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OR5H14 Gene

protein-coding   GIFtS: 37
GCID: GC03P097868

Olfactory Receptor, Family 5, Subfamily H, Member 14

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily H, Member 141 2
Olfactory Receptor 5H142
Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 312861   Entrez Gene: 4032732   Ensembl: ENSG000002360327   UniProtKB: A6NHG93   

Export aliases for OR5H14 gene to outside databases

Previous GC identifers: GC03U900516 GC03P099350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5H14 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5H14 Gene:
OR5H14 (olfactory receptor, family 5, subfamily H, member 14) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5H15.

UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9
Function: Odorant receptor (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5H14 gene promoter:
         FOXO3   Lmo2   HNF-3beta   E4BP4   FOXO3b   c-Rel   FOXC1   Nkx6-1   FOXO4   FOXO3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5H14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3q11.2

OR5H14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5H14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P097868:  view genomic region     (about GC identifiers)

Start:
97,868,230 bp from pter      End:
97,869,159 bp from pter
Size:
930 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9 (See protein sequence)
Recommended Name: Olfactory receptor 5H14  
Size: 310 amino acids; 35099 Da
Secondary accessions: B9EH15

Explore the universe of human proteins at neXtProt for OR5H14: NX_A6NHG9

Explore proteomics data for OR5H14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR5H14

    See OR5H14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005514.1  
    ENSEMBL proteins: 
     ENSP00000401706  
    Reactome Protein details: A6NHG9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry A6NHG9

    ProtoNet protein and cluster: A6NHG9

    UniProtKB/Swiss-Prot: O5H14_HUMAN, A6NHG9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5H14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O5H14_HUMAN, A6NHG9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5H14           About GenesLikeMe


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       genOway: Develop your customized and physiologically relevant rodent model for OR5H14

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O5H14_HUMAN, A6NHG9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5H14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5H14 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82


    Find genes that share SuperPaths with OR5H14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5H14
        Olfactory Signaling Pathway


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    Interactions:

        Search GeneGlobe Interaction Network for OR5H14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5H14 (ENSP000004017064) via UniProtKB, MINT, STRING, and/or I2D (see all 271)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR4F6ENSP000003275254STRING: ENSP00000327525
    OR5AR1ENSP000003026394STRING: ENSP00000302639
    OR6A2ENSP000003303844STRING: ENSP00000330384
    OR7A10ENSP000002480584STRING: ENSP00000248058
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5H14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5H14 (O5H14)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5H14 gene: 
    NM_001005514.1  

    Unigene Cluster for OR5H14:

    Olfactory receptor, family 5, subfamily H, member 14
    Hs.554714
    Unigene Representative Sequence: NM_001005514
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000437310(uc003dsg.1)
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      QuantiFast Probe-based Assays in human, mouse, rat OR5H14

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    OR5H14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5H14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554714
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5H14 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1931 olfactory receptor 193 78.03(n)
    72.73(a)
      257972  NM_001011791.1  NP_001011791.1 


    ENSEMBL Gene Tree for OR5H14 (if available)
    TreeFam Gene Tree for OR5H14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5H14 gene
    OR5H152  OR5K32  OR5K12  OR5H62  OR5AC22  OR5K22  OR5H22  OR5K42  
    OR5H8P2  OR5H12  OR5AC12  
    Selected SIMAP similar genes for OR5H14 using alignment to 2 protein entries:     O5H14_HUMAN (see all proteins) (see all similar genes):
    OR5H6    OR5H1    OR5H15    OR5H2    OR5AC1    OR5AC2
    OR5K1    OR5K3    OR5K2    OR5K4    OR8D1    OR8G1
    OR8B12    OR8U1    OR8U8    OR8U9    OR8G5    OR5AP2

    Find genes that share paralogs with OR5H14           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for OR5H14
    PGOHUM00000238107 PGOHUM00000238108


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5H14 (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502769681,2
    --97866248(+) GGTTTC/TCTAAG 1 -- us2k10--------
    rs2010678061,2
    --97866332(+) CTGTG-/TTTTTT 1 -- us2k10--------
    rs1118639021,2
    C,F--97866345(+) TCTGTT/CTTAGA 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1884479641,2
    --97866476(+) AATTTC/TTGATC 1 -- us2k10--------
    rs48570731,2
    C,F,A--97866526(+) TAACTG/ATTACT 1 -- us2k115Minor allele frequency- A:0.36EA NA WA CSA 588
    rs784458991,2
    C--97866623(+) ATTATC/TTTGTT 1 -- us2k14Minor allele frequency- T:0.10NA WA EA 360
    rs1129013511,2
    C,F--97866653(+) CATATG/TATCTA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1853144451,2
    --97866809(+) AAACTA/CCTGTA 1 -- us2k10--------
    rs1388752431,2
    --97866884(+) AGGTAA/CCTTTA 1 -- us2k10--------
    rs1489907721,2
    --97867063(+) AAAGCA/GGTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5H14 ( 97868230 - 97869159 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for OR5H14:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv824e201CNV Deletion23290073
    esv2667633CNV Deletion23128226
    esv2677041CNV Deletion23128226
    dgv872e199CNV Deletion23128226
    dgv823e201CNV Deletion23290073
    nsv877210CNV Loss21882294
    nsv877209CNV Gain21882294
    nsv460768CNV Gain19166990
    nsv877207CNV Gain21882294
    nsv834773CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5H14 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5H14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 403273 HGNC: 31286 Ensembl:ENSG00000236032 euGenes: HUgn403273 ECgene: OR5H14
    H-InvDB: OR5H14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5H14 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5H14 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5H14 gene:
    Search GeneIP for patents involving OR5H14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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