRING: ENSP00000334418
OR4C15ENSP000003249584STRING: ENSP00000324958
OR4C16ENSP000003249134STRING: ENSP00000324913
OR4C3ENSP000003214194STRING: ENSP00000321419
OR4C46ENSP000003290564STRING: ENSP00000329056
OR4C5ENSP000003213384STRING: ENSP00000321338
OR4C6ENSP000003247694STRING: ENSP00000324769
OR4D11ENSP000003200774STRING: ENSP00000320077
OR4D5ENSP000003059704STRING: ENSP00000305970
OR4D6ENSP000003001274STRING: ENSP00000300127
OR4D9ENSP000003285634STRING: ENSP00000328563
OR4E2ENSP000003861954STRING: ENSP00000386195
OR4F15ENSP000003331844STRING: ENSP00000333184
OR4F6ENSP000003275254STRING: ENSP00000327525
OR4K1ENSP000002856004STRING: ENSP00000285600
OR4K13ENSP000003193224STRING: ENSP00000319322
OR4K14ENSP000003050114STRING: ENSP00000305011
OR4K15ENSP000003040774STRING: ENSP00000304077
OR4K17ENSP000003191974STRING: ENSP00000319197
OR4K2ENSP000002986424STRING: ENSP00000298642
OR4K5ENSP000003195114STRING: ENSP00000319511
OR4L1ENSP000003192174STRING: ENSP00000319217
OR4N2ENSP000003196014STRING: ENSP00000319601
OR4N4ENSP000003325004STRING: ENSP00000332500
OR4N5ENSP000003321104STRING: ENSP00000332110
OR4P4ENSP000003248314STRING: ENSP00000324831
OR4S1ENSP000003214474STRING: ENSP00000321447
OR4S2ENSP000003103374STRING: ENSP00000310337
OR4X1ENSP000003215064STRING: ENSP00000321506
OR4X2ENSP000003077514STRING: ENSP00000307751
OR51A7ENSP000003523054STRING: ENSP00000352305
OR51B2ENSP000003275404STRING: ENSP00000327540
OR51B4ENSP000003695734STRING: ENSP00000369573
OR51B5ENSP000003007734STRING: ENSP00000300773
OR51B6ENSP000003695684STRING: ENSP00000369568
OR51D1ENSP000003502224STRING: ENSP00000350222
OR51E1ENSP000003801554STRING: ENSP00000380155
OR51E2ENSP000003801534STRING: ENSP00000380153
OR51F1ENSP000003451634STRING: ENSP00000345163
OR51F2ENSP000003239524STRING: ENSP00000323952
OR51G1ENSP000003225464STRING: ENSP00000322546
OR51G2ENSP000003225934STRING: ENSP00000322593
OR51H1PENSP000003227244STRING: ENSP00000322724
OR51I1ENSP000003695594STRING: ENSP00000369559
OR51I2ENSP000003419874STRING: ENSP00000341987
OR51J1ENSP000003324734STRING: ENSP00000332473
OR51L1ENSP000003221564STRING: ENSP00000322156
OR51M1ENSP000003331964STRING: ENSP00000333196
OR51Q1ENSP000003007784STRING: ENSP00000300778
OR51S1ENSP000003227544STRING: ENSP00000322754
OR51T1ENSP000003697384STRING: ENSP00000369738
OR51V1ENSP000003217294STRING: ENSP00000321729
OR52A5ENSP000003034694STRING: ENSP00000303469
OR52B4ENSP000003861604STRING: ENSP00000386160
OR52B6ENSP000003415814STRING: ENSP00000341581
OR52D1ENSP000003262324STRING: ENSP00000326232
OR52E2ENSP000003220884STRING: ENSP00000322088
OR52E4ENSP000003214264STRING: ENSP00000321426
OR52H1ENSP000003262594STRING: ENSP00000326259
OR52J3ENSP000003697284STRING: ENSP00000369728
OR52M1ENSP000003533434STRING: ENSP00000353343
OR52N1ENSP000003228234STRING: ENSP00000322823
OR52N2ENSP000003228014STRING: ENSP00000322801
OR52N4ENSP000003232244STRING: ENSP00000323224
OR52N5ENSP000003228664STRING: ENSP00000322866
OR52R1ENSP000003697424STRING: ENSP00000369742
OR52W1ENSP000003096734STRING: ENSP00000309673
OR56A1ENSP000003212464STRING: ENSP00000321246
OR56A3ENSP000003315724STRING: ENSP00000331572
OR56A4ENSP000003282154STRING: ENSP00000328215
OR56B1ENSP000003229394STRING: ENSP00000322939
OR56B4ENSP000003211964STRING: ENSP00000321196
OR5A1ENSP000003030964STRING: ENSP00000303096
OR5A2ENSP000003038344STRING: ENSP00000303834
OR5AK2ENSP000003227844STRING: ENSP00000322784
OR5AN1ENSP000003203024STRING: ENSP00000320302
OR5AP2ENSP000003031114STRING: ENSP00000303111
OR5AR1ENSP000003026394STRING: ENSP00000302639
OR5AS1ENSP000003241114STRING: ENSP00000324111
OR5AU1ENSP000003020574STRING: ENSP00000302057
OR5B12ENSP000003066574STRING: ENSP00000306657
OR5B17ENSP000003499454STRING: ENSP00000349945
OR5B2ENSP000003030764STRING: ENSP00000303076
OR5B21ENSP000003535374STRING: ENSP00000353537
OR5B3ENSP000003082704STRING: ENSP00000308270
OR5C1ENSP000003627844STRING: ENSP00000362784
OR5D13ENSP000003548004STRING: ENSP00000354800
OR5D14ENSP000003344564STRING: ENSP00000334456
OR5D16ENSP000003676494STRING: ENSP00000367649
OR5D18ENSP000003350254STRING: ENSP00000335025
OR5F1ENSP000002784094STRING: ENSP00000278409
