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OR5C1 Gene

protein-coding   GIFtS: 45
GCID: GC09P125551

Olfactory Receptor, Family 5, Subfamily C, Member 1


(Previous symbol: OR5C2P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily C, Member 11 2     OR9-312
OR5C2P1 2 3     hRPK-465_F_212
Olfactory Receptor 5C22 3     Olfactory Receptor 5C12
Olfactory Receptor 9-F2 3     Olfactory Receptor, Family 5, Subfamily C, Member 2 Pseudogene2
OR9-F2 3     

External Ids:    HGNC: 83311   Entrez Gene: 3923912   Ensembl: ENSG000001482157   UniProtKB: Q8NGR43   

Export aliases for OR5C1 gene to outside databases

Previous GC identifers: GC09U990110 GC09P120928 GC09P122630 GC09P124590


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5C1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5C1 Gene:
OR5C1 (olfactory receptor, family 5, subfamily C, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot: OR5C1_HUMAN, Q8NGR4
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5C1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5C1 gene promoter:
         SREBP-1c   CUTL1   Tal-1beta   Egr-4   SREBP-1b   SREBP-1a   POU2F1   POU2F1a   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5C1 promoter sequence
   Search Chromatin IP Primers for OR5C1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.2

OR5C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5C1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125551:  view genomic region     (about GC identifiers)

Start:
125,551,212 bp from pter      End:
125,552,171 bp from pter
Size:
960 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OR5C1_HUMAN, Q8NGR4 (See protein sequence)
Recommended Name: Olfactory receptor 5C1  
Size: 320 amino acids; 34991 Da
Secondary accessions: B2RN54 B9EGT0 Q96RC4

Explore the universe of human proteins at neXtProt for OR5C1: NX_Q8NGR4

Explore proteomics data for OR5C1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR5C1

    See OR5C1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001923.1  
    ENSEMBL proteins: 
     ENSP00000362784  
    Reactome Protein details: Q8NGR4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGR4

    ProtoNet protein and cluster: Q8NGR4

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5C1_HUMAN, Q8NGR4
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5C1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5C1_HUMAN, Q8NGR4
    Function: Odorant receptor (Potential)

         Genatlas biochemistry entry for OR5C1:
    olfactory receptor,family 5,subfamily C,member 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5C1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR5C1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5C1_HUMAN, Q8NGR4: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5C1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5C1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5C1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5C1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5C1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5C1
    Interactions:

        Search GeneGlobe Interaction Network for OR5C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5C1 (ENSP000003627844) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10J3ENSP000003317894STRING: ENSP00000331789
    OR14C36ENSP000003245344STRING: ENSP00000324534
    OR1N2ENSP000003627924STRING: ENSP00000362792
    OR51G2ENSP000003225934STRING: ENSP00000322593
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5C1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5C1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5C1 gene: 
    NM_001001923.1  

    Unigene Cluster for OR5C1:

    Olfactory receptor, family 5, subfamily C, member 1
    Hs.534761
    Unigene Representative Sequence: BC136701
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373680(uc011lzd.2)
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    Additional mRNA sequence: 

    BC136700.1 BC136701.1 

    1 DOTS entry:

    DT.92039702 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTGCGCC
    OR5C1 Expression
    About this image

    OR5C1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5C1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534761
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR5C1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr3681 , 5 olfactory receptor 3681, 5 83.44(n)1
    84.69(a)1
      2 (24.19 cM)5
    2583711  NM_146374.11  NP_666486.11 
     373317495 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    49(a)
    many ↔ many
    1(92320553-92321485)


    ENSEMBL Gene Tree for OR5C1 (if available)
    TreeFam Gene Tree for OR5C1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5C1 gene
    OR5W22  OR5AR12  OR5T22  OR5T12  OR5AS12  OR5I12  OR5J22  OR5T32  
    Selected SIMAP similar genes for OR5C1 using alignment to 2 protein entries:     OR5C1_HUMAN (see all proteins) (see all similar genes):
    OR5AS1    OR5AR1    OR5W2    OR5J2    OR5R1    OR8U9
    OR9I1    OR5A1    OR5A2    OR5B21    OR5T1    OR5T3
    OR8U1    OR2G3    OR5AL1    OR5B12    OR5B3    OR5L2

    Find genes that share paralogs with OR5C1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5C1 (see all 179)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73576561,2
    C,F,H--125549380(+) tcatgG/Tatatg 1 -- us2k14Minor allele frequency- T:0.01NS EA 414
    rs1834094361,2
    --125549396(+) ATAGGC/GAAAAA 1 -- us2k10--------
    rs790935231,2
    C,F--125549417(+) ATAGGG/TTTCAG 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1886451951,2
    --125549464(+) GGAACA/GTATTC 1 -- us2k10--------
    rs755184991,2
    F--125549476(+) CCATAG/AATAAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1144862211,2
    F--125549481(+) GATAAG/AGGGGA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1421440881,2
    --125549520(+) ACAGAA/CAAGAA 1 -- us2k10--------
    rs1512221591,2
    --125549657(+) CATTGC/TATTTT 1 -- us2k10--------
    rs1119243481,2
    C,F--125549681(+) TACTTC/TTGATT 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1455459681,2
    --125549747(+) CCATTC/TGCAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5C1 ( 125551212 - 125552171 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR5C1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518250CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5C1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)2 Fuchs T.... Shamir R. (Genomics 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 392391 HGNC: 8331 Ensembl:ENSG00000148215 euGenes: HUgn392391 ECgene: OR5C1 Kegg: 392391
    H-InvDB: OR5C1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5C1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5C1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5C1 gene:
    Search GeneIP for patents involving OR5C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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