OR6A2 Gene
protein-coding GIFtS: 50
GCID: GC11M006815
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olfactory receptor, family 6, subfamily A, member 2
(Previous symbols: OR6A2P, OR6A1)
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Aliases
for OR6A2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 6, Subfamily A, Member 21 2 | | HP2 Olfactory Receptor2 3 | | OR11-551 2 3 | | I72 | | OR6A11 2 3 | | HI7 Olfactory Receptor2 | | OR6A2P1 2 3 | | Olfactory Receptor 6A22 | | Olfactory Receptor 11-552 3 | | Olfactory Receptor, Family 6, Subfamily A, Member 12 | | Olfactory Receptor 6A12 3 | | Olfactory Receptor, Family 6, Subfamily A, Member 2 Pseudogene2 | | Olfactory Receptor OR11-832 3 | | Seven Transmembrane Helix Receptor2 |
Export aliases for OR6A2 gene to outside databasesPrevious GC identifers: GC11M006781 GC11M006772 |
Summaries
for OR6A2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR6A2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: OR6A2_HUMAN, O95222Function: Odorant receptor (Potential)
Gene Wiki entry for OR6A2
|
Genomic Views
for OR6A2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR6A2 gene promoter:
Pbx1a Nkx2-5 LCR-F1 Tal-1beta HNF-4alpha1 HNF-1A E47 PPAR-alpha FAC1 HNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR6A2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR6A2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4OR6A2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M006815: view genomic region
(about GC identifiers)
Start:
|
6,815,959 bp from pter |
End:
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6,816,939 bp from pter |
Size:
|
981 bases |
Orientation:
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minus strand |
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Proteins
for OR6A2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OR6A2_HUMAN, O95222 (See
protein sequence)Recommended Name: Olfactory receptor 6A2 Size: 327 amino acids; 36154 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3MJC7 Q6IF35 Q9H206Explore the universe of human proteins at neXtProt for OR6A2: NX_O95222
HORDE protein sequence for OR6A2
OR6A2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003687.2
ENSEMBL proteins: ENSP00000330384 Reactome Protein details: O95222
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
OR6A2 for ontologies About GeneDecksing
OR6A2 Antibody Products:
Assay Products for OR6A2: |
Protein
Domains /
Families
for OR6A2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR6A2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95222ProtoNet protein and cluster: O95222 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR6A2_HUMAN, O95222Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR6A2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: OR6A2_HUMAN, O95222Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6A2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | 14983052 |
OR6A2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for OR6A2:
Animal Models:
1 MGI phenotypic allele  for Olfr2 (no phenotypes)
OR6A2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OR6A2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | | | 3 | Class A/1 (Rhodopsin-like receptors) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for OR6A2
4 
Reactome Pathways for OR6A2
1 
Kegg Pathway (Kegg details for OR6A2):
OR6A2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6A2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR6A2 (ENSP000003303844) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
OR6A2 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR6A2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR6A2
Search CenterWatch for drugs/clinical trials and news about OR6A2
|
Transcripts
for OR6A2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR6A2 gene: NM_003696.2 Unigene Cluster for OR6A2: Olfactory receptor, family 6, subfamily A, member 2 Hs.652252 Unigene Representative Sequence: NM_0036961 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000332601(uc001mes.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR6A2 (NM_003696) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR6A2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR6A2 |
Additional cDNA sequence: BC101489.1 BC101491.1 1 DOTS entry: DT.91983401 1 AceView cDNA sequence: NM_003696
GeneLoc Exon Structure
|
Expression
for OR6A2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR6A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTGATATG
About this image
See OR6A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OR6A2
SOURCE GeneReport for Unigene cluster: Hs.652252
SABiosciences Custom PCR Arrays for OR6A2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR6A2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR6A2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR6A2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR6A2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6A2 |
Orthologs
for OR6A2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OR6A2 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for OR6A2 (if available)
TreeFam Gene Tree for OR6A2 (if available) |
Paralogs
for OR6A2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR6A2 gene
- OR6N12 OR6B12 OR6K32 OR6Q12 OR6B32 OR6Y12 OR6N22 OR6K22
- OR6K62 OR11L12 OR6B22 OR6P12
18/442 SIMAP similar genes for OR6A2 using alignment to 1 protein entry: OR6A2_HUMAN(see all similar genes):OR6B3 OR6P1 OR6B2 OR6B1 OR6Y1 OR6F1
OR6Q1 OR10J4 OR11G2 OR1L4 OR1L6 OR2B3
OR5A2 OR6S1 OR10G7 OR10G8 OR10Q1 OR10R2
OR6A2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR6A2
PGOHUM00000238657 PGOHUM00000238658
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Genomic Variants
for OR6A2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR6A2 ( 6815959 - 6816939 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR6A2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR6A2 |
|
Disorders
/ Diseases
for OR6A2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR6A2 for disorders About GeneDecksing
OMIM gene information: 608495
OMIM disorders: --
2  diseases for OR6A2: About MalaCardsmitral valve stenosis neuronitis
Export disorders for OR6A2 gene to outside databases
|
Publications
for OR6A2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR6A2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR6A2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genomic analysis of orthologous mouse and human olfactory receptor loci. (PubMed id 11416212)1, 2 Lane R.P.... Trask B.J. (2001)
- Organization and evolution of olfactory receptor genes on human chromosome 11. (PubMed id 9787077)1, 2 Buettner J.A....Evans G.A. (1998)
- Discrimination of saturated aldehydes by the rat I7 o lfactory receptor. (PubMed id 20608641)1 Kurland M.D....Batista V.S. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR6A2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR6A2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR6A2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR6A2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR6A2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR6A2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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| | |
About This Section
| Patent Information for OR6A2 gene:
Search GeneIP for patents involving OR6A2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR6A2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR6A2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR6A2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR6A2 | | | OriGene Protein Over-expression Lysate for OR6A2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR6A2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR6A2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for OR6A2 |
| |  |  |  |  | | | | |
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 | | | OR6A2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR6A2 |
|  |  |  | | | | ThermoFisher Antibodies for OR6A2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR6A2 |
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