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OR5AR1 Gene

protein-coding   GIFtS: 47
GCID: GC11P056431

Olfactory Receptor, Family 5, Subfamily AR, Member 1 (Gene/Pseudogene)

(Previous names: olfactory receptor, family 5, subfamily AR, member 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily AR, Member 1
(Gene/Pseudogene)1
Olfactory Receptor, Family 5, Subfamily AR, Member 11 2
Olfactory Receptor OR11-2092 3
OR11-2092
Olfactory Receptor 5AR12

External Ids:    HGNC: 152601   Entrez Gene: 2194932   Ensembl: ENSG000001724597   UniProtKB: Q8NGP93   

Export aliases for OR5AR1 gene to outside databases

Previous GC identifers: GC11U990454 GC11P056207 GC11P056187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5AR1 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5AR1 Gene:
OR5AR1 (olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5W2.

UniProtKB/Swiss-Prot: O5AR1_HUMAN, Q8NGP9
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5AR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5AR1 gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   RP58   Tal-1   Pax-6   Nkx3-1 v3   Nkx3-1 v1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOR5AR1 promoter sequence
   Search Chromatin IP Primers for OR5AR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5AR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q11

OR5AR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5AR1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P056431:  view genomic region     (about GC identifiers)

Start:
56,431,162 bp from pter      End:
56,432,091 bp from pter
Size:
930 bases      Orientation:
plus strand

1 alternative location:
Chr11+,NW_003571044 482,040-482,972     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: O5AR1_HUMAN, Q8NGP9 (See protein sequence)
Recommended Name: Olfactory receptor 5AR1  
Size: 310 amino acids; 34815 Da
Secondary accessions: Q6IF61

Explore the universe of human proteins at neXtProt for OR5AR1: NX_Q8NGP9

Explore proteomics data for OR5AR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5
  • Modification sites at PhosphoSitePlus
  • HORDE protein sequence for OR5AR1

    See OR5AR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004730.1  
    ENSEMBL proteins: 
     ENSP00000302639  
    Reactome Protein details: Q8NGP9

    OR5AR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for OR5AR1

     
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    antibodies-online antibodies for OR5AR1 (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q8NGP9

    ProtoNet protein and cluster: Q8NGP9

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O5AR1_HUMAN, Q8NGP9
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with OR5AR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O5AR1_HUMAN, Q8NGP9
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity IEA--
         
    Find genes that share ontologies with OR5AR1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for OR5AR1

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O5AR1_HUMAN, Q8NGP9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with OR5AR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5AR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with OR5AR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5AR1
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5AR1):
        Olfactory transduction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5AR1
    Interactions:

        Search GeneGlobe Interaction Network for OR5AR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5AR1 (ENSP000003026394) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10A4ENSP000003691574STRING: ENSP00000369157
    OR10J5ENSP000003344414STRING: ENSP00000334441
    OR4E2ENSP000003861954STRING: ENSP00000386195
    OR4F6ENSP000003275254STRING: ENSP00000327525
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OR5AR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5AR1 (O5AR1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OR5AR1 gene: 
    NM_001004730.1  

    Unigene Cluster for OR5AR1:

    Olfactory receptor, family 5, subfamily AR, member 1
    Hs.553633
    Unigene Representative Sequence: BC140745
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302969(uc010rjm.2)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat OR5AR1

    Additional mRNA sequence: BC140745.1 

    1 AceView cDNA sequence:

    NM_001004730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5AR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OR5AR1 Expression
    About this image

    OR5AR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5AR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553633
        Custom PCR Arrays for OR5AR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5AR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OR5AR1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr10191 , 5 olfactory receptor 10191, 5 87.63(n)1
    92.58(a)1
      2 (49.68 cM)5
    2590171  NM_147015.11  NP_667226.11 
     858408575 
    lizard
    (Anolis carolinensis)
    Reptilia OR5AR16
    olfactory receptor, family 5, subfamily AR, member...
    61(a)
    1 ↔ 1
    1(92343511-92344455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017326931 olfactory receptor 5V1-like 55.74(n)
    47.08(a)
      101732693  XM_004917474.1  XP_004917531.1 


