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Aliases for OR5M3 Gene

Aliases for OR5M3 Gene

  • Olfactory Receptor Family 5 Subfamily M Member 3 2 3 5
  • Olfactory Receptor OR11-191 3 4
  • Olfactory Receptor, Family 5, Subfamily M, Member 3 2
  • Olfactory Receptor 5M3 3
  • OR11-191 3

External Ids for OR5M3 Gene

Previous GeneCards Identifiers for OR5M3 Gene

  • GC11U990361
  • GC11M056014
  • GC11M055993
  • GC11M056237

Summaries for OR5M3 Gene

Entrez Gene Summary for OR5M3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5M3 Gene

OR5M3 (Olfactory Receptor Family 5 Subfamily M Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5M9.

UniProtKB/Swiss-Prot for OR5M3 Gene

  • Odorant receptor.

Gene Wiki entry for OR5M3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5M3 Gene

Genomics for OR5M3 Gene

Regulatory Elements for OR5M3 Gene

Enhancers for OR5M3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F056895 0.3 FANTOM5 11.8 -425.3 -425278 0.0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2P1
GH11F056474 0.2 ENCODE 0.8 -4.4 -4402 0.2 OR5R1 OR5AL1 RTN4RL2 OR5M3 OR5M2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5M3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5M3 Gene

Chromosome:
11
Start:
56,469,488 bp from pter
End:
56,470,538 bp from pter
Size:
1,051 bases
Orientation:
Minus strand

Genomic View for OR5M3 Gene

Genes around OR5M3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5M3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5M3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5M3 Gene

Proteins for OR5M3 Gene

  • Protein details for OR5M3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP4-OR5M3_HUMAN
    Recommended name:
    Olfactory receptor 5M3
    Protein Accession:
    Q8NGP4
    Secondary Accessions:
    • B2RNM7
    • Q6IEW4
    • Q96RC0

    Protein attributes for OR5M3 Gene

    Size:
    307 amino acids
    Molecular mass:
    35156 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5M3 Gene

Post-translational modifications for OR5M3 Gene

  • Glycosylation at Asn 3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5M3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5M3 Gene

Domains & Families for OR5M3 Gene

Gene Families for OR5M3 Gene

Protein Domains for OR5M3 Gene

Suggested Antigen Peptide Sequences for OR5M3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGP4

UniProtKB/Swiss-Prot:

OR5M3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5M3: view

Function for OR5M3 Gene

Molecular function for OR5M3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5M3: view

Phenotypes for OR5M3 Gene

genes like me logo Genes that share phenotypes with OR5M3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5M3 Gene

Localization for OR5M3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5M3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5M3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5M3: view

Pathways & Interactions for OR5M3 Gene

genes like me logo Genes that share pathways with OR5M3: view

Pathways by source for OR5M3 Gene

Gene Ontology (GO) - Biological Process for OR5M3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5M3: view

No data available for SIGNOR curated interactions for OR5M3 Gene

Transcripts for OR5M3 Gene

mRNA/cDNA for OR5M3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5M3 Gene

No ASD Table

Relevant External Links for OR5M3 Gene

GeneLoc Exon Structure for
OR5M3
ECgene alternative splicing isoforms for
OR5M3

Expression for OR5M3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5M3 Gene

Protein differential expression in normal tissues from HIPED for OR5M3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5M3 Gene



Protein tissue co-expression partners for OR5M3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5M3 Gene:

OR5M3

SOURCE GeneReport for Unigene cluster for OR5M3 Gene:

Hs.553631
genes like me logo Genes that share expression patterns with OR5M3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OR5M3 Gene

Orthologs for OR5M3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5M3 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Or5m3b 55 Olfr1033 35
  • 89 (a)
OneToMany
Or5m3 55 Olfr1032 34 16 35
  • 85.62 (n)
dog
(Canis familiaris)
Mammalia OR5M3 34 35
  • 87.73 (n)
cow
(Bos Taurus)
Mammalia OR5M3 34 35
  • 87.58 (n)
rat
(Rattus norvegicus)
Mammalia Olr473 34
  • 85.73 (n)
oppossum
(Monodelphis domestica)
Mammalia OR5M3 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
Species where no ortholog for OR5M3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5M3 Gene

ENSEMBL:
Gene Tree for OR5M3 (if available)
TreeFam:
Gene Tree for OR5M3 (if available)

Paralogs for OR5M3 Gene

Paralogs for OR5M3 Gene

(448) SIMAP similar genes for OR5M3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5M3 Gene

genes like me logo Genes that share paralogs with OR5M3: view

Variants for OR5M3 Gene

Sequence variations from dbSNP and Humsavar for OR5M3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11228544 -- 56,471,599(+) TACAC(A/G)TCATT upstream-variant-2KB
rs112887160 -- 56,469,897(+) GCCGG(C/G/T)AAGTA reference, missense
rs11381716 -- 56,469,209(+) TTTTT(-/T)CTGCC downstream-variant-500B
rs115612441 -- 56,471,741(+) AGAAA(C/T)TCCAT upstream-variant-2KB
rs116825876 -- 56,470,590(+) TTATA(C/T)CTTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5M3 Gene

Variant ID Type Subtype PubMed ID
dgv220n67 CNV gain 20364138
esv3579724 CNV loss 25503493
nsv825910 CNV gain 20364138
nsv825911 CNV gain 20364138

Variation tolerance for OR5M3 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5M3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5M3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5M3 Gene

Disorders for OR5M3 Gene

Relevant External Links for OR5M3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5M3

No disorders were found for OR5M3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5M3 Gene

Publications for OR5M3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR5M3 Gene

Sources for OR5M3 Gene

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