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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OR5D14 Gene

protein-coding GIFtS: 46
GCID: GC11P055563

olfactory receptor, family 5, subfamily D, member 14

Explore 1 disease affiliated with
OR5D14 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Olfactory Receptor, Family 5, Subfamily D, Member 14¹ ²
Olfactory Receptor OR11-141² ³
Olfactory Receptor OR11-150² ³
OR11-141²
OR11-150²
Olfactory Receptor 5D14²

External Ids:	HGNC: 15281¹	Entrez Gene: 219436²	Ensembl: ENSG00000186113⁷	UniProtKB: Q8NGL3³

Export aliases for OR5D14 gene to outside databases

Previous GC identifers: GC11U990433 GC11P055339 GC11P055319

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR5D14:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: OR5DE_HUMAN, Q8NGL3

Function: Odorant receptor (Potential)

Gene Wiki entry for OR5D14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR5D14 gene promoter:
Nkx3-1 v4 AML1a AP-1 c-Ets-1 C/EBPalpha CHOP-10 CREB deltaCREB Nkx3-1 v3 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OR5D14 promoter sequence

Search SABiosciences Chromatin IP Primers for OR5D14

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5D14

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q11 HGNC cytogenetic band: 11q11

OR5D14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5D14 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P055563: view genomic region (about GC identifiers)

Start:	55,563,032 bp from pter	End:	55,563,973 bp from pter
Size:	942 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OR5DE_HUMAN, Q8NGL3 (See protein sequence)

Recommended Name: Olfactory receptor 5D14

Size: 314 amino acids; 35823 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6IF69 Q6IFD4 Q96RB5

Explore the universe of human proteins at neXtProt for OR5D14: NX_Q8NGL3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NGL3

HORDE protein sequence for OR5D14
OR5D14 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004735.1

ENSEMBL proteins:

ENSP00000334456

Reactome Protein details: Q8NGL3
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

OR5D14 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR5D14 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000725 Olfact_rcpt

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGL3

ProtoNet protein and cluster: Q8NGL3

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR5DE_HUMAN, Q8NGL3

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OR5DE_HUMAN, Q8NGL3

Function: Odorant receptor (Potential)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

OR5D14 for ontologies About GeneDecksing

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Olfactory transduction

Olfactory transduction

1.00

Olfactory Signaling Pathway

0.77

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for OR5D14

	GPCR downstream signaling
	Olfactory Signaling Pathway
	Signal Transduction
	Signaling by GPCR

1 Kegg Pathway (Kegg details for OR5D14):

Olfactory transduction

OR5D14 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR5D14

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/273 Interacting proteins for OR5D14 (ENSP00000334456⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 273)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR52E6	ENSP00000328878⁴	STRING: ENSP00000369279 STRING: ENSP00000328878
GNAL	ENSP00000334051⁴	STRING: ENSP00000334051
GNGT1	ENSP00000248572⁴	STRING: ENSP00000248572
OR10A3	ENSP00000353988⁴	STRING: ENSP00000353988
OR10A4	ENSP00000369157⁴	STRING: ENSP00000369157

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for OR5D14
Search CenterWatch for drugs/clinical trials and news about OR5D14 / OR5DE

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OR5D14 gene:

NM_001004735.1

Unigene Cluster for OR5D14:

Olfactory receptor, family 5, subfamily D, member 14

Hs.553622

Unigene Representative Sequence: NM_001004735

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000335605(uc010rim.2)

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1 AceView cDNA sequence:

NM_001004735

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OR5D14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

OR5D14 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OR5D14 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553622

SABiosciences Custom PCR Arrays for OR5D14

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for OR5D14 (if available)
TreeFam Gene Tree for OR5D14 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OR5D14 gene

OR5D16² OR5D18² OR5L2² OR5D13² OR5L1²

18/438 SIMAP similar genes for OR5D14 using alignment to 1 protein entry: OR5DE_HUMAN(see all similar genes):

