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Aliases for OR5D18 Gene

Aliases for OR5D18 Gene

  • Olfactory Receptor, Family 5, Subfamily D, Member 18 2 3
  • Olfactory Receptor OR11-143 3 4
  • Olfactory Receptor OR11-152 3 4
  • Olfactory Receptor 5D18 3
  • OR11-143 3

External Ids for OR5D18 Gene

Summaries for OR5D18 Gene

Entrez Gene Summary for OR5D18 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5D18 Gene

OR5D18 (Olfactory Receptor, Family 5, Subfamily D, Member 18) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5D14.

UniProtKB/Swiss-Prot for OR5D18 Gene

  • Odorant receptor.

Gene Wiki entry for OR5D18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5D18 Gene

Genomics for OR5D18 Gene

Genomic Location for OR5D18 Gene

Start:
55,819,630 bp from pter
End:
55,820,571 bp from pter
Size:
942 bases
Orientation:
Plus strand

Genomic View for OR5D18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5D18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5D18 Gene

Regulatory Elements for OR5D18 Gene

Proteins for OR5D18 Gene

  • Protein details for OR5D18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGL1-OR5DI_HUMAN
    Recommended name:
    Olfactory receptor 5D18
    Protein Accession:
    Q8NGL1
    Secondary Accessions:
    • Q6IF67
    • Q6IFD3
    • Q96RB3

    Protein attributes for OR5D18 Gene

    Size:
    313 amino acids
    Molecular mass:
    35348 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5D18 Gene

Proteomics data for OR5D18 Gene at MOPED

Post-translational modifications for OR5D18 Gene

Other Protein References for OR5D18 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5D18 Gene

Domains for OR5D18 Gene

Gene Families for OR5D18 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5D18 Gene

Suggested Antigen Peptide Sequences for OR5D18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGL1

UniProtKB/Swiss-Prot:

OR5DI_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8NGL1
genes like me logo Genes that share domains with OR5D18: view

Function for OR5D18 Gene

Molecular function for OR5D18 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5D18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5D18: view

Phenotypes for OR5D18 Gene

MGI mutant phenotypes for OR5D18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with OR5D18: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5D18 Gene

Localization for OR5D18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5D18 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5D18 Gene COMPARTMENTS Subcellular localization image for OR5D18 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5D18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5D18: view

Pathways for OR5D18 Gene

genes like me logo Genes that share pathways with OR5D18: view

Pathways by source for OR5D18 Gene

Interacting Proteins for OR5D18 Gene

Gene Ontology (GO) - Biological Process for OR5D18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5D18: view

Transcripts for OR5D18 Gene

mRNA/cDNA for OR5D18 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5D18 Gene

No ASD Table

Relevant External Links for OR5D18 Gene

GeneLoc Exon Structure for
OR5D18
ECgene alternative splicing isoforms for
OR5D18

Expression for OR5D18 Gene

mRNA expression in normal human tissues for OR5D18 Gene

SOURCE GeneReport for Unigene cluster for OR5D18 Gene Hs.553624

genes like me logo Genes that share expressions with OR5D18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR5D18 Gene

Orthologs for OR5D18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5D18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466539 35
  • 98.83 (n)
  • 97.76 (a)
OR5D18 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
LOC513384 35
  • 82.43 (n)
  • 75.4 (a)
dog
(Canis familiaris)
Mammalia OR5D18 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1155 35
  • 80.02 (n)
  • 81.41 (a)
Olfr1161 36
  • 73 (a)
OneToMany
Olfr73 16
Olfr73 36
  • 82 (a)
OneToMany
Olfr74 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 72 (a)
OneToMany
Species with no ortholog for OR5D18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5D18 Gene

ENSEMBL:
Gene Tree for OR5D18 (if available)
TreeFam:
Gene Tree for OR5D18 (if available)

Paralogs for OR5D18 Gene

Paralogs for OR5D18 Gene

Selected SIMAP similar genes for OR5D18 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5D18: view

Variants for OR5D18 Gene

Sequence variations from dbSNP and Humsavar for OR5D18 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs297080 -- 55,820,789(-) CCCAT(A/G)CTATA downstream-variant-500B
rs297081 - 55,820,035(-) CATGT(C/T)AACTG reference, missense
rs297082 -- 55,819,641(+) CTGAC(A/T)GATAG synonymous-codon, reference
rs297083 -- 55,818,858(-) ACTAG(A/G)GTTTT upstream-variant-2KB
rs7924378 -- 55,818,219(+) TTCAT(A/G)AGTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5D18 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv821668 CNV Loss 15273396
esv782 CNV CNV 17122850
nsv428256 CNV Loss 18775914
nsv517440 CNV Gain+Loss 19592680
nsv437717 CNV Loss 16327808
esv22842 CNV Gain+Loss 19812545
nsv469958 CNV Loss 18288195
dgv382e1 CNV Complex 17122850
dgv50e55 CNV Loss 17911159
dgv13n68 CNV Loss 17160897
dgv212e199 CNV Deletion 23128226
dgv12n64 CNV Loss 17921354
dgv383e1 CNV Complex 17122850
dgv51e55 CNV Loss 17911159
nsv469885 CNV Loss 16826518
dgv150n27 CNV Loss 19166990
nsv832158 CNV Gain 17160897
esv2744537 CNV Deletion 23290073

Relevant External Links for OR5D18 Gene

HapMap Linkage Disequilibrium report
OR5D18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5D18 Gene

Disorders for OR5D18 Gene

Relevant External Links for OR5D18

Genetic Association Database (GAD)
OR5D18
genes like me logo Genes that share disorders with OR5D18: view

No data available for UniProtKB/Swiss-Prot for OR5D18 Gene

Publications for OR5D18 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5D18 Gene

Sources for OR5D18 Gene

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