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Aliases for OR6A2 Gene

Aliases for OR6A2 Gene

  • Olfactory Receptor Family 6 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR11-83 3 4
  • Olfactory Receptor 11-55 3 4
  • HP2 Olfactory Receptor 3 4
  • Olfactory Receptor 6A1 3 4
  • OR11-55 3 4
  • OR6A2P 3 4
  • OR6A1 3 4
  • Olfactory Receptor, Family 6, Subfamily A, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 6, Subfamily A, Member 2 2
  • Olfactory Receptor, Family 6, Subfamily A, Member 1 3
  • Seven Transmembrane Helix Receptor 3
  • HI7 Olfactory Receptor 3
  • I7 3

External Ids for OR6A2 Gene

Previous HGNC Symbols for OR6A2 Gene

  • OR6A2P
  • OR6A1

Previous GeneCards Identifiers for OR6A2 Gene

  • GC11M006781
  • GC11M006772

Summaries for OR6A2 Gene

Entrez Gene Summary for OR6A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR6A2 Gene

OR6A2 (Olfactory Receptor Family 6 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR11L1.

UniProtKB/Swiss-Prot for OR6A2 Gene

  • Odorant receptor.

Gene Wiki entry for OR6A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR6A2 Gene

Genomics for OR6A2 Gene

Regulatory Elements for OR6A2 Gene

Genomic Location for OR6A2 Gene

Chromosome:
11
Start:
6,794,525 bp from pter
End:
6,795,908 bp from pter
Size:
1,384 bases
Orientation:
Minus strand

Genomic View for OR6A2 Gene

Genes around OR6A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR6A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR6A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR6A2 Gene

Proteins for OR6A2 Gene

  • Protein details for OR6A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95222-OR6A2_HUMAN
    Recommended name:
    Olfactory receptor 6A2
    Protein Accession:
    O95222
    Secondary Accessions:
    • Q3MJC7
    • Q6IF35
    • Q9H206

    Protein attributes for OR6A2 Gene

    Size:
    327 amino acids
    Molecular mass:
    36154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR6A2 Gene

Proteomics data for OR6A2 Gene at MOPED

Post-translational modifications for OR6A2 Gene

  • Glycosylation at Asn 5 and Asn 191

Other Protein References for OR6A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR6A2 Gene

Domains & Families for OR6A2 Gene

Gene Families for OR6A2 Gene

Protein Domains for OR6A2 Gene

Suggested Antigen Peptide Sequences for OR6A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95222

UniProtKB/Swiss-Prot:

OR6A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR6A2: view

Function for OR6A2 Gene

Molecular function for OR6A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
genes like me logo Genes that share phenotypes with OR6A2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR6A2 Gene

Localization for OR6A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR6A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR6A2 Gene COMPARTMENTS Subcellular localization image for OR6A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 14983052
genes like me logo Genes that share ontologies with OR6A2: view

Pathways & Interactions for OR6A2 Gene

genes like me logo Genes that share pathways with OR6A2: view

Pathways by source for OR6A2 Gene

1 KEGG pathway for OR6A2 Gene

Interacting Proteins for OR6A2 Gene

Gene Ontology (GO) - Biological Process for OR6A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell NAS 14983052
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 14983052
genes like me logo Genes that share ontologies with OR6A2: view

No data available for SIGNOR curated interactions for OR6A2 Gene

Drugs & Compounds for OR6A2 Gene

No Compound Related Data Available

Transcripts for OR6A2 Gene

mRNA/cDNA for OR6A2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR6A2 Gene

No ASD Table

Relevant External Links for OR6A2 Gene

GeneLoc Exon Structure for
OR6A2
ECgene alternative splicing isoforms for
OR6A2

Expression for OR6A2 Gene

mRNA expression in normal human tissues for OR6A2 Gene

mRNA differential expression in normal tissues according to GTEx for OR6A2 Gene

This gene is overexpressed in Testis (x8.3).

SOURCE GeneReport for Unigene cluster for OR6A2 Gene Hs.652252

genes like me logo Genes that share expression patterns with OR6A2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR6A2 Gene

Orthologs for OR6A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR6A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR6A2 36
  • 99 (a)
OneToOne
LOC466418 35
  • 99.18 (n)
  • 99.08 (a)
cow
(Bos Taurus)
Mammalia OR6A2 35
  • 88.3 (n)
  • 89.34 (a)
OR6A2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR6A2 36
  • 91 (a)
OneToOne
LOC485348 35
  • 88.34 (n)
  • 90.8 (a)
mouse
(Mus musculus)
Mammalia Olfr2 16
Olfr2 36
  • 90 (a)
OneToOne
Olfr2 35
  • 87.32 (n)
  • 90.18 (a)
oppossum
(Monodelphis domestica)
Mammalia OR6A2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911376 35
  • 86.91 (n)
  • 89.88 (a)
chicken
(Gallus gallus)
Aves OR6A2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
Species with no ortholog for OR6A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR6A2 Gene

ENSEMBL:
Gene Tree for OR6A2 (if available)
TreeFam:
Gene Tree for OR6A2 (if available)

Paralogs for OR6A2 Gene

Paralogs for OR6A2 Gene

(441) SIMAP similar genes for OR6A2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR6A2 Gene

genes like me logo Genes that share paralogs with OR6A2: view

Variants for OR6A2 Gene

Sequence variations from dbSNP and Humsavar for OR6A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_053217 -

Structural Variations from Database of Genomic Variants (DGV) for OR6A2 Gene

Variant ID Type Subtype PubMed ID
nsv832060 CNV Gain 17160897
nsv467701 CNV Loss 19166990

Variation tolerance for OR6A2 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR6A2 Gene

HapMap Linkage Disequilibrium report
OR6A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR6A2 Gene

Disorders for OR6A2 Gene

Relevant External Links for OR6A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR6A2

No disorders were found for OR6A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR6A2 Gene

Publications for OR6A2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Discrimination of saturated aldehydes by the rat I7 olfactory receptor. (PMID: 20608641) Kurland M.D. … Batista V.S. (Biochemistry 2010) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane R.P. … Trask B.J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3

Products for OR6A2 Gene

Sources for OR6A2 Gene

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