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Aliases for OR5C1 Gene

Aliases for OR5C1 Gene

  • Olfactory Receptor Family 5 Subfamily C Member 1 2 3 5
  • Olfactory Receptor 5C2 3 4
  • Olfactory Receptor 9-F 3 4
  • OR5C2P 3 4
  • OR9-F 3 4
  • Olfactory Receptor, Family 5, Subfamily C, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily C, Member 1 2
  • Olfactory Receptor 5C1 3
  • HRPK-465_F_21 3
  • OR9-31 3

External Ids for OR5C1 Gene

Previous HGNC Symbols for OR5C1 Gene

  • OR5C2P

Previous GeneCards Identifiers for OR5C1 Gene

  • GC09U990110
  • GC09P120928
  • GC09P122630
  • GC09P124590
  • GC09P125551

Summaries for OR5C1 Gene

Entrez Gene Summary for OR5C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5C1 Gene

OR5C1 (Olfactory Receptor Family 5 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot for OR5C1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5C1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5C1 Gene

Genomics for OR5C1 Gene

Regulatory Elements for OR5C1 Gene

Enhancers for OR5C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G122819 1.4 Ensembl ENCODE dbSUPER 10.5 +32.0 31963 3.6 HDAC1 PKNOX1 FOXA2 TBL1XR1 TCF12 ZNF766 GATA2 FOS RELB CREM OR1K1 OR5C1 SNORD90 GC09M122816 PDCL
GH09G122815 1.2 Ensembl ENCODE dbSUPER 10.5 +27.4 27419 1.8 BCOR MAX ZMYM3 ZIC2 YY1 ZNF316 GATA2 POLR2A ADNP HNF4G OR5C1 SNORD90 GC09M122816 OR1K1
GH09G122463 1.2 Ensembl ENCODE 9.8 -324.1 -324127 1.9 PKNOX1 ARID4B BRCA1 ZNF2 ZNF143 DEK JUNB REST MIER2 TBX21 OR1Q1 OR1K1 OR1N1 OR1J4 PTGS1 OR5C1 RBM18 MRRF TTLL11 ENSG00000231465
GH09G122443 1 ENCODE 10.2 -343.6 -343550 4.5 PKNOX1 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 FOS PTGS1 OR1K1 ENSG00000231465 OR5C1 TTLL11 OR1J2 ENSG00000229245
GH09G122453 1 Ensembl ENCODE 9.7 -335.6 -335608 0.3 GTF2F1 CTCF SIN3A MAX CEBPG RAD21 RFX5 ZNF143 SMC3 DEK PTGS1 OR1K1 TTLL11 OR5C1 OR1J2 ENSG00000231465
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5C1 Gene

122,788,933 bp from pter
122,789,895 bp from pter
963 bases
Plus strand

Genomic View for OR5C1 Gene

Genes around OR5C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5C1 Gene

Proteins for OR5C1 Gene

  • Protein details for OR5C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5C1
    Protein Accession:
    Secondary Accessions:
    • B2RN54
    • B9EGT0
    • Q96RC4

    Protein attributes for OR5C1 Gene

    320 amino acids
    Molecular mass:
    34991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5C1 Gene

Post-translational modifications for OR5C1 Gene

Other Protein References for OR5C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5C1 Gene

Domains & Families for OR5C1 Gene

Gene Families for OR5C1 Gene

Protein Domains for OR5C1 Gene

Suggested Antigen Peptide Sequences for OR5C1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5C1: view

Function for OR5C1 Gene

Molecular function for OR5C1 Gene

GENATLAS Biochemistry:
olfactory receptor,family 5,subfamily C,member 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5C1: view

Phenotypes for OR5C1 Gene

GenomeRNAi human phenotypes for OR5C1:
genes like me logo Genes that share phenotypes with OR5C1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5C1 Gene

Localization for OR5C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5C1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5C1: view

Pathways & Interactions for OR5C1 Gene

genes like me logo Genes that share pathways with OR5C1: view

Pathways by source for OR5C1 Gene

Interacting Proteins for OR5C1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)
Selected Interacting proteins: Q8NGR4-OR5C1_HUMAN ENSP00000362784 for OR5C1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for OR5C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5C1: view

No data available for SIGNOR curated interactions for OR5C1 Gene

Drugs & Compounds for OR5C1 Gene

No Compound Related Data Available

Transcripts for OR5C1 Gene

mRNA/cDNA for OR5C1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5C1 Gene

Olfactory receptor, family 5, subfamily C, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5C1 Gene

No ASD Table

Relevant External Links for OR5C1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5C1 Gene:


SOURCE GeneReport for Unigene cluster for OR5C1 Gene:


Evidence on tissue expression from TISSUES for OR5C1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with OR5C1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5C1 Gene

Orthologs for OR5C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5C1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC473050 34
  • 99.06 (n)
OR5C1 35
  • 98 (a)
(Canis familiaris)
Mammalia OR5C1 34 35
  • 87.76 (n)
(Bos Taurus)
Mammalia OR5C1 34 35
  • 85.63 (n)
(Mus musculus)
Mammalia Or5c1 55 Olfr368 34 16 35
  • 83.44 (n)
(Rattus norvegicus)
Mammalia Olr434 34
  • 83.23 (n)
(Monodelphis domestica)
Mammalia OR5C1 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
Species where no ortholog for OR5C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5C1 Gene

Gene Tree for OR5C1 (if available)
Gene Tree for OR5C1 (if available)

Paralogs for OR5C1 Gene

Paralogs for OR5C1 Gene

(423) SIMAP similar genes for OR5C1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5C1: view

Variants for OR5C1 Gene

Sequence variations from dbSNP and Humsavar for OR5C1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000008912 -- 122,788,517(+) GACCA(G/T)CCTGA upstream-variant-2KB
rs1001819480 -- 122,788,447(+) TGGCT(A/C)ATGCC upstream-variant-2KB
rs1003861514 -- 122,787,681(+) TCTCC(A/G)ATCTT upstream-variant-2KB
rs1003944152 -- 122,787,117(+) TAGGG(-/A)AAAAA upstream-variant-2KB
rs1004392931 -- 122,789,974(+) CTGTC(A/G)GTAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR5C1 Gene

Variant ID Type Subtype PubMed ID
nsv518250 CNV loss 19592680

Variation tolerance for OR5C1 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5C1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5C1 Gene

Disorders for OR5C1 Gene

Relevant External Links for OR5C1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5C1 Gene

Publications for OR5C1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 4 64

Products for OR5C1 Gene

Sources for OR5C1 Gene

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