Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5L2 Gene

Aliases for OR5L2 Gene

  • Olfactory Receptor Family 5 Subfamily L Member 2 2 3 5
  • Olfactory Receptor OR11-153 3 4
  • HTPCRX16 3 4
  • Olfactory Receptor, Family 5, Subfamily L, Member 1 3
  • Olfactory Receptor, Family 5, Subfamily L, Member 2 2
  • Olfactory Receptor 5L2 3
  • HSHTPCRX16 3
  • OR11-153 3

External Ids for OR5L2 Gene

Previous GeneCards Identifiers for OR5L2 Gene

  • GC11P057988
  • GC11U900022
  • GC11P055845
  • GC11P055371
  • GC11P055351
  • GC11P055594

Summaries for OR5L2 Gene

Entrez Gene Summary for OR5L2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5L2 Gene

OR5L2 (Olfactory Receptor Family 5 Subfamily L Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5L1.

UniProtKB/Swiss-Prot for OR5L2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5L2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5L2 Gene

Genomics for OR5L2 Gene

Regulatory Elements for OR5L2 Gene

Enhancers for OR5L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F055430 0.3 FANTOM5 14.7 -396.9 -396888 0.0 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6 OR4S2 OR4A16 OR4C11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5L2 Gene

Chromosome:
11
Start:
55,827,219 bp from pter
End:
55,828,154 bp from pter
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR5L2 Gene

Genes around OR5L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5L2 Gene

Proteins for OR5L2 Gene

  • Protein details for OR5L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL0-OR5L2_HUMAN
    Recommended name:
    Olfactory receptor 5L2
    Protein Accession:
    Q8NGL0
    Secondary Accessions:
    • Q6IF66
    • Q96RB2

    Protein attributes for OR5L2 Gene

    Size:
    311 amino acids
    Molecular mass:
    34682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5L2 Gene

Post-translational modifications for OR5L2 Gene

  • Glycosylation at Asn 5 and Asn 195
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5L2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5L2 Gene

Domains & Families for OR5L2 Gene

Gene Families for OR5L2 Gene

Protein Domains for OR5L2 Gene

Suggested Antigen Peptide Sequences for OR5L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGL0

UniProtKB/Swiss-Prot:

OR5L2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5L2: view

Function for OR5L2 Gene

Molecular function for OR5L2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5L2: view

Phenotypes for OR5L2 Gene

genes like me logo Genes that share phenotypes with OR5L2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5L2 Gene

Localization for OR5L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5L2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5L2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5L2: view

Pathways & Interactions for OR5L2 Gene

genes like me logo Genes that share pathways with OR5L2: view

Pathways by source for OR5L2 Gene

Gene Ontology (GO) - Biological Process for OR5L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5L2: view

No data available for SIGNOR curated interactions for OR5L2 Gene

Transcripts for OR5L2 Gene

mRNA/cDNA for OR5L2 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5L2 Gene

No ASD Table

Relevant External Links for OR5L2 Gene

GeneLoc Exon Structure for
OR5L2
ECgene alternative splicing isoforms for
OR5L2

Expression for OR5L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5L2 Gene:

OR5L2

SOURCE GeneReport for Unigene cluster for OR5L2 Gene:

Hs.528356
genes like me logo Genes that share expression patterns with OR5L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR5L2 Gene

Orthologs for OR5L2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466540 34
  • 98.93 (n)
OR5L2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 82 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia OR5L2 34
  • 78.24 (n)
-- 35
  • 77 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1157 35
  • 78 (a)
OneToMany
Olfr1156 34 16
  • 76.96 (n)
rat
(Rattus norvegicus)
Mammalia Olr601 34
  • 76.95 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
Species where no ortholog for OR5L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5L2 Gene

ENSEMBL:
Gene Tree for OR5L2 (if available)
TreeFam:
Gene Tree for OR5L2 (if available)

Paralogs for OR5L2 Gene

Paralogs for OR5L2 Gene

(446) SIMAP similar genes for OR5L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5L2: view

Variants for OR5L2 Gene

Sequence variations from dbSNP and Humsavar for OR5L2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111324632 -- 55,825,305(+) CATGC(A/G)ACTTG upstream-variant-2KB
rs112459888 -- 55,828,004(+) AGGCC(A/G)AGTTC reference, synonymous-codon
rs112845939 -- 55,827,815(+) CTGCT(C/G)TTCCT reference, synonymous-codon
rs114998631 -- 55,827,351(+) TGGGC(A/G)TGACT reference, missense
rs115103531 -- 55,825,833(+) TTTAA(A/G)AGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5L2 Gene

Variant ID Type Subtype PubMed ID
nsv972027 CNV duplication 23825009
nsv832158 CNV gain 17160897
nsv821668 CNV loss 15273396
nsv554801 CNV loss 21841781
nsv517440 CNV gain+loss 19592680
nsv469958 CNV loss 18288195
nsv469885 CNV loss 16826518
nsv437717 CNV loss 16327808
nsv428256 CNV loss 18775914
nsv39282 CNV deletion 16902084
nsv1044174 CNV loss 25217958
esv3626456 CNV loss 21293372
esv3626454 CNV gain 21293372
esv3626453 CNV loss 21293372
esv3579782 CNV gain 25503493
esv3579771 CNV gain 25503493
esv2760216 CNV loss 21179565
esv2759828 CNV gain+loss 17122850
esv2751030 CNV gain 17911159
esv2744537 CNV deletion 23290073
esv22842 CNV gain+loss 19812545
dgv51e55 CNV loss 17911159
dgv50e55 CNV loss 17911159
dgv212e199 CNV deletion 23128226
dgv1941n54 CNV loss 21841781
dgv1905n54 CNV gain 21841781
dgv150n27 CNV loss 19166990
dgv12n64 CNV loss 17921354
dgv1205n100 CNV gain 25217958
dgv1204n100 CNV loss 25217958
dgv1193n100 CNV loss 25217958

Variation tolerance for OR5L2 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.85; 79.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5L2 Gene

Disorders for OR5L2 Gene

Relevant External Links for OR5L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5L2

No disorders were found for OR5L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5L2 Gene

Publications for OR5L2 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M. … Vassart G. (Nature 1992) 2 3 4 64
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64

Products for OR5L2 Gene

Sources for OR5L2 Gene

Content
Loading form....