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Aliases for OR5H14 Gene

Aliases for OR5H14 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 14 2 3 5
  • Olfactory Receptor, Family 5, Subfamily H, Member 14 2

External Ids for OR5H14 Gene

Previous GeneCards Identifiers for OR5H14 Gene

  • GC03U900516
  • GC03P099350
  • GC03P097868

Summaries for OR5H14 Gene

Entrez Gene Summary for OR5H14 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H14 Gene

OR5H14 (Olfactory Receptor Family 5 Subfamily H Member 14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H1.

UniProtKB/Swiss-Prot for OR5H14 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H14 Gene

Genomics for OR5H14 Gene

Regulatory Elements for OR5H14 Gene

Genomic Location for OR5H14 Gene

Chromosome:
3
Start:
98,148,718 bp from pter
End:
98,150,405 bp from pter
Size:
1,688 bases
Orientation:
Plus strand

Genomic View for OR5H14 Gene

Genes around OR5H14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H14 Gene

Proteins for OR5H14 Gene

  • Protein details for OR5H14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHG9-O5H14_HUMAN
    Recommended name:
    Olfactory receptor 5H14
    Protein Accession:
    A6NHG9
    Secondary Accessions:
    • B9EH15

    Protein attributes for OR5H14 Gene

    Size:
    310 amino acids
    Molecular mass:
    35099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H14 Gene

Proteomics data for OR5H14 Gene at MOPED

Post-translational modifications for OR5H14 Gene

Other Protein References for OR5H14 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H14 Gene

Domains & Families for OR5H14 Gene

Gene Families for OR5H14 Gene

Protein Domains for OR5H14 Gene

Suggested Antigen Peptide Sequences for OR5H14 Gene

Graphical View of Domain Structure for InterPro Entry

A6NHG9

UniProtKB/Swiss-Prot:

O5H14_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H14: view

Function for OR5H14 Gene

Molecular function for OR5H14 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H14: view

Phenotypes for OR5H14 Gene

genes like me logo Genes that share phenotypes with OR5H14: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H14 Gene

Localization for OR5H14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5H14 Gene COMPARTMENTS Subcellular localization image for OR5H14 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H14: view

Pathways & Interactions for OR5H14 Gene

genes like me logo Genes that share pathways with OR5H14: view

Pathways by source for OR5H14 Gene

Interacting Proteins for OR5H14 Gene

Gene Ontology (GO) - Biological Process for OR5H14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H14: view

No data available for SIGNOR curated interactions for OR5H14 Gene

Drugs & Compounds for OR5H14 Gene

No Compound Related Data Available

Transcripts for OR5H14 Gene

mRNA/cDNA for OR5H14 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H14 Gene

No ASD Table

Relevant External Links for OR5H14 Gene

GeneLoc Exon Structure for
OR5H14
ECgene alternative splicing isoforms for
OR5H14

Expression for OR5H14 Gene

mRNA expression in normal human tissues for OR5H14 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5H14 Gene



SOURCE GeneReport for Unigene cluster for OR5H14 Gene Hs.554714

genes like me logo Genes that share expression patterns with OR5H14: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5H14 Gene

Orthologs for OR5H14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H14 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Olfr193 35
  • 78.03 (n)
  • 72.73 (a)
Olfr193 16
Olfr191 36
  • 72 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC738383 35
  • 96.45 (n)
  • 94.19 (a)
rat
(Rattus norvegicus)
Mammalia Olr1547 35
  • 76.39 (n)
  • 72.79 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
Species with no ortholog for OR5H14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H14 Gene

ENSEMBL:
Gene Tree for OR5H14 (if available)
TreeFam:
Gene Tree for OR5H14 (if available)

Paralogs for OR5H14 Gene

Paralogs for OR5H14 Gene

(451) SIMAP similar genes for OR5H14 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OR5H14 Gene

genes like me logo Genes that share paralogs with OR5H14: view

Variants for OR5H14 Gene

Sequence variations from dbSNP and Humsavar for OR5H14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_037393 -
VAR_037394 -
rs4857072 -- 98,147,333(+) ATCTT(A/C)TGGCA upstream-variant-2KB
rs58533976 -- 98,146,908(+) GGAAC(G/T)TGGTA upstream-variant-2KB
rs72927975 -- 98,146,764(+) TCTCT(A/T)GGAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5H14 Gene

Variant ID Type Subtype PubMed ID
nsv877207 CNV Gain 21882294
nsv877209 CNV Gain 21882294
dgv823e201 CNV Deletion 23290073
esv2677041 CNV Deletion 23128226
dgv824e201 CNV Deletion 23290073
nsv460768 CNV Gain 19166990
esv2667633 CNV Deletion 23128226
nsv834773 CNV Gain 17160897
nsv877210 CNV Loss 21882294
dgv872e199 CNV Deletion 23128226

Variation tolerance for OR5H14 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5H14 Gene

HapMap Linkage Disequilibrium report
OR5H14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H14 Gene

Disorders for OR5H14 Gene

Relevant External Links for OR5H14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5H14

No disorders were found for OR5H14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H14 Gene

Publications for OR5H14 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5H14 Gene

Sources for OR5H14 Gene

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