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Aliases for OR5H2 Gene

Aliases for OR5H2 Gene

  • Olfactory Receptor, Family 5, Subfamily H, Member 2 2 3
  • Olfactory Receptor OR3-10 3 4
  • Olfactory Receptor 5H2 3
  • OR3-10 3

External Ids for OR5H2 Gene

Summaries for OR5H2 Gene

Entrez Gene Summary for OR5H2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H2 Gene

OR5H2 (Olfactory Receptor, Family 5, Subfamily H, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5H2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5H2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H2 Gene

Genomics for OR5H2 Gene

Genomic Location for OR5H2 Gene

Start:
98,282,888 bp from pter
End:
98,283,832 bp from pter
Size:
945 bases
Orientation:
Plus strand

Genomic View for OR5H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H2 Gene

Regulatory Elements for OR5H2 Gene

Proteins for OR5H2 Gene

  • Protein details for OR5H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV7-OR5H2_HUMAN
    Recommended name:
    Olfactory receptor 5H2
    Protein Accession:
    Q8NGV7
    Secondary Accessions:
    • Q6IF87

    Protein attributes for OR5H2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35974 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H2 Gene

Proteomics data for OR5H2 Gene at MOPED

Post-translational modifications for OR5H2 Gene

Other Protein References for OR5H2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5H2 Gene

Domains for OR5H2 Gene

Gene Families for OR5H2 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5H2 Gene

UniProtKB/Swiss-Prot:

OR5H2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGV7
genes like me logo Genes that share domains with OR5H2: view

Function for OR5H2 Gene

Molecular function for OR5H2 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5H2 Gene

Localization for OR5H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5H2 Gene COMPARTMENTS Subcellular localization image for OR5H2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5H2: view

Pathways for OR5H2 Gene

genes like me logo Genes that share pathways with OR5H2: view

Pathways by source for OR5H2 Gene

Interacting Proteins for OR5H2 Gene

Gene Ontology (GO) - Biological Process for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H2: view

Transcripts for OR5H2 Gene

mRNA/cDNA for OR5H2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H2 Gene

No ASD Table

Relevant External Links for OR5H2 Gene

GeneLoc Exon Structure for
OR5H2
ECgene alternative splicing isoforms for
OR5H2

Expression for OR5H2 Gene

mRNA expression in normal human tissues for OR5H2 Gene

SOURCE GeneReport for Unigene cluster for OR5H2 Gene Hs.554711

genes like me logo Genes that share expressions with OR5H2: view

Orthologs for OR5H2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100611442 36
  • 99.15 (n)
  • 97.76 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 74 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 77 (a)
ManyToMany
OR5H2 36
  • 80.8 (n)
  • 77.35 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr186 16
Olfr186 37
  • 77 (a)
ManyToMany
Olfr196 36
  • 81.49 (n)
  • 75.32 (a)
Olfr196 37
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1535 36
  • 80.63 (n)
  • 75.32 (a)
Species with no ortholog for OR5H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H2 Gene

ENSEMBL:
Gene Tree for OR5H2 (if available)
TreeFam:
Gene Tree for OR5H2 (if available)

Paralogs for OR5H2 Gene

Paralogs for OR5H2 Gene

Selected SIMAP similar genes for OR5H2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5H2 Gene

genes like me logo Genes that share paralogs with OR5H2: view

Variants for OR5H2 Gene

Sequence variations from dbSNP and Humsavar for OR5H2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1587279 -- 98,282,508(-) CCAGA(A/G)ACAGG upstream-variant-2KB
rs2316276 -- 98,282,488(-) GGAGG(A/G)GGGCT upstream-variant-2KB
rs4311250 -- 98,281,971(+) agaac(C/T)taagg upstream-variant-2KB
rs11917362 -- 98,284,247(+) TAAAG(A/G)TCTCA downstream-variant-500B
rs12631348 -- 98,281,525(+) AACTT(C/G)TCAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5H2 Gene

Variant ID Type Subtype PubMed ID
nsv877209 CNV Gain 21882294
nsv834773 CNV Gain 17160897
esv2725674 CNV Deletion 23290073
nsv877212 CNV Loss 21882294

Relevant External Links for OR5H2 Gene

HapMap Linkage Disequilibrium report
OR5H2

Disorders for OR5H2 Gene

Relevant External Links for OR5H2

Genetic Association Database (GAD)
OR5H2
genes like me logo Genes that share disorders with OR5H2: view

No data available for UniProtKB/Swiss-Prot for OR5H2 Gene

Publications for OR5H2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PMID: 19483685) Daly A.K. … . (Nat. Genet. 2009) 3 49
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4

Products for OR5H2 Gene

Sources for OR5H2 Gene

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