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Aliases for OR6C1 Gene

Aliases for OR6C1 Gene

  • Olfactory Receptor, Family 6, Subfamily C, Member 1 2 3
  • OST267 3 4
  • Olfactory Receptor 6C1 3

External Ids for OR6C1 Gene

Summaries for OR6C1 Gene

Entrez Gene Summary for OR6C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6C1 Gene

OR6C1 (Olfactory Receptor, Family 6, Subfamily C, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6C3.

UniProtKB/Swiss-Prot for OR6C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6C1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6C1 Gene

Genomics for OR6C1 Gene

Genomic Location for OR6C1 Gene

Start:
55,320,561 bp from pter
End:
55,321,624 bp from pter
Size:
1,064 bases
Orientation:
Plus strand

Genomic View for OR6C1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6C1 Gene

Regulatory Elements for OR6C1 Gene

Proteins for OR6C1 Gene

  • Protein details for OR6C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RD1-OR6C1_HUMAN
    Recommended name:
    Olfactory receptor 6C1
    Protein Accession:
    Q96RD1
    Secondary Accessions:
    • B2RNM0

    Protein attributes for OR6C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    35660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6C1 Gene

Proteomics data for OR6C1 Gene at MOPED

Post-translational modifications for OR6C1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3

Other Protein References for OR6C1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR6C1 Gene

Domains for OR6C1 Gene

Gene Families for OR6C1 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6C1 Gene

UniProtKB/Swiss-Prot:

OR6C1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96RD1
genes like me logo Genes that share domains with OR6C1: view

Function for OR6C1 Gene

Molecular function for OR6C1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR6C1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR6C1 Gene

Localization for OR6C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6C1 Gene COMPARTMENTS Subcellular localization image for OR6C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6C1: view

Pathways for OR6C1 Gene

genes like me logo Genes that share pathways with OR6C1: view

Pathways by source for OR6C1 Gene

Interacting Proteins for OR6C1 Gene

Gene Ontology (GO) - Biological Process for OR6C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6C1: view

Transcripts for OR6C1 Gene

mRNA/cDNA for OR6C1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6C1 Gene

No ASD Table

Relevant External Links for OR6C1 Gene

GeneLoc Exon Structure for
OR6C1
ECgene alternative splicing isoforms for
OR6C1

Expression for OR6C1 Gene

mRNA expression in normal human tissues for OR6C1 Gene

SOURCE GeneReport for Unigene cluster for OR6C1 Gene Hs.553763

genes like me logo Genes that share expressions with OR6C1: view

Orthologs for OR6C1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR6C1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746860 36
  • 98.82 (n)
  • 97.12 (a)
OR6C1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
OR6C1 36
  • 88.74 (n)
  • 87.34 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
LOC100683479 36
  • 85.85 (n)
  • 82.32 (a)
mouse
(Mus musculus)
Mammalia Olfr786 37
  • 84 (a)
OneToMany
Olfr802 36
  • 83.82 (n)
  • 84.89 (a)
Olfr802 16
Olfr802 37
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia OR6C1 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 62 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 61 (a)
ManyToMany
-- 37
  • 62 (a)
ManyToMany
-- 37
  • 65 (a)
ManyToMany
-- 37
  • 56 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr964 36
  • 82.63 (n)
  • 82.52 (a)
Species with no ortholog for OR6C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6C1 Gene

ENSEMBL:
Gene Tree for OR6C1 (if available)
TreeFam:
Gene Tree for OR6C1 (if available)

Paralogs for OR6C1 Gene

Selected SIMAP similar genes for OR6C1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6C1 Gene

genes like me logo Genes that share paralogs with OR6C1: view

Variants for OR6C1 Gene

Sequence variations from dbSNP and Humsavar for OR6C1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4432101 -- 55,320,315(-) ACTTT(C/T)CTGAC upstream-variant-2KB
rs5798345 -- 55,320,622(+) ATAAC(-/A)AGAGT reference, frameshift-variant
rs7132347 - 55,321,092(+) AGCTT(C/G)ATTAC reference, missense
rs7132431 - 55,320,988(+) GCATT(A/G)CTTGA missense, reference
rs7132600 - 55,321,264(+) CAGAA(C/T)AATTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR6C1 Gene

Variant ID Type Subtype PubMed ID
nsv826381 CNV Loss 20364138
nsv718 CNV Insertion 18451855
nsv82 CNV Insertion 15895083
nsv438211 CNV Loss 16468122

Relevant External Links for OR6C1 Gene

HapMap Linkage Disequilibrium report
OR6C1

Disorders for OR6C1 Gene

(1) University of Copenhagen DISEASES for OR6C1 Gene

Relevant External Links for OR6C1

Genetic Association Database (GAD)
OR6C1
Human Genome Epidemiology (HuGE) Navigator
OR6C1
genes like me logo Genes that share disorders with OR6C1: view

No data available for UniProtKB/Swiss-Prot for OR6C1 Gene

Publications for OR6C1 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn P.T. … Mollon J.D. (Genes Brain Behav. 2014) 3

Products for OR6C1 Gene

Sources for OR6C1 Gene

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