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Aliases for OR6B3 Gene

Aliases for OR6B3 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 3 2 3 5
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 Pseudogene 2 3
  • Olfactory Receptor OR2-2 3 4
  • OR6B3P 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 3 2
  • OR6B3Q 3

External Ids for OR6B3 Gene

Previous HGNC Symbols for OR6B3 Gene

  • OR6B3P

Previous GeneCards Identifiers for OR6B3 Gene

  • GC02U900017
  • GC02M241306
  • GC02M240689
  • GC02M240633
  • GC02M240984

Summaries for OR6B3 Gene

Entrez Gene Summary for OR6B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B3 Gene

OR6B3 (Olfactory Receptor Family 6 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR11L1.

UniProtKB/Swiss-Prot for OR6B3 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B3 Gene

Genomics for OR6B3 Gene

Regulatory Elements for OR6B3 Gene

Genomic Location for OR6B3 Gene

Chromosome:
2
Start:
240,044,636 bp from pter
End:
240,053,711 bp from pter
Size:
9,076 bases
Orientation:
Minus strand

Genomic View for OR6B3 Gene

Genes around OR6B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B3 Gene

Proteins for OR6B3 Gene

  • Protein details for OR6B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGW1-OR6B3_HUMAN
    Recommended name:
    Olfactory receptor 6B3
    Protein Accession:
    Q8NGW1
    Secondary Accessions:
    • Q6IFH3

    Protein attributes for OR6B3 Gene

    Size:
    331 amino acids
    Molecular mass:
    37232 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA04687.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6B3 Gene

Proteomics data for OR6B3 Gene at MOPED

Post-translational modifications for OR6B3 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B3 Gene

Domains & Families for OR6B3 Gene

Gene Families for OR6B3 Gene

Protein Domains for OR6B3 Gene

Suggested Antigen Peptide Sequences for OR6B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGW1

UniProtKB/Swiss-Prot:

OR6B3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B3: view

Function for OR6B3 Gene

Molecular function for OR6B3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR6B3: view
genes like me logo Genes that share phenotypes with OR6B3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6B3 Gene

Localization for OR6B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6B3 Gene COMPARTMENTS Subcellular localization image for OR6B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B3: view

Pathways & Interactions for OR6B3 Gene

genes like me logo Genes that share pathways with OR6B3: view

Pathways by source for OR6B3 Gene

Interacting Proteins for OR6B3 Gene

Gene Ontology (GO) - Biological Process for OR6B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B3: view

No data available for SIGNOR curated interactions for OR6B3 Gene

Drugs & Compounds for OR6B3 Gene

No Compound Related Data Available

Transcripts for OR6B3 Gene

mRNA/cDNA for OR6B3 Gene

(2) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B3 Gene

No ASD Table

Relevant External Links for OR6B3 Gene

GeneLoc Exon Structure for
OR6B3
ECgene alternative splicing isoforms for
OR6B3

Expression for OR6B3 Gene

mRNA expression in normal human tissues for OR6B3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR6B3 Gene

This gene is overexpressed in Nerve - Tibial (x40.7).

SOURCE GeneReport for Unigene cluster for OR6B3 Gene Hs.626616

genes like me logo Genes that share expression patterns with OR6B3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6B3 Gene

Orthologs for OR6B3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr1414 35
  • 86.86 (n)
  • 87.95 (a)
Olfr1414 16
Olfr1414 36
  • 87 (a)
ManyToMany
Olfr1415 36
  • 84 (a)
ManyToMany
Olfr1416 36
  • 84 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1345 35
  • 87.38 (n)
  • 87.38 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
-- 36
  • 82 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
-- 36
  • 80 (a)
ManyToMany
OR12C12 36
  • 79 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
OneToMany
Species with no ortholog for OR6B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B3 Gene

ENSEMBL:
Gene Tree for OR6B3 (if available)
TreeFam:
Gene Tree for OR6B3 (if available)

Paralogs for OR6B3 Gene

Paralogs for OR6B3 Gene

(455) SIMAP similar genes for OR6B3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6B3: view

Variants for OR6B3 Gene

Sequence variations from dbSNP and Humsavar for OR6B3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12465491 - 240,045,372(+) TCCAG(C/T)AGCCG reference, missense
rs4853971 -- 240,052,477(-) ACTTT(A/C)TCTAT intron-variant
rs4853972 -- 240,048,572(-) AGAGG(C/T)ATAGC intron-variant
rs4854047 -- 240,051,350(-) TCTTG(C/T)CTTTA intron-variant
rs4854048 -- 240,048,384(-) GTGGG(G/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OR6B3 Gene

Variant ID Type Subtype PubMed ID
nsv876099 CNV Gain 21882294
nsv483047 CNV Loss 15286789
nsv525278 CNV Gain 19592680
nsv876112 CNV Loss 21882294
nsv876113 CNV Loss 21882294
nsv3236 CNV Insertion 18451855

Variation tolerance for OR6B3 Gene

Residual Variation Intolerance Score: 95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6B3 Gene

HapMap Linkage Disequilibrium report
OR6B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B3 Gene

Disorders for OR6B3 Gene

Relevant External Links for OR6B3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6B3

No disorders were found for OR6B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B3 Gene

Publications for OR6B3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for OR6B3 Gene

Sources for OR6B3 Gene

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