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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OR5I1 Gene

protein-coding   GIFtS: 53
GCID: GC11M055703

Olfactory Receptor, Family 5, Subfamily I, Member 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Olfactory Receptor, Family 5, Subfamily I, Member 11 2
Olfactory Receptor OR11-1592 3
Olfactory Receptor-Like Protein OLF12 3
OLF12 3
HSOlf12
Olfactory Receptor 5I12

External Ids:    HGNC: 83471   Entrez Gene: 107982   Ensembl: ENSG000001678257   OMIM: 6084965   UniProtKB: Q136063   

Export aliases for OR5I1 gene to outside databases

Previous GC identifers: GC11M058096 GC11M057215 GC11M055953 GC11M055456 GC11M055478 GC11M055459


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR5I1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5I1 Gene: 
OR5I1 (olfactory receptor, family 5, subfamily I, member 1) is a protein-coding gene. Diseases associated with OR5I1 include neuronitis, and among its related super-pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot: OR5I1_HUMAN, Q13606
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5I1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR5I1 gene promoter:
         Pbx1a   SREBP-1c   SREBP-1b   NF-AT   NF-AT4   NF-AT2   SREBP-1a   NF-AT3   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5I1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OR5I1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5I1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR5I1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5I1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M055703:  view genomic region     (about GC identifiers)

Start:
55,702,935 bp from pter      End:
55,703,876 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OR5I1_HUMAN, Q13606 (See protein sequence)
Recommended Name: Olfactory receptor 5I1  
Size: 314 amino acids; 36049 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IEU4

Explore the universe of human proteins at neXtProt for OR5I1: NX_Q13606

Explore proteomics data for OR5I1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13606

  • HORDE protein sequence for OR5I1
    OR5I1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OR5I1 Protein Expression
    REFSEQ proteins: NP_006628.1  
    ENSEMBL proteins: 
     ENSP00000301532  
    Reactome Protein details: Q13606
    Human Recombinant Protein Products for OR5I1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OR5I1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    OR5I1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q13606

    ProtoNet protein and cluster: Q13606

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5I1_HUMAN, Q13606
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR5I1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5I1_HUMAN, Q13606
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR5I1:
    olfactory receptor,family 5,subfamily I,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR5I1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OR5I1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory transduction
    Olfactory Signaling Pathway0.81
    Olfactory transduction0.81
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Class A/1 (Rhodopsin-like receptors)
    GPCRs, Class A Rhodopsin-like0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for OR5I1
        GPCRs, Class A Rhodopsin-like

    4        Reactome Pathways for OR5I1
        GPCR downstream signaling
    Olfactory Signaling Pathway
    Signal Transduction
    Signaling by GPCR


    1         Kegg Pathway  (Kegg details for OR5I1):
        Olfactory transduction


    OR5I1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR5I1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/273 Interacting proteins for OR5I1 (ENSP000003015324) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10H2ENSP000003060954STRING: ENSP00000306095
    OR10J1ENSP000003990784STRING: ENSP00000399078
    OR1A1ENSP000003052074STRING: ENSP00000305207
    OR1A2ENSP000003713774STRING: ENSP00000371377
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS9787077
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR5I1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OR5I1

    Search CenterWatch for drugs/clinical trials and news about OR5I1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OR5I1 gene: 
    NM_006637.1  

    Unigene Cluster for OR5I1:

    Olfactory receptor, family 5, subfamily I, member 1
    Hs.533706
    Unigene Representative Sequence: NM_006637
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301532(uc010ris.2)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR5I1

    Additional mRNA sequence: BC069093.1 

    1 DOTS entry:

    DT.92061558 

    2 AceView cDNA sequences:

    NM_006637 BC069093 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OR5I1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCTCTCAC
    OR5I1 Expression
    About this image


