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Aliases for OR5AS1 Gene

Aliases for OR5AS1 Gene

  • Olfactory Receptor, Family 5, Subfamily AS, Member 1 2 3
  • Olfactory Receptor OR11-168 3 4
  • Olfactory Receptor 5AS1 3
  • OR11-168 3

External Ids for OR5AS1 Gene

Summaries for OR5AS1 Gene

Entrez Gene Summary for OR5AS1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AS1 Gene

OR5AS1 (Olfactory Receptor, Family 5, Subfamily AS, Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5I1.

UniProtKB/Swiss-Prot for OR5AS1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AS1 Gene

Genomics for OR5AS1 Gene

Genomic Location for OR5AS1 Gene

Start:
56,030,419 bp from pter
End:
56,031,393 bp from pter
Size:
975 bases
Orientation:
Plus strand

Genomic View for OR5AS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AS1 Gene

Regulatory Elements for OR5AS1 Gene

Proteins for OR5AS1 Gene

  • Protein details for OR5AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N127-O5AS1_HUMAN
    Recommended name:
    Olfactory receptor 5AS1
    Protein Accession:
    Q8N127
    Secondary Accessions:
    • Q6IFB8

    Protein attributes for OR5AS1 Gene

    Size:
    324 amino acids
    Molecular mass:
    36653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AS1 Gene

Proteomics data for OR5AS1 Gene at MOPED

Post-translational modifications for OR5AS1 Gene

Other Protein References for OR5AS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5AS1 Gene

Domains for OR5AS1 Gene

Gene Families for OR5AS1 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5AS1 Gene

Suggested Antigen Peptide Sequences for OR5AS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N127

UniProtKB/Swiss-Prot:

O5AS1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q8N127
genes like me logo Genes that share domains with OR5AS1: view

Function for OR5AS1 Gene

Molecular function for OR5AS1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AS1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5AS1 Gene

Localization for OR5AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AS1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5AS1 Gene COMPARTMENTS Subcellular localization image for OR5AS1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5AS1: view

Pathways for OR5AS1 Gene

genes like me logo Genes that share pathways with OR5AS1: view

Pathways by source for OR5AS1 Gene

Interacting Proteins for OR5AS1 Gene

Gene Ontology (GO) - Biological Process for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AS1: view

Transcripts for OR5AS1 Gene

mRNA/cDNA for OR5AS1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AS1 Gene

No ASD Table

Relevant External Links for OR5AS1 Gene

GeneLoc Exon Structure for
OR5AS1
ECgene alternative splicing isoforms for
OR5AS1

Expression for OR5AS1 Gene

mRNA expression in normal human tissues for OR5AS1 Gene

SOURCE GeneReport for Unigene cluster for OR5AS1 Gene Hs.553625

genes like me logo Genes that share expressions with OR5AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR5AS1 Gene

Orthologs for OR5AS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466544 35
  • 98.97 (n)
  • 98.46 (a)
OR5AS1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR5AS1 35
  • 86.3 (n)
  • 87.38 (a)
OR5AS1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR5AS1 35
  • 87.95 (n)
  • 89.58 (a)
OR5AS1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1111 35
  • 80.91 (n)
  • 82.2 (a)
Olfr1111 16
Olfr1111 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR5AS1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr544 35
  • 79.61 (n)
  • 80.91 (a)
chicken
(Gallus gallus)
Aves OR5AS1 35
  • 62.74 (n)
  • 60.19 (a)
OR5AS1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491956 35
  • 58.17 (n)
  • 49.67 (a)
Species with no ortholog for OR5AS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AS1 Gene

ENSEMBL:
Gene Tree for OR5AS1 (if available)
TreeFam:
Gene Tree for OR5AS1 (if available)

Paralogs for OR5AS1 Gene

Paralogs for OR5AS1 Gene

Selected SIMAP similar genes for OR5AS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5AS1: view

Variants for OR5AS1 Gene

Sequence variations from dbSNP and Humsavar for OR5AS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1482010 -- 56,029,243(+) ATCTA(A/G)CTTCC upstream-variant-2KB
rs1482011 -- 56,030,676(+) TTCTT(A/G)GCATC synonymous-codon, reference
rs2512767 -- 56,030,169(-) ATAAT(A/G)TAGTA upstream-variant-2KB
rs2512950 -- 56,028,694(-) GGTTT(G/T)GTAGT upstream-variant-2KB
rs10674368 -- 56,029,551(+) CACAC(-/AC/ACAC)GACTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5AS1 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv821668 CNV Loss 15273396
nsv437718 CNV Loss 16327808
nsv468568 CNV Loss 19166990
nsv469959 CNV Loss 18288195
nsv517590 CNV Loss 19592680
dgv52e55 CNV Loss 17911159
dgv384e1 CNV Complex 17122850
nsv521440 CNV Loss 19592680
nsv832160 CNV Gain 17160897

Relevant External Links for OR5AS1 Gene

HapMap Linkage Disequilibrium report
OR5AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AS1 Gene

Disorders for OR5AS1 Gene

Relevant External Links for OR5AS1

Genetic Association Database (GAD)
OR5AS1
genes like me logo Genes that share disorders with OR5AS1: view

No data available for UniProtKB/Swiss-Prot for OR5AS1 Gene

Publications for OR5AS1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 48

Products for OR5AS1 Gene

  • antibodies-online peptides for OR5AS1
  • antibodies-online antibodies for OR5AS1
  • antibodies-online kits for OR5AS1

Sources for OR5AS1 Gene

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