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Aliases for OR5AL1 Gene

Aliases for OR5AL1 Gene

  • Olfactory Receptor Family 5 Subfamily AL Member 1 (Gene/Pseudogene) 2 3
  • Olfactory Receptor, Family 5, Subfamily AL, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR11-184 3 4
  • OR5AL1P 3 4
  • Olfactory Receptor, Family 5, Subfamily AL, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor 5AL1 3
  • AP002512.3 5

External Ids for OR5AL1 Gene

Previous HGNC Symbols for OR5AL1 Gene

  • OR5AL1P

Previous GeneCards Identifiers for OR5AL1 Gene

  • GC11P055937
  • GC11P056181

Summaries for OR5AL1 Gene

Entrez Gene Summary for OR5AL1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR5AL1 Gene

OR5AL1 (Olfactory Receptor Family 5 Subfamily AL Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR5AL1 Gene

  • Odorant receptor.

Additional gene information for OR5AL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AL1 Gene

Genomics for OR5AL1 Gene

Regulatory Elements for OR5AL1 Gene

Enhancers for OR5AL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H056394 0.2 ENCODE 0.4 -17.8 -17817 0 OR5R1 OR5AL2P OR5AL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR5AL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5AL1 Gene

Chromosome:
11
Start:
56,412,696 bp from pter
End:
56,413,681 bp from pter
Size:
986 bases
Orientation:
Plus strand

Genomic View for OR5AL1 Gene

Genes around OR5AL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AL1 Gene

Proteins for OR5AL1 Gene

  • Protein details for OR5AL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C617-O5AL1_HUMAN
    Recommended name:
    Olfactory receptor 5AL1
    Protein Accession:
    P0C617

    Protein attributes for OR5AL1 Gene

    Size:
    328 amino acids
    Molecular mass:
    36816 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AL1 Gene

Post-translational modifications for OR5AL1 Gene

  • Glycosylation at Asn21
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR5AL1 Gene

Domains & Families for OR5AL1 Gene

Gene Families for OR5AL1 Gene

Protein Domains for OR5AL1 Gene

Suggested Antigen Peptide Sequences for OR5AL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C617

UniProtKB/Swiss-Prot:

O5AL1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AL1: view

Function for OR5AL1 Gene

Molecular function for OR5AL1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR5AL1 Gene

Gene Ontology (GO) - Molecular Function for OR5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AL1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for OR5AL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AL1 Gene

Localization for OR5AL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AL1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AL1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR5AL1 Gene

Pathways & Interactions for OR5AL1 Gene

genes like me logo Genes that share pathways with OR5AL1: view

Pathways by source for OR5AL1 Gene

Interacting Proteins for OR5AL1 Gene

Gene Ontology (GO) - Biological Process for OR5AL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AL1: view

No data available for SIGNOR curated interactions for OR5AL1 Gene

Drugs & Compounds for OR5AL1 Gene

No Compound Related Data Available

Transcripts for OR5AL1 Gene

mRNA/cDNA for OR5AL1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for OR5AL1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AL1 Gene

No ASD Table

Relevant External Links for OR5AL1 Gene

GeneLoc Exon Structure for
OR5AL1
ECgene alternative splicing isoforms for
OR5AL1

Expression for OR5AL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR5AL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AL1 Gene:

OR5AL1
genes like me logo Genes that share expression patterns with OR5AL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR5AL1 Gene

Orthologs for OR5AL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5AL1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or5al1 52 Olfr1042
  • chr2:86,159,430-86,160,368
Or5al5 52 Olfr1039
  • chr2:86,130,705-86,131,661
Or5al6 52 Olfr1040
  • chr2:86,145,794-86,146,732
Species where no ortholog for OR5AL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AL1 Gene

ENSEMBL:
Gene Tree for OR5AL1 (if available)
TreeFam:
Gene Tree for OR5AL1 (if available)

Paralogs for OR5AL1 Gene

(448) SIMAP similar genes for OR5AL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5AL1: view

No data available for Paralogs for OR5AL1 Gene

Variants for OR5AL1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AL1 Gene

O5AL1_HUMAN-P0C617
A double nucleotide deletion at position Cys-156 in the gene coding for this protein produces a stop codon which is responsible for functional diversity thus producing a pseudogene.

Sequence variations from dbSNP and Humsavar for OR5AL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs141036956 -- 56,412,911(+) CTTCA(A/C/T)ACACC nc-transcript-variant, reference, synonymous-codon, missense
rs191218987 -- 56,412,551(+) GAATT(A/G/T)CTACT upstream-variant-2KB
rs562123883 -- 56,412,625(+) ACATA(A/C/G)GATCA nc-transcript-variant, utr-variant-5-prime

Relevant External Links for OR5AL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR5AL1

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR5AL1 Gene

Disorders for OR5AL1 Gene

Relevant External Links for OR5AL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR5AL1

No disorders were found for OR5AL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AL1 Gene

Publications for OR5AL1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  2. Different noses for different people. (PMID: 12730696) Menashe I … Gilad Y (Nature genetics 2003) 3 4 60
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 60
  5. Population differences in the human functional olfactory repertoire. (PMID: 12644552) Gilad Y … Lancet D (Molecular biology and evolution 2003) 3 60

Products for OR5AL1 Gene

Sources for OR5AL1 Gene

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