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Aliases for OR5AP2 Gene

Aliases for OR5AP2 Gene

  • Olfactory Receptor Family 5 Subfamily AP Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AP, Member 2 2 3
  • Olfactory Receptor, Family 9, Subfamily J, Member 1 3
  • OR9J1 3

External Ids for OR5AP2 Gene

Previous GeneCards Identifiers for OR5AP2 Gene

  • GC11U990456
  • GC11M056185
  • GC11M056165
  • GC11M056408

Summaries for OR5AP2 Gene

Entrez Gene Summary for OR5AP2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AP2 Gene

OR5AP2 (Olfactory Receptor Family 5 Subfamily AP Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot for OR5AP2 Gene

  • Odorant receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AP2 Gene

Genomics for OR5AP2 Gene

Regulatory Elements for OR5AP2 Gene

Enhancers for OR5AP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR5AP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5AP2 Gene

Chromosome:
11
Start:
56,641,466 bp from pter
End:
56,642,471 bp from pter
Size:
1,006 bases
Orientation:
Minus strand

Genomic View for OR5AP2 Gene

Genes around OR5AP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AP2 Gene

Proteins for OR5AP2 Gene

  • Protein details for OR5AP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGF4-O5AP2_HUMAN
    Recommended name:
    Olfactory receptor 5AP2
    Protein Accession:
    Q8NGF4
    Secondary Accessions:
    • B2RNM8

    Protein attributes for OR5AP2 Gene

    Size:
    316 amino acids
    Molecular mass:
    35508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AP2 Gene

Proteomics data for OR5AP2 Gene at MOPED

Post-translational modifications for OR5AP2 Gene

  • Glycosylation at Asn 11
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AP2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AP2 Gene

Domains & Families for OR5AP2 Gene

Gene Families for OR5AP2 Gene

Protein Domains for OR5AP2 Gene

Suggested Antigen Peptide Sequences for OR5AP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NGF4

UniProtKB/Swiss-Prot:

O5AP2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AP2: view

Function for OR5AP2 Gene

Molecular function for OR5AP2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AP2: view

Phenotypes for OR5AP2 Gene

genes like me logo Genes that share phenotypes with OR5AP2: view

Animal Model Products

CRISPR Products

miRNA for OR5AP2 Gene

miRTarBase miRNAs that target OR5AP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR5AP2 Gene

Localization for OR5AP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AP2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OR5AP2 Gene COMPARTMENTS Subcellular localization image for OR5AP2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AP2: view

Pathways & Interactions for OR5AP2 Gene

genes like me logo Genes that share pathways with OR5AP2: view

Pathways by source for OR5AP2 Gene

Interacting Proteins for OR5AP2 Gene

Gene Ontology (GO) - Biological Process for OR5AP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AP2: view

No data available for SIGNOR curated interactions for OR5AP2 Gene

Drugs & Compounds for OR5AP2 Gene

No Compound Related Data Available

Transcripts for OR5AP2 Gene

mRNA/cDNA for OR5AP2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AP2 Gene

Olfactory receptor, family 5, subfamily AP, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AP2 Gene

No ASD Table

Relevant External Links for OR5AP2 Gene

GeneLoc Exon Structure for
OR5AP2
ECgene alternative splicing isoforms for
OR5AP2

Expression for OR5AP2 Gene

mRNA expression in normal human tissues for OR5AP2 Gene

SOURCE GeneReport for Unigene cluster for OR5AP2 Gene Hs.449692

genes like me logo Genes that share expression patterns with OR5AP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for OR5AP2 Gene

Orthologs for OR5AP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100683182 35
  • 88.82 (n)
  • 89.24 (a)
OR5AP2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Olfr1020 35
  • 81.86 (n)
  • 85.76 (a)
Olfr1020 16
Olfr1020 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC466575 35
  • 98.95 (n)
  • 97.78 (a)
OR5AP2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olr463 35
  • 82.49 (n)
  • 84.18 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia OR5AP2 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC430735 35
  • 60.73 (n)
  • 53.8 (a)
-- 36
  • 47 (a)
ManyToMany
COR6 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
Species with no ortholog for OR5AP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AP2 Gene

ENSEMBL:
Gene Tree for OR5AP2 (if available)
TreeFam:
Gene Tree for OR5AP2 (if available)

Paralogs for OR5AP2 Gene

Paralogs for OR5AP2 Gene

(454) SIMAP similar genes for OR5AP2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OR5AP2: view

Variants for OR5AP2 Gene

Sequence variations from dbSNP and Humsavar for OR5AP2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11606499 - 56,642,127(+) CTGGG(C/T)AGCAC reference, missense
rs61710550 -- 56,644,115(+) TCCCA(C/G)CACTT upstream-variant-2KB
rs61732328 -- 56,642,123(+) AGAAC(C/T)GGGCA reference, missense
rs61742762 -- 56,641,563(+) GAGGG(G/T)ATTTA reference, missense
rs61743175 -- 56,642,057(+) CATAG(C/T)GGTCA reference, missense

Variation tolerance for OR5AP2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for OR5AP2 Gene

Disorders for OR5AP2 Gene

Relevant External Links for OR5AP2

Genetic Association Database (GAD)
OR5AP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5AP2

No disorders were found for OR5AP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AP2 Gene

Publications for OR5AP2 Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5AP2 Gene

Sources for OR5AP2 Gene

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