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Aliases for OR5K4 Gene

Aliases for OR5K4 Gene

  • Olfactory Receptor, Family 5, Subfamily K, Member 4 2 3

External Ids for OR5K4 Gene

Previous GeneCards Identifiers for OR5K4 Gene

  • GC03U900519
  • GC03P099556
  • GC03P098072

Summaries for OR5K4 Gene

Entrez Gene Summary for OR5K4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K4 Gene

OR5K4 (Olfactory Receptor, Family 5, Subfamily K, Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5K4 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5K4 Gene

Genomics for OR5K4 Gene

Regulatory Elements for OR5K4 Gene

Genomic Location for OR5K4 Gene

Start:
98,353,854 bp from pter
End:
98,354,819 bp from pter
Size:
966 bases
Orientation:
Plus strand

Genomic View for OR5K4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5K4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K4 Gene

Proteins for OR5K4 Gene

  • Protein details for OR5K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMS3-OR5K4_HUMAN
    Recommended name:
    Olfactory receptor 5K4
    Protein Accession:
    A6NMS3
    Secondary Accessions:

    Protein attributes for OR5K4 Gene

    Size:
    321 amino acids
    Molecular mass:
    36711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5K4 Gene

Proteomics data for OR5K4 Gene at MOPED

Post-translational modifications for OR5K4 Gene

Other Protein References for OR5K4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K4 Gene

Domains for OR5K4 Gene

Gene Families for OR5K4 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5K4 Gene

Suggested Antigen Peptide Sequences for OR5K4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMS3

UniProtKB/Swiss-Prot:

OR5K4_HUMAN :
  • A6NMS3
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K4: view

Function for OR5K4 Gene

Molecular function for OR5K4 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5K4: view

Phenotypes for OR5K4 Gene

GenomeRNAi human phenotypes for OR5K4:
genes like me logo Genes that share phenotypes with OR5K4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5K4 Gene

Localization for OR5K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5K4 Gene COMPARTMENTS Subcellular localization image for OR5K4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5K4: view

Pathways for OR5K4 Gene

genes like me logo Genes that share pathways with OR5K4: view

Pathways by source for OR5K4 Gene

Interacting Proteins for OR5K4 Gene

Gene Ontology (GO) - Biological Process for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K4: view

Transcripts for OR5K4 Gene

mRNA/cDNA for OR5K4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5K4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR5K4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K4 Gene

No ASD Table

Relevant External Links for OR5K4 Gene

GeneLoc Exon Structure for
OR5K4
ECgene alternative splicing isoforms for
OR5K4

Expression for OR5K4 Gene

mRNA expression in normal human tissues for OR5K4 Gene

SOURCE GeneReport for Unigene cluster for OR5K4 Gene Hs.554710

genes like me logo Genes that share expressions with OR5K4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR5K4 Gene

Orthologs for OR5K4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738524 35
  • 97.36 (n)
  • 94.94 (a)
cow
(Bos Taurus)
Mammalia OR5K4 35
  • 83.11 (n)
  • 78.48 (a)
dog
(Canis familiaris)
Mammalia OR5K4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr178 36
  • 75 (a)
OneToMany
Olfr180 35
  • 82.9 (n)
  • 78.06 (a)
Olfr180 16
Olfr180 36
  • 77 (a)
OneToMany
Olfr181 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
-- 36
  • 67 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1559 35
  • 82.49 (n)
  • 78.16 (a)
Species with no ortholog for OR5K4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5K4 Gene

ENSEMBL:
Gene Tree for OR5K4 (if available)
TreeFam:
Gene Tree for OR5K4 (if available)

Paralogs for OR5K4 Gene

Paralogs for OR5K4 Gene

Selected SIMAP similar genes for OR5K4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5K4: view

Variants for OR5K4 Gene

Sequence variations from dbSNP and Humsavar for OR5K4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1497530 -- 98,353,433(-) CTCTT(A/T)AGGCA upstream-variant-2KB
rs4857376 -- 98,352,459(+) GGCCG(C/G)GCGAG upstream-variant-2KB
rs9822460 - 98,354,469(+) TACCA(A/G)TTCAA reference, missense
rs11288615 -- 98,354,748(+) TTCTT(-/A)AAAAA frameshift-variant, reference
rs11331424 -- 98,352,667(+) GTCTC(-/A)AAAAA upstream-variant-2KB

Relevant External Links for OR5K4 Gene

HapMap Linkage Disequilibrium report
OR5K4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OR5K4 Gene

Disorders for OR5K4 Gene

No disorders were found for OR5K4 Gene.

No data available for UniProtKB/Swiss-Prot for OR5K4 Gene

Publications for OR5K4 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for OR5K4 Gene

Sources for OR5K4 Gene

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