OR5H14 Gene
protein-coding GIFtS: 34
GCID: GC03P097868
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olfactory receptor, family 5, subfamily H, member 14
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Aliases
for OR5H14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 5, Subfamily H, Member 141 2 | | Olfactory Receptor 5H142 | | Seven Transmembrane Helix Receptor2 |
Export aliases for OR5H14 gene to outside databasesPrevious GC identifers: GC03U900516 GC03P099350 |
Summaries
for OR5H14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR5H14:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9Function: Odorant receptor (Potential)
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Genomic Views
for OR5H14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR5H14 gene promoter:
FOXO3 Lmo2 HNF-3beta E4BP4 FOXO3b c-Rel FOXC1 Nkx6-1 FOXO4 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR5H14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5H14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.1 Ensembl cytogenetic band: 3q11.2 HGNC chromosome: 3OR5H14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P097868: view genomic region
(about GC identifiers)
Start:
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97,868,230 bp from pter |
End:
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97,869,159 bp from pter |
Size:
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930 bases |
Orientation:
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plus strand |
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Proteins
for OR5H14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9 (See
protein sequence)Recommended Name: Olfactory receptor 5H14 Size: 310 amino acids; 35099 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B9EH15Explore the universe of human proteins at neXtProt for OR5H14: NX_A6NHG9
HORDE protein sequence for OR5H14
OR5H14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001005514.1
ENSEMBL proteins: ENSP00000401706 Reactome Protein details: A6NHG9
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
OR5H14 for ontologies About GeneDecksing
OR5H14 Antibody Products:
Assay Products for OR5H14: |
Protein
Domains /
Families
for OR5H14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR5H14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A6NHG9ProtoNet protein and cluster: A6NHG9 UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR5H14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: OR5H14 (NM_001005514) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR5H14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5H14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
OR5H14 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR5H14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR5H14
OR5H14 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR5H14
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/271 Interacting proteins for OR5H14 (ENSP000004017064) via UniProtKB, MINT, STRING, and/or I2D (see all 271)About this table
|
Drugs & Compounds
for OR5H14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR5H14
Search CenterWatch for drugs/clinical trials and news about OR5H14 / O5H14
|
Transcripts
for OR5H14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR5H14 gene: NM_001005514.1 Unigene Clusters for OR5H14: Olfactory receptor, family 5, subfamily H, member 14 Hs.554714 , Hs.719887 Unigene Representative Sequences: NM_001005514, BC1369841 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000437310(uc003dsg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR5H14 (NM_001005514) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR5H14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5H14 |
Additional cDNA sequence: BC136984.1
GeneLoc Exon Structure
|
Expression
for OR5H14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR5H14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See OR5H14 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene clusters: Hs.554714 Hs.719887
SABiosciences Custom PCR Arrays for OR5H14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR5H14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat OR5H14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR5H14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR5H14 |
Orthologs
for OR5H14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR5H14 (if available)
TreeFam Gene Tree for OR5H14 (if available) |
Paralogs
for OR5H14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR5H14 gene
- OR5H152 OR5K32 OR5H62 OR5K12 OR5AC22 OR5K22 OR5H22 OR5K42
- OR5H12
18/453 SIMAP similar genes for OR5H14 using alignment to 2 protein entries: O5H14_HUMAN (see all proteins)
(see all similar genes):OR5H6 OR5H1 OR5H15 OR5H2 OR5AC1 OR5AC2
OR5K1 OR5K3 OR5K2 OR5K4 OR8G1 OR8D1
OR8B12 OR8U1 OR8U8 OR8U9 OR8G5 OR5AP2
OR5H14 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR5H14
PGOHUM00000238107 PGOHUM00000238108
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Genomic Variants
for OR5H14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR5H14 ( 97868230 - 97869159 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR5H14: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR5H14 |
|
Disorders
/ Diseases
for OR5H14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR5H14 for disorders About GeneDecksing
1  disease for OR5H14: About MalaCardsneuronitis
Export disorders for OR5H14 gene to outside databases
|
Publications
for OR5H14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR5H14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR5H14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for OR5H14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing OR5H14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR5H14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR5H14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR5H14 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR5H14 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
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About This Section
| Patent Information for OR5H14 gene:
Search GeneIP for patents involving OR5H14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR5H14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR5H14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR5H14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR5H14 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR5H14 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5H14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR5H14 | | OriGene Custom Protein Services for OR5H14 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR5H14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR5H14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5H14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR5H14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR5H14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR5H14 |
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| | | |  |  |  | | | | Search ThermoFisher Antibodies for OR5H14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5H14 |
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