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Aliases for OR6B2 Gene

Aliases for OR6B2 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 2 2 3 5
  • Olfactory Receptor, Family 6, Subfamily B, Member 2 Pseudogene 2 3
  • Olfactory Receptor OR2-1 3 4
  • OR6B2P 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 2 2
  • OR2-1 3

External Ids for OR6B2 Gene

Previous HGNC Symbols for OR6B2 Gene

  • OR6B2P

Previous GeneCards Identifiers for OR6B2 Gene

  • GC02U900763
  • GC02M240690
  • GC02M240617
  • GC02M240968

Summaries for OR6B2 Gene

Entrez Gene Summary for OR6B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B2 Gene

OR6B2 (Olfactory Receptor Family 6 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR11L1.

UniProtKB/Swiss-Prot for OR6B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B2 Gene

Genomics for OR6B2 Gene

Genomic Location for OR6B2 Gene

240,028,965 bp from pter
240,033,858 bp from pter
4,894 bases
Minus strand

Genomic View for OR6B2 Gene

Genes around OR6B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B2 Gene

Proteins for OR6B2 Gene

  • Protein details for OR6B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6B2
    Protein Accession:
    Secondary Accessions:
    • B2RPR3
    • Q8NGW0

    Protein attributes for OR6B2 Gene

    312 amino acids
    Molecular mass:
    35029 Da
    Quaternary structure:
    No Data Available
    • Sequence=DAA04686.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR6B2 Gene

Proteomics data for OR6B2 Gene at MOPED

Post-translational modifications for OR6B2 Gene

No Post-translational modifications

Other Protein References for OR6B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B2 Gene

Domains & Families for OR6B2 Gene

Gene Families for OR6B2 Gene

Protein Domains for OR6B2 Gene

Suggested Antigen Peptide Sequences for OR6B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B2: view

Function for OR6B2 Gene

Molecular function for OR6B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR6B2: view
genes like me logo Genes that share phenotypes with OR6B2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR6B2 Gene

Localization for OR6B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6B2 Gene COMPARTMENTS Subcellular localization image for OR6B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR6B2: view

Pathways & Interactions for OR6B2 Gene

genes like me logo Genes that share pathways with OR6B2: view

Pathways by source for OR6B2 Gene

Interacting Proteins for OR6B2 Gene

Gene Ontology (GO) - Biological Process for OR6B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B2: view

No data available for SIGNOR curated interactions for OR6B2 Gene

Drugs & Compounds for OR6B2 Gene

No Compound Related Data Available

Transcripts for OR6B2 Gene

mRNA/cDNA for OR6B2 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B2 Gene

Olfactory receptor, family 6, subfamily B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B2 Gene

No ASD Table

Relevant External Links for OR6B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6B2 Gene

mRNA expression in normal human tissues for OR6B2 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B2 Gene

This gene is overexpressed in Nerve - Tibial (x43.0) and Testis (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR6B2 Gene

SOURCE GeneReport for Unigene cluster for OR6B2 Gene Hs.531343

genes like me logo Genes that share expression patterns with OR6B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6B2 Gene

Orthologs for OR6B2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC618817 35
  • 89.11 (n)
  • 85.81 (a)
-- 36
  • 86 (a)
-- 36
  • 83 (a)
(Canis familiaris)
Mammalia LOC100856687 35
  • 87.49 (n)
  • 83.82 (a)
-- 36
  • 83 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
-- 36
  • 82 (a)
OR12C12 36
  • 80 (a)
(Mus musculus)
Mammalia Olfr1416 35
  • 86.32 (n)
  • 85.9 (a)
Olfr1416 16
Olfr1414 36
  • 87 (a)
Olfr1415 36
  • 86 (a)
Olfr1416 36
  • 86 (a)
(Pan troglodytes)
Mammalia LOC470698 35
  • 98.72 (n)
  • 97.76 (a)
(Rattus norvegicus)
Mammalia Olr1343 35
  • 86.08 (n)
  • 86.08 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
Species with no ortholog for OR6B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B2 Gene

Gene Tree for OR6B2 (if available)
Gene Tree for OR6B2 (if available)

Paralogs for OR6B2 Gene

Paralogs for OR6B2 Gene

(455) SIMAP similar genes for OR6B2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR6B2: view

Variants for OR6B2 Gene

Sequence variations from dbSNP and Humsavar for OR6B2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10187574 - 240,029,895(+) GTCAC(A/G)GAAGA reference, missense
rs60841887 - 240,029,751(+) GATGC(A/C/G)CAGGA reference, missense
rs1595799 -- 240,034,414(-) tatat(A/C)tccaa upstream-variant-2KB
rs874060 -- 240,032,033(+) AGATC(C/T)TCCAT intron-variant, upstream-variant-2KB
rs4854055 -- 240,034,067(-) atagg(A/G)gactg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6B2 Gene

Variant ID Type Subtype PubMed ID
nsv876099 CNV Gain 21882294
nsv834584 CNV Gain 17160897
nsv876106 CNV Gain 21882294
nsv876108 CNV Loss 21882294
nsv483047 CNV Loss 15286789
nsv525278 CNV Gain 19592680
nsv876112 CNV Loss 21882294
nsv876113 CNV Loss 21882294

Variation tolerance for OR6B2 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.96; 94.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR6B2 Gene

Disorders for OR6B2 Gene

Relevant External Links for OR6B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B2 Gene

Publications for OR6B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. (PMID: 23910658) McRae J.F. … Newcomb R.D. (Curr. Biol. 2013) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR6B2 Gene

Sources for OR6B2 Gene