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OR5P3 Gene

protein-coding   GIFtS: 48
GCID: GC11M007846

Olfactory Receptor, Family 5, Subfamily P, Member 3

  Search for OR5P3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily P, Member 31 2
Olfactory Receptor OR11-942 3
Olfactory Receptor-Like Protein JCG12 3
JCG12
Olfactory Receptor 5P32

External Ids:    HGNC: 147841   Entrez Gene: 1200662   Ensembl: ENSG000001823347   UniProtKB: Q8WZ943   

Export aliases for OR5P3 gene to outside databases

Previous GC identifers: GC11U990302 GC11M007811 GC11M007803


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5P3 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5P3 Gene:
OR5P3 (olfactory receptor, family 5, subfamily P, member 3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5P2.

UniProtKB/Swiss-Prot: OR5P3_HUMAN, Q8WZ94
Function: Odorant receptor (Potential). May be involved in taste perception

Gene Wiki entry for OR5P3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  NT_187583.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5P3 gene promoter:
         PPAR-gamma1   Pbx1a   POU2F1   POU2F1a   FOXD1   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5P3 promoter sequence
   Search Chromatin IP Primers for OR5P3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5P3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR5P3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5P3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M007846:  view genomic region     (about GC identifiers)

Start:
7,846,587 bp from pter      End:
7,847,519 bp from pter
Size:
933 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR5P3_HUMAN, Q8WZ94 (See protein sequence)
Recommended Name: Olfactory receptor 5P3  
Size: 311 amino acids; 34296 Da
Sequence caution: Sequence=BAC05990.1; Type=Erroneous initiation;
Secondary accessions: Q6IFE1 Q8NGM2

Explore the universe of human proteins at neXtProt for OR5P3: NX_Q8WZ94

Explore proteomics data for OR5P3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR5P3

    See OR5P3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_703146.1  
    ENSEMBL proteins: 
     ENSP00000332068  
    Reactome Protein details: Q8WZ94

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8WZ94

    ProtoNet protein and cluster: Q8WZ94

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5P3_HUMAN, Q8WZ94
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5P3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5P3_HUMAN, Q8WZ94
    Function: Odorant receptor (Potential). May be involved in taste perception

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5P3           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5P3_HUMAN, Q8WZ94: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5P3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5P3 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5P3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5P3
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5P3):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5P3
    Interactions:

        Search GeneGlobe Interaction Network for OR5P3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5P3 (ENSP000003320684) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10G3ENSP000003024374STRING: ENSP00000302437
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR1A1ENSP000003052074STRING: ENSP00000305207
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5P3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR5P3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5P3 gene: 
    NM_153445.1  

    Unigene Cluster for OR5P3:

    Olfactory receptor, family 5, subfamily P, member 3
    Hs.351825
    Unigene Representative Sequence: AF158377
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328375(uc010rbg.2)
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      QuantiFast Probe-based Assays in human, mouse, rat OR5P3

    Additional mRNA sequence: AF158377.1 

    1 DOTS entry:

    DT.95326744 

    2 AceView cDNA sequences:

    AF158377 NM_153445 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5P3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR5P3 Expression
    About this image

    OR5P3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5P3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351825

    UniProtKB/Swiss-Prot: OR5P3_HUMAN, Q8WZ94
    Tissue specificity: Expressed in the tongue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5P3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr5081 , 5 olfactory receptor 5081, 5 81.63(n)1
    79.54(a)1
      7 (57.21 cM)5
    2587691  NM_146773.11  NP_666984.11 
     1086299945 


    ENSEMBL Gene Tree for OR5P3 (if available)
    TreeFam Gene Tree for OR5P3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5P3 gene
    OR5P22  
    Selected SIMAP similar genes for OR5P3 using alignment to 1 protein entry:     OR5P3_HUMAN(see all similar genes):
    PJCG1    JCG4    OR5P2    OR5AP2    OR5B21    OR8J2
    OR8U9    OR5AK3P    OR5T1    OR8H2    OR8U1    OR8U8
    OR5AR1    OR5A2    OR5B12    OR5B2    OR5J2    OR5T2

    Find genes that share paralogs with OR5P3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for OR5P3
    PGOHUM00000242163 PGOHUM00000242584


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5P3 (see all 133)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1902566901,2
    --7846097(+) AAGCTC/GATTGT 1 -- ds50010--------
    rs1470042931,2
    --7846211(+) CATGTA/GTCTCA 1 -- ds50010--------
    rs753535101,2
    F--7846260(+) TTAAAG/TGTATG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs746658031,2
    C--7846452(+) CCCTCC/TTGATT 1 -- ds50010--------
    rs169324881,2
    C,F,H--7846506(+) ATTTTG/CACCAC 1 -- ds500124Minor allele frequency- C:0.23NA NS EA CSA WA 2726
    rs1817139961,2
    C--7846581(+) TAGTTC/TCATCA 1 -- ds50010--------
    rs617348161,2
    C,F--7846599(+) ATTTTT/CATTCT 2 /I /M mis14Minor allele frequency- C:0.02NS WA NA EU 5321
    rs2009730331,2
    --7846629(+) CCCTTA/TATCTC 2 I syn10--------
    rs1134937951,2
    C--7846640(+) CTTGTC/TCCTGA 2 N D mis11Minor allele frequency- T:0.50CSA 2
    rs2000187581,2
    C--7846682(+) CACCAC/TGGTGT 2 M V mis10--------

    HapMap Linkage Disequilibrium report for OR5P3 ( 7846587 - 7847519 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for OR5P3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656938CNV Deletion23128226
    nsv509387CNV Insertion20534489
    nsv7660CNV Loss18451855
    nsv896977CNV Loss21882294
    esv24404CNV Loss19812545
    nsv896979CNV Gain21882294
    nsv510998CNV Complex20534489
    nsv7215OTHER Inversion18451855
    nsv499766OTHER Inversion21111241

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5P3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5P3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. New GPCRs from a human lingual cDNA library. (PubMed id 11705801)1, 2 Gaudin J.-C.... Haertle T. (Chem. Senses 2001)
    3. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 120066 HGNC: 14784 AceView: OR5P3 Ensembl:ENSG00000182334 euGenes: HUgn120066
    ECgene: OR5P3 Kegg: 120066 H-InvDB: OR5P3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5P3 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5P3 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5P3 gene:
    Search GeneIP for patents involving OR5P3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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