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OR5B12 Gene

protein-coding   GIFtS: 47
GCID: GC11M058206

Olfactory Receptor, Family 5, Subfamily B, Member 12


(Previous symbols: OR5B12P, OR5B16)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily B, Member 121 2     OR11-2412
OR5B12P1 2 3     OST7432
OR5B161 2 3     Olfactory Receptor 5B122
Olfactory Receptor 5B162 3     Olfactory Receptor, Family 5, Subfamily B, Member 12 Pseudogene2
Olfactory Receptor OR11-2412 3     Olfactory Receptor, Family 5, Subfamily B, Member 162

External Ids:    HGNC: 154321   Entrez Gene: 3901912   Ensembl: ENSG000001723627   UniProtKB: Q96R083   

Export aliases for OR5B12 gene to outside databases

Previous GC identifers: GC11M057983 GC11M057963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5B12 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5B12 Gene:
OR5B12 (olfactory receptor, family 5, subfamily B, member 12) is a protein-coding gene. Diseases associated with OR5B12 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5AK2.

UniProtKB/Swiss-Prot: OR5BC_HUMAN, Q96R08
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5B12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5B12 gene promoter:
         c-Fos   FOXL1   Meis-1b   YY1   POU2F1   POU2F1a   c-Jun   Meis-1a   TGIF   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5B12 promoter sequence
   Search Chromatin IP Primers for OR5B12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5B12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

OR5B12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5B12 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M058206:  view genomic region     (about GC identifiers)

Start:
58,206,683 bp from pter      End:
58,207,624 bp from pter
Size:
942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OR5BC_HUMAN, Q96R08 (See protein sequence)
Recommended Name: Olfactory receptor 5B12  
Size: 314 amino acids; 35182 Da
Secondary accessions: B2RNL2 Q6IEV5

Explore the universe of human proteins at neXtProt for OR5B12: NX_Q96R08

Explore proteomics data for OR5B12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn261
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR5B12

    See OR5B12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004733.1  
    ENSEMBL proteins: 
     ENSP00000306657  
    Reactome Protein details: Q96R08

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96R08

    ProtoNet protein and cluster: Q96R08

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: OR5BC_HUMAN, Q96R08
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR5B12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OR5BC_HUMAN, Q96R08
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    OR5B12 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OR5BC_HUMAN, Q96R08: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    OR5B12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5B12 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5B12
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5B12):
        Olfactory transduction


    OR5B12 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5B12
    Interactions:

        Search GeneGlobe Interaction Network for OR5B12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5B12 (ENSP000003066574) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR1F1ENSP000003054244STRING: ENSP00000305424
    OR4D6ENSP000003001274STRING: ENSP00000300127
    OR5B17ENSP000003499454STRING: ENSP00000349945
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    OR5B12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR5B12 (OR5BC)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR5B12 gene: 
    NM_001004733.2  

    Unigene Cluster for OR5B12:

    Olfactory receptor, family 5, subfamily B, member 12
    Hs.553754
    Unigene Representative Sequence: NM_001004733
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302572(uc010rkh.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR5B12

    Additional mRNA sequence: 

    BC136947.1 BC136948.1 

    1 AceView cDNA sequence:

    NM_001004733 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5B12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATCCAC
    OR5B12 Expression
    About this image

    OR5B12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5B12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553754
        Custom PCR Arrays for OR5B12
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5B12 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr14485
    Olfr14451
    olfactory receptor 14485
    olfactory receptor 14451
    80.89(n)1
    80.57(a)1
      19 (8.73 cM)5
    2586941  NM_146699.11  NP_666910.11 
     129193635 


    ENSEMBL Gene Tree for OR5B12 (if available)
    TreeFam Gene Tree for OR5B12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5B12 gene
    OR5AK22  OR5AU12  OR9Q12  OR5AP22  OR8H32  OR8H12  OR5B32  OR9Q22  
    OR5F12  OR9I12  OR5B212  OR8I22  OR5B22  OR5B172  OR8H22  
    Selected SIMAP similar genes for OR5B12 using alignment to 1 protein entry:     OR5BC_HUMAN(see all similar genes):
    OR5B2    OR5B21    OR5B3    OR5B17    OR5AR1    OR8D1
    OR8H2    OR8U1    OR8U8    OR8U9    OR5AP2    OR5AS1
    OR5L2    OR5T1    OR5T3    OR8B12    OR8B3    OR8H3

    OR5B12 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for OR5B12
    PGOHUM00000242281 PGOHUM00000257827 PGOHUM00000242298 PGOHUM00000239443 PGOHUM00000262560


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5B12 (see all 107)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174666521,2
    F--58206172(+) TGAACT/CTGAGG 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs766078071,2
    --58206193(+) AGGACA/GTGAAG 1 -- ds50010--------
    rs108967801,2
    C,F,A,H--58206228(+) GGAGCG/ACTGAA 1 -- ds500114Minor allele frequency- A:0.46NS EA NA WA CSA 734
    rs108967811,2
    C,F,A,H--58206237(+) AAAACG/ATGCTC 1 -- ds500114Minor allele frequency- A:0.46NS EA NA WA CSA 780
    rs108967821,2
    C,F,A,H--58206314(+) CTTTAC/TCCAAT 1 -- ds500113Minor allele frequency- T:0.38NS EA WA NA CSA 783
    rs1824474461,2
    --58206385(+) GCAGAA/GTTAAC 1 -- ds50010--------
    rs1870688931,2
    --58206400(+) GTAACC/TCAGGA 1 -- ds50010--------
    rs127855781,2
    C,F,H--58206432(+) TACCAC/TCAACA 1 -- ds500120Minor allele frequency- T:0.24NS EA NA WA 2346
    rs1919868721,2
    --58206592(+) AGAAAC/TTGTCC 1 -- ds50010--------
    rs1816989701,2
    --58206595(+) AACTGC/TCCATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for OR5B12 ( 58206683 - 58207624 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for OR5B12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517849CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR5B12:    
    About MalaCards
    neuronitis


    OR5B12 for disorders           About GeneDecksing


    Export disorders for OR5B12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5B12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5B12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2, 3 Fuchs T.... Shamir R. (Genomics 2002)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390191 HGNC: 15432 AceView: OR5B12 Ensembl:ENSG00000172362 euGenes: HUgn390191
    ECgene: OR5B12 Kegg: 390191 H-InvDB: OR5B12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5B12 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5B12 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5B12 gene:
    Search GeneIP for patents involving OR5B12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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