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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR6B3 Gene

protein-coding GIFtS: 44
GCID: GC02M240984

olfactory receptor, family 6, subfamily B, member 3

(Previous names: olfactory receptor, family 6, subfamily B, member 3 pseudogene...)
(Previous symbol: OR6B3P)

Explore 1 disease affiliated with
OR6B3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 6, Subfamily B, Member 3¹ ²
OR6B3P¹ ² ³
OR6B3Q¹ ²
Olfactory Receptor, Family 6, Subfamily B, Member 3 Pseudogene¹ ²
Olfactory Receptor OR2-2² ³
Olfactory Receptor 6B3²

External Ids:	HGNC: 15042¹	Entrez Gene: 150681²	Ensembl: ENSG00000178586⁷	UniProtKB: Q8NGW1³

Export aliases for OR6B3 gene to outside databases

Previous GC identifers: GC02U900017 GC02M241306 GC02M240689 GC02M240633

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6B3:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: OR6B3_HUMAN, Q8NGW1

Function: Odorant receptor (Potential)

Gene Wiki entry for OR6B3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005416.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR6B3 gene promoter:
USF1 Nkx2-5 RORalpha2 GATA-2 Roaz MZF-1 CREB USF-1 SEF-1 (1) ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR6B3 promoter sequence

Search SABiosciences Chromatin IP Primers for OR6B3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6B3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC chromosome: 2

OR6B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6B3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M240984: view genomic region (about GC identifiers)

Start:	240,984,497 bp from pter	End:	240,985,489 bp from pter
Size:	993 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR6B3_HUMAN, Q8NGW1 (See protein sequence)

Recommended Name: Olfactory receptor 6B3

Size: 331 amino acids; 37232 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=DAA04687.1; Type=Erroneous initiation;

Secondary accessions: Q6IFH3

Explore the universe of human proteins at neXtProt for OR6B3: NX_Q8NGW1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NGW1

HORDE protein sequence for OR6B3
OR6B3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775486.1

ENSEMBL proteins:

ENSP00000322435

Reactome Protein details: Q8NGW1
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

OR6B3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR6B3 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGW1

ProtoNet protein and cluster: Q8NGW1

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6B3_HUMAN, Q8NGW1

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OR6B3_HUMAN, Q8NGW1

Function: Odorant receptor (Potential)

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

OR6B3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Olfactory transduction

Olfactory transduction

1.00

Olfactory Signaling Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for OR6B3

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

1 Kegg Pathway (Kegg details for OR6B3):

Olfactory transduction

OR6B3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR6B3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for OR6B3 (ENSP00000322435⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADRBK2	ENSP00000317578⁴	STRING: ENSP00000317578
ARRB2	ENSP00000269260⁴	STRING: ENSP00000269260
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR6B3
Search CenterWatch for drugs/clinical trials and news about OR6B3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OR6B3 gene:

NM_173351.1

Unigene Cluster for OR6B3:

Olfactory receptor, family 6, subfamily B, member 3

Hs.626616

Unigene Representative Sequence: NM_173351

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000319423(uc010zoe.2)

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3 AceView cDNA sequences:

BC065821 NM_001001962 BQ893658

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR6B3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See OR6B3 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.626616

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OR6B3 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	62(a)	1 → many	GL343253.1(706790-707725)
zebrafish (Danio rerio)	Actinopterygii	or103-2⁶ or103-4⁶ (see all 12)	odorant receptor, family C, subfamily 103, member ... odorant receptor, family C, subfamily 103, member ... (see all 12)	31(a) 31(a) (see all 12)	many ↔ many many ↔ many (see all 12)	15(30733509-30735663) 15(30736120-30743311)

ENSEMBL Gene Tree for OR6B3 (if available)
TreeFam Gene Tree for OR6B3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR6B3 gene

OR6B2¹ ² OR6N1² OR6B1² OR6K3² OR6Q1² OR6Y1² OR6N2² OR6K2²

OR6K6² OR6A2² OR11L1² OR6P1²

18/456 SIMAP similar genes for OR6B3 using alignment to 2 protein entries: OR6B3_HUMAN (see all proteins) (see all similar genes):

