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OR5H8 Gene(Protein Coding)

Olfactory Receptor Family 5 Subfamily H Member 8 (Gene/Pseudogene)

GCID:
GC03P098311
GIFtS:
12
Genes Participants
UDN Logo

Aliases for OR5H8 Gene

Aliases for OR5H8 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 8 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 5, Subfamily H, Member 8 Pseudogene 2 3
  • OR5H8P 3 4
  • Olfactory Receptor, Family 5, Subfamily H, Member 8 (Gene/Pseudogene) 2
  • Olfactory Receptor OR3-7 Pseudogene 3
  • Olfactory Receptor 5H8 Pseudogene 4
  • Olfactory Receptor OR3-7 4
  • OR3-7 3

External Ids for OR5H8 Gene

Previous HGNC Symbols for OR5H8 Gene

  • OR5H8P

Summaries for OR5H8 Gene

Entrez Gene Summary for OR5H8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR5H8 Gene

OR5H8 (Olfactory Receptor Family 5 Subfamily H Member 8 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5H8 Gene

  • Odorant receptor.

Additional gene information for OR5H8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H8 Gene

Genomics for OR5H8 Gene

Products:

  1. Regulatory Element

Genomic Locations for OR5H8 Gene

Genomic Locations for OR5H8 Gene
chr3:98,306,752-98,312,843
(GRCh38/hg38)
Size:
6,092 bases
Orientation:
Plus strand
chr3:98,030,757-98,031,687
(GRCh37/hg19)

Genomic View for OR5H8 Gene

Genes around OR5H8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H8 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OR5H8 Gene

No data available for GeneHancer (GH) Regulatory Elements for OR5H8 Gene

Proteins for OR5H8 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for OR5H8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN80-OR5H8_HUMAN
    Recommended name:
    Olfactory receptor 5H8
    Protein Accession:
    P0DN80

    Protein attributes for OR5H8 Gene

    Size:
    308 amino acids
    Molecular mass:
    34772 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H8 Gene

Post-translational modifications for OR5H8 Gene

No Post-translational modifications

Other Protein References for OR5H8 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for OR5H8 Gene

Domains & Families for OR5H8 Gene

Gene Families for OR5H8 Gene

HGNC:

Protein Domains for OR5H8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DN80

UniProtKB/Swiss-Prot:

OR5H8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H8: view

No data available for Suggested Antigen Peptide Sequences for OR5H8 Gene

Function for OR5H8 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for OR5H8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR5H8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H8 Gene

Localization for OR5H8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H8 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR5H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H8: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR5H8 Gene

Pathways & Interactions for OR5H8 Gene

SuperPathways for OR5H8 Gene

PathCards logo More details on SuperPathways for OR5H8
No Data Available

Interacting Proteins for OR5H8 Gene

Gene Ontology (GO) - Biological Process for OR5H8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H8: view

No data available for Pathways by source and SIGNOR curated interactions for OR5H8 Gene

Drugs & Compounds for OR5H8 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for OR5H8 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for OR5H8 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H8 Gene

No ASD Table

Relevant External Links for OR5H8 Gene

GeneLoc Exon Structure for
OR5H8
ECgene alternative splicing isoforms for
OR5H8

Expression for OR5H8 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5H8 Gene

mRNA expression in normal human tissues for OR5H8 Gene
mRNA expression by GTEx for OR5H8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5H8 Gene:

OR5H8
genes like me logo Genes that share expression patterns with OR5H8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5H8 Gene

Orthologs for OR5H8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia -- 34
  • 63 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Or5h19 51 Olfr187 34
  • 61 (a)
 ManyToMany
Or5ad1-ps 51 Olfr185-ps1
  • chr16:59,021,994-59,022,863
Or5h17 51 Olfr183
  • chr16:58,999,687-59,000,613
Or5h20-ps 51 Olfr188-ps1
  • chr16:59,050,389-59,051,289
Or5h21-ps 51 Olfr189-ps1
  • chr16:59,063,611-59,064,364
Or5h22 51 Olfr190
  • chr16:59,074,158-59,075,078
Or5h23 51 Olfr191
  • chr16:59,085,555-59,086,481
Or5h24-ps 51 Olfr192-ps1
  • chr16:59,098,069-59,098,990
Or5h25 51 Olfr193
  • chr16:59,109,682-59,110,608
Or5h26 51 Olfr196
  • chr16:59,167,215-59,168,141
Or5h27-ps 51 Olfr197-ps1
  • chr16:59,185,559-59,186,481
cow
(Bos Taurus)
 Mammalia -- 34
  • 60 (a)
 ManyToMany
-- 34
  • 58 (a)
 ManyToMany
-- 34
  • 58 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 48 (a)
 OneToMany
Species where no ortholog for OR5H8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H8 Gene

ENSEMBL:
Gene Tree for OR5H8 (if available)
TreeFam:
Gene Tree for OR5H8 (if available)

Paralogs for OR5H8 Gene

Paralogs for OR5H8 Gene

genes like me logo Genes that share paralogs with OR5H8: view

Variants for OR5H8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H8 Gene

OR5H8_HUMAN-P0DN80
Segregating pseudogene, locus showing both intact and pseudogene forms in the population. A single nucleotide deletion at position Lys-229 in the gene coding for this protein is responsible for functional diversity, producing a pseudogene.

Additional Variant Information for OR5H8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5H8

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR5H8 Gene

Disorders for OR5H8 Gene

No disorders were found for OR5H8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR5H8 Gene

Publications for OR5H8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 4 58
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 58
  4. Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y … Pääbo S (American journal of human genetics 2003) 3 58

Products for OR5H8 Gene

Sources for OR5H8 Gene

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