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Aliases for OR5B12 Gene

Aliases for OR5B12 Gene

  • Olfactory Receptor Family 5 Subfamily B Member 12 2 3 5
  • Olfactory Receptor OR11-241 3 4
  • Olfactory Receptor 5B16 3 4
  • OR5B12P 3 4
  • OR5B16 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 12 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily B, Member 12 2
  • Olfactory Receptor, Family 5, Subfamily B, Member 16 3
  • Olfactory Receptor 5B12 3
  • OR11-241 3
  • OST743 3

External Ids for OR5B12 Gene

Previous HGNC Symbols for OR5B12 Gene

  • OR5B12P
  • OR5B16

Previous GeneCards Identifiers for OR5B12 Gene

  • GC11M057983
  • GC11M057963
  • GC11M058206

Summaries for OR5B12 Gene

Entrez Gene Summary for OR5B12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B12 Gene

OR5B12 (Olfactory Receptor Family 5 Subfamily B Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B3.

UniProtKB/Swiss-Prot for OR5B12 Gene

  • Odorant receptor.

Gene Wiki entry for OR5B12 Gene

Additional gene information for OR5B12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5B12 Gene

Genomics for OR5B12 Gene

Regulatory Elements for OR5B12 Gene

Enhancers for OR5B12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H058632 0.3 FANTOM5 13.7 -189.5 -189483 0 OR5B12 OR1S1 OR5B3 OR10W1 OR10Q1 OR5B2 OR9Q2 OR1S2 ENSG00000280010 ENSG00000197254
GH11H057946 0.3 FANTOM5 9.2 +496.3 496324 0 OR10W1 OR10Q1 OR9Q2 OR5B2 OR9Q1 OR5B12 MED19 OR5B3 OR1S1 OR9I1
GH11H058033 0.3 FANTOM5 1.9 +408.8 408796 0 OR6Q1 OR1S1 OR5B12 OR9I1 ENSG00000255146
GH11H058495 0.5 FANTOM5 0.2 -53.1 -53073 0 IKZF1 EED JUNB OR5B21 LPXN ENSG00000255299 OR5B12
GH11H058497 0.4 ENCODE 0.2 -55.9 -55927 1 FOXA2 LOC100420019 LPXN ENSG00000255299 OR5B12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5B12 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5B12 Gene

Chromosome:
11
Start:
58,439,077 bp from pter
End:
58,442,758 bp from pter
Size:
3,682 bases
Orientation:
Minus strand

Genomic View for OR5B12 Gene

Genes around OR5B12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5B12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5B12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B12 Gene

Proteins for OR5B12 Gene

  • Protein details for OR5B12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R08-OR5BC_HUMAN
    Recommended name:
    Olfactory receptor 5B12
    Protein Accession:
    Q96R08
    Secondary Accessions:
    • B2RNL2
    • Q6IEV5

    Protein attributes for OR5B12 Gene

    Size:
    314 amino acids
    Molecular mass:
    35182 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B12 Gene

Post-translational modifications for OR5B12 Gene

  • Glycosylation at Asn3 and Asn261
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5B12 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5B12 Gene

Domains & Families for OR5B12 Gene

Gene Families for OR5B12 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR5B12 Gene

Suggested Antigen Peptide Sequences for OR5B12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96R08

UniProtKB/Swiss-Prot:

OR5BC_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5B12: view

Function for OR5B12 Gene

Molecular function for OR5B12 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5B12 Gene

Gene Ontology (GO) - Molecular Function for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5B12: view

Phenotypes for OR5B12 Gene

genes like me logo Genes that share phenotypes with OR5B12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5B12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5B12 Gene

Localization for OR5B12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR5B12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5B12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR5B12 Gene

Pathways & Interactions for OR5B12 Gene

genes like me logo Genes that share pathways with OR5B12: view

Pathways by source for OR5B12 Gene

Interacting Proteins for OR5B12 Gene

Gene Ontology (GO) - Biological Process for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B12: view

No data available for SIGNOR curated interactions for OR5B12 Gene

Drugs & Compounds for OR5B12 Gene

No Compound Related Data Available

Transcripts for OR5B12 Gene

mRNA/cDNA for OR5B12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR5B12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B12 Gene

No ASD Table

Relevant External Links for OR5B12 Gene

GeneLoc Exon Structure for
OR5B12
ECgene alternative splicing isoforms for
OR5B12

Expression for OR5B12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5B12 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5B12 Gene:

OR5B12

SOURCE GeneReport for Unigene cluster for OR5B12 Gene:

Hs.553754
genes like me logo Genes that share expression patterns with OR5B12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5B12 Gene

Orthologs for OR5B12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC786211 33
  • 84.03 (n)
-- 34
  • 79 (a)
OneToMany
-- 34
  • 78 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Olr340 33
  • 81.63 (n)
mouse
(Mus musculus)
Mammalia Or5b12 52 Olfr1448 34
  • 81 (a)
OneToMany
Or5b12b 52 Olfr1445 33 16 34
  • 80.89 (n)
Or5b116 52 Olfr1471
  • chr19:13,445,014-13,445,955
Or5b117 52 Olfr1472
  • chr19:13,453,574-13,454,515
Or5b118 52 Olfr1474
  • chr19:13,470,972-13,471,913
Or5b119 52 Olfr1475
  • chr19:13,479,255-13,480,325
Or5b120 52 Olfr1477
  • chr19:13,502,345-13,503,289
Or5b121 52 Olfr1480
  • chr19:13,529,612-13,530,619
Or5b122 52 Olfr1484
  • chr19:13,585,240-13,586,250
Or5b123 52 Olfr1487
  • chr19:13,619,164-13,620,108
Or5b124 52 Olfr1489
  • chr19:13,633,113-13,634,051
Or5bc4-ps 52 Olfr1473-ps1
  • chr19:13,462,690-13,463,635
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
ManyToMany
-- 34
  • 74 (a)
ManyToMany
-- 34
  • 74 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
-- 34
  • 73 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 75 (a)
ManyToMany
Species where no ortholog for OR5B12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B12 Gene

ENSEMBL:
Gene Tree for OR5B12 (if available)
TreeFam:
Gene Tree for OR5B12 (if available)

Paralogs for OR5B12 Gene

Paralogs for OR5B12 Gene

(451) SIMAP similar genes for OR5B12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for OR5B12 Gene

genes like me logo Genes that share paralogs with OR5B12: view

Variants for OR5B12 Gene

Sequence variations from dbSNP and Humsavar for OR5B12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000388672 -- 58,441,728(+) TATGG(A/T)TATAA upstream-variant-2KB
rs1000491598 -- 58,441,099(+) ACCAT(C/T)AGTCG upstream-variant-2KB
rs1000822935 -- 58,441,361(+) GTTGA(C/T)ATTCC upstream-variant-2KB
rs1001125599 -- 58,440,131(+) TCAGT(C/T)ACCTC reference, synonymous-codon
rs1001822618 -- 58,441,869(+) TAGAT(A/G)AGGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5B12 Gene

Variant ID Type Subtype PubMed ID
nsv517849 CNV gain 19592680

Variation tolerance for OR5B12 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5B12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5B12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5B12 Gene

Disorders for OR5B12 Gene

Relevant External Links for OR5B12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5B12

No disorders were found for OR5B12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5B12 Gene

Publications for OR5B12 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 2 3 4 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for OR5B12 Gene

Sources for OR5B12 Gene

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