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Aliases for OR5W2 Gene

Aliases for OR5W2 Gene

  • Olfactory Receptor Family 5 Subfamily W Member 2 2 3 5
  • Olfactory Receptor OR11-155 3 4
  • Olfactory Receptor 5W3 3 4
  • OR5W2P 3 4
  • OR5W3P 3 4
  • Olfactory Receptor, Family 5, Subfamily W, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily W, Member 2 2
  • Olfactory Receptor 5W2 3

External Ids for OR5W2 Gene

Previous HGNC Symbols for OR5W2 Gene

  • OR5W2P
  • OR5W3P

Previous GeneCards Identifiers for OR5W2 Gene

  • GC11U900575
  • GC11M055437
  • GC11M055684

Summaries for OR5W2 Gene

Entrez Gene Summary for OR5W2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5W2 Gene

OR5W2 (Olfactory Receptor Family 5 Subfamily W Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5C1.

UniProtKB/Swiss-Prot for OR5W2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5W2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5W2 Gene

Genomics for OR5W2 Gene

Regulatory Elements for OR5W2 Gene

Enhancers for OR5W2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F055430 0.4 FANTOM5 1.8 +484.3 484251 0.0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR5W2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5W2 Gene

Chromosome:
11
Start:
55,913,650 bp from pter
End:
55,914,582 bp from pter
Size:
933 bases
Orientation:
Minus strand

Genomic View for OR5W2 Gene

Genes around OR5W2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5W2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5W2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5W2 Gene

Proteins for OR5W2 Gene

  • Protein details for OR5W2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH69-OR5W2_HUMAN
    Recommended name:
    Olfactory receptor 5W2
    Protein Accession:
    Q8NH69

    Protein attributes for OR5W2 Gene

    Size:
    310 amino acids
    Molecular mass:
    35167 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5W2 Gene

Post-translational modifications for OR5W2 Gene

No Post-translational modifications

Other Protein References for OR5W2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5W2 Gene

Domains & Families for OR5W2 Gene

Gene Families for OR5W2 Gene

Protein Domains for OR5W2 Gene

Suggested Antigen Peptide Sequences for OR5W2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH69

UniProtKB/Swiss-Prot:

OR5W2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5W2: view

Function for OR5W2 Gene

Molecular function for OR5W2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5W2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5W2: view

Phenotypes for OR5W2 Gene

genes like me logo Genes that share phenotypes with OR5W2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5W2 Gene

Localization for OR5W2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5W2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5W2 Gene COMPARTMENTS Subcellular localization image for OR5W2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5W2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5W2: view

Pathways & Interactions for OR5W2 Gene

genes like me logo Genes that share pathways with OR5W2: view

Pathways by source for OR5W2 Gene

Gene Ontology (GO) - Biological Process for OR5W2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5W2: view

No data available for SIGNOR curated interactions for OR5W2 Gene

Transcripts for OR5W2 Gene

mRNA/cDNA for OR5W2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5W2 Gene

No ASD Table

Relevant External Links for OR5W2 Gene

GeneLoc Exon Structure for
OR5W2
ECgene alternative splicing isoforms for
OR5W2

Expression for OR5W2 Gene

mRNA expression in normal human tissues for OR5W2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5W2 Gene:

OR5W2

SOURCE GeneReport for Unigene cluster for OR5W2 Gene:

Hs.554526
genes like me logo Genes that share expression patterns with OR5W2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR5W2 Gene

Orthologs for OR5W2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5W2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747267 34
  • 98.71 (n)
OR5W2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100685567 34
  • 83.87 (n)
OR5W2 35
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 83 (a)
OneToMany
LOC789300 34
  • 82.25 (n)
-- 35
  • 82 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or8w1 55 Olfr1132 35
  • 79 (a)
OneToMany
Or5w11 55 Olfr1131 35
  • 78 (a)
OneToMany
Or5w15 55 Olfr1138 35
  • 78 (a)
OneToMany
Or5w22 55 Olfr153 35
  • 78 (a)
OneToMany
Or5w8 55 Olfr1151 34 16 35
  • 77.71 (n)
Or5w12 55 Olfr1135 35
  • 76 (a)
OneToMany
Or5w19 55 Olfr1152 35
  • 76 (a)
OneToMany
Or5w18 55 Olfr1143 35
  • 75 (a)
OneToMany
Or5w14 55 Olfr1137 35
  • 73 (a)
OneToMany
Or5w20 55 Olfr1153 35
  • 73 (a)
OneToMany
Or5w16 55 Olfr1140 35
  • 72 (a)
OneToMany
Or5w13 55 Olfr1136 35
  • 71 (a)
OneToMany
Olfr1141 35
  • 67 (a)
OneToMany
Or5w17-ps 55 Olfr1141-ps1
  • chr2:87,753,059-87,753,991
Or5w21-ps 55 Olfr1159-ps1
  • chr2:87,998,299-87,999,177
Or5w9-ps 55 Olfr1127-ps1
  • chr2:87,523,526-87,524,367
Or8m1-ps 55 Olfr1142-ps1
  • chr2:87,786,045-87,786,811
rat
(Rattus norvegicus)
Mammalia Olr596 34
  • 77.81 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
Species where no ortholog for OR5W2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5W2 Gene

ENSEMBL:
Gene Tree for OR5W2 (if available)
TreeFam:
Gene Tree for OR5W2 (if available)

Paralogs for OR5W2 Gene

Paralogs for OR5W2 Gene

(428) SIMAP similar genes for OR5W2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5W2 Gene

genes like me logo Genes that share paralogs with OR5W2: view

Variants for OR5W2 Gene

Sequence variations from dbSNP and Humsavar for OR5W2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10501340 -- 55,915,319(+) AATCA(A/G)AATGT upstream-variant-2KB
rs10591577 -- 55,916,014(+) GATTA(-/ATTA)GATTC upstream-variant-2KB
rs111972519 -- 55,916,154(+) TCATG(A/G)TTATC upstream-variant-2KB
rs11231529 -- 55,913,860(+) GAAGT(A/G)CATGT reference, synonymous-codon
rs11231538 -- 55,916,147(+) GTATG(C/T)TTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5W2 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1905n54 CNV gain 21841781
esv2751030 CNV gain 17911159
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626458 CNV gain 21293372
esv3626459 CNV loss 21293372
esv3626460 CNV gain 21293372
esv3892013 CNV gain 25118596
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897

Variation tolerance for OR5W2 Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.91; 83.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5W2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5W2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5W2 Gene

Disorders for OR5W2 Gene

Relevant External Links for OR5W2

Genetic Association Database (GAD)
OR5W2
Human Genome Epidemiology (HuGE) Navigator
OR5W2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5W2

No disorders were found for OR5W2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5W2 Gene

Publications for OR5W2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64

Products for OR5W2 Gene

Sources for OR5W2 Gene

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