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OR6B1 Gene

protein-coding   GIFtS: 47
GCID: GC07P143701

Olfactory Receptor, Family 6, Subfamily B, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 6, Subfamily B, Member 11 2
Olfactory Receptor 7-32 3
Olfactory Receptor OR7-92 3
OR7-32 3
OR7-92
Olfactory Receptor 6B12

External Ids:    HGNC: 83541   Entrez Gene: 1359462   Ensembl: ENSG000002218137   UniProtKB: O950073   

Export aliases for OR6B1 gene to outside databases

Previous GC identifers: GC07U990166 GC07P143090 GC07P143138 GC07P143332


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR6B1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR6B1 Gene:
OR6B1 (olfactory receptor, family 6, subfamily B, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR6Q1.

UniProtKB/Swiss-Prot: OR6B1_HUMAN, O95007
Function: Odorant receptor (Potential)

Gene Wiki entry for OR6B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR6B1 gene promoter:
         ISGF-3   FOXF2   FOXO3   FOXO3b   YY1   C/EBPalpha   CHOP-10   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR6B1 promoter sequence
   Search Chromatin IP Primers for OR6B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR6B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q33-q35

OR6B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6B1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P143701:  view genomic region     (about GC identifiers)

Start:
143,701,090 bp from pter      End:
143,702,022 bp from pter
Size:
933 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 143,039,260-143,040,195     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR6B1_HUMAN, O95007 (See protein sequence)
Recommended Name: Olfactory receptor 6B1  
Size: 311 amino acids; 35299 Da
Secondary accessions: A4D2G2 B9EH47 Q6IFP6 Q96R38

Explore the universe of human proteins at neXtProt for OR6B1: NX_O95007

Explore proteomics data for OR6B1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR6B1

    See OR6B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005281.1  
    ENSEMBL proteins: 
     ENSP00000386151  
    Reactome Protein details: O95007

    OR6B1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR6: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95007

    ProtoNet protein and cluster: O95007

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR6B1_HUMAN, O95007
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR6B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR6B1_HUMAN, O95007
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR6B1:
    olfactory receptor,family 6,subfamily B,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR6B1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR6B1
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    hsa-mir-335-5p (MIRT017805)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR6B1_HUMAN, O95007: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR6B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR6B1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide ligand-binding receptors
    GPCRs, Class A Rhodopsin-like0.43


    Find genes that share SuperPaths with OR6B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR6B1
        GPCRs, Class A Rhodopsin-like

    1 Reactome Pathway for OR6B1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR6B1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR6B1
    Interactions:

        Search GeneGlobe Interaction Network for OR6B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR6B1 (ENSP000003861514) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A7ENSP000003267184STRING: ENSP00000326718
    OR10K2ENSP000003242514STRING: ENSP00000324251
    OR10R2ENSP000003571344STRING: ENSP00000357134
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR6B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR6B1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR6B1 gene: 
    NM_001005281.1  

    Unigene Cluster for OR6B1:

    Olfactory receptor, family 6, subfamily B, member 1
    Hs.632031  [show with all ESTs]
    Unigene Representative Sequence: BC137047
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408922(uc003wdt.1)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OR6B1
      QuantiTect SYBR Green Assays in human, mouse, rat OR6B1
      QuantiFast Probe-based Assays in human, mouse, rat OR6B1

    Additional mRNA sequence: 

    BC137042.1 BC137047.1 

    1 DOTS entry:

    DT.121125204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR6B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR6B1 Expression
    About this image

    OR6B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR6B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632031
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR6B1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr4491 , 5 olfactory receptor 4491, 5 86.28(n)1
    92.6(a)1
      6 (20.93 cM)5
    2590671  NM_147064.11  NP_667275.11 
     428378835 
    chicken
    (Gallus gallus)
    Aves COR7A1 chick olfactory receptor 7a 64.78(n)
    63.46(a)
      415340  NM_001030392.1  NP_001025563.1 
    lizard
    (Anolis carolinensis)
    Reptilia OR6B16
    olfactory receptor, family 6, subfamily B, member ...
    64(a)
    1 ↔ 1
    GL343253.1(754192-755148)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004860331 olfactory receptor 6B1-like 62.13(n)
    62.79(a)
      100486033  XM_002934301.1  XP_002934347.1 


    ENSEMBL Gene Tree for OR6B1 (if available)
    TreeFam Gene Tree for OR6B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR6B1 gene
    OR6Q12  OR2AT42  OR6Y12  OR6B32  OR6B22  OR6A22  OR11L12  OR6P12  
    Selected SIMAP similar genes for OR6B1 using alignment to 1 protein entry:     OR6B1_HUMAN(see all similar genes):
    OR6B3    OR6A2    OR6B2    OR6P1    OR6Y1    OR6Q1
    OR11A1    OR10AG1    OR11L1    OR1L4    OR5A2    OR6C6
    OR6C65    OR6C74    OR6F1    OR6N1    OR6N2    OR6X1

    Find genes that share paralogs with OR6B1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR6B1 (see all 119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs731542971,2
    C,F--143699115(+) AATTTC/TAGCAG 1 -- us2k12Minor allele frequency- T:0.08NA 122
    rs1427847411,2
    --143699173(+) ACATTA/GGTAAG 1 -- us2k10--------
    rs755094121,2
    C,F--143699247(+) TCGGAC/TCTGGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1837067561,2
    --143699341(+) ATAGCA/CATGTC 1 -- us2k10--------
    rs1880079311,2
    --143699450(+) AACTGA/GTAGTA 1 -- us2k10--------
    rs1506266081,2
    C--143699560(+) TCCTCC/TGTGAT 1 -- us2k10--------
    rs1401694211,2
    C--143699622(+) TTCTGC/TTTCTA 1 -- us2k10--------
    rs1922407401,2
    --143699630(+) CTAACA/GTGTAT 1 -- us2k10--------
    rs755219371,2
    F--143699674(+) AGTTCA/GCTGTC 1 -- us2k10--------
    rs1850796611,2
    --143699747(+) AGTCCA/GTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR6B1 ( 143701090 - 143702022 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR6B1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422489CNV Duplication17116639
    nsv5987CNV Loss18451855
    nsv482912CNV Loss15286789
    nsv831173CNV Gain17160897
    nsv889336CNV Gain21882294
    nsv522225CNV Gain19592680
    nsv889340CNV Gain21882294
    esv2752147CNV Gain17911159
    dgv7520n71CNV Gain21882294
    dgv842n27CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR6B1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR6B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 135946 HGNC: 8354 Ensembl:ENSG00000221813 euGenes: HUgn135946 ECgene: OR6B1 Kegg: 135946
    H-InvDB: OR6B1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR6B1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR6B1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR6B1 gene:
    Search GeneIP for patents involving OR6B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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