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Aliases for OR5H6 Gene

Aliases for OR5H6 Gene

  • Olfactory Receptor, Family 5, Subfamily H, Member 6 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR3-11 3 4
  • Olfactory Receptor, Family 5, Subfamily H, Member 6 2
  • Olfactory Receptor 5H6 3
  • OR3-11 3

External Ids for OR5H6 Gene

Summaries for OR5H6 Gene

Entrez Gene Summary for OR5H6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H6 Gene

OR5H6 (Olfactory Receptor, Family 5, Subfamily H, Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR5H6 Gene

  • Odorant receptor.

Gene Wiki entry for OR5H6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H6 Gene

Genomics for OR5H6 Gene

Genomic Location for OR5H6 Gene

Start:
98,264,285 bp from pter
End:
98,265,262 bp from pter
Size:
978 bases
Orientation:
Plus strand

Genomic View for OR5H6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5H6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H6 Gene

Regulatory Elements for OR5H6 Gene

Proteins for OR5H6 Gene

  • Protein details for OR5H6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV6-OR5H6_HUMAN
    Recommended name:
    Olfactory receptor 5H6
    Protein Accession:
    Q8NGV6
    Secondary Accessions:
    • Q6IF88

    Protein attributes for OR5H6 Gene

    Size:
    325 amino acids
    Molecular mass:
    36713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR5H6 Gene

Proteomics data for OR5H6 Gene at MOPED

Post-translational modifications for OR5H6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn21

Other Protein References for OR5H6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5H6 Gene

Domains for OR5H6 Gene

Gene Families for OR5H6 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5H6 Gene

UniProtKB/Swiss-Prot:

OR5H6_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGV6
genes like me logo Genes that share domains with OR5H6: view

Function for OR5H6 Gene

Molecular function for OR5H6 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5H6 Gene

Localization for OR5H6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5H6 Gene COMPARTMENTS Subcellular localization image for OR5H6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5H6: view

Pathways for OR5H6 Gene

genes like me logo Genes that share pathways with OR5H6: view

Pathways by source for OR5H6 Gene

Interacting Proteins for OR5H6 Gene

Selected Interacting proteins: Q8NGV6-OR5H6_HUMAN for OR5H6 Gene via I2D

Symbol External ID(s) Details
IGHM

Gene Ontology (GO) - Biological Process for OR5H6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H6: view

Transcripts for OR5H6 Gene

mRNA/cDNA for OR5H6 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H6 Gene

No ASD Table

Relevant External Links for OR5H6 Gene

GeneLoc Exon Structure for
OR5H6
ECgene alternative splicing isoforms for
OR5H6

Expression for OR5H6 Gene

mRNA expression in normal human tissues for OR5H6 Gene

mRNA differential expression in normal tissues according to GTEx for OR5H6 Gene

This gene is overexpressed in Testis (17.3).

SOURCE GeneReport for Unigene cluster for OR5H6 Gene Hs.554712

genes like me logo Genes that share expressions with OR5H6: view

Orthologs for OR5H6 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR5H6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC738707 36
  • 97.95 (n)
  • 96.62 (a)
mouse
(Mus musculus)
Mammalia Olfr187 36
  • 78.39 (n)
  • 74.92 (a)
Olfr187 16
Species with no ortholog for OR5H6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H6 Gene

ENSEMBL:
Gene Tree for OR5H6 (if available)
TreeFam:
Gene Tree for OR5H6 (if available)

Paralogs for OR5H6 Gene

Selected SIMAP similar genes for OR5H6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5H6: view

No data available for Paralogs for OR5H6 Gene

Variants for OR5H6 Gene

Sequence variations from dbSNP and Humsavar for OR5H6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2132894 -- 98,264,413(-) AGGAA(C/G)AGCGG reference, synonymous-codon
rs2173236 -, - 98,264,547(-) ATAAC(A/C/G)AAGCA reference, missense
rs4241469 -- 98,264,092(+) AATGC(A/G)TCTTT upstream-variant-2KB
rs4241470 -- 98,264,196(+) TATAG(C/T)ACTGA upstream-variant-2KB
rs4241471 -- 98,264,273(+) TCACA(A/G)TTCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5H6 Gene

Variant ID Type Subtype PubMed ID
nsv877209 CNV Gain 21882294
nsv834773 CNV Gain 17160897
nsv877210 CNV Loss 21882294
esv2725674 CNV Deletion 23290073
nsv877212 CNV Loss 21882294
nsv877213 CNV Loss 21882294

Relevant External Links for OR5H6 Gene

HapMap Linkage Disequilibrium report
OR5H6

Disorders for OR5H6 Gene

No disorders were found for OR5H6 Gene.

No data available for UniProtKB/Swiss-Prot for OR5H6 Gene

Publications for OR5H6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5H6 Gene

Sources for OR5H6 Gene

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