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Aliases for OR6B1 Gene

Aliases for OR6B1 Gene

  • Olfactory Receptor Family 6 Subfamily B Member 1 2 3 5
  • Olfactory Receptor OR7-9 3 4
  • Olfactory Receptor 7-3 3 4
  • OR7-3 3 4
  • Olfactory Receptor, Family 6, Subfamily B, Member 1 2
  • Olfactory Receptor 6B1 3
  • OR7-9 3

External Ids for OR6B1 Gene

Previous GeneCards Identifiers for OR6B1 Gene

  • GC07U990166
  • GC07P143090
  • GC07P143138
  • GC07P143332
  • GC07P143701

Summaries for OR6B1 Gene

Entrez Gene Summary for OR6B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B1 Gene

OR6B1 (Olfactory Receptor Family 6 Subfamily B Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6A2.

UniProtKB/Swiss-Prot for OR6B1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B1 Gene

Genomics for OR6B1 Gene

Regulatory Elements for OR6B1 Gene

Enhancers for OR6B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143972 0.6 ENCODE 12.4 -29.8 -29813 2.3 ELF3 GATA3 JUND CTBP1 CEBPB TCF7L2 OR6B1 OR2A5 LOC100422324 ENSG00000243583
GH07F144127 0.4 ENCODE 10.7 +124.0 123974 0.2 CBX3 TBL1XR1 WRNIP1 RAD21 SCRT2 ZNF143 ZNF654 USF2 REST RAD51 OR6B1 OR2A15P OR2A13P
GH07F143989 0.4 ENCODE 0.4 -14.5 -14507 0.2 PKNOX1 CBX3 ESRRA MTA2 NR2F1 TAL1 NR4A1 CHAMP1 ARID1B GATA2 ENSG00000243583 OR2F1 OR2A5 SLC16A1P1 OR6B1
GH07F144018 1.1 Ensembl ENCODE 0.3 +16.2 16181 3.4 SOX13 JUN CEBPG RAD21 GATA3 CTBP1 FOS FOSL2 MAFK TCF7L2 ARHGEF35 OR2A5 ENSG00000243583 OR2F1 LOC154761 OR6B1
GH07F144022 0.2 ENCODE 0.3 +18.5 18511 0.1 OR6B1 OR2A5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR6B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR6B1 Gene

144,003,929 bp from pter
144,004,983 bp from pter
1,055 bases
Plus strand

Genomic View for OR6B1 Gene

Genes around OR6B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B1 Gene

Proteins for OR6B1 Gene

  • Protein details for OR6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 6B1
    Protein Accession:
    Secondary Accessions:
    • A4D2G2
    • B9EH47
    • Q6IFP6
    • Q96R38

    Protein attributes for OR6B1 Gene

    311 amino acids
    Molecular mass:
    35299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6B1 Gene

Post-translational modifications for OR6B1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR6B1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6B1 Gene

Domains & Families for OR6B1 Gene

Gene Families for OR6B1 Gene

Protein Domains for OR6B1 Gene

Suggested Antigen Peptide Sequences for OR6B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6B1: view

Function for OR6B1 Gene

Molecular function for OR6B1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 6,subfamily B,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with OR6B1: view

Animal Model Products

miRNA for OR6B1 Gene

miRTarBase miRNAs that target OR6B1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6B1 Gene

Localization for OR6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR6B1 Gene COMPARTMENTS Subcellular localization image for OR6B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6B1: view

Pathways & Interactions for OR6B1 Gene

genes like me logo Genes that share pathways with OR6B1: view

Pathways by source for OR6B1 Gene

1 KEGG pathway for OR6B1 Gene

Gene Ontology (GO) - Biological Process for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B1: view

No data available for SIGNOR curated interactions for OR6B1 Gene

Transcripts for OR6B1 Gene

mRNA/cDNA for OR6B1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B1 Gene

Olfactory receptor, family 6, subfamily B, member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B1 Gene

No ASD Table

Relevant External Links for OR6B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR6B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR6B1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B1 Gene

This gene is overexpressed in Testis (x44.6) and Brain - Amygdala (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of OR6B1 Gene:


SOURCE GeneReport for Unigene cluster for OR6B1 Gene:

genes like me logo Genes that share expression patterns with OR6B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR6B1 Gene

Orthologs for OR6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR6B1 34 35
  • 88.53 (n)
(Bos Taurus)
Mammalia OR6B1 34 35
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Olr811 34
  • 86.39 (n)
(Mus musculus)
Mammalia Or6b1 55 Olfr449 34 16 35
  • 86.28 (n)
Or6z1 55 Olfr1348
  • chr7:6,501,289-6,502,224
(Monodelphis domestica)
Mammalia OR6B1 35
  • 85 (a)
(Gallus gallus)
Aves COR7A 34 35
  • 64.78 (n)
(Anolis carolinensis)
Reptilia OR6B1 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486033 34
  • 62.13 (n)
Species where no ortholog for OR6B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B1 Gene

Gene Tree for OR6B1 (if available)
Gene Tree for OR6B1 (if available)

Paralogs for OR6B1 Gene

Paralogs for OR6B1 Gene

(449) SIMAP similar genes for OR6B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6B1: view

Variants for OR6B1 Gene

Sequence variations from dbSNP and Humsavar for OR6B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10246251 -- 144,003,063(+) AATCT(C/T)CACTC upstream-variant-2KB
rs10246751 -- 144,003,449(+) ATCTC(C/T)GCTAC upstream-variant-2KB
rs10665770 -- 144,003,810(+) CACAC(-/ACAC/ACACAC)GGCTA upstream-variant-2KB
rs114579019 -- 144,003,599(+) GTCAG(A/G)TGTAT upstream-variant-2KB
rs11979319 -- 144,003,934(+) TAGCT(A/G)GGCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6B1 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1023400 CNV gain 25217958
nsv428188 CNV gain+loss 18775914
nsv522225 CNV gain 19592680
nsv5987 CNV deletion 18451855
nsv608682 CNV gain 21841781
nsv8227 CNV gain+loss 18304495
nsv831173 CNV gain 17160897

Variation tolerance for OR6B1 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.06; 84.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6B1 Gene

Disorders for OR6B1 Gene

Relevant External Links for OR6B1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR6B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6B1 Gene

Publications for OR6B1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4 64

Products for OR6B1 Gene

Sources for OR6B1 Gene

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