Aliases for OR5H8 Gene
Aliases for OR5H8 Gene
- Olfactory Receptor Family 5 Subfamily H Member 8 (Gene/Pseudogene) 2 3 5
- Olfactory Receptor, Family 5, Subfamily H, Member 8 Pseudogene 2 3
- OR5H8P 3 4
- Olfactory Receptor, Family 5, Subfamily H, Member 8 (Gene/Pseudogene) 2
- Olfactory Receptor OR3-7 Pseudogene 3
- Olfactory Receptor 5H8 Pseudogene 4
- Olfactory Receptor OR3-7 4
- OR3-7 3
External Ids for OR5H8 Gene
- HGNC: 14773
- Entrez Gene: 79289
- Ensembl: ENSG00000232535
- UniProtKB: P0DN80
Previous HGNC Symbols for OR5H8 Gene
- OR5H8P
Summaries for OR5H8 Gene
-
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
GeneCards Summary for OR5H8 Gene
OR5H8 (Olfactory Receptor Family 5 Subfamily H Member 8 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is OR5H1.
UniProtKB/Swiss-Prot for OR5H8 Gene
-
Odorant receptor.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H8 Gene
Genomics for OR5H8 Gene
Regulatory Element Products
Genomic Location for OR5H8 Gene
- Chromosome:
- 3
- Start:
- 98,311,913 bp from pter
- End:
- 98,312,843 bp from pter
- Size:
- 931 bases
- Orientation:
- Plus strand
Genomic View for OR5H8 Gene
Genes around OR5H8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q11.2 by Ensembl
- 3q11.2 by Entrez Gene
- 3q11.2 by HGNC
OR5H8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OR5H8 Gene
No data available for Regulatory Elements for OR5H8 Gene
Proteins for OR5H8 Gene
-
Protein details for OR5H8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0DN80-OR5H8_HUMAN
- Recommended name:
- Olfactory receptor 5H8
- Protein Accession:
- P0DN80
Protein attributes for OR5H8 Gene
- Size:
- 308 amino acids
- Molecular mass:
- 34772 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for OR5H8 Gene
No Post-translational modifications
Other Protein References for OR5H8 Gene
- ENSEMBL proteins:
Antibody Products
- Search GeneTex for Antibodies for OR5H8
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for OR5H8
- Origene Custom Protein Services for OR5H8
- Search GeneTex for Proteins for OR5H8
No data available for DME Specific Peptides for OR5H8 Gene
Domains & Families for OR5H8 Gene
Gene Families for OR5H8 Gene
Protein Domains for OR5H8 Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0DN80- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
No data available for Suggested Antigen Peptide Sequences for OR5H8 Gene
Function for OR5H8 Gene
Molecular function for OR5H8 Gene
- UniProtKB/Swiss-Prot Function:
- Odorant receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004984 | olfactory receptor activity | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
- Search ViGene Biosciences for OR5H8
CRISPR Products
- Browse CRISPR knockouts for OR5H8
miRNA Products
- Search ViGene Biosciences for OR5H8
Inhibitory RNA Products
- Search ViGene Biosciences for OR5H8
Clone Products
- GenScript: Custom all cDNA clones Services for OR5H8
- VectorBuilder custom plasmid, inducible vectors for OR5H8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OR5H8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H8 Gene
Localization for OR5H8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OR5H8 Gene
- Cell membrane; Multi-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS for OR5H8 Gene
Pathways & Interactions for OR5H8 Gene
No Data Available
Interacting Proteins for OR5H8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for OR5H8 Gene
Transcripts for OR5H8 Gene
mRNA/cDNA for OR5H8 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for OR5H8
miRNA Products
- Search ViGene Biosciences for OR5H8
Inhibitory RNA Products
- Search ViGene Biosciences for OR5H8
Clone Products
- GenScript: Custom all cDNA clones Services for OR5H8
- VectorBuilder custom plasmid, inducible vectors for OR5H8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OR5H8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for OR5H8 Gene
NURSA nuclear receptor signaling pathways regulating expression of OR5H8 Gene:
OR5H8Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5H8 Gene
Orthologs for OR5H8 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Or5h19 55 Olfr187 35 |
|
ManyToMany |
|
| Or5ad1-ps 55 Olfr185-ps1 |
|
|
|||
| Or5h17 55 Olfr183 |
|
|
|||
| Or5h20-ps 55 Olfr188-ps1 |
|
|
|||
| Or5h21-ps 55 Olfr189-ps1 |
|
|
|||
| Or5h22 55 Olfr190 |
|
|
|||
| Or5h23 55 Olfr191 |
|
|
|||
| Or5h24-ps 55 Olfr192-ps1 |
|
|
|||
| Or5h25 55 Olfr193 |
|
|
|||
| Or5h26 55 Olfr196 |
|
|
|||
| Or5h27-ps 55 Olfr197-ps1 |
|
|
|||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany |
- Species where no ortholog for OR5H8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for OR5H8 Gene
Variants for OR5H8 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H8 Gene
- OR5H8_HUMAN-P0DN80
- Segregating pseudogene, locus showing both intact and pseudogene forms in the population. A single nucleotide deletion at position Lys-229 in the gene coding for this protein is responsible for functional diversity, producing a pseudogene.
Relevant External Links for OR5H8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OR5H8
No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR5H8 Gene
Disorders for OR5H8 Gene
No disorders were found for OR5H8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for OR5H8 Gene
Publications for OR5H8 Gene
- The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
- Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 4 64
- The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64
- Natural selection on the olfactory receptor gene family in humans and chimpanzees. (PMID: 12908129) Gilad Y. … Paabo S. (Am. J. Hum. Genet. 2003) 3 64
Products for OR5H8 Gene
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- Search GeneTex for Antibodies for OR5H8
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- Cyagen custom Knockout/knockin (KOKI) mouse models for OR5H8
- VectorBuilder custom plasmid, inducible vectors for OR5H8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OR5H8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for OR5H8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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