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Aliases for OR5AC2 Gene

Aliases for OR5AC2 Gene

  • Olfactory Receptor Family 5 Subfamily AC Member 2 2 3 5
  • HSA1 3 4
  • Olfactory Receptor, Family 5, Subfamily AC, Member 2 2
  • Olfactory Receptor 5AC2 3

External Ids for OR5AC2 Gene

Previous GeneCards Identifiers for OR5AC2 Gene

  • GC03P094426
  • GC00U905518
  • GC03P099126
  • GC03P099104
  • GC03P099289
  • GC03P097806

Summaries for OR5AC2 Gene

Entrez Gene Summary for OR5AC2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR5AC2 Gene

OR5AC2 (Olfactory Receptor Family 5 Subfamily AC Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and odorant binding. An important paralog of this gene is OR5H2.

UniProtKB/Swiss-Prot for OR5AC2 Gene

  • Odorant receptor.

Gene Wiki entry for OR5AC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR5AC2 Gene

Genomics for OR5AC2 Gene

Regulatory Elements for OR5AC2 Gene

Enhancers for OR5AC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F098341 0.9 FANTOM5 3 +254.1 254127 0.0 OR5H2 OR5H6 OR5K4 OR5AC2 GC03M098326
GH03F097981 1 FANTOM5 Ensembl ENCODE 2.8 -104.2 -104197 3.0 PKNOX1 STAT1 ATF3 JUN CEBPB BCL6 RARA ARL6 MINA OR5K3 OR5AC2 GABRR3
GH03F097668 0.8 FANTOM5 1.6 -418.0 -418038 0.3 ZNF384 EPHA6 OR5AC2 GC03M097706 GC03M097617
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OR5AC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR5AC2 Gene

98,087,173 bp from pter
98,088,102 bp from pter
930 bases
Plus strand

Genomic View for OR5AC2 Gene

Genes around OR5AC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR5AC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR5AC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR5AC2 Gene

Proteins for OR5AC2 Gene

  • Protein details for OR5AC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 5AC2
    Protein Accession:

    Protein attributes for OR5AC2 Gene

    309 amino acids
    Molecular mass:
    35304 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR5AC2 Gene

Post-translational modifications for OR5AC2 Gene

  • Glycosylation at Asn 7
  • Modification sites at PhosphoSitePlus

Other Protein References for OR5AC2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR5AC2 Gene

Domains & Families for OR5AC2 Gene

Gene Families for OR5AC2 Gene

Protein Domains for OR5AC2 Gene

Suggested Antigen Peptide Sequences for OR5AC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR5AC2: view

Function for OR5AC2 Gene

Molecular function for OR5AC2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 10706615
GO:0005549 odorant binding IBA --
genes like me logo Genes that share ontologies with OR5AC2: view

Phenotypes for OR5AC2 Gene

genes like me logo Genes that share phenotypes with OR5AC2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR5AC2 Gene

Localization for OR5AC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR5AC2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OR5AC2 Gene COMPARTMENTS Subcellular localization image for OR5AC2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10706615
genes like me logo Genes that share ontologies with OR5AC2: view

Pathways & Interactions for OR5AC2 Gene

genes like me logo Genes that share pathways with OR5AC2: view

Pathways by source for OR5AC2 Gene

1 BioSystems pathway for OR5AC2 Gene
1 KEGG pathway for OR5AC2 Gene

Interacting Proteins for OR5AC2 Gene

Gene Ontology (GO) - Biological Process for OR5AC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell NAS 10706615
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR5AC2: view

No data available for SIGNOR curated interactions for OR5AC2 Gene

Transcripts for OR5AC2 Gene

mRNA/cDNA for OR5AC2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR5AC2 Gene

No ASD Table

Relevant External Links for OR5AC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR5AC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR5AC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR5AC2 Gene:


SOURCE GeneReport for Unigene cluster for OR5AC2 Gene:

genes like me logo Genes that share expression patterns with OR5AC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OR5AC2 Gene

Orthologs for OR5AC2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR5AC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC738237 34
  • 79.04 (n)
(Bos Taurus)
Mammalia LOC783655 34
  • 78.25 (n)
-- 35
  • 71 (a)
(Canis familiaris)
Mammalia LOC487942 34
  • 77.63 (n)
-- 35
  • 74 (a)
(Mus musculus)
Mammalia Olfr198 34 16 35
  • 73.62 (n)
(Rattus norvegicus)
Mammalia Olr1537 34
  • 72.63 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
-- 35
  • 67 (a)
-- 35
  • 65 (a)
-- 35
  • 64 (a)
-- 35
  • 62 (a)
Species where no ortholog for OR5AC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR5AC2 Gene

Gene Tree for OR5AC2 (if available)
Gene Tree for OR5AC2 (if available)

Paralogs for OR5AC2 Gene

Paralogs for OR5AC2 Gene

(453) SIMAP similar genes for OR5AC2 Gene using alignment to 1 proteins: Pseudogenes for OR5AC2 Gene

genes like me logo Genes that share paralogs with OR5AC2: view

Variants for OR5AC2 Gene

Sequence variations from dbSNP and Humsavar for OR5AC2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs193920759 Uncertain significance 98,087,902(+) CATGC(A/G)GCGCC reference, missense
rs10640108 -- 98,085,295(+) AAATA(-/ATA)TAAAT upstream-variant-2KB
rs10687513 -- 98,085,291(+) TTAAA(-/AAT)AATAT upstream-variant-2KB
rs111557896 -- 98,088,206(+) GAGGG(C/T)TAGTG downstream-variant-500B
rs112246201 -- 98,085,293(+) AAAAA(-/ATA/TAA)TATAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OR5AC2 Gene

Variant ID Type Subtype PubMed ID
nsv1013060 CNV gain 25217958

Variation tolerance for OR5AC2 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR5AC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR5AC2 Gene

Disorders for OR5AC2 Gene

Relevant External Links for OR5AC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OR5AC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR5AC2 Gene

Publications for OR5AC2 Gene

  1. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64
  2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PMID: 10706615) Rouquier S. … Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 64

Products for OR5AC2 Gene

Sources for OR5AC2 Gene

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