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Aliases for OR5B2 Gene

Aliases for OR5B2 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 2 2 3 5
  • Olfactory Receptor OR11-240 3 4
  • OST073 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 2 2
  • Olfactory Receptor 5B2 3
  • OR11-240 3

External Ids for OR5B2 Gene

Previous GeneCards Identifiers for OR5B2 Gene

  • GC00U990608
  • GC11M057946
  • GC11M058189

Summaries for OR5B2 Gene

Entrez Gene Summary for OR5B2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B2 Gene

OR5B2 (Olfactory Receptor Family 5 Subfamily B Member 2) is a Protein Coding gene. Among its related pathways are Olfactory Signaling Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B3.

UniProtKB/Swiss-Prot for OR5B2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5B2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5B2 Gene

Genomics for OR5B2 Gene

Regulatory Elements for OR5B2 Gene

Enhancers for OR5B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G057946 0.4 FANTOM5 10 +476.9 476879 0.0 RFX1 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3 OR1S1 OR9I1
GH11G058632 0.3 FANTOM5 6.4 -208.9 -208928 0.1 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 ENSG00000197254
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5B2 Gene

Chromosome:
11
Start:
58,422,265 bp from pter
End:
58,423,313 bp from pter
Size:
1,049 bases
Orientation:
Minus strand

Genomic View for OR5B2 Gene

Genes around OR5B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B2 Gene

Proteins for OR5B2 Gene

  • Protein details for OR5B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R09-OR5B2_HUMAN
    Recommended name:
    Olfactory receptor 5B2
    Protein Accession:
    Q96R09
    Secondary Accessions:
    • B2RNJ6
    • B9EGY7
    • Q6IEV7
    • Q8NGF5

    Protein attributes for OR5B2 Gene

    Size:
    309 amino acids
    Molecular mass:
    34568 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B2 Gene

Post-translational modifications for OR5B2 Gene

Other Protein References for OR5B2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B2 Gene

Domains & Families for OR5B2 Gene

Gene Families for OR5B2 Gene

Protein Domains for OR5B2 Gene

Suggested Antigen Peptide Sequences for OR5B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R09

UniProtKB/Swiss-Prot:

OR5B2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B2: view

Function for OR5B2 Gene

Molecular function for OR5B2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5B2: view
genes like me logo Genes that share phenotypes with OR5B2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B2 Gene

Localization for OR5B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B2: view

Pathways & Interactions for OR5B2 Gene

genes like me logo Genes that share pathways with OR5B2: view

Pathways by source for OR5B2 Gene

Interacting Proteins for OR5B2 Gene

Gene Ontology (GO) - Biological Process for OR5B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B2: view

No data available for SIGNOR curated interactions for OR5B2 Gene

Drugs & Compounds for OR5B2 Gene

No Compound Related Data Available

Transcripts for OR5B2 Gene

mRNA/cDNA for OR5B2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B2 Gene

No ASD Table

Relevant External Links for OR5B2 Gene

GeneLoc Exon Structure for
OR5B2
ECgene alternative splicing isoforms for
OR5B2

Expression for OR5B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5B2 Gene:

OR5B2

SOURCE GeneReport for Unigene cluster for OR5B2 Gene:

Hs.553753
genes like me logo Genes that share expression patterns with OR5B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B2 Gene

Orthologs for OR5B2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR5B2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC785258 34
  • 81.65 (n)
OR5B2 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR5B2 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or5b99 55 Olfr1451 35
  • 73 (a)
OneToOne
Or5b115-ps 55 Olfr1470-ps1
  • chr19:13,434,089-13,435,095
Or8aa1-ps 55 Olfr1078-ps1
  • chr2:86,529,801-86,530,386
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
ManyToMany
-- 35
  • 70 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 67 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 65 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 64 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
Species where no ortholog for OR5B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B2 Gene

ENSEMBL:
Gene Tree for OR5B2 (if available)
TreeFam:
Gene Tree for OR5B2 (if available)

Paralogs for OR5B2 Gene

Paralogs for OR5B2 Gene

(449) SIMAP similar genes for OR5B2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5B2: view

Variants for OR5B2 Gene

Sequence variations from dbSNP and Humsavar for OR5B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000137295 -- 58,423,501(+) CCAAT(A/G)TTTCC upstream-variant-2KB
rs1001168008 -- 58,422,191(+) TAAAA(A/G)ATTGA downstream-variant-500B
rs1001617765 -- 58,422,782(+) AATAT(A/G)CCCCC reference, synonymous-codon
rs1004513561 -- 58,425,120(+) ATGCA(C/T)CTTGC upstream-variant-2KB
rs1004575838 -- 58,423,605(+) CTAAT(A/C)TGGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5B2 Gene

Variant ID Type Subtype PubMed ID
nsv517849 CNV gain 19592680

Variation tolerance for OR5B2 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5B2 Gene

Disorders for OR5B2 Gene

Relevant External Links for OR5B2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5B2

No disorders were found for OR5B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B2 Gene

Publications for OR5B2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR5B2 Gene

Sources for OR5B2 Gene

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