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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR5P2 Gene

protein-coding   GIFtS: 50
GCID: GC11M007817

olfactory receptor, family 5, subfamily P, member 2

 Explore 1 disease affiliated with
OR5P2 via our new
 Human Malady Compendium 
Biological research products
for OR5P2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 5, Subfamily P, Member 21 2
JCG31 2
Olfactory Receptor-Like Protein JCG32 3
JCG42
Olfactory Receptor 5P22
Olfactory Receptor OR11-932

External Ids:    HGNC: 147831   Entrez Gene: 1200652   Ensembl: ENSG000001833037   UniProtKB: Q8WZ923   

Export aliases for OR5P2 gene to outside databases

Previous GC identifers: GC11U990303 GC11M007782 GC11M007774


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR5P2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OR5P2_HUMAN, Q8WZ92
Function: Odorant receptor (Potential). May be involved in taste perception

Gene Wiki entry for OR5P2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR5P2 gene promoter:
         GR   Max1   GR-beta   USF2   Nkx5-1   Meis-1b   Meis-1a   GR-alpha   Meis-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5P2 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR5P2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

OR5P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5P2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M007817:  view genomic region     (about GC identifiers)

Start:
7,817,524 bp from pter      End:
7,818,489 bp from pter
Size:
966 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR5P2_HUMAN, Q8WZ92 (See protein sequence)
Recommended Name: Olfactory receptor 5P2  
Size: 322 amino acids; 35786 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3MIS8

Explore the universe of human proteins at neXtProt for OR5P2: NX_Q8WZ92

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WZ92

  • HORDE protein sequence for OR5P2
    OR5P2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_703145.1  
    ENSEMBL proteins: 
     ENSP00000331823  
    Reactome Protein details: Q8WZ92
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    Uscn Proteins for OR5P2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    OR5P2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OR5P2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8WZ92

    ProtoNet protein and cluster: Q8WZ92

    1 Blocks protein family: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5P2_HUMAN, Q8WZ92
    Similarity: Belongs to the G-protein coupled receptor 1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OR5P2_HUMAN, Q8WZ92
    Function: Odorant receptor (Potential). May be involved in taste perception

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--


    OR5P2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    2Olfactory transduction
    Olfactory transduction1.00
    Olfactory Signaling Pathway0.77

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for OR5P2
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR5P2):
        Olfactory transduction


    OR5P2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR5P2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR5P2 (ENSP000003318234) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR2K2ENSP000003050554STRING: ENSP00000305055
    OR5P3ENSP000003320684STRING: ENSP00000332068
    OR6Q1ENSP000003077344STRING: ENSP00000307734
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR5P2
    Search CenterWatch for drugs/clinical trials and news about OR5P2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR5P2 gene: 
    NM_153444.1  

    Unigene Cluster for OR5P2:

    Olfactory receptor, family 5, subfamily P, member 2
    Hs.351824
    Unigene Representative Sequence: BC113557
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329434(uc001mfp.1)

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    Additional cDNA sequence: 

    AF173006.1 AF220494.1 BC101710.1 BC113557.1 

    1 DOTS entry:

    DT.95245587 

    3 AceView cDNA sequences:

    AF173006 NM_153444 AF220494 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR5P2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAACCCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    OR5P2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive Endoderm (Generation of beta c...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See OR5P2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR5P2

    SOURCE GeneReport for Unigene cluster: Hs.351824

    UniProtKB/Swiss-Prot: OR5P2_HUMAN, Q8WZ92
    Tissue specificity: Expressed in the tongue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5P2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR5P2 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ250756.12   -- 74.28(n)    AJ250756.1 


    ENSEMBL Gene Tree for OR5P2 (if available)
    TreeFam Gene Tree for OR5P2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR5P2 gene
    OR5P32  
    18/447 SIMAP similar genes for OR5P2 using alignment to 1 protein entry:     OR5P2_HUMAN(see all similar genes):
    JCG4    PJCG1    OR5P3    OR5AR1    OR5B2    OR5R1
    OR5T1    OR8J3    OR2C3    OR5A2    OR5AS1    OR5B21
    OR5G3    OR5T2    OR5T3    OR5W2    OR8D1    OR8G1

    OR5P2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/111 NCBI SNPs in OR5P2 are shown (see all 111    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753080371,2
    F,--7817036(+) GCAAAT/CGCATA 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs1180856861,2
    --7817185(+) CTCTGT/CTATAG 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1474346741,2
    --7817290(+) AGCAGA/GAACAA 1 -- ds50010--------
    rs4418031,2
    H--7817299(+) AAATGC/TTTCAT 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1822888051,2
    --7817318(+) CCATTA/GATTCA 1 -- ds50010--------
    rs79318751,2
    C,F,A,H,--7817344(+) TCTCTC/TCATTT 1 -- ds500111Minor allele frequency- T:0.22NS EA NA CSA WA 792
    rs745390031,2
    C,F,--7817348(+) TCCATT/CTTAAA 1 -- ds50012Minor allele frequency- C:0.17WA NA 238
    rs1869095651,2
    --7817377(+) AAGTTC/TTAGAA 1 -- ds50010--------
    rs778401521,2
    C,F,--7817379(+) GTTCTA/GGAAAC 1 -- ds50012Minor allele frequency- G:0.17WA NA 238
    rs79495461,2
    C,F,H,--7817420(+) AAAGAT/AGTGGT 1 -- ds50019Minor allele frequency- A:0.20NS EA WA CSA NA 664

    HapMap Linkage Disequilibrium report for OR5P2 ( 7817524 - 7818489 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for OR5P2
         11 CNVs: 85638 85641 85639 38039 37481 75537 22901 65859 35017 85640 35016

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OR5P2 for disorders           About GeneDecksing

    1 disease for OR5P2:    About MalaCards
    neuronitis


    Export disorders for OR5P2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR5P2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR5P2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. New GPCRs from a human lingual cDNA library. (PubMed id 11705801)1, 2 Gaudin J.-C.... Haertle T. (2001)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 120065 HGNC: 14783 AceView: OR5P2 Ensembl:ENSG00000183303 euGenes: HUgn120065
    ECgene: OR5P2 Kegg: 120065 H-InvDB: OR5P2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR5P2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5P2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR5P2 gene:
    Search GeneIP for patents involving OR5P2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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