OR5H14ENSP000004017064STRING: ENSP00000401706
OR5H2ENSP000003474184STRING: ENSP00000347418
OR5I1ENSP000003015324STRING: ENSP00000301532
OR5J2ENSP000003107884STRING: ENSP00000310788
OR5K3ENSP000003731944STRING: ENSP00000373194
OR5K4ENSP000003470034STRING: ENSP00000347003
OR5M8ENSP000003233544STRING: ENSP00000323354
OR5M9ENSP000002797914STRING: ENSP00000279791
OR5P2ENSP000003318234STRING: ENSP00000331823
OR5P3ENSP000003320684STRING: ENSP00000332068
OR5R1ENSP000003085954STRING: ENSP00000308595
OR5T1ENSP000003236124STRING: ENSP00000323612
OR5T2ENSP000003236884STRING: ENSP00000323688
OR5T3ENSP000003054034STRING: ENSP00000305403
OR5W2ENSP000003424484STRING: ENSP00000342448
OR6A2ENSP000003303844STRING: ENSP00000330384
OR6B1ENSP000003861514STRING: ENSP00000386151
OR6C1ENSP000003689904STRING: ENSP00000368990
OR6C4ENSP000003777994STRING: ENSP00000377799
OR6C6ENSP000003512114STRING: ENSP00000351211
OR6C65ENSP000003689864STRING: ENSP00000368986
OR6C68ENSP000003689834STRING: ENSP00000368983
OR6C70ENSP000003291534STRING: ENSP00000329153
OR6C74ENSP000003428364STRING: ENSP00000342836
OR6C75ENSP000003689874STRING: ENSP00000368987
OR6C76ENSP000003284024STRING: ENSP00000328402
OR6F1ENSP000003056404STRING: ENSP00000305640
OR6K2ENSP000003526264STRING: ENSP00000352626
OR6K3ENSP000003571284STRING: ENSP00000357128
OR6K6ENSP000003571264STRING: ENSP00000357126
OR6M1ENSP000003110384STRING: ENSP00000311038
OR6N1ENSP000003355354STRING: ENSP00000335535
OR6N2ENSP000003441014STRING: ENSP00000344101
OR6P1ENSP000003347214STRING: ENSP00000334721
OR6Q1ENSP000003077344STRING: ENSP00000307734
OR6S1ENSP000003131104STRING: ENSP00000313110
OR6T1ENSP000003252034STRING: ENSP00000325203
OR6V1ENSP000003960854STRING: ENSP00000396085
OR6X1ENSP000003337244STRING: ENSP00000333724
OR6Y1ENSP000003048074STRING: ENSP00000304807
OR7A10ENSP000002480584STRING: ENSP00000248058
OR7A17ENSP000003281444STRING: ENSP00000328144
OR7A5ENSP000003169554STRING: ENSP00000316955
OR7C1ENSP000002480734STRING: ENSP00000248073
OR7C2ENSP000002480724STRING: ENSP00000248072
OR7D2ENSP000003455634STRING: ENSP00000345563
OR7D4ENSP000003104884STRING: ENSP00000310488
OR7E24ENSP000003875234STRING: ENSP00000387523
OR7G1ENSP000002936144STRING: ENSP00000293614
OR7G2ENSP000003038224STRING: ENSP00000303822
OR7G3ENSP000003028674STRING: ENSP00000302867
OR8A1ENSP000002842874STRING: ENSP00000284287
OR8B12ENSP000003071594STRING: ENSP00000307159
OR8B4ENSP000003484494STRING: ENSP00000348449
OR8B8ENSP000003302804STRING: ENSP00000330280
OR8D1ENSP000003504744STRING: ENSP00000350474
OR8D2ENSP000003500224STRING: ENSP00000350022
OR8D4ENSP000003253814STRING: ENSP00000325381
OR8H1ENSP000003235954STRING: ENSP00000323595
OR8I2ENSP000003038644STRING: ENSP00000303864
OR8J1ENSP000003040604STRING: ENSP00000304060
OR8J3ENSP000003015294STRING: ENSP00000301529
OR8K1ENSP000002797834STRING: ENSP00000279783
OR8K3ENSP000003235554STRING: ENSP00000323555
OR8K5ENSP000003238534STRING: ENSP00000323853
OR8S1ENSP000003106324STRING: ENSP00000310632
OR8U1ENSP000003041884STRING: ENSP00000304188
OR9A2ENSP000003165184STRING: ENSP00000316518
OR9G1ENSP000003090124STRING: ENSP00000309012
OR9G4ENSP000003075154STRING: ENSP00000307515
OR9I1ENSP000003026064STRING: ENSP00000302606
OR9K2ENSP000003075984STRING: ENSP00000307598
OR9Q1ENSP000003349344STRING: ENSP00000334934
OR9Q2ENSP000003087144STRING: ENSP00000308714
ADRBK2ENSP000003175784STRING: ENSP00000317578
ARRB2ENSP000002692604STRING: ENSP00000269260
--ENSP000004079654STRING: ENSP00000407965
--ENSP000003970244STRING: ENSP00000397024
--ENSP000003861484STRING: ENSP00000386148
--ENSP000003677004STRING: ENSP00000367700
--ENSP000003539474STRING: ENSP00000353947
--ENSP000003444534STRING: ENSP00000344453
--ENSP000003443874STRING: ENSP00000344387
--ENSP000003275644STRING: ENSP00000327564
--ENSP000003213984STRING: ENSP00000321398
--ENSP000003088214STRING: ENSP00000308821
--ENSP000003038174STRING: ENSP00000303817
--ENSP000002840814STRING: ENSP00000284081
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007608sensory perception of smell NAS10706615
GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS10706615

