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Aliases for OR5K4 Gene

Aliases for OR5K4 Gene

  • Olfactory Receptor Family 5 Subfamily K Member 4 2 3 5
  • Olfactory Receptor, Family 5, Subfamily K, Member 4 2

External Ids for OR5K4 Gene

Previous GeneCards Identifiers for OR5K4 Gene

  • GC03U900519
  • GC03P099556
  • GC03P098072

Summaries for OR5K4 Gene

Entrez Gene Summary for OR5K4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5K4 Gene

OR5K4 (Olfactory Receptor Family 5 Subfamily K Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5K3.

UniProtKB/Swiss-Prot for OR5K4 Gene

  • Odorant receptor.

Additional gene information for OR5K4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5K4 Gene

Genomics for OR5K4 Gene

Regulatory Elements for OR5K4 Gene

Enhancers for OR5K4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H098324 1.2 FANTOM5 ENCODE dbSUPER 11.9 -27.5 -27529 2.9 MAX JUNB MNT ELF1 BATF POLR2A ETV6 MYC OR5K4 GC03M098323 GC03M098326
GH03H098038 1.1 Ensembl ENCODE 10.1 -314.4 -314408 1 HDGF ATF1 RB1 MLX BRCA1 RAD21 SCRT2 ZNF143 ZNF207 ATF7 OR5K4 CRYBG3 GABRR3 GC03P098051
GH03H098329 0.9 ENCODE dbSUPER 11.9 -24.2 -24173 0.2 CTCF ZNF654 FOXA2 FOXA3 MAX TRIM22 ZNF384 REST RAD21 FOXA1 OR5K4 GC03M098326 GC03M098323
GH03H098512 0.9 ENCODE dbSUPER 10.1 +159.3 159340 2.3 ZNF10 CEBPB FEZF1 REST EP300 JUND PRDM6 POLR2A FOSL2 FOS CPOX OR5K4 OR5K2 ENSG00000248839
GH03H098341 0.3 FANTOM5 10.4 -12.6 -12555 0 OR5H2 OR5H6 OR5K4 OR5AC2 GC03M098326
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5K4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OR5K4 Gene

Genomic Locations for OR5K4 Gene
966 bases
Plus strand

Genomic View for OR5K4 Gene

Genes around OR5K4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5K4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5K4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5K4 Gene

Proteins for OR5K4 Gene

  • Protein details for OR5K4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5K4
    Protein Accession:

    Protein attributes for OR5K4 Gene

    321 amino acids
    Molecular mass:
    36711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5K4 Gene

Post-translational modifications for OR5K4 Gene

Other Protein References for OR5K4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5K4 Gene

Domains & Families for OR5K4 Gene

Gene Families for OR5K4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5K4 Gene

Suggested Antigen Peptide Sequences for OR5K4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5K4: view

Function for OR5K4 Gene

Molecular function for OR5K4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5K4 Gene

Gene Ontology (GO) - Molecular Function for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5K4: view
genes like me logo Genes that share phenotypes with OR5K4: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5K4 Gene

Localization for OR5K4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5K4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5K4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5K4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5K4 Gene

Pathways & Interactions for OR5K4 Gene

genes like me logo Genes that share pathways with OR5K4: view

Pathways by source for OR5K4 Gene

Interacting Proteins for OR5K4 Gene

Gene Ontology (GO) - Biological Process for OR5K4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5K4: view

No data available for SIGNOR curated interactions for OR5K4 Gene

Drugs & Compounds for OR5K4 Gene

No Compound Related Data Available

Transcripts for OR5K4 Gene

mRNA/cDNA for OR5K4 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5K4 Gene

No ASD Table

Relevant External Links for OR5K4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5K4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5K4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5K4 Gene:


SOURCE GeneReport for Unigene cluster for OR5K4 Gene:

genes like me logo Genes that share expression patterns with OR5K4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5K4 Gene

Orthologs for OR5K4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5K4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738524 33
  • 97.36 (n)
(Bos Taurus)
Mammalia OR5K4 33
  • 83.11 (n)
(Canis familiaris)
Mammalia OR5K4 34
  • 83 (a)
(Mus musculus)
Mammalia Or5k16 52 Olfr180 33 16 34
  • 82.9 (n)
Or5k17 52 Olfr181 34
  • 78 (a)
Or5k15 52 Olfr178 34
  • 75 (a)
Or5k8 52 Olfr175
  • chr16:58,823,784-58,824,707
(Rattus norvegicus)
Mammalia Olr1559 33
  • 82.49 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 67 (a)
Species where no ortholog for OR5K4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5K4 Gene

Gene Tree for OR5K4 (if available)
Gene Tree for OR5K4 (if available)

Paralogs for OR5K4 Gene

Paralogs for OR5K4 Gene

(450) SIMAP similar genes for OR5K4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5K4: view

Variants for OR5K4 Gene

Sequence variations from dbSNP and Humsavar for OR5K4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000354659 -- 98,353,962(+) ATCTG(A/G)TCACC reference, missense
rs1001629350 -- 98,352,625(+) AGCTA(C/T)TCGGG upstream-variant-2KB
rs1001914737 -- 98,352,888(+) AAACT(A/C)AAATA upstream-variant-2KB
rs1004036109 -- 98,354,443(+) TGAAC(G/T)AATGA reference, missense
rs1005694319 -- 98,353,373(+) CAAAA(A/G)CATTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5K4 Gene

Variant ID Type Subtype PubMed ID
nsv1013060 CNV gain 25217958
nsv1000834 CNV gain 25217958

Variation tolerance for OR5K4 Gene

Residual Variation Intolerance Score: 97.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.44; 95.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5K4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5K4 Gene

Disorders for OR5K4 Gene

Relevant External Links for OR5K4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5K4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5K4 Gene

Publications for OR5K4 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60

Products for OR5K4 Gene

Sources for OR5K4 Gene

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