OR6B2 OR6A2 OR6B1 OR6P1 OR11A1 OR1L4

OR2G3 OR6Y1 OR1L6 OR10T2 OR2W1 OR5A2

OR6Q1 OR1J1 HSA12 OR2B8P OR5AU1 OR10R3P

OR6B3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs13393875^1,2	C,F,H,	--	240984010(+)	`TTTTAT/ATTTCT`	2	--	ds500¹ us2k¹		13		NS EA WA NA	1194
rs184700024^1,2		--	240984040(+)	`CAGTAA/GGGGTT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs731664^1,2	C,F,H,	--	240984089(+)	`AATCAG/TAGAAC`	2	--	ds500¹ us2k¹		14		NS NA WA	2014
rs114609904^1,2		--	240984212(+)	`CACACC/TGCAAT`	2	--	ds500¹ us2k¹		1		NA	120
rs150750440^1,2		--	240984306(+)	`AATTCA/CTTAAG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs73107455^1,2	C,	--	240984318(+)	`TTTACG/TAACTA`	2	--	ds500¹ us2k¹		1		WA	2
rs116592175^1,2	F,	--	240984332(+)	`CTTTGC/TTCATC`	2	--	ds500¹ us2k¹		1		NA	120
rs188913990^1,2	C,	--	240984474(+)	`TAATGC/TAAACA`	1	--	ds500¹		0	--	--	--	--
rs142989073^1,2	C,	--	240984515(+)	`TGTATC/TTGGAG`	2	Q	syn¹		0	--	--	--	--
rs77973167^1,2	C,	--	240984517(+)	`TATTTG/TGAGAT`	2	K Q	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OR6B3 ( 240984497 - 240985489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OR6B3
1 CNV: 0031

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR6B3 for disorders About GeneDecksing

1 disease for OR6B3: About MalaCards

neuronitis

Export disorders for OR6B3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR6B3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR6B3)

Utopia: connect your pdf to the dynamic
world of online information

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 150681	HGNC: 15042	AceView: OR6B3	Ensembl:ENSG00000178586	euGenes: HUgn150681
ECgene: OR6B3	Kegg: 150681	H-InvDB: OR6B3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR6B3	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR6B3	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR6B3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR6B3 gene:
Search GeneIP for patents involving OR6B3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OR6B3 gene at Home site.

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OR6B3 Gene

olfactory receptor, family 6, subfamily B, member 3

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OR6B3 Gene

olfactory receptor, family 6, subfamily B, member 3

Aliasesfor OR6B3 gene

Summariesfor OR6B3 gene

Genomic Viewsfor OR6B3 gene

Proteinsfor OR6B3 gene

Protein Domains /Familiesfor OR6B3 gene

Functionfor OR6B3 gene

Pathways & Interactionsfor OR6B3 gene

Drugs & Compoundsfor OR6B3 gene

Transcriptsfor OR6B3 gene

Expression for OR6B3 gene

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Disorders / Diseasesfor OR6B3 gene

Publicationsfor OR6B3 gene

External Searches for OR6B3 gene

Genome Databases showing OR6B3 gene

Other Databases showing OR6B3 gene

Specialized Databases showing OR6B3 gene

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Aliases
for OR6B3 gene

Summaries
for OR6B3 gene

Genomic Views
for OR6B3 gene

Proteins
for OR6B3 gene

Protein Domains /
Families
for OR6B3 gene

Function
for OR6B3 gene

Pathways & Interactions
for OR6B3 gene

Drugs & Compounds
for OR6B3 gene

Transcripts
for OR6B3 gene

Expression
for OR6B3 gene

Orthologs
for OR6B3 gene

Paralogs
for OR6B3 gene

Genomic Variants
for OR6B3 gene

Disorders / Diseases
for OR6B3 gene

Publications
for OR6B3 gene

Intellectual Property
for OR6B3 gene

Products
for OR6B3 gene