Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OR5F1 Gene

Aliases for OR5F1 Gene

  • Olfactory Receptor Family 5 Subfamily F Member 1 2 3 5
  • Olfactory Receptor, Family 5, Subfamily F, Member 1 2 3
  • Olfactory Receptor OR11-167 3 4
  • Olfactory Receptor 11-10 3 4
  • OR11-10 3 4

External Ids for OR5F1 Gene

Previous GeneCards Identifiers for OR5F1 Gene

  • GC11M058154
  • GC11M057274
  • GC11M055536
  • GC11M055517
  • GC11M055761

Summaries for OR5F1 Gene

Entrez Gene Summary for OR5F1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5F1 Gene

OR5F1 (Olfactory Receptor Family 5 Subfamily F Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot for OR5F1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5F1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5F1 Gene

Genomics for OR5F1 Gene

Regulatory Elements for OR5F1 Gene

Enhancers for OR5F1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR5F1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5F1 Gene

55,993,681 bp from pter
55,994,625 bp from pter
945 bases
Minus strand

Genomic View for OR5F1 Gene

Genes around OR5F1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5F1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5F1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5F1 Gene

Proteins for OR5F1 Gene

  • Protein details for OR5F1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5F1
    Protein Accession:
    Secondary Accessions:
    • Q495D1
    • Q6IFB9

    Protein attributes for OR5F1 Gene

    314 amino acids
    Molecular mass:
    35132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5F1 Gene

Proteomics data for OR5F1 Gene at MOPED

Post-translational modifications for OR5F1 Gene

  • Glycosylation at Asn 5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5F1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

Antibody Products

  • Abcam antibodies for OR5F1
  • Santa Cruz Biotechnology (SCBT) Antibodies for OR5F1

No data available for DME Specific Peptides for OR5F1 Gene

Domains & Families for OR5F1 Gene

Gene Families for OR5F1 Gene

Protein Domains for OR5F1 Gene

Suggested Antigen Peptide Sequences for OR5F1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5F1: view

Function for OR5F1 Gene

Molecular function for OR5F1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily F,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5F1: view

Phenotypes for OR5F1 Gene

GenomeRNAi human phenotypes for OR5F1:
genes like me logo Genes that share phenotypes with OR5F1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5F1 Gene

Localization for OR5F1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5F1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5F1 Gene COMPARTMENTS Subcellular localization image for OR5F1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 9787077
genes like me logo Genes that share ontologies with OR5F1: view

Pathways & Interactions for OR5F1 Gene

genes like me logo Genes that share pathways with OR5F1: view

Pathways by source for OR5F1 Gene

1 KEGG pathway for OR5F1 Gene

Interacting Proteins for OR5F1 Gene

Gene Ontology (GO) - Biological Process for OR5F1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell NAS 9787077
genes like me logo Genes that share ontologies with OR5F1: view

No data available for SIGNOR curated interactions for OR5F1 Gene

Drugs & Compounds for OR5F1 Gene

No Compound Related Data Available

Transcripts for OR5F1 Gene

mRNA/cDNA for OR5F1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5F1 Gene

No ASD Table

Relevant External Links for OR5F1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5F1 Gene

mRNA expression in normal human tissues for OR5F1 Gene

SOURCE GeneReport for Unigene cluster for OR5F1 Gene Hs.553702

genes like me logo Genes that share expression patterns with OR5F1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5F1 Gene

Orthologs for OR5F1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5F1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747344 35
  • 98.09 (n)
  • 96.5 (a)
OR5F1 36
  • 96 (a)
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
-- 36
  • 81 (a)
-- 36
  • 81 (a)
(Canis familiaris)
Mammalia OR5F1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OPOR117 36
  • 75 (a)
(Mus musculus)
Mammalia Olfr1323 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
(Gallus gallus)
Aves COR3 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
-- 36
  • 54 (a)
Species with no ortholog for OR5F1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5F1 Gene

Gene Tree for OR5F1 (if available)
Gene Tree for OR5F1 (if available)

Paralogs for OR5F1 Gene

Paralogs for OR5F1 Gene

(457) SIMAP similar genes for OR5F1 Gene using alignment to 2 proteins: Pseudogenes for OR5F1 Gene

genes like me logo Genes that share paralogs with OR5F1: view

Variants for OR5F1 Gene

Sequence variations from dbSNP and Humsavar for OR5F1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2449134 - 55,993,745(-) CAGGA(A/G)TAAGG reference, missense
rs11825964 - 55,993,794(+) TGTGT(A/G)GAACA reference, missense
rs35607186 - 55,994,052(+) GATTG(C/T)GTCAG reference, missense
rs2128152 -- 55,994,262(+) ATACC(G/T)GTCAT reference, synonymous-codon
rs7128453 -- 55,996,203(+) ATTTT(A/G)TAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5F1 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv821668 CNV Loss 15273396
nsv437718 CNV Loss 16327808
nsv468568 CNV Loss 19166990
nsv469959 CNV Loss 18288195
nsv517590 CNV Loss 19592680
dgv52e55 CNV Loss 17911159
dgv384e1 CNV Complex 17122850
esv2666045 CNV Deletion 23128226

Variation tolerance for OR5F1 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR5F1 Gene

Disorders for OR5F1 Gene

Relevant External Links for OR5F1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5F1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5F1 Gene

Publications for OR5F1 Gene

  1. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner J.A. … Evans G.A. (Genomics 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5F1 Gene

Sources for OR5F1 Gene