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OR5R1 Gene

protein-coding   GIFtS: 46
GCID: GC11M056186

Olfactory Receptor, Family 5, Subfamily R, Member 1


(Previous symbol: OR5R1P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily R, Member 11 2
OR5R1P1 2 3
Olfactory Receptor OR11-1852 3
OR11-1852
Olfactory Receptor 5R12
Olfactory Receptor, Family 5, Subfamily R, Member 1 Pseudogene2

External Ids:    HGNC: 148411   Entrez Gene: 2194792   Ensembl: ENSG000001749427   UniProtKB: Q8NH853   

Export aliases for OR5R1 gene to outside databases

Previous GC identifers: GC11M055961 GC11M055941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5R1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5R1 Gene:
OR5R1 (olfactory receptor, family 5, subfamily R, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8U1.

UniProtKB/Swiss-Prot: OR5R1_HUMAN, Q8NH85
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5R1 gene promoter:
         HFH-3   SRF   TBP   HTF   SRF (504 AA)   CUTL1   STAT5A   YY1   FOXI1   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5R1 promoter sequence
   Search Chromatin IP Primers for OR5R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR5R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5R1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M056186:  view genomic region     (about GC identifiers)

Start:
56,184,737 bp from pter      End:
56,185,708 bp from pter
Size:
972 bases      Orientation:
minus strand

1 alternative location:
Chr11-,NW_003571044 235,612-236,586     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR5R1_HUMAN, Q8NH85 (See protein sequence)
Recommended Name: Olfactory receptor 5R1  
Size: 324 amino acids; 36708 Da

Explore the universe of human proteins at neXtProt for OR5R1: NX_Q8NH85

Explore proteomics data for OR5R1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn265
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR5R1

    See OR5R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004744.1  
    ENSEMBL proteins: 
     ENSP00000308595  
    Reactome Protein details: Q8NH85

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NH85

    ProtoNet protein and cluster: Q8NH85

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5R1_HUMAN, Q8NH85
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5R1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5R1_HUMAN, Q8NH85
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5R1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR5R1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5R1_HUMAN, Q8NH85: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5R1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5R1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5R1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5R1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5R1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5R1
    Interactions:

        Search GeneGlobe Interaction Network for OR5R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5R1 (ENSP000003085954) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    OR10A4ENSP000003691574STRING: ENSP00000369157
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5R1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR5R1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5R1 gene: 
    NM_001004744.1  

    Unigene Cluster for OR5R1:

    Olfactory receptor, family 5, subfamily R, member 1
    Hs.553630
    Unigene Representative Sequence: NM_001004744
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312253(uc010rji.2)
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    1 AceView cDNA sequence:

    NM_001004744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAAATTC
    OR5R1 Expression
    About this image

    OR5R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553630
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5R1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1038-ps1 , 5 olfactory receptor 1038, pseudogene1, 5 84.01(n)1
    90.6(a)1
      2 (49.73 cM)5
    2590151  NM_147013.21  NP_667224.11 
     861219255 


    ENSEMBL Gene Tree for OR5R1 (if available)
    TreeFam Gene Tree for OR5R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5R1 gene
    OR8U12  OR8K12  OR8K52  OR5M112  OR5M82  OR8J32  OR5M102  OR8K32  
    OR5M32  OR5M92  OR8J12  OR5M12  
    Selected SIMAP similar genes for OR5R1 using alignment to 1 protein entry:     OR5R1_HUMAN(see all similar genes):
    OR8U9    OR8U1    OR8U8    OR8J2    OR8K3    OR5AR1
    OR5M11    OR8K1    OR8K5    OR8J1    OR8J3    OR5AL1
    OR5B12    OR5B21    OR5D18    OR5E1P    OR5M1    OR5M10

    Find genes that share paralogs with OR5R1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for OR5R1 (see all 6)
    PGOHUM00000257824 PGOHUM00000242290 PGOHUM00000242586 PGOHUM00000242726 PGOHUM00000262555


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5R1 (see all 131)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs79396981,2
    H--56184350(+) gttagG/Atccta 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs108963531,2
    C,F,H--56184374(+) TTGGAA/GACAAA 1 -- ds500117Minor allele frequency- G:0.09NS EA NA WA CSA 780
    rs1452304651,2
    --56184487(+) CATGCC/TGCTGC 1 -- ds50010--------
    rs112283061,2
    C,F,A,H--56184659(+) AGGTCC/TATTAA 1 -- ds500131Minor allele frequency- T:0.30NA NS EA WA CSA 2903
    rs2000935861,2
    --56184732(+) TGCTTA/GTTTAA 1 -- ds50010--------
    rs2016949741,2
    --56184803(+) GCTTTC/TTTTGA 2 K syn10--------
    rs1454340761,2
    C,F--56184811(+) TGAGGC/TATCTT 2 T A mis11Minor allele frequency- T:0.00NA 3830
    rs1476192741,2
    C,F--56184871(+) CACCAC/TTGTGT 2 M V mis11Minor allele frequency- T:0.01NA 4544
    rs9985441,2,,4
    C,F,O,A,H--56184888(-) GATGGC/TTTCTG 2 A V mis1 ese333Minor allele frequency- N:0.00NA EA NS WA CSA EU 9071
    rs1865084781,2
    C--56185020(+) GAGTAC/GAGCGG 2 S C mis10--------

    HapMap Linkage Disequilibrium report for OR5R1 ( 56184737 - 56185708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR5R1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825905CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR5R1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR5R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5R1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219479 HGNC: 14841 AceView: OR5R1 Ensembl:ENSG00000174942 euGenes: HUgn219479
    ECgene: OR5R1 Kegg: 219479 H-InvDB: OR5R1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5R1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5R1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5R1 gene:
    Search GeneIP for patents involving OR5R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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