OR6C2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for OR6C2

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR6C2 gene: 
NM_054105.1  

Unigene Cluster for OR6C2:

Olfactory receptor, family 6, subfamily C, member 2
Hs.524483
Unigene Representative Sequence: NM_054105
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000322678(uc001sgz.1)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR6C2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTGTGGTTT
OR6C2 Expression
About this image


See OR6C2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.524483
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for OR6C2 gene from 1/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Olfr7915
Olfr7801
olfactory receptor 7915
olfactory receptor 7801
76.92(n)1
76.92(a)1
  10 (77.37 cM)5
2582811  NM_146284.11  NP_666396.11 
 1295262295 


ENSEMBL Gene Tree for OR6C2 (if available)
TreeFam Gene Tree for OR6C2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OR6C2 gene
OR6C702  OR6C652  OR6C752  OR6C62  OR2AP12  OR6C32  OR6C42  OR6C762  
OR6C12  OR6C682  OR6C742  
18/444 SIMAP similar genes for OR6C2 using alignment to 1 protein entry:     OR6C2_HUMAN(see all similar genes):
OR6C68    OR6C74    OR6C76    OR6C3    OR6C4    OR6C75
OR6C65    OR6C1    OR2AP1    OR6C6    OR6C70    OR6M1
OR6F1    OR6T1    OR10R3P    OR5B12    OR6S1    OR8J3

OR6C2 for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for OR6C2
PGOHUM00000238765 PGOHUM00000239468 PGOHUM00000239805 PGOHUM00000239806 PGOHUM00000260629


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/111 SNPs in OR6C2 are shown (see all 111)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1403324831,2
Cuntested155846490(+) AGCTCA/GAATTC 2 K E mis10--------
rs1510726131,2
C--55844115(+) GCAGAC/TAAGAG 1 -- us2k10--------
rs43969351,2
C,F,A,H--55844172(-) TTCATG/AGCTCA 1 -- us2k126Minor allele frequency- A:0.18NS EA NA WA CSA 2486
rs1142789141,2
C,F--55844238(+) CCCATG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.07WA 118
rs1157225411,2
F--55844404(+) TTTTAC/TCTGAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
rs1845371861,2
--55844459(+) GTAGAA/GGGTAA 1 -- us2k10--------
rs1894208061,2
--55844465(+) GGTAAA/GAAGAG 1 -- us2k10--------
rs1409253131,2
C--55844510(+) GATTAA/TTGAGA 1 -- us2k10--------
rs79800981,2
C,F,H--55844694(+) GCTTCA/GACAGT 1 -- us2k19Minor allele frequency- G:0.31NS EA NA WA 772
rs79667701,2
C,F,H--55844717(+) GCAGAT/CTCTTC 1 -- us2k121Minor allele frequency- C:0.32NS EA NA WA 2756

HapMap Linkage Disequilibrium report for OR6C2 ( 55845998 - 55846933 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for OR6C2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv832422CNV Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for OR6C2:    About MalaCards
rosacea    neuronitis


OR6C2 for disorders           About GeneDecksing


Export disorders for OR6C2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OR6C2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR6C2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 341416 HGNC: 15436 Ensembl:ENSG00000179695 euGenes: HUgn341416 ECgene: OR6C2 Kegg: 341416
H-InvDB: OR6C2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OR6C2 Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6C2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for OR6C2 gene:
Search GeneIP for patents involving OR6C2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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