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Aliases for OR5V1 Gene

Aliases for OR5V1 Gene

  • Olfactory Receptor, Family 5, Subfamily V, Member 1 2 3
  • Olfactory Receptor OR6-26 3 4
  • Hs6M1-21 3 4
  • Olfactory Receptor 5V1 3
  • 6M1-21 3

External Ids for OR5V1 Gene

Previous GeneCards Identifiers for OR5V1 Gene

  • GC06M029380
  • GC06M029431
  • GC06M029430
  • GC06M029345
  • GC06Mo29253

Summaries for OR5V1 Gene

Entrez Gene Summary for OR5V1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5V1 Gene

OR5V1 (Olfactory Receptor, Family 5, Subfamily V, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR3A1.

UniProtKB/Swiss-Prot for OR5V1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5V1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5V1 Gene

Genomics for OR5V1 Gene

Regulatory Elements for OR5V1 Gene

Genomic Location for OR5V1 Gene

Start:
29,355,230 bp from pter
End:
29,431,967 bp from pter
Size:
76,738 bases
Orientation:
Minus strand

Genomic View for OR5V1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR5V1 Gene

  • Protein details for OR5V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGF6-OR5V1_HUMAN
    Recommended name:
    Olfactory receptor 5V1
    Protein Accession:
    Q9UGF6
    Secondary Accessions:
    • A2BDZ0
    • B0S860
    • Q5SQI9
    • Q6NTB5
    • Q8IVL3

    Protein attributes for OR5V1 Gene

    Size:
    321 amino acids
    Molecular mass:
    36057 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5V1 Gene

Proteomics data for OR5V1 Gene at MOPED

Post-translational modifications for OR5V1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5V1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5V1 Gene

Domains for OR5V1 Gene

Gene Families for OR5V1 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5V1 Gene

Suggested Antigen Peptide Sequences for OR5V1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGF6

UniProtKB/Swiss-Prot:

OR5V1_HUMAN :
  • Q9UGF6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5V1: view

Function for OR5V1 Gene

Molecular function for OR5V1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR5V1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5V1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5V1 Gene

Localization for OR5V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5V1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5V1 Gene COMPARTMENTS Subcellular localization image for OR5V1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR5V1: view

Pathways for OR5V1 Gene

genes like me logo Genes that share pathways with OR5V1: view

Pathways by source for OR5V1 Gene

1 KEGG pathway for OR5V1 Gene

Interacting Proteins for OR5V1 Gene

Gene Ontology (GO) - Biological Process for OR5V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5V1: view

Transcripts for OR5V1 Gene

mRNA/cDNA for OR5V1 Gene

(2) Additional mRNA sequences :
(20) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5V1 Gene

Olfactory receptor, family 5, subfamily V, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5V1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR5V1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5V1 Gene

No ASD Table

Relevant External Links for OR5V1 Gene

GeneLoc Exon Structure for
OR5V1
ECgene alternative splicing isoforms for
OR5V1

Expression for OR5V1 Gene

mRNA expression in normal human tissues for OR5V1 Gene

mRNA differential expression in normal tissues according to GTEx for OR5V1 Gene

This gene is overexpressed in Testis (42.4).

SOURCE GeneReport for Unigene cluster for OR5V1 Gene Hs.666316

genes like me logo Genes that share expressions with OR5V1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for OR5V1 Gene

Orthologs for OR5V1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471937 35
  • 98.86 (n)
  • 97.51 (a)
OR5V1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
OR5V1 35
  • 85.76 (n)
  • 86.08 (a)
mouse
(Mus musculus)
Mammalia Olfr110 16
Olfr110 36
  • 82 (a)
OneToMany
Olfr111 35
  • 81.33 (n)
  • 82.59 (a)
Olfr111 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR5V1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr1730 35
  • 81.86 (n)
  • 81.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491436 35
  • 57.73 (n)
  • 58.76 (a)
Species with no ortholog for OR5V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5V1 Gene

ENSEMBL:
Gene Tree for OR5V1 (if available)
TreeFam:
Gene Tree for OR5V1 (if available)

Paralogs for OR5V1 Gene

Paralogs for OR5V1 Gene

Selected SIMAP similar genes for OR5V1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5V1: view

Variants for OR5V1 Gene

Sequence variations from dbSNP and Humsavar for OR5V1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3117438 -- 29,355,482(+) GTAGA(A/G)AAGGC reference, synonymous-codon
rs3129684 -- 29,357,383(+) GGTAG(C/G)TTTAT upstream-variant-2KB
rs3129685 -- 29,357,825(+) GCTCA(A/G)GGCCT upstream-variant-2KB
rs4713210 -- 29,357,656(+) ACAAT(C/T)AATTT upstream-variant-2KB
rs6930033 - 29,356,128(+) ACTGC(A/C)ATTCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR5V1 Gene

Variant ID Type Subtype PubMed ID
nsv830624 CNV Loss 17160897
nsv520169 CNV Gain 19592680

Relevant External Links for OR5V1 Gene

HapMap Linkage Disequilibrium report
OR5V1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5V1 Gene

Disorders for OR5V1 Gene

Relevant External Links for OR5V1

Genetic Association Database (GAD)
OR5V1
Human Genome Epidemiology (HuGE) Navigator
OR5V1
genes like me logo Genes that share disorders with OR5V1: view

No data available for UniProtKB/Swiss-Prot for OR5V1 Gene

Publications for OR5V1 Gene

  1. Complex transcription and splicing of odorant receptor genes. (PMID: 12637542) Volz A. … Ziegler A. (J. Biol. Chem. 2003) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  4. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson E.E. … Ober C. (Hum. Immunol. 2010) 3 48
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for OR5V1 Gene

Sources for OR5V1 Gene

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