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Aliases for OR5T2 Gene

Aliases for OR5T2 Gene

  • Olfactory Receptor, Family 5, Subfamily T, Member 2 2 3
  • Olfactory Receptor OR11-177 3 4
  • Olfactory Receptor 5T2 3
  • OR11-177 3

External Ids for OR5T2 Gene

Summaries for OR5T2 Gene

Entrez Gene Summary for OR5T2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5T2 Gene

OR5T2 (Olfactory Receptor, Family 5, Subfamily T, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include olfactory receptor activity and serotonin receptor activity. An important paralog of this gene is OR5I1.

UniProtKB/Swiss-Prot for OR5T2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5T2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5T2 Gene

Genomics for OR5T2 Gene

Genomic Location for OR5T2 Gene

Start:
56,232,106 bp from pter
End:
56,233,185 bp from pter
Size:
1,080 bases
Orientation:
Minus strand

Genomic View for OR5T2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5T2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5T2 Gene

Regulatory Elements for OR5T2 Gene

Proteins for OR5T2 Gene

  • Protein details for OR5T2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGG2-OR5T2_HUMAN
    Recommended name:
    Olfactory receptor 5T2
    Protein Accession:
    Q8NGG2
    Secondary Accessions:
    • B9EGX5
    • Q6IFC8

    Protein attributes for OR5T2 Gene

    Size:
    359 amino acids
    Molecular mass:
    40696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5T2 Gene

Proteomics data for OR5T2 Gene at MOPED

Post-translational modifications for OR5T2 Gene

Other Protein References for OR5T2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5T2 Gene

Domains for OR5T2 Gene

Gene Families for OR5T2 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5T2 Gene

UniProtKB/Swiss-Prot:

OR5T2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGG2
genes like me logo Genes that share domains with OR5T2: view

Function for OR5T2 Gene

Molecular function for OR5T2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR5T2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5T2 Gene

Localization for OR5T2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5T2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5T2 Gene COMPARTMENTS Subcellular localization image for OR5T2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5T2: view

Pathways for OR5T2 Gene

genes like me logo Genes that share pathways with OR5T2: view

Pathways by source for OR5T2 Gene

Interacting Proteins for OR5T2 Gene

Gene Ontology (GO) - Biological Process for OR5T2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5T2: view

Transcripts for OR5T2 Gene

mRNA/cDNA for OR5T2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5T2 Gene

No ASD Table

Relevant External Links for OR5T2 Gene

GeneLoc Exon Structure for
OR5T2
ECgene alternative splicing isoforms for
OR5T2

Expression for OR5T2 Gene

mRNA expression in normal human tissues for OR5T2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OR5T2 Gene

SOURCE GeneReport for Unigene cluster for OR5T2 Gene Hs.553627

genes like me logo Genes that share expressions with OR5T2: view

Orthologs for OR5T2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5T2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466553 36
  • 98.79 (n)
  • 97.21 (a)
OR5T2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC610544 36
  • 85.16 (n)
  • 81.5 (a)
OR5T2 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1086 36
  • 79.63 (n)
  • 74.84 (a)
Olfr1086 16
Olfr1086 37
  • 74 (a)
OneToMany
Olfr1095 37
  • 75 (a)
OneToMany
Olfr1101 37
  • 74 (a)
OneToMany
Olfr141 37
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr510 36
  • 79.55 (n)
  • 75.32 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
OneToMany
Species with no ortholog for OR5T2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5T2 Gene

ENSEMBL:
Gene Tree for OR5T2 (if available)
TreeFam:
Gene Tree for OR5T2 (if available)

Paralogs for OR5T2 Gene

Paralogs for OR5T2 Gene

Selected SIMAP similar genes for OR5T2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5T2: view

Variants for OR5T2 Gene

Sequence variations from dbSNP and Humsavar for OR5T2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3919907 - 56,233,124(-) TCATT(A/C)TTTTT missense, reference
rs7121880 - 56,232,261(+) GTCAT(C/G)GTCCG reference, missense
rs7122000 -- 56,232,421(+) TAGGA(A/G)ATCAG reference, synonymous-codon
rs7122514 - 56,232,812(+) TTGTC(A/G/T)TAAAA missense, reference
rs10791893 - 56,232,927(+) GACCA(C/G)TAAAA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for OR5T2 Gene

Variant ID Type Subtype PubMed ID
nsv521440 CNV Loss 19592680

Relevant External Links for OR5T2 Gene

HapMap Linkage Disequilibrium report
OR5T2

Disorders for OR5T2 Gene

No disorders were found for OR5T2 Gene.

No data available for UniProtKB/Swiss-Prot for OR5T2 Gene

Publications for OR5T2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5T2 Gene

Sources for OR5T2 Gene

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