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Aliases for OR5H2 Gene

Aliases for OR5H2 Gene

  • Olfactory Receptor, Family 5, Subfamily H, Member 2 2 3
  • Olfactory Receptor OR3-10 3 4
  • OR3-10 3

External Ids for OR5H2 Gene

Previous GeneCards Identifiers for OR5H2 Gene

  • GC03U990195
  • GC03P099485
  • GC03P098001

Summaries for OR5H2 Gene

Entrez Gene Summary for OR5H2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H2 Gene

OR5H2 (Olfactory Receptor, Family 5, Subfamily H, Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H14.

UniProtKB/Swiss-Prot for OR5H2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5H2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H2 Gene

Genomics for OR5H2 Gene

Regulatory Elements for OR5H2 Gene

Genomic Location for OR5H2 Gene

Chromosome:
3
Start:
98,282,888 bp from pter
End:
98,283,832 bp from pter
Size:
945 bases
Orientation:
Plus strand

Genomic View for OR5H2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H2 Gene

Proteins for OR5H2 Gene

  • Protein details for OR5H2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGV7-OR5H2_HUMAN
    Recommended name:
    Olfactory receptor 5H2
    Protein Accession:
    Q8NGV7
    Secondary Accessions:
    • Q6IF87

    Protein attributes for OR5H2 Gene

    Size:
    314 amino acids
    Molecular mass:
    35974 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H2 Gene

Proteomics data for OR5H2 Gene at MOPED

Post-translational modifications for OR5H2 Gene

Other Protein References for OR5H2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H2 Gene

Domains & Families for OR5H2 Gene

Gene Families for OR5H2 Gene

Protein Domains for OR5H2 Gene

Suggested Antigen Peptide Sequences for OR5H2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGV7

UniProtKB/Swiss-Prot:

OR5H2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H2: view

Function for OR5H2 Gene

Molecular function for OR5H2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H2: view

Phenotypes for OR5H2 Gene

GenomeRNAi human phenotypes for OR5H2:
genes like me logo Genes that share phenotypes with OR5H2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5H2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H2 Gene

Localization for OR5H2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5H2 Gene COMPARTMENTS Subcellular localization image for OR5H2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5H2: view

Pathways & Interactions for OR5H2 Gene

genes like me logo Genes that share pathways with OR5H2: view

Pathways by source for OR5H2 Gene

Interacting Proteins for OR5H2 Gene

Gene Ontology (GO) - Biological Process for OR5H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H2: view

No data available for SIGNOR curated interactions for OR5H2 Gene

Drugs & Compounds for OR5H2 Gene

No Compound Related Data Available

Transcripts for OR5H2 Gene

mRNA/cDNA for OR5H2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5H2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H2 Gene

No ASD Table

Relevant External Links for OR5H2 Gene

GeneLoc Exon Structure for
OR5H2
ECgene alternative splicing isoforms for
OR5H2

Expression for OR5H2 Gene

mRNA expression in normal human tissues for OR5H2 Gene

SOURCE GeneReport for Unigene cluster for OR5H2 Gene Hs.554711

genes like me logo Genes that share expression patterns with OR5H2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5H2 Gene

Orthologs for OR5H2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR5H2 35
  • 80.8 (n)
  • 77.35 (a)
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 77 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr196 35
  • 81.49 (n)
  • 75.32 (a)
Olfr186 16
Olfr186 36
  • 77 (a)
ManyToMany
Olfr196 36
  • 75 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100611442 35
  • 99.15 (n)
  • 97.76 (a)
rat
(Rattus norvegicus)
Mammalia Olr1535 35
  • 80.63 (n)
  • 75.32 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 78 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
Species with no ortholog for OR5H2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H2 Gene

ENSEMBL:
Gene Tree for OR5H2 (if available)
TreeFam:
Gene Tree for OR5H2 (if available)

Paralogs for OR5H2 Gene

Paralogs for OR5H2 Gene

(442) SIMAP similar genes for OR5H2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5H2 Gene

genes like me logo Genes that share paralogs with OR5H2: view

Variants for OR5H2 Gene

Sequence variations from dbSNP and Humsavar for OR5H2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_053195 -
VAR_053196 -
VAR_053197 -

Structural Variations from Database of Genomic Variants (DGV) for OR5H2 Gene

Variant ID Type Subtype PubMed ID
nsv877209 CNV Gain 21882294
nsv834773 CNV Gain 17160897
esv2725674 CNV Deletion 23290073
nsv877212 CNV Loss 21882294

Variation tolerance for OR5H2 Gene

Residual Variation Intolerance Score: 91.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.30; 76.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5H2 Gene

HapMap Linkage Disequilibrium report
OR5H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H2 Gene

Disorders for OR5H2 Gene

Relevant External Links for OR5H2

Genetic Association Database (GAD)
OR5H2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5H2
genes like me logo Genes that share disorders with OR5H2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H2 Gene

Publications for OR5H2 Gene

  1. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PMID: 19483685) Daly A.K. … . (Nat. Genet. 2009) 67
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 67
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 67

Products for OR5H2 Gene

Sources for OR5H2 Gene

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