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OR5AC2 Gene

protein-coding   GIFtS: 44
GCID: GC03P097806

Olfactory Receptor, Family 5, Subfamily AC, Member 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Olfactory Receptor, Family 5, Subfamily AC, Member 21 2
HSA12 3
Olfactory Receptor 5AC22

External Ids:    HGNC: 154311   Entrez Gene: 810502   Ensembl: ENSG000001965787   UniProtKB: Q9NZP53   

Export aliases for OR5AC2 gene to outside databases

Previous GC identifers: GC03P094426 GC00U905518 GC03P099126 GC03P099104 GC03P099289


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OR5AC2 Gene:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled
receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain
structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G
protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the
genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent
of other organisms. (provided by RefSeq, Jul 2008)

GeneCards Summary for OR5AC2 Gene:
OR5AC2 (olfactory receptor, family 5, subfamily AC, member 2) is a protein-coding gene. Diseases associated with OR5AC2 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR5H15.

UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5
Function: Odorant receptor (Potential)

Gene Wiki entry for OR5AC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the OR5AC2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Brachyury   Nkx3-1 v1   Nkx3-1 v2   PPAR-gamma1   Nkx6-1   FOXC1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OR5AC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.1   Ensembl cytogenetic band:  3q11.2   HGNC cytogenetic band: 3q11.2

OR5AC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR5AC2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P097806:  view genomic region     (about GC identifiers)

Start:
97,806,017 bp from pter      End:
97,806,943 bp from pter
Size:
927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5 (See protein sequence)
Recommended Name: Olfactory receptor 5AC2  
Size: 309 amino acids; 35304 Da

Explore the universe of human proteins at neXtProt for OR5AC2: NX_Q9NZP5

Explore proteomics data for OR5AC2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn7
  • HORDE protein sequence for OR5AC2

    See OR5AC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_473447.1  
    ENSEMBL proteins: 
     ENSP00000351466  
    Reactome Protein details: Q9NZP5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    OR5: GPCR / Class A : Olfactory receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000725 Olfact_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9NZP5

    ProtoNet protein and cluster: Q9NZP5

    1 Blocks protein domain: IPB000725 Olfactory receptor signature

    UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OR5AC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: O5AC2_HUMAN, Q9NZP5
    Function: Odorant receptor (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004984olfactory receptor activity NAS10706615
         
    OR5AC2 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    O5AC2_HUMAN, Q9NZP5: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    chloroplast1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS10706615

    OR5AC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OR5AC2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Olfactory Signaling Pathway
    Olfactory Signaling Pathway0.82
    Olfactory transduction0.82
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for OR5AC2
        Olfactory Signaling Pathway


    1 Kegg Pathway  (Kegg details for OR5AC2):
        Olfactory transduction


    OR5AC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OR5AC2
    Interactions:

        Search GeneGlobe Interaction Network for OR5AC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OR5AC2 (ENSP000003514664) via UniProtKB, MINT, STRING, and/or I2D (see all 273)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OR52E6ENSP000003288784STRING: ENSP00000369279 STRING: ENSP00000328878
    OR10Q1ENSP000003143244STRING: ENSP00000314324
    OR1J2ENSP000003355754STRING: ENSP00000335575
    OR4A16ENSP000003251284STRING: ENSP00000325128
    OR4A5ENSP000003676644STRING: ENSP00000367664
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007608sensory perception of smell NAS10706615
    GO:0050911detection of chemical stimulus involved in sensory perception of smell NAS10706615

    OR5AC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OR5AC2 (O5AC2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OR5AC2 gene: 
    NM_054106.1  

    Unigene Cluster for OR5AC2:

    Olfactory receptor, family 5, subfamily AC, member 2
    Hs.554715
    Unigene Representative Sequence: NM_054106
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000358642(uc011bgs.2)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OR5AC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTGAGAAG
    OR5AC2 Expression
    About this image

    OR5AC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OR5AC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554715
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for OR5AC2 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Olfr1981 , 5 olfactory receptor 1981, 5 73.62(n)1
    70.53(a)1
      16 (34.83 cM)5
    2580361  NM_001011808.11  NP_001011808.11 
     592015045 


    ENSEMBL Gene Tree for OR5AC2 (if available)
    TreeFam Gene Tree for OR5AC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OR5AC2 gene
    OR5H152  OR5K32  OR5K12  OR5H142  OR5H62  OR5K22  OR5H22  OR5K42  
    OR5H8P2  OR5H12  OR5AC12  
    Selected SIMAP similar genes for OR5AC2 using alignment to 1 protein entry:     O5AC2_HUMAN(see all similar genes):
    OR5AC1    OR5H2    OR5H1    OR5H6    OR5H14    OR5H15
    OR5K1    OR5K2    OR5K3    OR5K4    OR8D1    OR5AP2
    OR5AR1    OR8G5    OR8B2    OR8B3    OR8G1    OR5A2

    OR5AC2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for OR5AC2
    PGOHUM00000238103 PGOHUM00000238104


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OR5AC2 (see all 147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162810991,2
    C,F--97804039(+) TCTACG/ACTGGA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs14920521,2
    C,F,A,H--97804043(+) CGCTGA/GAAATT 1 -- us2k121Minor allele frequency- G:0.48NS EA NA WA CSA 2134
    rs1867133051,2
    --97804090(+) AATCTG/TTATCT 1 -- us2k10--------
    rs1924994721,2
    --97804123(+) TATACA/GCAAAA 1 -- us2k10--------
    rs106875131,2
    C--97804135(+) TTAAA-/AATAATAT 1 -- cds1 tfbs30--------
    rs665955601,2
    C--97804136(+) TAAAA-/AATATATA 1 -- cds10--------
    rs725849031,2
    C--97804138(+) AWAAT-/A/ATA 
            
    ATAAA
    2 -- us2k1 cds10--------
    rs1147585891,2
    F--97804203(+) ATTGAG/AAAAAT 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1155595721,2
    F--97804214(+) GCTCCG/AATTTT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1127710391,2
    F--97804346(+) CTTCAT/GGAACA 1 -- us2k12Minor allele frequency- G:0.06CSA WA 120

    HapMap Linkage Disequilibrium report for OR5AC2 ( 97806017 - 97806943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OR5AC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877207CNV Gain21882294
    nsv877209CNV Gain21882294

    Human Gene Mutation Database (HGMD): OR5AC2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for OR5AC2:    About MalaCards
    neuronitis


    OR5AC2 for disorders           About GeneDecksing


    Export disorders for OR5AC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OR5AC2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OR5AC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    2. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (Proc. Natl. Acad. Sci. U.S.A. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81050 HGNC: 15431 Ensembl:ENSG00000196578 euGenes: HUgn81050 ECgene: OR5AC2 Kegg: 81050
    H-InvDB: OR5AC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OR5AC2 Pharmacogenomics, SNPs, Pathways
    HORDE entry for OR5AC2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OR5AC2 gene:
    Search GeneIP for patents involving OR5AC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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