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Aliases for OR5P3 Gene

Aliases for OR5P3 Gene

  • Olfactory Receptor Family 5 Subfamily P Member 3 2 3 5
  • Olfactory Receptor-Like Protein JCG1 3 4
  • Olfactory Receptor OR11-94 3 4
  • Olfactory Receptor, Family 5, Subfamily P, Member 3 2
  • Olfactory Receptor 5P3 3
  • JCG1 3

External Ids for OR5P3 Gene

Previous GeneCards Identifiers for OR5P3 Gene

  • GC11U990302
  • GC11M007811
  • GC11M007803

Summaries for OR5P3 Gene

Entrez Gene Summary for OR5P3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5P3 Gene

OR5P3 (Olfactory Receptor Family 5 Subfamily P Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5P2.

UniProtKB/Swiss-Prot for OR5P3 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR5P3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5P3 Gene

Genomics for OR5P3 Gene

Regulatory Elements for OR5P3 Gene

Enhancers for OR5P3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F007615 0.3 FANTOM5 1.3 +210.4 210418 0.3 CYB5R2 PPFIBP2 OR5P3 GC11P007617 LOC105376535
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5P3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5P3 Gene

Chromosome:
11
Start:
7,825,037 bp from pter
End:
7,825,972 bp from pter
Size:
936 bases
Orientation:
Minus strand

Genomic View for OR5P3 Gene

Genes around OR5P3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5P3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5P3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5P3 Gene

Proteins for OR5P3 Gene

  • Protein details for OR5P3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ94-OR5P3_HUMAN
    Recommended name:
    Olfactory receptor 5P3
    Protein Accession:
    Q8WZ94
    Secondary Accessions:
    • Q6IFE1
    • Q8NGM2

    Protein attributes for OR5P3 Gene

    Size:
    311 amino acids
    Molecular mass:
    34296 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05990.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5P3 Gene

Post-translational modifications for OR5P3 Gene

Other Protein References for OR5P3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5P3 Gene

Domains & Families for OR5P3 Gene

Gene Families for OR5P3 Gene

Protein Domains for OR5P3 Gene

Suggested Antigen Peptide Sequences for OR5P3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ94

UniProtKB/Swiss-Prot:

OR5P3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5P3: view

Function for OR5P3 Gene

Molecular function for OR5P3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR5P3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5P3: view
genes like me logo Genes that share phenotypes with OR5P3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR5P3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5P3 Gene

Localization for OR5P3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5P3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5P3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5P3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5P3: view

Pathways & Interactions for OR5P3 Gene

genes like me logo Genes that share pathways with OR5P3: view

Pathways by source for OR5P3 Gene

Gene Ontology (GO) - Biological Process for OR5P3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5P3: view

No data available for SIGNOR curated interactions for OR5P3 Gene

Transcripts for OR5P3 Gene

mRNA/cDNA for OR5P3 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for OR5P3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5P3 Gene

No ASD Table

Relevant External Links for OR5P3 Gene

GeneLoc Exon Structure for
OR5P3
ECgene alternative splicing isoforms for
OR5P3

Expression for OR5P3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5P3 Gene

mRNA differential expression in normal tissues according to GTEx for OR5P3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x15.4), Skin - Sun Exposed (Lower leg) (x14.3), Bladder (x6.3), and Testis (x4.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5P3 Gene



NURSA nuclear receptor signaling pathways regulating expression of OR5P3 Gene:

OR5P3

SOURCE GeneReport for Unigene cluster for OR5P3 Gene:

Hs.351825

mRNA Expression by UniProt/SwissProt for OR5P3 Gene:

Q8WZ94-OR5P3_HUMAN
Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR5P3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for OR5P3 Gene

Orthologs for OR5P3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5P3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466431 34
  • 99.36 (n)
OR5P3 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5P3 34 35
  • 85.15 (n)
mouse
(Mus musculus)
Mammalia Or5p80 55 Olfr508 34 16 35
  • 81.63 (n)
Or5p57 55 Olfr480 35
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
Species where no ortholog for OR5P3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5P3 Gene

ENSEMBL:
Gene Tree for OR5P3 (if available)
TreeFam:
Gene Tree for OR5P3 (if available)

Paralogs for OR5P3 Gene

Paralogs for OR5P3 Gene

(439) SIMAP similar genes for OR5P3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5P3 Gene

genes like me logo Genes that share paralogs with OR5P3: view

Variants for OR5P3 Gene

Sequence variations from dbSNP and Humsavar for OR5P3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11041591 -- 7,827,441(+) TGTGA(C/G)TGCCT upstream-variant-2KB
rs111727690 -- 7,825,608(+) CATAG(C/T)GATCA reference, missense
rs112804649 -- 7,827,971(+) GCCAG(C/T)TGATG upstream-variant-2KB
rs113014826 -- 7,827,142(+) TCTTG(C/G)ACTTC upstream-variant-2KB
rs113493795 -- 7,825,093(+) CTTGT(C/T)CCTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OR5P3 Gene

Variant ID Type Subtype PubMed ID
dgv1633n54 CNV loss 21841781
esv24404 CNV loss 19812545
esv2656938 CNV deletion 23128226
esv3579351 CNV loss 25503493
esv3625303 CNV gain 21293372
esv3625305 CNV loss 21293372
esv3891927 CNV loss 25118596
nsv1035675 CNV loss 25217958
nsv1044303 CNV loss 25217958
nsv1047533 CNV loss 25217958
nsv499766 OTHER inversion 21111241
nsv509387 CNV insertion 20534489
nsv510998 OTHER complex 20534489
nsv553409 CNV loss 21841781
nsv7215 OTHER inversion 18451855
nsv7660 CNV deletion 18451855

Variation tolerance for OR5P3 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5P3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5P3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5P3 Gene

Disorders for OR5P3 Gene

Relevant External Links for OR5P3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5P3

No disorders were found for OR5P3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5P3 Gene

Publications for OR5P3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin J.-C. … Haertle T. (Chem. Senses 2001) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 64

Products for OR5P3 Gene

Sources for OR5P3 Gene

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