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Aliases for OR5H1 Gene

Aliases for OR5H1 Gene

  • Olfactory Receptor Family 5 Subfamily H Member 1 2 3 5
  • HTPCRX14 3 4
  • Olfactory Receptor, Family 5, Subfamily H, Member 1 2
  • Olfactory Receptor 5H1 3
  • HSHTPCRX14 3

External Ids for OR5H1 Gene

Previous GeneCards Identifiers for OR5H1 Gene

  • GC03P094471
  • GC03P097190
  • GC03P099132
  • GC03U900512
  • GC03P099335
  • GC03P097851

Summaries for OR5H1 Gene

Entrez Gene Summary for OR5H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5H1 Gene

OR5H1 (Olfactory Receptor Family 5 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H15.

UniProtKB/Swiss-Prot for OR5H1 Gene

  • Odorant receptor.

Additional gene information for OR5H1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5H1 Gene

Genomics for OR5H1 Gene

Regulatory Elements for OR5H1 Gene


Genomic Location for OR5H1 Gene

Chromosome:
3
Start:
98,130,721 bp from pter
End:
98,138,548 bp from pter
Size:
7,828 bases
Orientation:
Plus strand

Genomic View for OR5H1 Gene

Genes around OR5H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5H1 Gene

Proteins for OR5H1 Gene

  • Protein details for OR5H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKK0-OR5H1_HUMAN
    Recommended name:
    Olfactory receptor 5H1
    Protein Accession:
    A6NKK0

    Protein attributes for OR5H1 Gene

    Size:
    313 amino acids
    Molecular mass:
    35387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5H1 Gene

Post-translational modifications for OR5H1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5H1 Gene

Domains & Families for OR5H1 Gene

Gene Families for OR5H1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5H1 Gene

Suggested Antigen Peptide Sequences for OR5H1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKK0

UniProtKB/Swiss-Prot:

OR5H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5H1: view

Function for OR5H1 Gene

Molecular function for OR5H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5H1: view

Phenotypes for OR5H1 Gene

GenomeRNAi human phenotypes for OR5H1:
genes like me logo Genes that share phenotypes with OR5H1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5H1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5H1 Gene

Localization for OR5H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5H1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5H1 Gene

Pathways & Interactions for OR5H1 Gene

genes like me logo Genes that share pathways with OR5H1: view

Pathways by source for OR5H1 Gene

Interacting Proteins for OR5H1 Gene

Gene Ontology (GO) - Biological Process for OR5H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5H1: view

No data available for SIGNOR curated interactions for OR5H1 Gene

Drugs & Compounds for OR5H1 Gene

No Compound Related Data Available

Transcripts for OR5H1 Gene

mRNA/cDNA for OR5H1 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5H1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR5H1 Gene

No ASD Table

Relevant External Links for OR5H1 Gene

GeneLoc Exon Structure for
OR5H1
ECgene alternative splicing isoforms for
OR5H1

Expression for OR5H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5H1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5H1 Gene:

OR5H1

SOURCE GeneReport for Unigene cluster for OR5H1 Gene:

Hs.537383
genes like me logo Genes that share expression patterns with OR5H1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5H1 Gene

Orthologs for OR5H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5H1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC789957 33
  • 82.64 (n)
-- 34
  • 76 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC100684793 33
  • 80.84 (n)
-- 34
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr1541 33
  • 79.98 (n)
mouse
(Mus musculus)
Mammalia Olfr183 34
  • 75 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
OneToMany
Species where no ortholog for OR5H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5H1 Gene

ENSEMBL:
Gene Tree for OR5H1 (if available)
TreeFam:
Gene Tree for OR5H1 (if available)

Paralogs for OR5H1 Gene

Paralogs for OR5H1 Gene

(451) SIMAP similar genes for OR5H1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5H1: view

Variants for OR5H1 Gene

Sequence variations from dbSNP and Humsavar for OR5H1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000260541 -- 98,133,790(+) AATAT(A/G)TCTAT downstream-variant-500B
rs1000333685 -- 98,133,240(+) GACAC(A/T)ATCCC reference, synonymous-codon
rs1001820729 -- 98,132,525(+) ATGTC(C/T)TTATT upstream-variant-2KB
rs1002203163 -- 98,133,863(+) ATCAA(A/G)TAAAA downstream-variant-500B
rs1002730836 -- 98,131,640(+) CTTTT(G/T)GTTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5H1 Gene

Variant ID Type Subtype PubMed ID
dgv776e201 CNV deletion 23290073
dgv777e201 CNV deletion 23290073
esv2677041 CNV deletion 23128226
nsv1013060 CNV gain 25217958
nsv963342 CNV duplication 23825009
nsv979860 CNV duplication 23825009

Variation tolerance for OR5H1 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5H1 Gene

Disorders for OR5H1 Gene

Relevant External Links for OR5H1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5H1

No disorders were found for OR5H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5H1 Gene

Publications for OR5H1 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 60
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 4 60

Products for OR5H1 Gene

Sources for OR5H1 Gene

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