OR5AC2 Gene
protein-coding GIFtS: 43
GCID: GC03P097806
|
|
olfactory receptor, family 5, subfamily AC, member 2
| |
Aliases
for OR5AC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Olfactory Receptor, Family 5, Subfamily AC, Member 21 2 | | HSA11 2 3 | | Olfactory Receptor 5AC22 |
Export aliases for OR5AC2 gene to outside databasesPrevious GC identifers: GC03P094426 GC00U905518 GC03P099126 GC03P099104 GC03P099289 |
Summaries
for OR5AC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for OR5AC2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5Function: Odorant receptor (Potential)
Gene Wiki entry for OR5AC2
|
Genomic Views
for OR5AC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR5AC2 gene promoter:
Nkx3-1 Nkx3-1 v4 Brachyury Nkx3-1 v1 Nkx3-1 v2 PPAR-gamma1 Nkx6-1 FOXC1 Nkx3-1 v3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR5AC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5AC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q12.1 Ensembl cytogenetic band: 3q11.2 HGNC chromosome: 3OR5AC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P097806: view genomic region
(about GC identifiers)
Start:
|
97,806,017 bp from pter |
End:
|
97,806,943 bp from pter |
Size:
|
927 bases |
Orientation:
|
plus strand |
|
Proteins
for OR5AC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5 (See
protein sequence)Recommended Name: Olfactory receptor 5AC2 Size: 309 amino acids; 35304 Da
Subcellular location: Cell membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for OR5AC2: NX_Q9NZP5
HORDE protein sequence for OR5AC2
OR5AC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_473447.1
ENSEMBL proteins: ENSP00000351466 Reactome Protein details: Q9NZP5
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
OR5AC2 for ontologies About GeneDecksing
OR5AC2 Antibody Products:
Assay Products for OR5AC2: |
Protein
Domains /
Families
for OR5AC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR5AC2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZP5ProtoNet protein and cluster: Q9NZP5 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for OR5AC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: O5AC2_HUMAN, Q9NZP5Function: Odorant receptor (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OR5AC2 (NM_054106) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR5AC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5AC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5AC2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
NAS | 10706615 |
OR5AC2 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR5AC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by GPCR | | | 2 | Olfactory transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for OR5AC2
1 
Kegg Pathway (Kegg details for OR5AC2):
OR5AC2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR5AC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for OR5AC2 (ENSP000003514664) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007608 | sensory perception of smell |
NAS | 10706615 | | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
NAS | 10706615 |
OR5AC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR5AC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OR5AC2
Search CenterWatch for drugs/clinical trials and news about OR5AC2 / O5AC2
|
Transcripts
for OR5AC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OR5AC2 gene: NM_054106.1 Unigene Cluster for OR5AC2: Olfactory receptor, family 5, subfamily AC, member 2 Hs.554715 Unigene Representative Sequence: NM_0541061 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000358642(uc011bgs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OR5AC2 (NM_054106) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OR5AC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5AC2 |
GeneLoc Exon Structure
|
Expression
for OR5AC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OR5AC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTGAGAAG
About this image
See OR5AC2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.554715
SABiosciences Custom PCR Arrays for OR5AC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR5AC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OR5AC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR5AC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR5AC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5AC2 |
Orthologs
for OR5AC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for OR5AC2 (if available)
TreeFam Gene Tree for OR5AC2 (if available) |
Paralogs
for OR5AC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for OR5AC2 gene
- OR5H152 OR5K32 OR5H62 OR5K12 OR5H142 OR5K22 OR5H22 OR5K42
- OR5H12
18/455 SIMAP similar genes for OR5AC2 using alignment to 1 protein entry: O5AC2_HUMAN(see all similar genes):OR5AC1 OR5H2 OR5H1 OR5H6 OR5H14 OR5H15
OR5K1 OR5K2 OR5K3 OR5K4 OR8D1 OR5AP2
OR5AR1 OR8G5 OR8B2 OR8B3 OR8G1 OR5A2
OR5AC2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for OR5AC2
PGOHUM00000238103 PGOHUM00000238104
|
Genomic Variants
for OR5AC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OR5AC2 ( 97806017 - 97806943 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR5AC2: --
Human Gene Mutation Database (HGMD): OR5AC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR5AC2 |
|
Disorders
/ Diseases
for OR5AC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OR5AC2 for disorders About GeneDecksing
1  disease for OR5AC2: About MalaCardsneuronitis
Export disorders for OR5AC2 gene to outside databases
|
Publications
for OR5AC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OR5AC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OR5AC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
- The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. (PubMed id 10706615)1, 2 Rouquier S.... Giorgi D. (2000)
|
External Searches for OR5AC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OR5AC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR5AC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR5AC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OR5AC2 | Pharmacogenomics, SNPs, Pathways | | HORDE entry for OR5AC2 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR5AC2 gene:
Search GeneIP for patents involving OR5AC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR5AC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for OR5AC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OR5AC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OR5AC2 | | | OriGene Protein Over-expression Lysate for OR5AC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OR5AC2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OR5AC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OR5AC2 | | OriGene Custom Protein Services for OR5AC2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OR5AC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OR5AC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OR5AC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OR5AC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OR5AC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OR5AC2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OR5AC2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | OR5AC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OR5AC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for OR5AC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OR5AC2 |
|
|
|
|
