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Aliases for OR6B1 Gene

Aliases for OR6B1 Gene

  • Olfactory Receptor, Family 6, Subfamily B, Member 1 2 3
  • Olfactory Receptor OR7-9 3 4
  • Olfactory Receptor 7-3 3 4
  • OR7-3 3 4
  • Olfactory Receptor 6B1 3
  • OR7-9 3

External Ids for OR6B1 Gene

Summaries for OR6B1 Gene

Entrez Gene Summary for OR6B1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6B1 Gene

OR6B1 (Olfactory Receptor, Family 6, Subfamily B, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11L1.

UniProtKB/Swiss-Prot for OR6B1 Gene

  • Odorant receptor.

Gene Wiki entry for OR6B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6B1 Gene

Genomics for OR6B1 Gene

Genomic Location for OR6B1 Gene

Start:
144,003,929 bp from pter
End:
144,004,983 bp from pter
Size:
1,055 bases
Orientation:
Plus strand

Genomic View for OR6B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR6B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6B1 Gene

Regulatory Elements for OR6B1 Gene

Proteins for OR6B1 Gene

  • Protein details for OR6B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95007-OR6B1_HUMAN
    Recommended name:
    Olfactory receptor 6B1
    Protein Accession:
    O95007
    Secondary Accessions:
    • A4D2G2
    • B9EH47
    • Q6IFP6
    • Q96R38

    Protein attributes for OR6B1 Gene

    Size:
    311 amino acids
    Molecular mass:
    35299 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6B1 Gene

Proteomics data for OR6B1 Gene at MOPED

Post-translational modifications for OR6B1 Gene

Other Protein References for OR6B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR6B1 Gene

Domains for OR6B1 Gene

Gene Families for OR6B1 Gene

HGNC:
  • OR6 :GPCR / Class A : Olfactory receptors

Protein Domains for OR6B1 Gene

UniProtKB/Swiss-Prot:

OR6B1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O95007
genes like me logo Genes that share domains with OR6B1: view

Function for OR6B1 Gene

Molecular function for OR6B1 Gene

GENATLAS Biochemistry: olfactory receptor,family 6,subfamily B,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR6B1: view

miRNA for OR6B1 Gene

miRTarBase miRNAs that target OR6B1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for OR6B1 Gene

Localization for OR6B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6B1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6B1 Gene COMPARTMENTS Subcellular localization image for OR6B1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR6B1: view

Pathways for OR6B1 Gene

genes like me logo Genes that share pathways with OR6B1: view

Pathways by source for OR6B1 Gene

1 KEGG pathway for OR6B1 Gene

Interacting Proteins for OR6B1 Gene

Gene Ontology (GO) - Biological Process for OR6B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR6B1: view

Transcripts for OR6B1 Gene

mRNA/cDNA for OR6B1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR6B1 Gene

Olfactory receptor, family 6, subfamily B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR6B1 Gene

No ASD Table

Relevant External Links for OR6B1 Gene

GeneLoc Exon Structure for
OR6B1
ECgene alternative splicing isoforms for
OR6B1

Expression for OR6B1 Gene

mRNA expression in normal human tissues for OR6B1 Gene

mRNA differential expression in normal tissues according to GTEx for OR6B1 Gene

This gene is overexpressed in Testis (44.6) and Brain - Amygdala (4.9).

SOURCE GeneReport for Unigene cluster for OR6B1 Gene Hs.632031

genes like me logo Genes that share expressions with OR6B1: view

Orthologs for OR6B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR6B1 36
  • 87.85 (n)
  • 90.32 (a)
OR6B1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR6B1 36
  • 88.53 (n)
  • 91.32 (a)
OR6B1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr449 36
  • 86.28 (n)
  • 92.6 (a)
Olfr449 16
Olfr449 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR6B1 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr811 36
  • 86.39 (n)
  • 91.96 (a)
chicken
(Gallus gallus)
Aves COR7A 36
  • 64.78 (n)
  • 63.46 (a)
COR7A 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OR6B1 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486033 36
  • 62.13 (n)
  • 62.79 (a)
Species with no ortholog for OR6B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6B1 Gene

ENSEMBL:
Gene Tree for OR6B1 (if available)
TreeFam:
Gene Tree for OR6B1 (if available)

Paralogs for OR6B1 Gene

Paralogs for OR6B1 Gene

Selected SIMAP similar genes for OR6B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR6B1: view

Variants for OR6B1 Gene

Sequence variations from dbSNP and Humsavar for OR6B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs728275 -- 144,004,791(+) CATGC(C/T)TTCAA reference, synonymous-codon
rs1859506 -- 144,005,057(+) ACTTC(A/G)ATCTC downstream-variant-500B
rs7787378 - 144,004,423(+) GCTTC(C/T)GCCTC reference, missense
rs10246251 -- 144,003,063(+) AATCT(C/T)CACTC upstream-variant-2KB
rs10246751 -- 144,003,449(+) ATCTC(C/T)GCTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR6B1 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
esv2422489 CNV Duplication 17116639
nsv8227 CNV Gain+Loss 18304495
nsv522225 CNV Gain 19592680
esv1682998 OTHER Inversion 17803354
dgv842n27 CNV Gain 19166990
nsv889336 CNV Gain 21882294
dgv7520n71 CNV Gain 21882294
esv2752147 CNV Gain 17911159
nsv482912 CNV Loss 15286789
dgv2149e1 CNV Complex 17122850
nsv889340 CNV Gain 21882294
nsv831173 CNV Gain 17160897
nsv5987 CNV Loss 18451855

Relevant External Links for OR6B1 Gene

HapMap Linkage Disequilibrium report
OR6B1

Disorders for OR6B1 Gene

No disorders were found for OR6B1 Gene.

No data available for UniProtKB/Swiss-Prot for OR6B1 Gene

Publications for OR6B1 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 4

Products for OR6B1 Gene

Sources for OR6B1 Gene

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