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OR5B17 Gene

protein-coding   GIFtS: 41
GCID: GC11M058125

Olfactory Receptor, Family 5, Subfamily B, Member 17


(Previous symbol: OR5B20P)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily B, Member 171 2     OR11-2372
OR5B20P1 2 3     Olfactory Receptor 5B172
Olfactory Receptor 5B202 3     Olfactory Receptor, Family 5, Subfamily B, Member 20 Pseudogene2
Olfactory Receptor OR11-2372 3     

External Ids:    HGNC: 152671   Entrez Gene: 2199652   Ensembl: ENSG000001977867   UniProtKB: Q8NGF73   

Export aliases for OR5B17 gene to outside databases

Previous GC identifers: GC11U990447 GC11M057902 GC11M057882


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5B17 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5B17 Gene:
OR5B17 (olfactory receptor, family 5, subfamily B, member 17) is a protein-coding gene. Diseases associated with OR5B17 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5AK2.

UniProtKB/Swiss-Prot: OR5BH_HUMAN, Q8NGF7
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5B17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5B17 gene promoter:
         GR   RREB-1   Tal-1beta   Evi-1   E47   GATA-1   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for OR5B17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5B17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR5B17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5B17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M058125:  view genomic region     (about GC identifiers)

Start:
58,125,601 bp from pter      End:
58,126,542 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OR5BH_HUMAN, Q8NGF7 (See protein sequence)
Recommended Name: Olfactory receptor 5B17  
Size: 314 amino acids; 35091 Da
Secondary accessions: Q6IEX1

Explore the universe of human proteins at neXtProt for OR5B17: NX_Q8NGF7

Explore proteomics data for OR5B17 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3
  • HORDE protein sequence for OR5B17

    See OR5B17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005489.1  
    ENSEMBL proteins: 
     ENSP00000349945  
    Reactome Protein details: Q8NGF7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGF7

    ProtoNet protein and cluster: Q8NGF7

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5BH_HUMAN, Q8NGF7
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR5B17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5BH_HUMAN, Q8NGF7
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR5B17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OR5B17:
     Increased HPV18 LCR reporter a 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5BH_HUMAN, Q8NGF7: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR5B17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5B17 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5B17
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5B17):
        Olfactory transduction


    OR5B17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5B17
    Interactions:

        Search GeneGlobe Interaction Network for OR5B17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5B17 (ENSP000003499454) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR4D6ENSP000003001274STRING: ENSP00000300127
    OR5AC2ENSP000003514664STRING: ENSP00000351466
    OR5B12ENSP000003066574STRING: ENSP00000306657
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR5B17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5B17 (OR5BH)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR5B17 gene: 
    NM_001005489.1  

    Unigene Cluster for OR5B17:

    Olfactory receptor, family 5, subfamily B, member 17
    Hs.554517
    Unigene Representative Sequence: NM_001005489
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357377(uc010rke.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR5B17

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5B17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTTGTTG
    OR5B17 Expression
    About this image

    OR5B17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5B17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554517
        Custom PCR Arrays for OR5B17
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5B17 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr14695
    Olfr14671
    olfactory receptor 14695
    olfactory receptor 14671
    75.91(n)1
    68.65(a)1
      19 (8.73 cM)5
    2586861  NM_146691.11  NP_666902.11 
     134105715 


    ENSEMBL Gene Tree for OR5B17 (if available)
    TreeFam Gene Tree for OR5B17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5B17 gene
    OR5AK22  OR5B122  OR5AU12  OR9Q12  OR5AP22  OR8H32  OR8H12  OR5B32  
    OR9Q22  OR5F12  OR9I12  OR5B212  OR8I22  OR5B22  OR8H22  
    Selected SIMAP similar genes for OR5B17 using alignment to 1 protein entry:     OR5BH_HUMAN(see all similar genes):
    OR5B2    OR5B3    OR5B12    OR5B21    FKSG35    OR8D1
    OR5T1    OR8U8    OR8U9    OR5AR1    OR5AP2    OR5D18
    OR5T3    OR8H1    OR8H2    OR8H3    OR8J2    OR8K1

    OR5B17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5B17 (see all 104)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830384171,2
    --58125228(+) AATTAA/TCTCTG 1 -- ds50010--------
    rs1413907581,2
    C--58125300(+) TGAACA/TAGCTG 1 -- ds50010--------
    rs802915391,2
    F--58125308(+) CTGTAC/TCAAAT 1 -- ds50011Minor allele frequency- T:0.09WA 118
    rs19386691,2
    C,F,A,H--58125316(+) AATACC/ATAAAA 1 -- ds50018Minor allele frequency- A:0.45NA WA CSA EA 367
    rs1884242551,2
    C--58125512(+) ATTCTA/GTATAC 1 -- ds50010--------
    rs745939981,2
    F--58125533(+) TTTAAC/TATTTG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1463395051,2
    C--58125561(+) GATCTA/GAGTGA 1 -- ds50010--------
    rs1395867761,2
    C,F--58125600(+) TCATTA/GAAAGA 2 Q * stop-lost1Minor allele frequency- G:0.00NA 4484
    rs41273531,2,,4
    C,F,A,H--58125620(+) GAGAAC/TATTTT 2 Y C mis129Minor allele frequency- T:0.31NS EA NA WA CSA EU 8430
    rs1501977731,2
    C,F--58125660(+) CTTCAC/TGTCTT 2 M V mis11Minor allele frequency- T:0.00NA 4550

    HapMap Linkage Disequilibrium report for OR5B17 ( 58125601 - 58126542 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR5B17: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR5B17
    DNA2.0 Custom Variant and Variant Library Synthesis for OR5B17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR5B17:    
    About MalaCards
    neuronitis


    OR5B17 for disorders           About GeneDecksing


    Export disorders for OR5B17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5B17 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5B17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219965 HGNC: 15267 Ensembl:ENSG00000197786 euGenes: HUgn219965 ECgene: OR5B17 Kegg: 219965
    H-InvDB: OR5B17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5B17 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5B17 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5B17 gene:
    Search GeneIP for patents involving OR5B17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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