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Aliases for OR5AS1 Gene

Aliases for OR5AS1 Gene

  • Olfactory Receptor Family 5 Subfamily AS Member 1 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AS, Member 1 2 3
  • Olfactory Receptor OR11-168 3 4
  • OR11-168 3

External Ids for OR5AS1 Gene

Previous GeneCards Identifiers for OR5AS1 Gene

  • GC11U990453
  • GC11P055575
  • GC11P055554
  • GC11P055797

Summaries for OR5AS1 Gene

Entrez Gene Summary for OR5AS1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AS1 Gene

OR5AS1 (Olfactory Receptor Family 5 Subfamily AS Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5I1.

UniProtKB/Swiss-Prot for OR5AS1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AS1 Gene

Genomics for OR5AS1 Gene

Regulatory Elements for OR5AS1 Gene

Genomic Location for OR5AS1 Gene

Chromosome:
11
Start:
56,030,419 bp from pter
End:
56,031,393 bp from pter
Size:
975 bases
Orientation:
Plus strand

Genomic View for OR5AS1 Gene

Genes around OR5AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AS1 Gene

Proteins for OR5AS1 Gene

  • Protein details for OR5AS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N127-O5AS1_HUMAN
    Recommended name:
    Olfactory receptor 5AS1
    Protein Accession:
    Q8N127
    Secondary Accessions:
    • Q6IFB8

    Protein attributes for OR5AS1 Gene

    Size:
    324 amino acids
    Molecular mass:
    36653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AS1 Gene

Proteomics data for OR5AS1 Gene at MOPED

Post-translational modifications for OR5AS1 Gene

Other Protein References for OR5AS1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AS1 Gene

Domains & Families for OR5AS1 Gene

Gene Families for OR5AS1 Gene

Protein Domains for OR5AS1 Gene

Suggested Antigen Peptide Sequences for OR5AS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N127

UniProtKB/Swiss-Prot:

O5AS1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AS1: view

Function for OR5AS1 Gene

Molecular function for OR5AS1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AS1: view
genes like me logo Genes that share phenotypes with OR5AS1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AS1 Gene

Localization for OR5AS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AS1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5AS1 Gene COMPARTMENTS Subcellular localization image for OR5AS1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AS1: view

Pathways & Interactions for OR5AS1 Gene

genes like me logo Genes that share pathways with OR5AS1: view

Pathways by source for OR5AS1 Gene

Interacting Proteins for OR5AS1 Gene

Gene Ontology (GO) - Biological Process for OR5AS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AS1: view

No data available for SIGNOR curated interactions for OR5AS1 Gene

Drugs & Compounds for OR5AS1 Gene

No Compound Related Data Available

Transcripts for OR5AS1 Gene

mRNA/cDNA for OR5AS1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AS1 Gene

No ASD Table

Relevant External Links for OR5AS1 Gene

GeneLoc Exon Structure for
OR5AS1
ECgene alternative splicing isoforms for
OR5AS1

Expression for OR5AS1 Gene

mRNA expression in normal human tissues for OR5AS1 Gene

SOURCE GeneReport for Unigene cluster for OR5AS1 Gene Hs.553625

genes like me logo Genes that share expression patterns with OR5AS1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5AS1 Gene

Orthologs for OR5AS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR5AS1 36
  • 98 (a)
OneToOne
LOC466544 35
  • 98.97 (n)
  • 98.46 (a)
cow
(Bos Taurus)
Mammalia OR5AS1 36
  • 83 (a)
OneToOne
OR5AS1 35
  • 86.3 (n)
  • 87.38 (a)
dog
(Canis familiaris)
Mammalia OR5AS1 35
  • 87.95 (n)
  • 89.58 (a)
OR5AS1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1111 16
Olfr1111 36
  • 81 (a)
OneToOne
Olfr1111 35
  • 80.91 (n)
  • 82.2 (a)
oppossum
(Monodelphis domestica)
Mammalia OR5AS1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr544 35
  • 79.61 (n)
  • 80.91 (a)
chicken
(Gallus gallus)
Aves OR5AS1 35
  • 62.74 (n)
  • 60.19 (a)
OR5AS1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491956 35
  • 58.17 (n)
  • 49.67 (a)
Species with no ortholog for OR5AS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AS1 Gene

ENSEMBL:
Gene Tree for OR5AS1 (if available)
TreeFam:
Gene Tree for OR5AS1 (if available)

Paralogs for OR5AS1 Gene

Paralogs for OR5AS1 Gene

(449) SIMAP similar genes for OR5AS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5AS1: view

Variants for OR5AS1 Gene

Sequence variations from dbSNP and Humsavar for OR5AS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12224086 - 56,030,783(+) TGACC(A/G/T)CTATG reference, missense
rs17600939 - 56,031,347(+) TGGAT(A/G)TTCAA reference, missense
rs11827042 -- 56,030,208(+) TGCTA(C/T)CAATG upstream-variant-2KB
rs17600820 -- 56,029,136(+) AGAAA(A/G)GAGGT upstream-variant-2KB
rs61889972 -- 56,029,381(+) TGCAG(A/C)CCTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5AS1 Gene

Variant ID Type Subtype PubMed ID
esv2751030 CNV Gain 17911159
nsv821668 CNV Loss 15273396
nsv437718 CNV Loss 16327808
nsv468568 CNV Loss 19166990
nsv469959 CNV Loss 18288195
nsv517590 CNV Loss 19592680
dgv52e55 CNV Loss 17911159
dgv384e1 CNV Complex 17122850
nsv521440 CNV Loss 19592680
nsv832160 CNV Gain 17160897

Variation tolerance for OR5AS1 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5AS1 Gene

HapMap Linkage Disequilibrium report
OR5AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AS1 Gene

Disorders for OR5AS1 Gene

Relevant External Links for OR5AS1

Genetic Association Database (GAD)
OR5AS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5AS1

No disorders were found for OR5AS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AS1 Gene

Publications for OR5AS1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 67

Products for OR5AS1 Gene

Sources for OR5AS1 Gene

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