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Aliases for OR5AP2 Gene

Aliases for OR5AP2 Gene

  • Olfactory Receptor Family 5 Subfamily AP Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AP, Member 2 2
  • Olfactory Receptor, Family 9, Subfamily J, Member 1 3
  • Olfactory Receptor 5AP2 3
  • OR9J1 3

External Ids for OR5AP2 Gene

Previous GeneCards Identifiers for OR5AP2 Gene

  • GC11U990456
  • GC11M056185
  • GC11M056165
  • GC11M056408

Summaries for OR5AP2 Gene

Entrez Gene Summary for OR5AP2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AP2 Gene

OR5AP2 (Olfactory Receptor Family 5 Subfamily AP Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot for OR5AP2 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AP2 Gene

Genomics for OR5AP2 Gene

Regulatory Elements for OR5AP2 Gene

Enhancers for OR5AP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F056895 0.4 FANTOM5 12.8 -253.3 -253345 0.0 OR5M10 OR5M9 OR5AP2 OR5M1 OR5M3 OR5AR1 OR5M8 OR5R1 OR5M11 FADS2P1
GH11F056690 0.4 Ensembl 11.3 -47.8 -47830 0.2 OR5AP2 PIR40739 LOC642975
GH11F056533 0.2 ENCODE 9.9 +108.9 108882 0.1 OR5AP2 OR5G5P GC11M056535 GC11M056536 OR5M5P
GH11F056659 0.7 Ensembl ENCODE 0.3 -17.5 -17459 1.1 JUND BCL11A POLR2A TEAD4 POU5F1 OR5AR1 OR5AP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR5AP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5AP2 Gene

56,641,466 bp from pter
56,642,471 bp from pter
1,006 bases
Minus strand

Genomic View for OR5AP2 Gene

Genes around OR5AP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AP2 Gene

Proteins for OR5AP2 Gene

  • Protein details for OR5AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5AP2
    Protein Accession:
    Secondary Accessions:
    • B2RNM8

    Protein attributes for OR5AP2 Gene

    316 amino acids
    Molecular mass:
    35508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AP2 Gene

Post-translational modifications for OR5AP2 Gene

  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AP2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AP2 Gene

Domains & Families for OR5AP2 Gene

Gene Families for OR5AP2 Gene

Protein Domains for OR5AP2 Gene

Suggested Antigen Peptide Sequences for OR5AP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AP2: view

Function for OR5AP2 Gene

Molecular function for OR5AP2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AP2: view
genes like me logo Genes that share phenotypes with OR5AP2: view

Animal Model Products

miRNA for OR5AP2 Gene

miRTarBase miRNAs that target OR5AP2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR5AP2 Gene

Localization for OR5AP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AP2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5AP2 Gene COMPARTMENTS Subcellular localization image for OR5AP2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AP2: view

Pathways & Interactions for OR5AP2 Gene

genes like me logo Genes that share pathways with OR5AP2: view

Pathways by source for OR5AP2 Gene

Gene Ontology (GO) - Biological Process for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,IBA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AP2: view

No data available for SIGNOR curated interactions for OR5AP2 Gene

Transcripts for OR5AP2 Gene

mRNA/cDNA for OR5AP2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AP2 Gene

Olfactory receptor, family 5, subfamily AP, member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AP2 Gene

No ASD Table

Relevant External Links for OR5AP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5AP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AP2 Gene:


SOURCE GeneReport for Unigene cluster for OR5AP2 Gene:

genes like me logo Genes that share expression patterns with OR5AP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR5AP2 Gene

Orthologs for OR5AP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466575 34
  • 98.95 (n)
OR5AP2 35
  • 97 (a)
(Canis familiaris)
Mammalia OR5AP2 35
  • 89 (a)
LOC100683182 34
  • 88.82 (n)
(Rattus norvegicus)
Mammalia Olr463 34
  • 82.49 (n)
(Mus musculus)
Mammalia Or5ap2 55 Olfr1020 34 16 35
  • 81.86 (n)
Or5ap2b-ps 55 Olfr1021-ps1
  • chr2:85,863,413-85,864,361
(Monodelphis domestica)
Mammalia -- 35
  • 77 (a)
-- 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia OR5AP2 35
  • 55 (a)
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
(Gallus gallus)
Aves LOC430735 34
  • 60.73 (n)
COR6 35
  • 48 (a)
-- 35
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
Species where no ortholog for OR5AP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AP2 Gene

Gene Tree for OR5AP2 (if available)
Gene Tree for OR5AP2 (if available)

Paralogs for OR5AP2 Gene

Paralogs for OR5AP2 Gene

(454) SIMAP similar genes for OR5AP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5AP2: view

Variants for OR5AP2 Gene

Sequence variations from dbSNP and Humsavar for OR5AP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10690878 -- 56,643,260(+) AAGAA(-/AGAA)GGAAG upstream-variant-2KB
rs111667024 -- 56,642,693(+) TTGAA(A/T)AATTA upstream-variant-2KB
rs111927656 -- 56,642,566(+) AATAA(A/C)AGGTA upstream-variant-2KB
rs11228692 -- 56,644,377(+) aaaaa(A/G)aaaaa upstream-variant-2KB
rs113698330 -- 56,642,930(+) GCTTA(-/CAACTGTAATCC)CAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5AP2 Gene

Variant ID Type Subtype PubMed ID
nsv555099 CNV loss 21841781

Variation tolerance for OR5AP2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5AP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AP2 Gene

Disorders for OR5AP2 Gene

Relevant External Links for OR5AP2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5AP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AP2 Gene

Publications for OR5AP2 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OR5AP2 Gene

Sources for OR5AP2 Gene

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