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OR5AS1 Gene

protein-coding   GIFtS: 46
GCID: GC11P055797

Olfactory Receptor, Family 5, Subfamily AS, Member 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily AS, Member 11 2
Olfactory Receptor OR11-1682 3
OR11-1682
Olfactory Receptor 5AS12

External Ids:    HGNC: 152611   Entrez Gene: 2194472   Ensembl: ENSG000001817857   UniProtKB: Q8N1273   

Export aliases for OR5AS1 gene to outside databases

Previous GC identifers: GC11U990453 GC11P055575 GC11P055554


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5AS1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5AS1 Gene:
OR5AS1 (olfactory receptor, family 5, subfamily AS, member 1) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot: O5AS1_HUMAN, Q8N127
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5AS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5AS1 gene promoter:
         HOXA9B   HOXA9   Pbx1a   ATF-2   Meis-1b   GATA-1   CRE-BP1   GATA-6   En-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5AS1 promoter sequence
   Search Chromatin IP Primers for OR5AS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR5AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5AS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P055797:  view genomic region     (about GC identifiers)

Start:
55,797,895 bp from pter      End:
55,798,866 bp from pter
Size:
972 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O5AS1_HUMAN, Q8N127 (See protein sequence)
Recommended Name: Olfactory receptor 5AS1  
Size: 324 amino acids; 36653 Da
Secondary accessions: Q6IFB8

Explore the universe of human proteins at neXtProt for OR5AS1: NX_Q8N127

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • HORDE protein sequence for OR5AS1
    REFSEQ proteins: NP_001001921.1  
    ENSEMBL proteins: 
     ENSP00000324111  
    Reactome Protein details: Q8N127

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8N127

    ProtoNet protein and cluster: Q8N127

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O5AS1_HUMAN, Q8N127
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5AS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O5AS1_HUMAN, Q8N127
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5AS1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR5AS1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O5AS1_HUMAN, Q8N127: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5AS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5AS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5AS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5AS1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5AS1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5AS1
    Interactions:

        Search GeneGlobe Interaction Network for OR5AS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5AS1 (ENSP000003241114) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR14C36ENSP000003245344STRING: ENSP00000324534
    GNALENSP000003340514STRING: ENSP00000334051
    GNGT1ENSP000002485724STRING: ENSP00000248572
    OR10A3ENSP000003539884STRING: ENSP00000353988
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5AS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for OR5AS1 (O5AS1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5AS1 gene: 
    NM_001001921.1  

    Unigene Cluster for OR5AS1:

    Olfactory receptor, family 5, subfamily AS, member 1
    Hs.553625
    Unigene Representative Sequence: NM_001001921
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313555(uc010riw.2)
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    1 AceView cDNA sequence:

    NM_001001921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5AS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAATCCAA
    OR5AS1 Expression
    About this image

    OR5AS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.553625
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR5AS1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr11111 , 5 olfactory receptor 11111, 5 80.91(n)1
    82.2(a)1
      2 (49.86 cM)5
    2585861  NM_146593.21  NP_666804.21 
     871497215 
    chicken
    (Gallus gallus)
    Aves OR5AS11 olfactory receptor, family 5, subfamily AS, member more 62.74(n)
    60.19(a)
      428825  XM_004941305.1  XP_004941362.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004919561 olfactory receptor 1020-like 58.17(n)
    49.67(a)
      100491956  XM_002937039.2  XP_002937085.2 


    ENSEMBL Gene Tree for OR5AS1 (if available)
    TreeFam Gene Tree for OR5AS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5AS1 gene
    OR5W22  OR5AR12  OR5C12  OR5T22  OR5T12  OR5I12  OR5J22  OR5T32  
    Selected SIMAP similar genes for OR5AS1 using alignment to 1 protein entry:     O5AS1_HUMAN(see all similar genes):
    OR5AR1    OR5AP2    OR5I1    OR5E1P    OR5B12    OR5B21
    OR5C1    OR5G3    OR5J2    OR5W2    OR8U1    OR8U9
    OR5A2    OR5B2    OR5A1    OR5AL1    OR5AU1    OR5F1

    Find genes that share paralogs with OR5AS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5AS1 (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766923961,2
    F--55795896(+) CTCAGC/TACAAT 1 -- us2k10--------
    rs1898911251,2
    --55795960(+) GCGTAC/TCTCCT 1 -- us2k10--------
    rs1832697551,2
    --55795961(+) CGTATC/TTCCTT 1 -- us2k10--------
    rs798240681,2
    F--55796100(+) GCAGCA/GTGAGA 1 -- us2k10--------
    rs25129501,2
    C,F,O,A,H--55796170(-) GGTTTT/GGTAGT 1 -- us2k1 tfbs324Minor allele frequency- G:0.47NA NS EA WA CSA 2485
    rs1864992521,2
    --55796362(+) GCTAGG/TGTTGG 1 -- us2k10--------
    rs1905432121,2
    --55796372(+) GCCAGA/GAATAA 1 -- us2k10--------
    rs123609641,2
    F,H--55796464(+) AGAGTA/C/TGGGAT 1 -- us2k14NS EA 416
    rs1882134151,2
    --55796567(+) CTTCTC/TTTTTC 1 -- us2k10--------
    rs1927964501,2
    --55796588(+) GAAGAA/TTCCTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5AS1 ( 55797895 - 55798866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for OR5AS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv52e55CNV Loss17911159
    nsv521440CNV Loss19592680
    nsv821668CNV Loss15273396
    nsv437718CNV Loss16327808
    nsv468568CNV Loss19166990
    nsv517590CNV Loss19592680
    nsv469959CNV Loss18288195
    esv2751030CNV Gain17911159
    nsv832160CNV Gain17160897
    dgv384e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR5AS1           About GenesLikeMe

    Genetic Association Database (GAD): OR5AS1

    Export disorders for OR5AS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5AS1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5AS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    3. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219447 HGNC: 15261 AceView: OR5AS1 Ensembl:ENSG00000181785 euGenes: HUgn219447
    ECgene: OR5AS1 Kegg: 219447 H-InvDB: OR5AS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5AS1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5AS1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5AS1 gene:
    Search GeneIP for patents involving OR5AS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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