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Aliases for OR5AR1 Gene

Aliases for OR5AR1 Gene

  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor OR11-209 3 4
  • Olfactory Receptor, Family 5, Subfamily AR, Member 1 2
  • Olfactory Receptor 5AR1 3
  • OR11-209 3

External Ids for OR5AR1 Gene

Previous GeneCards Identifiers for OR5AR1 Gene

  • GC11U990454
  • GC11P056207
  • GC11P056187
  • GC11P056431

Summaries for OR5AR1 Gene

Entrez Gene Summary for OR5AR1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AR1 Gene

OR5AR1 (Olfactory Receptor, Family 5, Subfamily AR, Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR5AR1 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AR1 Gene

Genomics for OR5AR1 Gene

Regulatory Elements for OR5AR1 Gene

Genomic Location for OR5AR1 Gene

Start:
56,663,686 bp from pter
End:
56,664,618 bp from pter
Size:
933 bases
Orientation:
Plus strand

Genomic View for OR5AR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OR5AR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AR1 Gene

Proteins for OR5AR1 Gene

  • Protein details for OR5AR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGP9-O5AR1_HUMAN
    Recommended name:
    Olfactory receptor 5AR1
    Protein Accession:
    Q8NGP9
    Secondary Accessions:
    • Q6IF61

    Protein attributes for OR5AR1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34815 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AR1 Gene

Proteomics data for OR5AR1 Gene at MOPED

Post-translational modifications for OR5AR1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AR1 Gene

Domains for OR5AR1 Gene

Gene Families for OR5AR1 Gene

HGNC:
  • OR5 :GPCR / Class A : Olfactory receptors

Protein Domains for OR5AR1 Gene

Suggested Antigen Peptide Sequences for OR5AR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGP9

UniProtKB/Swiss-Prot:

O5AR1_HUMAN :
  • Q8NGP9
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AR1: view

Function for OR5AR1 Gene

Molecular function for OR5AR1 Gene

UniProtKB/Swiss-Prot Function: Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AR1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5AR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OR5AR1 Gene

Localization for OR5AR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5AR1 Gene COMPARTMENTS Subcellular localization image for OR5AR1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OR5AR1: view

Pathways for OR5AR1 Gene

genes like me logo Genes that share pathways with OR5AR1: view

Pathways by source for OR5AR1 Gene

Interacting Proteins for OR5AR1 Gene

Gene Ontology (GO) - Biological Process for OR5AR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AR1: view

Transcripts for OR5AR1 Gene

mRNA/cDNA for OR5AR1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OR5AR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for OR5AR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AR1 Gene

No ASD Table

Relevant External Links for OR5AR1 Gene

GeneLoc Exon Structure for
OR5AR1
ECgene alternative splicing isoforms for
OR5AR1

Expression for OR5AR1 Gene

mRNA expression in normal human tissues for OR5AR1 Gene

SOURCE GeneReport for Unigene cluster for OR5AR1 Gene Hs.553633

genes like me logo Genes that share expressions with OR5AR1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for OR5AR1 Gene

Orthologs for OR5AR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747894 35
  • 99.25 (n)
  • 98.06 (a)
cow
(Bos Taurus)
Mammalia OR5AR1 35
  • 90.86 (n)
  • 93.55 (a)
dog
(Canis familiaris)
Mammalia OR5AR1 35
  • 90.54 (n)
  • 93.55 (a)
mouse
(Mus musculus)
Mammalia Olfr1019 35
  • 87.63 (n)
  • 92.58 (a)
Olfr1019 16
rat
(Rattus norvegicus)
Mammalia Olr462 35
  • 87.74 (n)
  • 92.58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732693 35
  • 55.74 (n)
  • 47.08 (a)
Species with no ortholog for OR5AR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AR1 Gene

ENSEMBL:
Gene Tree for OR5AR1 (if available)
TreeFam:
Gene Tree for OR5AR1 (if available)

Paralogs for OR5AR1 Gene

Selected SIMAP similar genes for OR5AR1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5AR1: view

No data available for Paralogs for OR5AR1 Gene

Variants for OR5AR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AR1 Gene

Q8NGP9-O5AR1_HUMAN
A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional diversity thus producing a pseudogene

Sequence variations from dbSNP and Humsavar for OR5AR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1355247 -- 56,662,680(+) TTTTC(C/T)AAAGT upstream-variant-2KB
rs1355248 -- 56,662,855(+) TTTAC(A/G)CAATT upstream-variant-2KB
rs7935503 -- 56,661,716(+) aactc(C/T)gtctt upstream-variant-2KB
rs10896501 -- 56,662,480(+) TATTT(G/T)GAGAT upstream-variant-2KB
rs11228709 -- 56,663,583(+) AATAT(C/T)TCTGG upstream-variant-2KB

Relevant External Links for OR5AR1 Gene

HapMap Linkage Disequilibrium report
OR5AR1

No data available for Structural Variations from Database of Genomic Variants (DGV) for OR5AR1 Gene

Disorders for OR5AR1 Gene

Relevant External Links for OR5AR1

Genetic Association Database (GAD)
OR5AR1
genes like me logo Genes that share disorders with OR5AR1: view

No data available for UniProtKB/Swiss-Prot for OR5AR1 Gene

Publications for OR5AR1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  2. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 3 48
  3. Genetic elucidation of human hyperosmia to isovaleric acid. (PMID: 17973576) Menashe I. … Lancet D. (PLoS Biol. 2007) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5AR1 Gene

Sources for OR5AR1 Gene

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