OR5D16 OR5D18 OR5D13 OR5D3 OR5L1 OR5B2

OR5L2 OR5R1 OR5AS1 OR5B12 OR5B17 OR5I1

OR8U1 OR8U8 OR5B21 OR5B3 OR5T1 OR8D1

OR5D14 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185096975^1,2		--	55561053(+)	`TTAATA/GAATCA`	1	--	us2k¹		0	--	--	--	--
rs139667043^1,2		--	55561163(+)	`CAAATC/TATTGG`	1	--	us2k¹		0	--	--	--	--
rs78030293^1,2	C	--	55561220(+)	`TTCAGG/AAGGCT`	1	--	us2k¹		1		WA	2
rs144719020^1,2		--	55561340(+)	`TTTGTA/CTTTAA`	1	--	us2k¹		0	--	--	--	--
rs189032636^1,2		--	55561366(+)	`GCCACA/CTTAAG`	1	--	us2k¹		0	--	--	--	--
rs115443616^1,2		--	55561395(+)	`AGTTAT/CTCACT`	1	--	us2k¹		1		WA	118
rs181632248^1,2		--	55561416(+)	`CCAGCA/GTATCA`	1	--	us2k¹		0	--	--	--	--
rs186854584^1,2		--	55561426(+)	`ATGGGG/TAATCA`	1	--	us2k¹		0	--	--	--	--
rs12362828^1,2	C,F,H	--	55561444(+)	`ATGAGG/TCTCCT`	1	--	us2k¹		12		NS EA NA WA	714
rs11231080^1,2	C,F,A,H	--	55561447(+)	`AGGCTC/TCTATG`	1	--	us2k¹		11		EA NS WA NA CSA	644

HapMap Linkage Disequilibrium report for OR5D14 ( 55563032 - 55563973 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for OR5D14
15/18 CNVs (see all 18): 48056 9188 9187 48841 3852 85785 8690 10360 2926 48843 48840 1244 29911 65956 53429

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR5D14 for disorders About GeneDecksing

1 disease for OR5D14: About MalaCards

neuronitis

Export disorders for OR5D14 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OR5D14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR5D14)

Utopia: connect your pdf to the dynamic
world of online information

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 219436	HGNC: 15281	AceView: OR5D14	Ensembl:ENSG00000186113	euGenes: HUgn219436
ECgene: OR5D14	Kegg: 219436	H-InvDB: OR5D14

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OR5D14	Pharmacogenomics, SNPs, Pathways
HORDE entry for OR5D14	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR5D14 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OR5D14 gene:
Search GeneIP for patents involving OR5D14

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5D14

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for OR5D14

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OR5D14 gene at Home site.

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OR5D14 Gene

olfactory receptor, family 5, subfamily D, member 14

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OR5D14 Gene

olfactory receptor, family 5, subfamily D, member 14

Aliasesfor OR5D14 gene

Summariesfor OR5D14 gene

Genomic Viewsfor OR5D14 gene

Proteinsfor OR5D14 gene

Protein Domains /Familiesfor OR5D14 gene

Functionfor OR5D14 gene

Pathways & Interactionsfor OR5D14 gene

Drugs & Compoundsfor OR5D14 gene

Transcriptsfor OR5D14 gene

Expression for OR5D14 gene

Orthologsfor OR5D14 gene

Paralogsfor OR5D14 gene

Genomic Variantsfor OR5D14 gene

Disorders / Diseasesfor OR5D14 gene

Publicationsfor OR5D14 gene

External Searches for OR5D14 gene

Genome Databases showing OR5D14 gene

Other Databases showing OR5D14 gene

Specialized Databases showing OR5D14 gene

Intellectual Propertyfor OR5D14 gene

Productsfor OR5D14 gene

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Aliases
for OR5D14 gene

Summaries
for OR5D14 gene

Genomic Views
for OR5D14 gene

Proteins
for OR5D14 gene

Protein Domains /
Families
for OR5D14 gene

Function
for OR5D14 gene

Pathways & Interactions
for OR5D14 gene

Drugs & Compounds
for OR5D14 gene

Transcripts
for OR5D14 gene

Expression
for OR5D14 gene

Orthologs
for OR5D14 gene

Paralogs
for OR5D14 gene

Genomic Variants
for OR5D14 gene

Disorders / Diseases
for OR5D14 gene

Publications
for OR5D14 gene

Intellectual Property
for OR5D14 gene

Products
for OR5D14 gene