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Aliases for OR5H6 Gene

Aliases for OR5H6 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 6 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 5, Subfamily H, Member 6 2 3
  • Olfactory Receptor OR3-11 3 4
  • Olfactory Receptor, Family 5, Subfamily H, Member 6 (Gene/Pseudogene) 2
  • OR3-11 3

External Ids for OR5H6 Gene

Previous GeneCards Identifiers for OR5H6 Gene

  • GC03U990191
  • GC03P099466
  • GC03P097983

Summaries for OR5H6 Gene

Entrez Gene Summary for OR5H6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR5H6 Gene

OR5H6 (Olfactory Receptor Family 5 Subfamily H Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5H6 Gene

  • Odorant receptor.

Gene Wiki entry for OR5H6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H6 Gene

Genomics for OR5H6 Gene

Regulatory Elements for OR5H6 Gene

Genomic Location for OR5H6 Gene

Chromosome:
3
Start:
98,263,260 bp from pter
End:
98,265,350 bp from pter
Size:
2,091 bases
Orientation:
Plus strand

Genomic View for OR5H6 Gene

Genes around OR5H6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H6 Gene

Proteins for OR5H6 Gene

  • Protein details for OR5H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV6-OR5H6_HUMAN
    Recommended name:
    Olfactory receptor 5H6
    Protein Accession:
    Q8NGV6
    Secondary Accessions:
    • Q6IF88

    Protein attributes for OR5H6 Gene

    Size:
    325 amino acids
    Molecular mass:
    36713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5H6 Gene

Proteomics data for OR5H6 Gene at MOPED

Post-translational modifications for OR5H6 Gene

  • Glycosylation at Asn 21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5H6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H6 Gene

Domains & Families for OR5H6 Gene

Gene Families for OR5H6 Gene

Protein Domains for OR5H6 Gene

Suggested Antigen Peptide Sequences for OR5H6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGV6

UniProtKB/Swiss-Prot:

OR5H6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H6: view

Function for OR5H6 Gene

Molecular function for OR5H6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H6: view

Phenotypes for OR5H6 Gene

GenomeRNAi human phenotypes for OR5H6:
genes like me logo Genes that share phenotypes with OR5H6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H6 Gene

Localization for OR5H6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5H6 Gene COMPARTMENTS Subcellular localization image for OR5H6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H6: view

Pathways & Interactions for OR5H6 Gene

genes like me logo Genes that share pathways with OR5H6: view

Pathways by source for OR5H6 Gene

Gene Ontology (GO) - Biological Process for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H6: view

No data available for SIGNOR curated interactions for OR5H6 Gene

Drugs & Compounds for OR5H6 Gene

No Compound Related Data Available

Transcripts for OR5H6 Gene

mRNA/cDNA for OR5H6 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H6 Gene

No ASD Table

Relevant External Links for OR5H6 Gene

GeneLoc Exon Structure for
OR5H6
ECgene alternative splicing isoforms for
OR5H6

Expression for OR5H6 Gene

mRNA expression in normal human tissues for OR5H6 Gene

mRNA differential expression in normal tissues according to GTEx for OR5H6 Gene

This gene is overexpressed in Testis (x17.3).

SOURCE GeneReport for Unigene cluster for OR5H6 Gene Hs.554712

genes like me logo Genes that share expression patterns with OR5H6: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5H6 Gene

Orthologs for OR5H6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H6 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr187 35
  • 78.39 (n)
  • 74.92 (a)
Olfr187 16
Olfr193 36
  • 72 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738707 35
  • 97.95 (n)
  • 96.62 (a)
OR5H6 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
Species with no ortholog for OR5H6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H6 Gene

ENSEMBL:
Gene Tree for OR5H6 (if available)
TreeFam:
Gene Tree for OR5H6 (if available)

Paralogs for OR5H6 Gene

Paralogs for OR5H6 Gene

(454) SIMAP similar genes for OR5H6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5H6 Gene

genes like me logo Genes that share paralogs with OR5H6: view

Variants for OR5H6 Gene

Sequence variations from dbSNP and Humsavar for OR5H6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_054343 -
VAR_054344 -
VAR_054345 -
VAR_054346 -
VAR_054347 -

Structural Variations from Database of Genomic Variants (DGV) for OR5H6 Gene

Variant ID Type Subtype PubMed ID
nsv877209 CNV Gain 21882294
nsv834773 CNV Gain 17160897
nsv877210 CNV Loss 21882294
esv2725674 CNV Deletion 23290073
nsv877212 CNV Loss 21882294
nsv877213 CNV Loss 21882294

Variation tolerance for OR5H6 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.36; 96.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5H6 Gene

HapMap Linkage Disequilibrium report
OR5H6
Human Gene Mutation Database (HGMD)
OR5H6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H6 Gene

Disorders for OR5H6 Gene

Relevant External Links for OR5H6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5H6

No disorders were found for OR5H6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H6 Gene

Publications for OR5H6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T. … Lancet D. (BMC Genomics 2012) 3
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I. … Lancet D. (BMC Bioinformatics 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5H6 Gene

Sources for OR5H6 Gene

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