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Aliases for OR5AK2 Gene

Aliases for OR5AK2 Gene

  • Olfactory Receptor Family 5 Subfamily AK Member 2 2 3 5
  • Olfactory Receptor, Family 5, Subfamily AK, Member 2 2

External Ids for OR5AK2 Gene

Previous GeneCards Identifiers for OR5AK2 Gene

  • GC11U990463
  • GC11P056532
  • GC11P056512
  • GC11P056756

Summaries for OR5AK2 Gene

Entrez Gene Summary for OR5AK2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AK2 Gene

OR5AK2 (Olfactory Receptor Family 5 Subfamily AK Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5B12.

UniProtKB/Swiss-Prot for OR5AK2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AK2 Gene

Genomics for OR5AK2 Gene

Regulatory Elements for OR5AK2 Gene

Enhancers for OR5AK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OR5AK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5AK2 Gene

56,988,872 bp from pter
56,989,867 bp from pter
996 bases
Plus strand

Genomic View for OR5AK2 Gene

Genes around OR5AK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AK2 Gene

Proteins for OR5AK2 Gene

  • Protein details for OR5AK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5AK2
    Protein Accession:
    Secondary Accessions:
    • B2RNZ9

    Protein attributes for OR5AK2 Gene

    309 amino acids
    Molecular mass:
    34627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AK2 Gene

Proteomics data for OR5AK2 Gene at MOPED

Post-translational modifications for OR5AK2 Gene

  • Glycosylation at Asn 5, Asn 155, and Asn 265

Other Protein References for OR5AK2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AK2 Gene

Domains & Families for OR5AK2 Gene

Gene Families for OR5AK2 Gene

Protein Domains for OR5AK2 Gene

Suggested Antigen Peptide Sequences for OR5AK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AK2: view

Function for OR5AK2 Gene

Molecular function for OR5AK2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AK2: view
genes like me logo Genes that share phenotypes with OR5AK2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AK2 Gene

Localization for OR5AK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AK2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5AK2 Gene COMPARTMENTS Subcellular localization image for OR5AK2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

Pathways & Interactions for OR5AK2 Gene

genes like me logo Genes that share pathways with OR5AK2: view

Pathways by source for OR5AK2 Gene

Interacting Proteins for OR5AK2 Gene

Gene Ontology (GO) - Biological Process for OR5AK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AK2: view

No data available for SIGNOR curated interactions for OR5AK2 Gene

Drugs & Compounds for OR5AK2 Gene

No Compound Related Data Available

Transcripts for OR5AK2 Gene

mRNA/cDNA for OR5AK2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR5AK2 Gene

Olfactory receptor, family 5, subfamily AK, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AK2 Gene

No ASD Table

Relevant External Links for OR5AK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5AK2 Gene

mRNA expression in normal human tissues for OR5AK2 Gene

mRNA differential expression in normal tissues according to GTEx for OR5AK2 Gene

This gene is overexpressed in Spleen (x49.5).

Protein differential expression in normal tissues from HIPED for OR5AK2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR5AK2 Gene

SOURCE GeneReport for Unigene cluster for OR5AK2 Gene Hs.554520

genes like me logo Genes that share expression patterns with OR5AK2: view

Protein tissue co-expression partners for OR5AK2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for OR5AK2 Gene

Orthologs for OR5AK2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR5AK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100139408 35
  • 84.04 (n)
  • 79.15 (a)
OR5AK2 36
  • 77 (a)
(Canis familiaris)
Mammalia OR5AK2 35
  • 83.06 (n)
  • 78.32 (a)
OR5AK2 36
  • 42 (a)
(Mus musculus)
Mammalia Olfr993 35
  • 78.69 (n)
  • 75.74 (a)
Olfr993 16
Olfr993 36
  • 74 (a)
Olfr994 36
  • 74 (a)
Olfr995 36
  • 73 (a)
(Pan troglodytes)
Mammalia LOC466581 35
  • 98.27 (n)
  • 96.76 (a)
OR5AK2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Olr440 35
  • 77.6 (n)
  • 76.07 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
-- 36
  • 61 (a)
-- 36
  • 65 (a)
-- 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia OR5AK2 36
  • 49 (a)
(Gallus gallus)
Aves OR8D4 36
  • 45 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
-- 36
  • 43 (a)
-- 36
  • 41 (a)
-- 36
  • 43 (a)
-- 36
  • 41 (a)
Species with no ortholog for OR5AK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AK2 Gene

Gene Tree for OR5AK2 (if available)
Gene Tree for OR5AK2 (if available)

Paralogs for OR5AK2 Gene

Paralogs for OR5AK2 Gene

(442) SIMAP similar genes for OR5AK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR5AK2: view

Variants for OR5AK2 Gene

Sequence variations from dbSNP and Humsavar for OR5AK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10896563 - 56,988,924(+) ACTAG(G/T)AAACA reference, missense
rs2853083 - 56,989,189(+) TTGAT(A/G)TTATT reference, missense
rs12420424 - 56,989,041(+) TAATA(C/G)TGGAA reference, missense
rs7130724 -- 56,988,043(+) ATCCA(A/G)ATGAT upstream-variant-2KB
rs61886711 -- 56,989,546(+) ACTGG(A/G)TTGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for OR5AK2 Gene

Variant ID Type Subtype PubMed ID
nsv832162 CNV Loss 17160897

Variation tolerance for OR5AK2 Gene

Residual Variation Intolerance Score: 86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OR5AK2 Gene

Disorders for OR5AK2 Gene

Relevant External Links for OR5AK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5AK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AK2 Gene

Publications for OR5AK2 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B. … Buck L.B. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OR5AK2 Gene

Sources for OR5AK2 Gene