    ENSEMBL Gene Tree for OR5AR1 (if available)
    TreeFam Gene Tree for OR5AR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5AR1 gene
    OR5W22  OR5C12  OR5T22  OR5T12  OR5AS12  OR5I12  OR5J22  OR5T32  
    Selected SIMAP similar genes for OR5AR1 using alignment to 2 protein entries:     O5AR1_HUMAN (see all proteins) (see all similar genes):
    OR5AS1    OR5B21    OR5B12    OR5AP2    OR5B2    OR5A2
    OR5R1    OR5T1    OR8D1    OR8J2    OR5B3    OR5F1
    OR8B3    OR8U1    OR8U9    OR5AU1    OR5T3    OR5W2

    Find genes that share paralogs with OR5AR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    O5AR1_HUMAN, Q8NGP9: A stop codon in the gene coding for this protein at position Gln-19 is responsible for functional
    diversity thus producing a pseudogene


    Selected SNPs for OR5AR1 (see all 126)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472830271,2
    --56429184(+) CACAGC/TGAAAC 1 -- us2k10--------
    rs1391376111,2
    --56429185(+) ACAGCC/GAAACT 1 -- us2k10--------
    rs79355031,2
    C,F--56429192(+) aactcC/Tgtctt 1 -- us2k11Minor allele frequency- T:0.14WA 118
    rs1812862111,2
    --56429258(+) CTAGAC/TAGGTC 1 -- us2k10--------
    rs122804871,2
    C,F--56429356(+) GTTGTT/CGTTTG 1 -- us2k1 tfbs32Minor allele frequency- C:0.08NA EA 240
    rs2008665971,2
    C--56429369(-) AAAACA/GAAAAA 1 -- us2k10--------
    rs786243061,2
    C,F--56429370(+) TTTTCG/CTTTTT 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs776071821,2
    C,F--56429379(+) TTCCTG/AGTAGG 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1847098401,2
    --56429383(+) TGGTAG/TGTTAT 1 -- us2k10--------
    rs1895209491,2
    --56429524(+) CCCCTC/TAGCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OR5AR1 ( 56431162 - 56432091 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OR5AR1: --
    Human Gene Mutation Database (HGMD): OR5AR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OR5AR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OR5AR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OR5AR1           About GenesLikeMe

    Genetic Association Database (GAD): OR5AR1

    Export disorders for OR5AR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5AR1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5AR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1, 4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. Genetic elucidation of human hyperosmia to isovaleric acid. (PubMed id 17973576)2 Menashe I....Lancet D. (PLoS Biol. 2007)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 219493 HGNC: 15260 AceView: OR5AR1 Ensembl:ENSG00000172459 euGenes: HUgn219493
    ECgene: OR5AR1 Kegg: 219493 H-InvDB: OR5AR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5AR1 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5AR1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5AR1 gene:
    Search GeneIP for patents involving OR5AR1

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     OriGene Antibodies for OR5AR1   OriGene RNAi products in human, mouse, rat for OR5AR1  
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     Block miRNA regulation of human, mouse, rat OR5AR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OR5AR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5AR1 Predesigned siRNA for gene silencing in human, mouse, rat OR5AR1
     QuantiFast Probe-based Assays in human, mouse, rat OR5AR1 QuantiTect SYBR Green Assays in human, mouse, rat OR5AR1
     Custom PCR Arrays for OR5AR1 Search Chromatin IP Primers for OR5AR1
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     GenScript Custom Purified and Recombinant Proteins Services for OR5AR1 GenScript cDNA clones with any tag delivered in your preferred vector for OR5AR1
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     Search Tocris compounds for OR5AR1 (O5AR1)
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OR5AR1
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     Browse compounds at ApexBio
     Search Addgene for plasmids for OR5AR1
      Search eBioscience for proteins for OR5AR1
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for OR5AR1
     antibodies-online antibodies for OR5AR1 (11 products)
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      Search antibodies-online for peptides for OR5AR1
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