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Aliases for OR5M8 Gene

Aliases for OR5M8 Gene

  • Olfactory Receptor, Family 5, Subfamily M, Member 8 2 3
  • Olfactory Receptor OR11-194 3 4
  • Olfactory Receptor 5M8 3
  • OR11-194 3

External Ids for OR5M8 Gene

Previous GeneCards Identifiers for OR5M8 Gene

  • GC11U990339
  • GC11M056035
  • GC11M056015
  • GC11M056016
  • GC11M056257

Summaries for OR5M8 Gene

Entrez Gene Summary for OR5M8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5M8 Gene

OR5M8 (Olfactory Receptor, Family 5, Subfamily M, Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5M11.

UniProtKB/Swiss-Prot for OR5M8 Gene

  • Odorant receptor.

Gene Wiki entry for OR5M8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5M8 Gene

Genomics for OR5M8 Gene

Regulatory Elements for OR5M8 Gene

Genomic Location for OR5M8 Gene

Start:
56,490,435 bp from pter
End:
56,491,370 bp from pter
Size:
936 bases
Orientation:
Minus strand

Genomic View for OR5M8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5M8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5M8 Gene

Proteins for OR5M8 Gene

  • Protein details for OR5M8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP6-OR5M8_HUMAN
    Recommended name:
    Olfactory receptor 5M8
    Protein Accession:
    Q8NGP6
    Secondary Accessions:
    • B2RNM5
    • Q6IEW3
    • Q96RB8

    Protein attributes for OR5M8 Gene

    Size:
    311 amino acids
    Molecular mass:
    35603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5M8 Gene

Proteomics data for OR5M8 Gene at MOPED

Post-translational modifications for OR5M8 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5M8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5M8 Gene

Domains for OR5M8 Gene

Gene Families for OR5M8 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5M8 Gene

Suggested Antigen Peptide Sequences for OR5M8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGP6

UniProtKB/Swiss-Prot:

OR5M8_HUMAN :
  • Q8NGP6
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5M8: view

Function for OR5M8 Gene

Molecular function for OR5M8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5M8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5M8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5M8 Gene

Localization for OR5M8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5M8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5M8 Gene COMPARTMENTS Subcellular localization image for OR5M8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5M8: view

Pathways for OR5M8 Gene

genes like me logo Genes that share pathways with OR5M8: view

Pathways by source for OR5M8 Gene

Interacting Proteins for OR5M8 Gene

Gene Ontology (GO) - Biological Process for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5M8: view

Transcripts for OR5M8 Gene

mRNA/cDNA for OR5M8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5M8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5M8 Gene

No ASD Table

Relevant External Links for OR5M8 Gene

GeneLoc Exon Structure for
OR5M8
ECgene alternative splicing isoforms for
OR5M8

Expression for OR5M8 Gene

mRNA expression in normal human tissues for OR5M8 Gene

SOURCE GeneReport for Unigene cluster for OR5M8 Gene Hs.554522

genes like me logo Genes that share expressions with OR5M8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for OR5M8 Gene

Orthologs for OR5M8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5M8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC610404 35
  • 89.47 (n)
  • 90.13 (a)
OR08E12 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1031 35
  • 81.24 (n)
  • 84.57 (a)
Olfr1031 16
Olfr1031 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC466567 35
  • 98.5 (n)
  • 96.78 (a)
OR5M8 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr472 35
  • 81.24 (n)
  • 84.24 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
Species with no ortholog for OR5M8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5M8 Gene

ENSEMBL:
Gene Tree for OR5M8 (if available)
TreeFam:
Gene Tree for OR5M8 (if available)

Paralogs for OR5M8 Gene

Paralogs for OR5M8 Gene

Selected SIMAP similar genes for OR5M8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5M8: view

Variants for OR5M8 Gene

Sequence variations from dbSNP and Humsavar for OR5M8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs659254 -- 56,493,093(-) GTGAA(C/T)TGATT upstream-variant-2KB
rs660985 -- 56,492,684(-) AACAG(C/T)TTTTG upstream-variant-2KB
rs669453 -- 56,493,175(+) TTTAC(A/C)ACTAA upstream-variant-2KB
rs669501 -- 56,493,213(+) TATAA(G/T)CCAAA upstream-variant-2KB
rs695088 -- 56,492,302(-) GCTGG(A/C)GTGCA upstream-variant-2KB

Relevant External Links for OR5M8 Gene

HapMap Linkage Disequilibrium report
OR5M8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR5M8 Gene

Disorders for OR5M8 Gene

No disorders were found for OR5M8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for OR5M8 Gene

Publications for OR5M8 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5M8 Gene

Sources for OR5M8 Gene

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