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Aliases for OR5V1 Gene

Aliases for OR5V1 Gene

  • Olfactory Receptor Family 5 Subfamily V Member 1 2 3 5
  • Olfactory Receptor OR6-26 3 4
  • Hs6M1-21 3 4
  • Olfactory Receptor, Family 5, Subfamily V, Member 1 2
  • Olfactory Receptor 5V1 3
  • 6M1-21 3

External Ids for OR5V1 Gene

Previous GeneCards Identifiers for OR5V1 Gene

  • GC06M029380
  • GC06M029431
  • GC06M029430
  • GC06M029345
  • GC06Mo29253

Summaries for OR5V1 Gene

Entrez Gene Summary for OR5V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5V1 Gene

OR5V1 (Olfactory Receptor Family 5 Subfamily V Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR5V1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5V1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5V1 Gene

Genomics for OR5V1 Gene

Regulatory Elements for OR5V1 Gene

Enhancers for OR5V1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F028586 1.2 ENCODE 16.2 +869.9 869902 1.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GPX6 GPX5 ZNF603P ZNF90P2 KRT18P1 OR2W1 OR2AD1P OR2P1P ENSG00000228364 OR2B3
GH06F030065 1.2 ENCODE 16.2 -609.7 -609739 3.0 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 HCG4P3 PPP1R10 IFITM4P HLA-A TRIM26 PAIP1P1 RPL7P4 HCG4P7 HLA-P UBQLN1P1
GH06F030194 1.1 ENCODE 16.2 -738.3 -738261 1.6 ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF302 SP3 SP5 MXD4 ZHX2 HCG18 GTF2H4 PPP1R10 ETF1P1 DHX16 PAIP1P1 ZNRD1ASP HCG4P7 TRIM31 GNL1
GH06F029490 0.8 ENCODE 10.7 -33.8 -33772 0.2 HDAC1 ESRRA TBL1XR1 TAL1 DDX20 ZNF644 CCNT2 GATA2 NCOR1 CREM OR5V1 LINC01015 RPS17P1 LOC105375009
GH06F029477 0.6 FANTOM5 10.8 -21.0 -21031 0.6 GATA2 USF2 FOXJ2 MAS1L OR12D3 OR5V1 UBD LINC01015 OR2H2 OR14J1 MAS1LP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5V1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5V1 Gene

Chromosome:
6
Start:
29,355,230 bp from pter
End:
29,457,067 bp from pter
Size:
101,838 bases
Orientation:
Minus strand

Genomic View for OR5V1 Gene

Genes around OR5V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR5V1 Gene

  • Protein details for OR5V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGF6-OR5V1_HUMAN
    Recommended name:
    Olfactory receptor 5V1
    Protein Accession:
    Q9UGF6
    Secondary Accessions:
    • A2BDZ0
    • B0S860
    • Q5SQI9
    • Q6NTB5
    • Q8IVL3

    Protein attributes for OR5V1 Gene

    Size:
    321 amino acids
    Molecular mass:
    36057 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5V1 Gene

Post-translational modifications for OR5V1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5V1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5V1 Gene

Domains & Families for OR5V1 Gene

Gene Families for OR5V1 Gene

Protein Domains for OR5V1 Gene

Suggested Antigen Peptide Sequences for OR5V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGF6

UniProtKB/Swiss-Prot:

OR5V1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5V1: view

Function for OR5V1 Gene

Molecular function for OR5V1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR5V1: view
genes like me logo Genes that share phenotypes with OR5V1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5V1 Gene

Localization for OR5V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5V1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR5V1: view

Pathways & Interactions for OR5V1 Gene

genes like me logo Genes that share pathways with OR5V1: view

Pathways by source for OR5V1 Gene

1 KEGG pathway for OR5V1 Gene

Interacting Proteins for OR5V1 Gene

Gene Ontology (GO) - Biological Process for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5V1: view

No data available for SIGNOR curated interactions for OR5V1 Gene

Transcripts for OR5V1 Gene

mRNA/cDNA for OR5V1 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5V1 Gene

Olfactory receptor, family 5, subfamily V, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5V1 Gene

No ASD Table

Relevant External Links for OR5V1 Gene

GeneLoc Exon Structure for
OR5V1
ECgene alternative splicing isoforms for
OR5V1

Expression for OR5V1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5V1 Gene

mRNA differential expression in normal tissues according to GTEx for OR5V1 Gene

This gene is overexpressed in Testis (x42.4).

NURSA nuclear receptor signaling pathways regulating expression of OR5V1 Gene:

OR5V1

SOURCE GeneReport for Unigene cluster for OR5V1 Gene:

Hs.666316
genes like me logo Genes that share expression patterns with OR5V1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR5V1 Gene

Orthologs for OR5V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471937 34
  • 98.86 (n)
OR5V1 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5V1 34
  • 85.76 (n)
-- 35
  • 82 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Or5v1 55 Olfr110 35
  • 82 (a)
OneToMany
Or5v1b 55 Olfr111 34 16 35
  • 81.33 (n)
rat
(Rattus norvegicus)
Mammalia Olr1730 34
  • 81.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OR5V1 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491436 34
  • 57.73 (n)
Species where no ortholog for OR5V1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5V1 Gene

ENSEMBL:
Gene Tree for OR5V1 (if available)
TreeFam:
Gene Tree for OR5V1 (if available)

Paralogs for OR5V1 Gene

(449) SIMAP similar genes for OR5V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5V1: view

No data available for Paralogs for OR5V1 Gene

Variants for OR5V1 Gene

Sequence variations from dbSNP and Humsavar for OR5V1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1011985 -- 29,417,995(-) ACCAT(C/G)AAGTG intron-variant
rs1024470 -- 29,398,600(-) GTCTG(A/G)AAGTT intron-variant
rs1028411 -- 29,399,622(-) TGACC(A/C)AGGGT intron-variant
rs10456371 -- 29,368,148(+) ATCCA(A/G)TTTCT intron-variant
rs10456372 -- 29,373,672(+) aatgt(A/G)tacat intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OR5V1 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv3608473 CNV gain 21293372
esv3608477 CNV loss 21293372
nsv1015796 CNV gain 25217958
nsv1020683 CNV gain 25217958
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv520169 CNV gain 19592680
nsv601223 CNV loss 21841781
nsv830624 CNV loss 17160897

Variation tolerance for OR5V1 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5V1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5V1 Gene

Disorders for OR5V1 Gene

Relevant External Links for OR5V1

Genetic Association Database (GAD)
OR5V1
Human Genome Epidemiology (HuGE) Navigator
OR5V1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5V1

No disorders were found for OR5V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5V1 Gene

Publications for OR5V1 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson E.E. … Ober C. (Hum. Immunol. 2010) 3 46 64
  2. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 46 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  5. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4 64

Products for OR5V1 Gene

Sources for OR5V1 Gene

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