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Aliases for OR5B12 Gene

Aliases for OR5B12 Gene

  • Olfactory Receptor, Family 5, Subfamily B, Member 12 2 3
  • Olfactory Receptor OR11-241 3 4
  • Olfactory Receptor 5B16 3 4
  • OR5B12P 3 4
  • OR5B16 3 4
  • Olfactory Receptor, Family 5, Subfamily B, Member 12 Pseudogene 3
  • Olfactory Receptor, Family 5, Subfamily B, Member 16 3
  • Olfactory Receptor 5B12 3
  • OR11-241 3
  • OST743 3

External Ids for OR5B12 Gene

Previous Symbols for OR5B12 Gene

  • OR5B12P
  • OR5B16

Summaries for OR5B12 Gene

Entrez Gene Summary for OR5B12 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5B12 Gene

OR5B12 (Olfactory Receptor, Family 5, Subfamily B, Member 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR8H2.

UniProtKB/Swiss-Prot for OR5B12 Gene

  • Odorant receptor.

Gene Wiki entry for OR5B12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5B12 Gene

Genomics for OR5B12 Gene

Genomic Location for OR5B12 Gene

Start:
58,439,120 bp from pter
End:
58,440,173 bp from pter
Size:
1,054 bases
Orientation:
Minus strand

Genomic View for OR5B12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5B12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5B12 Gene

Regulatory Elements for OR5B12 Gene

Proteins for OR5B12 Gene

  • Protein details for OR5B12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96R08-OR5BC_HUMAN
    Recommended name:
    Olfactory receptor 5B12
    Protein Accession:
    Q96R08
    Secondary Accessions:
    • B2RNL2
    • Q6IEV5

    Protein attributes for OR5B12 Gene

    Size:
    314 amino acids
    Molecular mass:
    35182 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5B12 Gene

Proteomics data for OR5B12 Gene at MOPED

Post-translational modifications for OR5B12 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn3 and Asn261

Other Protein References for OR5B12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5B12 Gene

Domains for OR5B12 Gene

Gene Families for OR5B12 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5B12 Gene

UniProtKB/Swiss-Prot:

OR5BC_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96R08
genes like me logo Genes that share domains with OR5B12: view

Function for OR5B12 Gene

Molecular function for OR5B12 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5B12: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5B12 Gene

Localization for OR5B12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5B12 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5B12 Gene COMPARTMENTS Subcellular localization image for OR5B12 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5B12: view

Pathways for OR5B12 Gene

genes like me logo Genes that share pathways with OR5B12: view

Pathways by source for OR5B12 Gene

Interacting Proteins for OR5B12 Gene

Gene Ontology (GO) - Biological Process for OR5B12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5B12: view

Transcripts for OR5B12 Gene

mRNA/cDNA for OR5B12 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5B12 Gene

No ASD Table

Relevant External Links for OR5B12 Gene

GeneLoc Exon Structure for
OR5B12
ECgene alternative splicing isoforms for
OR5B12

Expression for OR5B12 Gene

mRNA expression in normal human tissues for OR5B12 Gene

SOURCE GeneReport for Unigene cluster for OR5B12 Gene Hs.553754

genes like me logo Genes that share expressions with OR5B12: view

Orthologs for OR5B12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5B12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 37
  • 79 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
LOC786211 36
  • 84.03 (n)
  • 84.03 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 75 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1445 36
  • 80.89 (n)
  • 80.57 (a)
Olfr1445 37
  • 81 (a)
OneToMany
Olfr1448 16
Olfr1448 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 67 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
-- 37
  • 69 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 59 (a)
ManyToMany
-- 37
  • 67 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 76 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 70 (a)
ManyToMany
-- 37
  • 72 (a)
ManyToMany
-- 37
  • 73 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 63 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr340 36
  • 81.63 (n)
  • 79.94 (a)
Species with no ortholog for OR5B12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5B12 Gene

ENSEMBL:
Gene Tree for OR5B12 (if available)
TreeFam:
Gene Tree for OR5B12 (if available)

Paralogs for OR5B12 Gene

Selected SIMAP similar genes for OR5B12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5B12: view

Variants for OR5B12 Gene

Sequence variations from dbSNP and Humsavar for OR5B12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4938895 - 58,439,731(+) CAGGC(A/G)AGCAC missense, reference
rs7929868 -- 58,441,945(+) AAATC(C/T)CTGAT upstream-variant-2KB
rs10896780 -- 58,438,755(+) GGAGC(A/G)CTGAA downstream-variant-500B
rs10896781 -- 58,438,764(+) AAAAC(A/G)TGCTC downstream-variant-500B
rs10896782 -- 58,438,841(+) CTTTA(C/T)CCAAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR5B12 Gene

Variant ID Type Subtype PubMed ID
nsv517849 CNV Gain 19592680

Relevant External Links for OR5B12 Gene

HapMap Linkage Disequilibrium report
OR5B12

Disorders for OR5B12 Gene

No disorders were found for OR5B12 Gene.

No data available for UniProtKB/Swiss-Prot for OR5B12 Gene

Publications for OR5B12 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T. … Shamir R. (Genomics 2002) 2 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5B12 Gene

  • antibodies-online peptides for OR5B12
  • antibodies-online antibodies for OR5B12
  • antibodies-online kits for OR5B12

Sources for OR5B12 Gene

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