    See OR5I1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OR5I1

    SOURCE GeneReport for Unigene cluster: Hs.533706
        SABiosciences Custom PCR Arrays for OR5I1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5I1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OR5I1 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1521 , 5 olfactory receptor 1521, 5 82.85(n)1
    90.42(a)1
      2 (49.95 cM)5
    2586401  NM_146646.21  NP_666857.21 
     877825425 
    chicken
    (Gallus gallus)
    Aves LOC4288271 olfactory receptor 1052-like 60.33(n)
    56.07(a)
      428827  XM_426384.2  XP_426384.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ250753.12   -- 75.4(n)    AJ250753.1 


    ENSEMBL Gene Tree for OR5I1 (if available)
    TreeFam Gene Tree for OR5I1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OR5I1 gene
    OR5W22  OR5AR12  OR5C12  OR5T22  OR5T12  OR5AS12  OR5J22  OR5T32  
    18/451 SIMAP similar genes for OR5I1 using alignment to 1 protein entry:     OR5I1_HUMAN(see all similar genes):
    OR5AS1    OR5AR1    OR5G3    OR5L2    OR5A2    OR5AP2
    OR5B2    OR5D18    OR5F1    OR5J2    OR5L1    OR5T1
    OR8U1    OR8U8    OR8U9    OR5B12    OR5B21    OR5D16

    OR5I1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/126 SNPs in OR5I1 are shown (see all 126)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927213151,2
    --55702459(+) TTTACA/GGATAA 1 -- ds50010--------
    rs1832513241,2
    C--55702464(+) AGATAA/GATGAG 1 -- ds50010--------
    rs1879583241,2
    C--55702508(+) CACTCA/TCTAGC 1 -- ds50010--------
    rs1431529641,2
    --55702517(+) GCCAAA/GTATAG 1 -- ds50010--------
    rs1467558471,2
    --55702533(+) GCATAC/TAAATC 1 -- ds50010--------
    rs1920452651,2
    --55702616(+) GATACA/GCACAT 1 -- ds50010--------
    rs1403702911,2
    --55702623(+) ACATGC/TACATG 1 -- ds50010--------
    rs744423141,2
    C,F--55702693(+) TTAGCA/TTAAAT 1 -- ds50012Minor allele frequency- T:0.06WA NA 238
    rs765462831,2
    C,F--55702729(+) AGTATA/GACTAG 1 -- ds50012Minor allele frequency- G:0.06WA NA 238
    rs595803541,2
    C,F--55702734(+) AACTAG/ACATTT 1 -- ds50011Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for OR5I1 ( 55702935 - 55703876 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for OR5I1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv52e55CNV Loss17911159
    nsv468571CNV Loss19166990
    nsv821668CNV Loss15273396
    nsv437718CNV Loss16327808
    nsv468568CNV Loss19166990
    nsv517590CNV Loss19592680
    dgv151n27CNV Loss19166990
    nsv469959CNV Loss18288195
    esv2751030CNV Gain17911159
    dgv384e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608496    OMIM disorders: --

    2 diseases for OR5I1:    About MalaCards
    neuronitis    


    OR5I1 for disorders           About GeneDecksing


    Export disorders for OR5I1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OR5I1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OR5I1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The evolution of mammalian olfactory receptor genes. (PubMed id 9017400)1, 2, 3 Issel-Tarver L. and Rine J. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
    4. Organization and evolution of olfactory receptor genes on human chromosome 11. (PubMed id 9787077)1, 3 Buettner J.A....Evans G.A. (1998)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Evidence for different chemosensory signal transduction pathways in olfactory and vomeronasal neurons. (PubMed id 8607864)9 Wu Y....Ryba N.J. (1996)
    7. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. (PubMed id 8034318)9 Buiakova O.I.... Margolis F.L. (1994)
    8. Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene. (PubMed id 15037199)9 Cayla C.... Paris H. (2004)
    9. Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expression. (PubMed id 10521600)9 Baumeister H....Margolis F.L. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10798 HGNC: 8347 AceView: OR5I1 Ensembl:ENSG00000167825 euGenes: HUgn10798
    ECgene: OR5I1 Kegg: 10798 H-InvDB: OR5I1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OR5I1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5I1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OR5I1 gene:
    Search GeneIP for patents involving OR5I1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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