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Aliases for OR5T1 Gene

Aliases for OR5T1 Gene

  • Olfactory Receptor, Family 5, Subfamily T, Member 1 2 3
  • Olfactory Receptor OR11-179 3 4
  • OR5T1P 3 4
  • Olfactory Receptor, Family 5, Subfamily T, Member 1 Pseudogene 3
  • OR11-179 3

External Ids for OR5T1 Gene

Previous HGNC Symbols for OR5T1 Gene

  • OR5T1P

Previous GeneCards Identifiers for OR5T1 Gene

  • GC11P055819
  • GC11P055799
  • GC11P056043

Summaries for OR5T1 Gene

Entrez Gene Summary for OR5T1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5T1 Gene

OR5T1 (Olfactory Receptor, Family 5, Subfamily T, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5I1.

UniProtKB/Swiss-Prot for OR5T1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5T1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5T1 Gene

Genomics for OR5T1 Gene

Regulatory Elements for OR5T1 Gene

Genomic Location for OR5T1 Gene

Chromosome:
11
Start:
56,275,639 bp from pter
End:
56,276,619 bp from pter
Size:
981 bases
Orientation:
Plus strand

Genomic View for OR5T1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5T1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5T1 Gene

Proteins for OR5T1 Gene

  • Protein details for OR5T1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG75-OR5T1_HUMAN
    Recommended name:
    Olfactory receptor 5T1
    Protein Accession:
    Q8NG75
    Secondary Accessions:
    • B2RNM9

    Protein attributes for OR5T1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5T1 Gene

Proteomics data for OR5T1 Gene at MOPED

Post-translational modifications for OR5T1 Gene

  • Glycosylation at Asn 17 and Asn 101
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5T1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5T1 Gene

Domains & Families for OR5T1 Gene

Gene Families for OR5T1 Gene

Protein Domains for OR5T1 Gene

Suggested Antigen Peptide Sequences for OR5T1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG75

UniProtKB/Swiss-Prot:

OR5T1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5T1: view

Function for OR5T1 Gene

Molecular function for OR5T1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004939 NOT beta-adrenergic receptor activity IBA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR5T1: view

Phenotypes for OR5T1 Gene

genes like me logo Genes that share phenotypes with OR5T1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5T1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5T1 Gene

Localization for OR5T1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5T1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR5T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5T1: view

No data available for Subcellular locations from COMPARTMENTS for OR5T1 Gene

Pathways & Interactions for OR5T1 Gene

genes like me logo Genes that share pathways with OR5T1: view

Pathways by source for OR5T1 Gene

Interacting Proteins for OR5T1 Gene

Gene Ontology (GO) - Biological Process for OR5T1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007267 cell-cell signaling IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with OR5T1: view

No data available for SIGNOR curated interactions for OR5T1 Gene

Drugs & Compounds for OR5T1 Gene

No Compound Related Data Available

Transcripts for OR5T1 Gene

mRNA/cDNA for OR5T1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5T1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5T1 Gene

No ASD Table

Relevant External Links for OR5T1 Gene

GeneLoc Exon Structure for
OR5T1
ECgene alternative splicing isoforms for
OR5T1

Expression for OR5T1 Gene

mRNA expression in normal human tissues for OR5T1 Gene

SOURCE GeneReport for Unigene cluster for OR5T1 Gene Hs.553747

genes like me logo Genes that share expression patterns with OR5T1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5T1 Gene

Orthologs for OR5T1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5T1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR5T1 35
  • 81.13 (n)
  • 77.99 (a)
-- 36
  • 77 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100685095 35
  • 84.9 (n)
  • 81.56 (a)
-- 36
  • 79 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC747561 35
  • 98.57 (n)
  • 96.63 (a)
OR5T1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr515 35
  • 80.33 (n)
  • 78.69 (a)
mouse
(Mus musculus)
Mammalia Olfr1094 16
Olfr1093 36
  • 75 (a)
ManyToMany
Olfr1094 36
  • 73 (a)
ManyToMany
Olfr1102 36
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
Species with no ortholog for OR5T1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5T1 Gene

ENSEMBL:
Gene Tree for OR5T1 (if available)
TreeFam:
Gene Tree for OR5T1 (if available)

Paralogs for OR5T1 Gene

Paralogs for OR5T1 Gene

(445) SIMAP similar genes for OR5T1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5T1: view

Variants for OR5T1 Gene

Sequence variations from dbSNP and Humsavar for OR5T1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs207471917 Uncertain significance, Uncertain significance 56,274,143(+) CATAC(A/C)TGAAT upstream-variant-2KB
rs267603000 untested, untested 56,275,806(+) TTAGG(A/G)CTGGT synonymous-codon, reference
VAR_034233 -
VAR_053210 -

Structural Variations from Database of Genomic Variants (DGV) for OR5T1 Gene

Variant ID Type Subtype PubMed ID
nsv521440 CNV Loss 19592680

Variation tolerance for OR5T1 Gene

Residual Variation Intolerance Score: 67.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5T1 Gene

HapMap Linkage Disequilibrium report
OR5T1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5T1 Gene

Disorders for OR5T1 Gene

Relevant External Links for OR5T1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5T1
genes like me logo Genes that share disorders with OR5T1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5T1 Gene

Publications for OR5T1 Gene

  1. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 67
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for OR5T1 Gene

Sources for OR5T1 Gene

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