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OR5D18 Gene

protein-coding   GIFtS: 42
GCID: GC11P055587

Olfactory Receptor, Family 5, Subfamily D, Member 18

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily D, Member 181 2
Olfactory Receptor OR11-1432 3
Olfactory Receptor OR11-1522 3
OR11-1432
Olfactory Receptor 5D182

External Ids:    HGNC: 152851   Entrez Gene: 2194382   Ensembl: ENSG000001861197   UniProtKB: Q8NGL13   

Export aliases for OR5D18 gene to outside databases

Previous GC identifers: GC11U990429 GC11P055363 GC11P055343


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5D18 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5D18 Gene:
OR5D18 (olfactory receptor, family 5, subfamily D, member 18) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5D14.

UniProtKB/Swiss-Prot: OR5DI_HUMAN, Q8NGL1
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5D18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5D18 gene promoter:
         Nkx3-1   Nkx3-1 v4   Lmo2   Nkx3-1 v1   Nkx3-1 v2   Chx10   Nkx3-1 v3   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5D18 promoter sequence
   Search Chromatin IP Primers for OR5D18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5D18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q11   HGNC cytogenetic band: 11q11

OR5D18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5D18 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055587:  view genomic region     (about GC identifiers)

Start:
55,587,106 bp from pter      End:
55,588,044 bp from pter
Size:
939 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR5DI_HUMAN, Q8NGL1 (See protein sequence)
Recommended Name: Olfactory receptor 5D18  
Size: 313 amino acids; 35348 Da
Secondary accessions: Q6IF67 Q6IFD3 Q96RB3

Explore the universe of human proteins at neXtProt for OR5D18: NX_Q8NGL1

Explore proteomics data for OR5D18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7
  • HORDE protein sequence for OR5D18

    See OR5D18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001952.1  
    ENSEMBL proteins: 
     ENSP00000335025  
    Reactome Protein details: Q8NGL1

    OR5D18 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGL1

    ProtoNet protein and cluster: Q8NGL1

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5DI_HUMAN, Q8NGL1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5D18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5DI_HUMAN, Q8NGL1
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5D18           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Olfr73):
     nervous system 

    Find genes that share phenotypes with OR5D18           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR5D18
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5DI_HUMAN, Q8NGL1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5D18           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5D18 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5D18           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5D18
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5D18):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5D18
    Interactions:

        Search GeneGlobe Interaction Network for OR5D18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5D18 (ENSP000003350254) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR11G2ENSP000003499304STRING: ENSP00000349930
    OR1N1ENSP000003069744STRING: ENSP00000306974
    OR2V1ENSP000004041024STRING: ENSP00000404102
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5D18           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5D18 (OR5DI)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5D18 gene: 
    NM_001001952.1  

    Unigene Cluster for OR5D18:

    Olfactory receptor, family 5, subfamily D, member 18
    Hs.553624
    Unigene Representative Sequence: BC136927
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333976(uc010rin.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR5D18

    Additional mRNA sequence: 

    BC136925.1 BC136927.1 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5D18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR5D18 Expression
    About this image

    OR5D18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5D18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553624
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5D18 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr735
    Olfr11551
    olfactory receptor 735
    olfactory receptor 11551
    80.02(n)1
    81.41(a)1
      2 (49.98 cM)5
    2586361  NM_146643.21  NP_666854.11 
     880341965 


    ENSEMBL Gene Tree for OR5D18 (if available)
    TreeFam Gene Tree for OR5D18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5D18 gene
    OR5D142  OR5D162  OR5L22  OR5D132  OR5L12  
    Selected SIMAP similar genes for OR5D18 using alignment to 1 protein entry:     OR5DI_HUMAN(see all similar genes):
    OR5D16    OR5D14    OR5D3    OR5D13    OR5L2    OR5L1
    OR5B12    OR5B2    OR5R1    OR5T1    OR5A2    OR5AL1
    OR5B17    OR5B21    OR5F1    OR5I1    OR5T2    OR5T3

    Find genes that share paralogs with OR5D18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5D18 (see all 128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs618963221,2
    C,F--55585198(+) GGAGGC/TGGAGG 1 -- us2k16Minor allele frequency- T:0.37NA CSA WA EA 364
    rs1176028761,2
    C,F--55585223(+) AATCAC/AGCCAC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1468211541,2
    --55585235(+) GCACTC/TCAGTC 1 -- us2k10--------
    rs353853911,2
    C--55585268(+) TCTCC-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs2006710741,2
    --55585281(+) AAAAG-/GAAA  
            
    GAAAG
    1 -- us2k10--------
    rs618963231,2
    C,F--55585438(+) AGCTCC/TGCCTC 1 -- us2k13Minor allele frequency- T:0.04NA 124
    rs562137181,2
    C,F--55585441(+) TCCGCC/TTCCTG 1 -- us2k16Minor allele frequency- T:0.10NA WA EA 364
    rs796426471,2
    C--55585463(+) TTCACG/CCCATT 1 -- us2k12Minor allele frequency- C:0.09CSA NA 122
    rs1406497271,2
    --55585507(+) CAGGCG/TCCTGC 1 -- us2k10--------
    rs1407354041,2
    C--55585670(+) CTTGA-/GGGTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5D18 ( 55587106 - 55588044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OR5D18 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744537CNV Deletion23290073
    dgv212e199CNV Deletion23128226
    nsv821668CNV Loss15273396
    nsv469885CNV Loss16826518
    nsv469958CNV Loss18288195
    dgv150n27CNV Loss19166990
    dgv51e55CNV Loss17911159
    dgv13n68CNV Loss17160897
    nsv437717CNV Loss16327808
    dgv50e55CNV Loss17911159

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing OR5D18
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR5D18           About GenesLikeMe

    Genetic Association Database (GAD): OR5D18

    Export disorders for OR5D18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5D18 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5D18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (Genomics 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219438 HGNC: 15285 Ensembl:ENSG00000186119 euGenes: HUgn219438 ECgene: OR5D18 Kegg: 219438
    H-InvDB: OR5D18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5D18 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5D18 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5D18 gene:
    Search GeneIP for patents involving OR5D18

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OR5D18  
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     OriGene Custom Antibody Services for OR5D18   OriGene Custom Protein Services for OR5D18  

     
     
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     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5D18 Predesigned siRNA for gene silencing in human, mouse, rat OR5D18
     QuantiFast Probe-based Assays in human, mouse, rat OR5D18 QuantiTect SYBR Green Assays in human, mouse, rat OR5D18
     Custom PCR Arrays for OR5D18 Search Chromatin IP Primers for OR5D18
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     Search Tocris compounds for OR5D18 (OR5DI)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR5D18
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OR5D18
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     Search Addgene for plasmids for OR5D18
      Search eBioscience for proteins for OR5D18
      Search eBioscience for elisas for OR5D18
      eBioscience FlowRNA Probe Sets
           
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