Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5M8 Gene

Aliases for OR5M8 Gene

  • Olfactory Receptor Family 5 Subfamily M Member 8 2 3 5
  • Olfactory Receptor OR11-194 3 4
  • Olfactory Receptor, Family 5, Subfamily M, Member 8 2
  • Olfactory Receptor 5M8 3
  • OR11-194 3

External Ids for OR5M8 Gene

Previous GeneCards Identifiers for OR5M8 Gene

  • GC11U990339
  • GC11M056035
  • GC11M056015
  • GC11M056016
  • GC11M056257

Summaries for OR5M8 Gene

Entrez Gene Summary for OR5M8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5M8 Gene

OR5M8 (Olfactory Receptor Family 5 Subfamily M Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5M3.

UniProtKB/Swiss-Prot for OR5M8 Gene

  • Odorant receptor.

Gene Wiki entry for OR5M8 Gene

Additional gene information for OR5M8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5M8 Gene

Genomics for OR5M8 Gene

Regulatory Elements for OR5M8 Gene

Enhancers for OR5M8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H056895 0.3 FANTOM5 6.9 -404.4 -404421 0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2P1
GH11H056486 0.2 ENCODE 0.7 +4.0 4015 2 FAM8A2P OR5M2P OR5M8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5M8 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5M8 Gene

Chromosome:
11
Start:
56,490,349 bp from pter
End:
56,491,395 bp from pter
Size:
1,047 bases
Orientation:
Minus strand

Genomic View for OR5M8 Gene

Genes around OR5M8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5M8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5M8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5M8 Gene

Proteins for OR5M8 Gene

  • Protein details for OR5M8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP6-OR5M8_HUMAN
    Recommended name:
    Olfactory receptor 5M8
    Protein Accession:
    Q8NGP6
    Secondary Accessions:
    • B2RNM5
    • Q6IEW3
    • Q96RB8

    Protein attributes for OR5M8 Gene

    Size:
    311 amino acids
    Molecular mass:
    35603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5M8 Gene

Post-translational modifications for OR5M8 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5M8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5M8 Gene

Domains & Families for OR5M8 Gene

Gene Families for OR5M8 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5M8 Gene

Suggested Antigen Peptide Sequences for OR5M8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGP6

UniProtKB/Swiss-Prot:

OR5M8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5M8: view

Function for OR5M8 Gene

Molecular function for OR5M8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5M8: view

Phenotypes for OR5M8 Gene

genes like me logo Genes that share phenotypes with OR5M8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5M8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5M8 Gene

Localization for OR5M8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5M8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5M8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5M8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5M8 Gene

Pathways & Interactions for OR5M8 Gene

genes like me logo Genes that share pathways with OR5M8: view

Pathways by source for OR5M8 Gene

Interacting Proteins for OR5M8 Gene

Gene Ontology (GO) - Biological Process for OR5M8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5M8: view

No data available for SIGNOR curated interactions for OR5M8 Gene

Drugs & Compounds for OR5M8 Gene

No Compound Related Data Available

Transcripts for OR5M8 Gene

mRNA/cDNA for OR5M8 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5M8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR5M8 Gene

No ASD Table

Relevant External Links for OR5M8 Gene

GeneLoc Exon Structure for
OR5M8
ECgene alternative splicing isoforms for
OR5M8

Expression for OR5M8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5M8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5M8 Gene:

OR5M8

SOURCE GeneReport for Unigene cluster for OR5M8 Gene:

Hs.554522
genes like me logo Genes that share expression patterns with OR5M8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5M8 Gene

Orthologs for OR5M8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5M8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466567 33
  • 98.5 (n)
OR5M8 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC610404 33
  • 89.47 (n)
OR08E12 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or5m8 52 Olfr1031 33 16 34
  • 81.24 (n)
rat
(Rattus norvegicus)
Mammalia Olr472 33
  • 81.24 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
Species where no ortholog for OR5M8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5M8 Gene

ENSEMBL:
Gene Tree for OR5M8 (if available)
TreeFam:
Gene Tree for OR5M8 (if available)

Paralogs for OR5M8 Gene

Paralogs for OR5M8 Gene

(452) SIMAP similar genes for OR5M8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5M8: view

Variants for OR5M8 Gene

Sequence variations from dbSNP and Humsavar for OR5M8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001900621 -- 56,491,837(+) TTGCC(C/T)GAGGA upstream-variant-2KB
rs1002839596 -- 56,492,199(+) GTGTG(C/G)TGGCA upstream-variant-2KB
rs1003063020 -- 56,490,173(+) GCATG(G/T)TGGTG downstream-variant-500B
rs1004776951 -- 56,493,050(+) AAAAG(A/T)TGAAT upstream-variant-2KB
rs1004811138 -- 56,493,287(+) TGTAA(C/T)AGGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5M8 Gene

Variant ID Type Subtype PubMed ID
nsv975927 CNV duplication 23825009

Variation tolerance for OR5M8 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.57; 44.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5M8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5M8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5M8 Gene

Disorders for OR5M8 Gene

Relevant External Links for OR5M8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5M8

No disorders were found for OR5M8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5M8 Gene

Publications for OR5M8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR5M8 Gene

Sources for OR5M8 Gene

Content
Loading form....